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  • reaction
  • During the reaction, molecular oxygen is heterolytically cleaved with sequential incorporation of one oxygen atom into BH4 and phenylalanine substrate. (wikipedia.org)
  • When productive, though, the Fe(IV)=O intermediate is added to phenylalanine in an electrophilic aromatic substitution reaction that reduces iron from the ferryl to the ferrous state. (wikipedia.org)
  • Although initially an arene oxide or radical intermediate was proposed, analyses of the related tryptophan and tyrosine hydroxylases have suggested that the reaction instead proceeds through a cationic intermediate that requires Fe(IV)=O to be coordinated to a water ligand rather than a hydroxo group. (wikipedia.org)
  • dopamine
  • In neurons that use DA as the transmitter, the decarboxylation of l-DOPA to DA is the final step in transmitter, However, in those neurons using norepinephrine (also known as noradrenaline) or epinephrine (adrenaline) as transmitters, the enzyme dopamine b-hydroxylase (DBH), which converts DA to yield NE, is also present. (wikipedia.org)
  • substrate
  • During the reaction, molecular oxygen is heterolytically cleaved with sequential incorporation of one oxygen atom into BH4 and phenylalanine substrate. (wikipedia.org)