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  • vaccination
  • This study indicated the existence of at least two major B. pertussis lineages related to the pre and post-vaccination periods (Harvill et al. (fiocruz.br)
  • The current vaccination schedule for pertussis comprise 3 primary doses of ACV at 2, 4, and 6 months of age, and a booster vaccination at 4 years of age. (cdc.gov)
  • In addition to presenting the newly recommended schedule for the administration of vaccines during childhood, this report addresses the previous differences between the AAP and ACIP childhood vaccination schedules and the rationale for changing previous recommendations. (cdc.gov)
  • For approximately 30 years, the Advisory Committee on Immunization Practices (ACIP) and the Committee on Infectious Diseases (COID) of the American Academy of Pediatrics (AAP) -- the two groups responsible for developing vaccine recommendations for the public and private sectors -- worked to develop similar schedules for routine childhood vaccination. (cdc.gov)
  • In 1994, the substantial differences between the recommended AAP and ACIP schedules included the schedule for infant hepatitis B vaccination and the timing of the third dose of oral poliovirus vaccine (OPV) and the second dose of MMR ( Table_2 ). (cdc.gov)
  • strain
  • A number of studies have documented the circulation of strains with allelic variants that differ from those of the vaccine strain (van Loo et al. (fiocruz.br)
  • 2010). A recent study based on whole-genome analyses evaluated B. pertussis strains recovered worldwide, though no Brazilian strain was included. (fiocruz.br)
  • Here, we report the first B. pertussis genome sequence of a clinical strain isolated in the northeastern region of Brazil (Bz181), in 2013. (fiocruz.br)
  • The B. pertussis Bz181 strain is deposited in the Collection of Bacteria of the Environment and Health at the Oswaldo Cruz Foundation (Fiocruz), Brazil. (fiocruz.br)
  • The lower immunogenicity of DTwP against pertussis may be related to the bacterial strain used or the formulation protocol adopted for the vaccine preparation. (ac.ir)
  • dose
  • The schedule would identify a specified age for administering each vaccine dose and provide an acceptable range of ages to ensure flexibility for health-care providers. (cdc.gov)
  • report
  • Practitioners should consult the Report of the Committee on Infectious Diseases (Red Book) (2), the vaccine-specific recommendations of ACIP, and the official manufacturers' package inserts or the Physician's Desk Reference (PDR) (7) for detailed information and specific recommendations for administration of vaccines. (cdc.gov)
  • determine
  • To determine the immunogenicity of locally manufactured DTwP vaccine administered to preschool children in a number of health centers of Tehran in 2006. (ac.ir)
  • years
  • In this prospective study, 350 children aged 4-6 years were injected with DTwP vaccine manu-factured by Razi Institute of Iran. (ac.ir)
  • specific
  • The immunogenicity of the vaccine was assayed by measurement of specific antibodies using enzyme-linked immunosorbent assay (ELISA) technique. (ac.ir)
  • toxin
  • In response to mass pertussis vaccination campaigns beginning in the 1950s, the B. pertussis microbe evolved to evade both whole cell and acellular pertussis vaccines, creating new strains producing more toxin to suppress immune function and cause more serious disease. (mercola.com)
  • Two lines of evidence implicate pertussis toxin as the active bacterial component. (pnas.org)
  • A mutant that produces a defective pertussis toxin had greatly diminished capacity to induce encephalopathy, whereas a hemolysin- and adenylate-cyclase-deficient avirulent mutant had the same activity in the mouse model as a virulent strain. (pnas.org)
  • Purified pertussis toxin plus bovine serum albumin was tested and found to induce the lethal encephalopathy, demonstrating that the toxin was the critical constituent of B. pertussis responsible for encephalopathy. (pnas.org)
  • Pertussis toxin is different where its pentameric ring is made up of four different protein components, where one of the components is repeated to form a heteropentamer. (wikipedia.org)
  • Cholera toxin, pertussis toxin, and shiga toxin all have their targets in the cytosol of the cell. (wikipedia.org)
  • The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. (wikipedia.org)
  • symptoms of pertussis
  • The study concluded that infant baboons given Sanofi DTaP (Daptacel) vaccine at two, four, and six months of age were protected against developing outward clinical symptoms of pertussis after being exposed to B. pertussis at seven months of age, but they were still able colonize and transmit B. pertussis to other baboons. (mercola.com)
  • Play media Play media The classic symptoms of pertussis are a paroxysmal cough, inspiratory whoop, and fainting, or vomiting after coughing. (wikipedia.org)
  • herd immunity
  • Very high pertussis vaccination rates in the U.S. and many other countries for the past several decades should be more than sufficient to achieve vaccine-acquired herd immunity, if the theory of vaccine-acquired herd immunity is correct. (mercola.com)
  • Rather, it was assumed that because wP vaccines appeared to confer herd immunity, they therefore blocked carriage. (mercola.com)
  • 2 This busts a major hole in the entire argument that vaccines achieve herd immunity, which is used as justification for mandatory vaccination campaigns. (mercola.com)
  • 1996
  • 1996 - Facility licensed for commercial production of Pertussis vaccine. (wikipedia.org)
  • Schneerson received the 1996 Albert Lasker Award for Clinical Medical Research and the Pasteur Award from the World Health Organization Children's Vaccine Initiative, both with her colleague Robbins. (wikipedia.org)
  • pregnant women
  • Doctors recommend that pregnant women get the pertussis vaccine during their third trimester. (kpbs.org)
  • It is recommended for pregnant women who have never received tetanus vaccine (i.e., have never received DTP, DTaP or DT as child or Td or TT as adult) to receive a series of three Td vaccinations starting during pregnancy to ensure protection against maternal and neonatal tetanus. (wikipedia.org)
  • 1985
  • The DPT vaccine was highly reactive and carried a high risk of serious allergic reactions and brain inflammation leading to permanent brain damage, as detailed in the groundbreaking 1985 book " DPT: A Shot in the Dark ," co-authored by Barbara Loe Fisher, cofounder of the National Vaccine Information Center. (mercola.com)
  • On February 12, 1985, the American Academy of Pediatrics hosted a meeting to discuss ways of dealing with the current shortage of diphtheria-tetanus-pertussis (DTP) vaccine. (cdc.gov)
  • Current information indicates that adequate supplies of DTP vaccine should become available in mid- or late 1985. (cdc.gov)
  • In 1985, Fisher and Harris Coulter co-authored a book, DPT: A Shot in the Dark, which asserted an association between the whole cell pertussis (whooping cough) vaccine in the DPT shot and autism. (wikipedia.org)
  • He has worked on protective and harmful immunological reactions to viruses, inflammatory lung disease and vaccine development since 1985, authoring over 200 scientific articles (H index= 52). (wikipedia.org)
  • With the added involvement of industry, three Hib-purified polysaccharide vaccines were produced and licensed in 1985. (wikipedia.org)
  • between 1985 and 1988, fewer than 100 children died from pertussis. (wikipedia.org)
  • conjugate
  • On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into, Pneumococcal Conjugate Vaccine (PCV13), Pneumococcal Polysaccharide Vaccine (PPSV23. (medindia.net)
  • Rappuoli led Chiron Corporation's development of adjuvanted influenza vaccines, MENJUGATE(R) conjugate vaccine against meningococcal-C disease and the first recombinant bacterial vaccine against pertussis. (wikipedia.org)
  • Quadrivalent, pentavalent, and hexavalent formulations contain DTaP with one or more of the additional vaccines: inactivated poliovirus vaccine (IPV), Haemophilus influenzae type b conjugate, Hepatitis B, with the availability varying in different countries. (wikipedia.org)
  • This novel process-called a "conjugate" vaccine-worked. (wikipedia.org)
  • Centers for Diseas
  • In this issue of Pediatrics , Moro et al 4 report on the safety of the DTaP vaccine, evaluated through the review of data from the Vaccine Adverse Event Reporting System (VAERS) of the Centers for Disease Control and Prevention in the United States. (aappublications.org)
  • The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recommend all children should be routinely vaccinated for pertussis. (sbwire.com)
  • bacterial
  • Erythromycin is a broad-spectrum antibiotic that treats a host of bacterial infections, including those that cause bronchitis, pertussis, pneumonia, rheuma. (reference.com)
  • The two became an inseparable research team, "dedicated to developing vaccines to protect children from bacterial diseases. (wikipedia.org)
  • Adverse Event Reporting System
  • In the early 1980s, the organization joined with the American Academy of Pediatrics to draft the original legislation for the National Childhood Vaccine Injury Act of 1986, which created a federal vaccine injury compensation program, mandated that doctors give parents vaccine benefit and risk information, and required the recording and reporting of vaccine injuries and deaths (see Vaccine Adverse Event Reporting System). (wikipedia.org)
  • 1997
  • The composition, safety, and immunogenicity of various DTaP vaccines were extensively studied before and after their licensure in 1991, when DTaP was recommended for the fourth and fifth doses in toddlers, and through and after 1997, when the recommendation was extended to the primary infant vaccination series. (aappublications.org)
  • 1997-1999 - Facility licensed by UK, MCA and Italian Health Branch for Meningitis C polysaccharide and CRM197 carrier protein for conjugated vaccine Menjugate. (wikipedia.org)
  • DTwP
  • The challenge for future pertussis vaccine development is to address the benefit-risk trade-off highlighted by our study," they wrote, "and to develop vaccines that induce long-lasting protection from the first dose, without the adverse events associated with DTwP use. (medpagetoday.com)
  • In many developed countries, including the U.S. and Australia, DTaP (diphtheria, tetanus, and acellular pertussis) replaced DTwP (diphtheria, tetanus, and whole-cell pertussis) in the 1990s because it carried a lower risk of such adverse events as injection-site reactions and fever. (medpagetoday.com)
  • Children who received the three-dose primary series with DTaP only had higher rates of pertussis compared with those who received the primary series with DTwP only, both during the pre-epidemic period (13.2 versus 5.2 per 100,000 per year) and the outbreak period (373.1 versus 113.3 per 100,000 per year). (medpagetoday.com)
  • In 2015, procurement of DTwP vaccine through UNICEF had reached 5.8 million doses for 18 countries and territories out of which four countries such as Egypt, Morocco, Uzbekistan, and Zimbabwe accounted for more than 80% of UNICEF's total procurement. (sbwire.com)
  • infant
  • We analyzed characteristics of fatal and nonfatal infant pertussis cases reported nationally during 1991-2008. (aappublications.org)
  • In fact, many scientists believed that a polysaccharide-based vaccine would never work because immature defenses of the infant immune system were not savvy enough to detect the polysaccharide and make antibodies. (wikipedia.org)
  • resurgence
  • The recent resurgence in pertussis infections is put down to a combination of waning immunity and new mutations in the pathogen that existing vaccines are unable to effectively control. (wikipedia.org)