• Plasmodium falciparum, the causative agent of malaria, is sensitive to oxidative stress and therefore the family of antioxidant enzymes, peroxiredoxins (Prxs) represent a target for antimalarial drug design. (rcsb.org)
  • Peroxiredoxins (Prxs), including cytosolic/nuclear 1-Cys-Prx, cytosolic PrxIIC, mitochondrial PrxIIE, and plastidic PrxIIF, 2-Cys-Prx, and PrxQ, were detected in both species, but Norway maple embryonic axes contained higher levels of PrxIIC and PrxIIE, two Prxs with the highest peroxide detoxification potential in Arabidopsis. (uni-bielefeld.de)
  • Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. (ewha.ac.kr)
  • Peroxiredoxins (Prxs) are a protein family that shows an amazing array of supramolecular assemblies, making them attractive tectons. (tue.nl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Peroxiredoxin 6 (PRDX6) in samples from serum, plasma, tissue homogenates or other biological fluids. (lotuskringpoeldijk.nl)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Peroxiredoxin 6 (PRDX6) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Peroxiredoxin 6 (PRDX6) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
  • Description: Quantitative sandwich ELISA for measuring Human Peroxiredoxin-6 (PRDX6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (lotuskringpoeldijk.nl)
  • The aim of the work was to study effects of peroxiredoxin 6 (PRDX6), a recombinant antioxidant protein , on the level of pro-inflammatory responses of RAW 264.7 macrophages to endotoxin exposure. (bvsalud.org)
  • Peroxiredoxin 6 added within the first hours of the development of acute pro-inflammatory response suppressed the P53 gene expression, indicating protective effect of PRDX6 that reduced apoptosis in the RAW 264.7 macrophages . (bvsalud.org)
  • However, a recently identified novel antioxidant from a family of peroxidases, the peroxiredoxins (Prx), has been shown to reduce hydroperoxides with the use of electrons provided by a thioredoxin or a glutaredoxin [ 16 ]. (biomedcentral.com)
  • Here, we demonstrate that the antioxidant PRDX1 (peroxiredoxin 1) has a crucial role in the maintenance of lipophagic flux in macrophages. (ewha.ac.kr)
  • The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv ), styled as a holiday wreath. (ucsf.edu)
  • 2-Cys peroxiredoxins are reduced by thiols such as thioredoxins, thioredoxin-like proteins, or possibly glutathione, whereas the 1-Cys enzymes may be reduced by ascorbic acid or glutathione in the presence of GST-π. (wikipedia.org)
  • Now, Keisuke Yoshida, Toru Hisabori and colleagues have identified two proteins, constituting the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade, that help control the reoxidation of these photosynthetic proteins by modifying key parts of the molecular players. (sciencedaily.com)
  • Kang SW, Baines IC, Rhee SG: Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (drugbank.com)
  • Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. (thermofisher.com)
  • The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). (wikipedia.org)
  • One of these upregulated proteins was identified as peroxiredoxin-4 (Prx4). (biomedcentral.com)
  • Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB: 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (drugbank.com)
  • 19 ] suggested that tocotrienol rich fraction directly influenced the expression dynamics of peroxiredoxin-2 in H 2 O 2 challenged lymphocyte cells to improve the cells ability to resist oxidative damage. (biomedcentral.com)
  • However, the physiological roles of the peroxiredoxins have not been determined. (ewha.ac.kr)
  • The active sites of the peroxiredoxins feature a redox-active cysteine residue (the peroxidatic cysteine), which undergoes oxidization to a sulfenic acid by the peroxide substrate. (wikipedia.org)
  • This is in contrast with the previously described effects of a Plasmodium berghei ANKA 2-cys-peroxiredoxin that promotes pro-inflammatory cytokine production. (biomedcentral.com)
  • Mice lacking peroxiredoxin 1 or 2 develop severe haemolytic anemia, and are predisposed to certain haematopoietic cancers. (wikipedia.org)
  • Peroxiredoxin 1 knockout mice have a 15% reduction in lifespan. (wikipedia.org)
  • Peroxiredoxin 6 knockout mice are viable and do not display obvious gross pathology, but are more sensitive to certain exogenous sources of oxidative stress, such as hyperoxia. (wikipedia.org)
  • To assist with identification of new members and the subgroup to which they belong, a searchable database (the PeroxiRedoxin classification indEX) including Prx sequences identified from GenBank (January 2008 through October 2011) was generated by bioinformatics analysis and is publicly available. (wikipedia.org)
  • Description: A sandwich ELISA kit for detection of Peroxiredoxin 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
  • The Crystal Structures of Oxidized Forms of Human Peroxiredoxin 5 with an Intramolecular Disulfide Bond Confirm the Proposed Enzymatic Mechanism for Atypical 2-Cys Peroxiredoxins. (expasy.org)
  • GTT might directly influence the expression dynamics of peroxiredoxin-4 to control proliferation in liver cancer. (biomedcentral.com)
  • Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. (elsevierpure.com)
  • Protective Effects of Peroxiredoxin 6 in Pro-Inflammatory Response Model Using Raw 264.7 Macrophages. (bvsalud.org)
  • E. Ratajczak, K.-J. Dietz, and E.M. Kalemba, "The Occurrence of Peroxiredoxins and Changes in Redox State in Acer platanoides and Acer pseudoplatanus During Seed Development", JOURNAL OF PLANT GROWTH REGULATION , vol. 38, 2019, pp. 298-314. (uni-bielefeld.de)
  • We show that ABHD10 is a member of the APT family of regulatory proteins and identify peroxiredoxin-5 (PRDX5), a key antioxidant protein, as a target of ABHD10 S -depalmitoylase activity. (nature.com)
  • Description: A sandwich ELISA for quantitative measurement of Human Peroxiredoxin 5 (PRDX5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (signetlabs.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Peroxiredoxin 5 (PRDX5) in Tissue homogenates, cerebrospinal fluid and other biological fluids. (signetlabs.com)
  • This study tested the hypothesis that two of these novel markers, copeptin (a C-terminal portion of provasopressin) and/or peroxiredoxin-4 (Prx4), an enzyme that degrades hydrogen peroxide, singly or together are helpful in predicting death in the near term among patients presenting to the ED with NSCs. (unibas.ch)
  • At present we study the role of another peroxisomal antioxidant enzyme, the peroxiredoxin Pmp20, in yeast ageing (Bener et al. (rug.nl)
  • Prdx6 is a unique member of the peroxiredoxin antioxidant enzyme family possessing both glutathione peroxidase and phospholipase A2 activities. (nih.gov)
  • PRDX1 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. (prospecbio.com)
  • Peroxiredoxins (PRDXs), a family of peroxidases, is composed of six PRDX isoforms (PRDX1 to PRDX6) which played important roles in anti-oxidation processes [ 3 , 4 ]. (jcancer.org)
  • 1 of the Peroxiredoxin 1 (PRDX1) Polyclonal Antibody (Mouse) can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. (peroxyredoxins.com)
  • Examination of the mitochondrial thioredoxin reductase 2 (TR2)-thioredoxin 2 (TRX2)-peroxiredoxin 3 (PRX3) antioxidant network revealed that TS modifies the electrophoretic mobility of PRX3. (nih.gov)
  • 2015). Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum . (up.pt)
  • Peroxiredoxin Q of Arabidopsis thaliana is attached to the thylakoids and functions in context of photosynthesis. (mpg.de)
  • Peroxiredoxins are frequently referred to as alkyl hydroperoxide reductase (AhpC) in bacteria. (wikipedia.org)
  • The active sites of the peroxiredoxins feature a redox-active cysteine residue (the peroxidatic cysteine), which undergoes oxidization to a sulfenic acid by the peroxide substrate. (wikipedia.org)
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). (expasy.org)
  • 11. Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer. (nih.gov)
  • Peroxiredoxin-1 is plays a role in redox regulation of the cell. (prospecbio.com)
  • 15. Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men. (nih.gov)
  • Peroxiredoxin 1 knockout mice have a 15% reduction in lifespan. (wikipedia.org)
  • Peroxiredoxin 6 knockout mice are viable and do not display obvious gross pathology, but are more sensitive to certain exogenous sources of oxidative stress, such as hyperoxia. (wikipedia.org)
  • Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. (wakehealth.edu)
  • Poynton RA, Peskin AV, Haynes AC, Lowther WT, Hampton MB, Winterbourn CC. Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. (wakehealth.edu)
  • 6. Systematic Characterization of Prognostic Values of Peroxiredoxin Family in Gastric Cancer. (nih.gov)
  • 12. Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer. (nih.gov)
  • Peroxiredoxin I, a cytosol form, is the most abundant and ubiquitously distributed member of the mammalian Prx family, and it has been identified in a large variety of organisms. (biomedcentral.com)
  • 2. The prognostic values of the peroxiredoxins family in ovarian cancer. (nih.gov)
  • 9. The Prognosis Of Peroxiredoxin Family In Breast Cancer. (nih.gov)
  • 18. Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins. (nih.gov)
  • 13. Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients. (nih.gov)
  • 19. Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. (nih.gov)
  • Peroxiredoxin decreases peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. (prospecbio.com)
  • Peroxiredoxin is involved in eliminating peroxides generated during metabolism. (prospecbio.com)
  • Mice lacking peroxiredoxin 1 or 2 develop severe haemolytic anemia, and are predisposed to certain haematopoietic cancers. (wikipedia.org)
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins. (expasy.org)
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. (expasy.org)
  • Peroxiredoxin participates in the signaling cascades of growth factors and TNF-alpha by regulating the intracellular concentrations of h(2)o(2). (prospecbio.com)
  • To assist with identification of new members and the subgroup to which they belong, a searchable database (the PeroxiRedoxin classification indEX) including Prx sequences identified from GenBank (January 2008 through October 2011) was generated by bioinformatics analysis and is publicly available. (wikipedia.org)
  • Zhang X, Gao F, Li N, Zhang J, Dai L, Yang H. Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis. (jcancer.org)
  • 1. Peroxiredoxin-5 is a negative survival predictor in ovarian cancer. (nih.gov)
  • 3. Peroxiredoxin-1 as a prognostic factor in patients with ovarian cancer. (nih.gov)
  • Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells. (nih.gov)