• GUR-3 detects hydrogen peroxide, whether it is found naturally in the environment or generated by light. (mit.edu)
  • There are many GUR-3 receptors in the I2 neuron, and through a mechanism that remains unknown, hydrogen peroxide stimulation of GUR-3 causes the pharynx to stop grinding. (mit.edu)
  • Another molecule called peroxiredoxin, an antioxidant, appears to help GUR-3 detect hydrogen peroxide. (mit.edu)
  • Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. (elsevierpure.com)
  • A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
  • This image shows where the GUR-3 protein is expressed in the worm, which includes the I2 neurons. (mit.edu)
  • death associated protein 3 [Source:HGN. (gsea-msigdb.org)
  • The cold-set gels of oil-in-water emulsions stabilized by mixtures of whey protein isolate (WPI) and pea protein isolate (PPI) with mass ratios of 10:0, 7:3, 5:5, 3:7, and 0:10 were investigated to evaluate the possibility of pea protein to replace milk protein. (bvsalud.org)
  • Three modifications (pH-shift, ultrasound, combined pH-shift/ultrasound) induced alterations in pure whey protein (WPI), pea protein (PPI), and mixed whey/pea protein (WPI/PPI) were investigated. (bvsalud.org)
  • Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB: 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (drugbank.com)
  • Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. (thermofisher.com)
  • The redox-sensitive transcription factor RAP2.4a mediates chloroplast-to-nucleus redox signaling and controls induction of the three most prominent chloroplast peroxidases, namely 2-Cys peroxiredoxin A (2CPA) and thylakoid- and stromal ascorbate peroxidase (tAPx and sAPx). (fu-berlin.de)
  • Plasmodium falciparum, the causative agent of malaria, is sensitive to oxidative stress and therefore the family of antioxidant enzymes, peroxiredoxins (Prxs) represent a target for antimalarial drug design. (rcsb.org)
  • The active sites of the peroxiredoxins feature a redox-active cysteine residue (the peroxidatic cysteine), which undergoes oxidization to a sulfenic acid by the peroxide substrate. (wikipedia.org)
  • Kang SW, Baines IC, Rhee SG: Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (drugbank.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Peroxiredoxin 6 (PRDX6) in samples from serum, plasma, tissue homogenates or other biological fluids. (lotuskringpoeldijk.nl)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Peroxiredoxin 6 (PRDX6) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Peroxiredoxin 6 (PRDX6) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
  • Description: Quantitative sandwich ELISA for measuring Human Peroxiredoxin-6 (PRDX6) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (lotuskringpoeldijk.nl)
  • Prxs were historically divided into three (mechanistic) classes: Typical 2-Cys Prxs Atypical 2-Cys Prxs and 1-Cys Prxs. (wikipedia.org)
  • Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol. (thermofisher.com)
  • Peroxiredoxin 6 knockout mice are viable and do not display obvious gross pathology, but are more sensitive to certain exogenous sources of oxidative stress, such as hyperoxia. (wikipedia.org)
  • Alvarez, M.N., Peluffo, G., Piacenza, L., Radi, R., Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity (2011) J. Biol. (uba.ar)
  • 2-Cys peroxiredoxins are reduced by thiols such as thioredoxins, thioredoxin-like proteins, or possibly glutathione, whereas the 1-Cys enzymes may be reduced by ascorbic acid or glutathione in the presence of GST-π. (wikipedia.org)
  • As more Prx homologs/orthologs became known later, it was clear that Prx enzymes are ubiquitously expressed, with multiple isoforms present in most organisms (three in Escherichia coli , five in Saccharomyces cerevisiae , six in Homo sapiens , and nine in Arabidopsis thaliana ). (molcells.org)
  • Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)
  • Peroxiredoxin-6, an important intracellular anti-oxidant. (koreamed.org)
  • Next, the scientists evaluated the impact the B. cinerea sRNAs had on plant immunity, generating transgenic Arabidopsis plants that ectopically expressed the three sRNAs under investigation. (genomeweb.com)
  • Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. (benthamscience.com)
  • Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. (benthamscience.com)
  • cDNA Sequencing Making use of procedures described previously (52) a direct sequencing approach encompassing the complete ABL kinase and ATP-loop domain (corresponding to amino acids 24295) was performed on cDNA products from RT-PCR using forward primer (5CATCACCATGAAGCACAAGC-3) and the reverse (5GCTGTGTAGGTGTCCCCTGT-3) primers. (piminhibitor.com)
  • The recycling of the sulfenic acid back to a thiol is what distinguishes the three enzyme classes. (wikipedia.org)
  • Peroxiredoxins are frequently referred to as alkyl hydroperoxide reductase (AhpC) in bacteria. (wikipedia.org)
  • To assist with identification of new members and the subgroup to which they belong, a searchable database (the PeroxiRedoxin classification indEX) including Prx sequences identified from GenBank (January 2008 through October 2011) was generated by bioinformatics analysis and is publicly available. (wikipedia.org)
  • Mice lacking peroxiredoxin 1 or 2 develop severe haemolytic anemia, and are predisposed to certain haematopoietic cancers. (wikipedia.org)
  • Peroxiredoxin 1 knockout mice have a 15% reduction in lifespan. (wikipedia.org)
  • The microbiome associated with healthy individuals of the red seaweed Laurencia dendroidea can fix nitrogen and provide relevant amino acids and vitamins to the seaweed ( 3 ). (asm.org)
  • Results: Control exposed U2-OS and 3-T-3 cells exhibited characteristic cell growth. (iiarjournals.org)
  • Ferroptosis inhibitors protect the Px I-III KO cells. (elifesciences.org)
  • Protection of Px I-III KO cells by Trolox, Dfx and α-Toc. (elifesciences.org)
  • Px I-III KO cells are affected in mitochondrial matrix - but not outer membrane - immuno-staining. (elifesciences.org)
  • The Px I-III KO cells were incubated ± Trolox for up to 4 hr, stained with MitoTracker or propidium iodide and subjected to flow cytometry. (elifesciences.org)
  • Typical human bone marrow (NBM) samples and bone marrow mononuclear cells (BMMNC) from IMS and IMR CML sufferers (Figure S3A, Table 1) had been cultured in HPGM (Lonza, Walkersville, MD) supplemented with 1 ngmL G-CSF (Calbiochem, Merck, Gibbstown, NJ), 25 ngmL SCF (Calbiochem) and 10 ngmL GM-CSF, IL-3, and IL-6 (Millipore). (piminhibitor.com)
  • siRNA ON-TARGET plus Clever pool human DNA ligase III (L0009227) or non targeting manage (D001810) siRNAs from Dharmacon RNA Technologies (Thermo Scientific, Chicago, IL) had been transiently transfected into cells (0.1 nmolsiRNA106 cells) using Amaxa Nucleofector Kit V (VCA-1003) inside a Nucleofector II Amaxa biosystems (Lonza, Allendale, NJ) in line with manufacturer's guidelines. (piminhibitor.com)
  • [3] Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans. (wikipedia.org)
  • The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. (gu.se)
  • The University of Alberta COSC 2018 Meeting has ten symposia, including seven Scientific Symposia and three Trainee Presentation Symposia organized from the submitted abstracts. (carleton.ca)
  • for example, glyceraldehyde 3-phosphate dehydrogenase has three substrates and two products. (wikipedia.org)
  • RNA 2',3'-cyclic phosphate and 5'-OH l. (gsea-msigdb.org)
  • The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). (wikipedia.org)
  • In this study, using an isobaric tags for relative and absolute quantitation (iTRAQ ) approach coupled with LC-MS / MS and bioinformatics, the proteomes were analyzed for the crucial three stages covering the fruiting body development of Ophiocordyceps sinensis , including sclerotium (ST), primordium (PR) and mature fruiting body (MF), with a focus on fruiting body development-related proteins and the potential mechanisms of the development. (peerj.com)
  • Conclusion: BZM can greatly enhance the efficacy of LDM against multiple myeloma by increasing the levels of cleaved caspase-3 and PARP, and remarkably increase the apoptosis induced by LDM through further activation of ERS. (researchgate.net)
  • Description: A sandwich ELISA kit for detection of Peroxiredoxin 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
  • Wealthy) at 37 in five CO2, supplemented with 10 ngmL GM-CSF and IL-3 for Rich) at 37 in five CO2, supplemented with ten ngmL GM-CSF and IL-3 for Mo7e and Baf3, respectively (Millipore, Temecula, CA). Media for IMR cell lines incorporated two M IM. (piminhibitor.com)
  • Besides, SOD activity increased across the three stages, while CAT activity has a strong increasement in MF compared to the stages of ST and PR. (peerj.com)
  • A particular molecular receptor in that neuron, gustatory receptor 3 (GUR-3), and a molecularly similar receptor found in other neurons (LITE-1) are critical to the response. (mit.edu)
  • Zhang Y, Sturgis EM , Sun Y, Sun C, Wei Q, Huang Z, Li G . A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer. (viictr.org)
  • Reactions with three or four substrates or products are less common, but they exist. (wikipedia.org)
  • [ 3 , 4 ] as a type of MDS with one or more cytopenias and dysplastic changes in two or more of the myeloid lineages (erythroid, granulocytic, or megakaryocytic). (medscape.com)
  • Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. (elsevierpure.com)
  • The expression levels of DNA ligase III and PARP1 had been normalized to that of GAPDH. (piminhibitor.com)
  • Colonies have been stained overnight with 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenlytetrazolium chloride (1 mgml, Sigma-Aldrich) just before counting using an automated image analysis method (Omincon FAS IV, BIOSYS GmbH, Karben, Germany). (piminhibitor.com)
  • Although the plants showed normal morphology and development in the absence of pathogen challenge, even though the target genes were suppressed, all three displayed "enhanced susceptibility" to infection upon introduction of B. cinerea . (genomeweb.com)
  • In order to confirm that the sRNAs suppressed their targets using their host's RNAi pathways, the investigators immunoprecipitated Argonaute 1 - the primary component of the RNA-induced silencing complex that enables RNAi - from Arabidopsis and identified the three sRNAs they have been studying in Ago1-associated fraction pulled from B. cinerea -infected plant samples but not controls. (genomeweb.com)