• Peritoneal dialysis (PD) remains limited by dialysis failure due to peritoneal membrane fibrosis driven by inflammation caused by infections or sterile cellular stress. (uni-luebeck.de)
  • Similarly, antibody blockade of TLR2, TLR4, or C5aR differentially inhibited bacteria-induced profibrotic and inflammatory mediator production by peritoneal leukocytes isolated from the peritoneal dialysis effluent (PDE) of noninfected uremic patients. (uni-luebeck.de)
  • By using next-generation sequencing, we documented a polyclonal B. cepacia complex outbreak affecting peritoneal dialysis patients in Hong Kong that was caused by contaminated chlorhexidine solutions. (cdc.gov)
  • 2 clusters of BCC strains among peritoneal dialysis patients caused by multiple brands of contaminated, prepackaged, single-use, 0.05% aqueous chlorhexidine (aqCHX) solutions. (cdc.gov)
  • All 4 patients had recent-onset serous to bloody discharge from their exit site (3 peritoneal dialysis catheter exit sites and 1 hemodialysis catheter exit site). (cdc.gov)
  • The hospital is a 1,700-bed university-affiliated tertiary referral center serving ≈270 peritoneal dialysis and 110 hemodialysis patients. (cdc.gov)
  • Peritoneal dialysis (PD) is a type of dialysis which uses the peritoneum in a person's abdomen as the membrane through which fluid and dissolved substances are exchanged with the blood. (wikipedia.org)
  • Peritoneal dialysis has better outcomes than hemodialysis during the first couple of years. (wikipedia.org)
  • In peritoneal dialysis, a specific solution is introduced through a permanent tube in the lower abdomen and then removed. (wikipedia.org)
  • This may either occur at regular intervals throughout the day, known as continuous ambulatory peritoneal dialysis (CAPD), or at night with the assistance of a machine, known as automated peritoneal dialysis (APD). (wikipedia.org)
  • The solution used for peritoneal dialysis is on the World Health Organization's List of Essential Medicines. (wikipedia.org)
  • As of 2009, peritoneal dialysis was available in 12 out of 53 African countries. (wikipedia.org)
  • Peritoneal dialysis is a method of renal replacement therapy for needing maintenance therapy for late stage chronic kidney disease. (wikipedia.org)
  • During long term peritoneal dialysis, prolonged exposure of peritoneum membrane to peritoneal dialysis solution causes peritoneal fibrosis. (ukessays.com)
  • Peritoneal Dialysis, an alternative to haemodialysis is being used about more than three decades ago to treat end stage renal disease. (ukessays.com)
  • Other factor which triggers fibrosis process in peritoneum membrane during dialysis is peritonitis. (ukessays.com)
  • Although most patients with nephrogenic systemic fibrosis have undergone hemodialysis for renal failure, some have never undergone dialysis and others have received only peritoneal dialysis. (medscape.com)
  • Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency. (nih.gov)
  • Most patients with NSF are undergoing hemodialysis or peritoneal dialysis or have had a renal transplantation. (medscape.com)
  • Dr Abu-Alfa has been a strong advocate for peritoneal dialysis (PD) for over 25 years. (yale.edu)
  • In addition to his strong engagement in these regional and international nephrology circles, Dr Abu-Alfa continues to teach and mentor students, residents and fellows while pursuing his scientific interests in the areas of peritoneal dialysis, complex hypertension, chronic kidney disease, imaging issues in kidney patients including nephrogenic systemic fibrosis and use of gadolinium-based contrast agents. (yale.edu)
  • Mesothelial-to-mesenchymal transition (MMT) is an auto-regulated physiological process of tissue repair that in uncontrolled conditions such as peritoneal dialysis (PD) can lead to peritoneal fibrosis. (uam.es)
  • AQP1 Promoter Variant, Water Transport, and Outcome in Peritoneal Dialysis. (bvsalud.org)
  • Will Zinc Supplements One Day Help Prevent Peritoneal Sclerosis? (homedialysis.org)
  • The maximum expression of peritoneal fibrosis induced by PD fluids and other peritoneal processes is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. (uam.es)
  • Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process? (uam.es)
  • BCC is a major pathogen among patients with cystic fibrosis and an opportunistic pathogen affecting patients with indwelling medical devices and immunosuppression ( 3 ). (cdc.gov)
  • Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. (frontiersin.org)
  • The relation between sonographically measured colonic wall thickness and pancreatic enzyme preparation and dose was studied in 86 children with cystic fibrosis (CF). Colonic wall thickness of a control group was also measured. (bmj.com)
  • In 1993, five children with cystic fibrosis (CF) were reported with what appeared to be meconium ileus equivalent, which did not respond to medical treatment, and four had thickening and strictures of the colon. (bmj.com)
  • CRPA: carbapenem-resistant P. aeruginosa isolated from normally sterile sites, urine, lower respiratory tract (LRT) specimens, wounds, or cystic fibrosis patient throat swabs from a resident of the surveillance area. (cdc.gov)
  • Pseudomonas aeruginosa is an important pulmonary pathogen in cystic fibrosis, but the means by which it evades host defenses is understood poorly. (jci.org)
  • The predilection of P. aeruginosa for lower airway disease in patients with cystic fibrosis might be explained in part by the unique dependency upon glucose for M phi phagocytosis. (jci.org)
  • The fixed-dose combination (FDC) tezacaftor/ivacaftor-FDC has received approval for patients with cystic fibrosis (CF) aged 12 years and older who are homozygous for the F508del mutation or who are heterozygous for the F508del mutation and one of a number of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (nihr.ac.uk)
  • The combination of tezacaftor and ivacaftor may result in an effective treatment for people with CF and may especially be a treatment option for those who cannot take a combination of ivacaftor and lumacaftor (another cystic fibrosis medicine), due to side effects or interactions with other medicines they are taking. (nihr.ac.uk)
  • Researchers have studied the ability of components of extra virgin olive oil to prevent or treat fibrosis and thickening of the peritoneal membrane, both in vivo and in vitro. (homedialysis.org)
  • Glucose in peritoneal dialysate drives inflammation and angiogenesis, which lead to fibrosis that can cause loss of use of the membrane. (homedialysis.org)
  • According to a 2020 review published in the American Journal of Nephrology, some studies suggest that the use of glucose increases the risk of peritonitis, possibly as a result of impaired host defenses, vascular disease, or damage to the peritoneal membrane. (wikipedia.org)
  • Mesothelial cells play a vital role in maintaining the structure of peritoneal membrane and peritoneal homeostasis. (ukessays.com)
  • 1,2] The primary function of peritoneal membrane is to provide support to abdominal organs. (ukessays.com)
  • In mice PD model, we demonstrated that MMT progressed in parallel with peritoneal membrane thickness. (uam.es)
  • We detected TLR2-, TLR4-, and C5aR-mediated proinflammatory and fibrotic responses to bacteria that were consistent with the expression of these receptors in peritoneal macrophages (TLR2/4, C5aR) and mesothelial cells (TLR2, C5aR). (uni-luebeck.de)
  • This literature review is about mechanism of mesothelial -mesenchymal transition (MMT), myofibroblasts and its origin hypothesis, clock genes and their cross relation with organ fibrosis. (ukessays.com)
  • Peritoneal cavity is rich in number of cells like mesothelial cells, fibroblasts, endothelial cells, adipocytes and immune cells like macrophages, T cells, B cells, mast cells. (ukessays.com)
  • In this designed project, we are going to focus on mesothelial cells along with Transforming growth factor-β (TGF-β1), which is considered as main mediator of organ fibrosis development. (ukessays.com)
  • Cardiovascular conditions secondary to pulmonary fibrosis. (cdc.gov)
  • Cor pulmonale can occur secondary to pulmonary fibrosis, mainly in patients with severe asbestosis. (cdc.gov)
  • La fibrosis peritoneal es una complicación frecuente de los pacientes en DIÁLISIS PERITONEAL y contribuye a la disminución gradual de su eficiencia. (bvsalud.org)
  • Liver enlargement is common in advanced cases, and is frequently associated with an accumulation of fluid in the peritoneal cavity and hypertension of the abdominal blood vessels. (who.int)
  • Peritoneal cavity is potential space between both layers and is comprised of small amount of lubricating fluid, also known as serosal fluid which prevents friction between closely packed organs and allows free movement of them. (ukessays.com)
  • Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
  • Nephrogenic systemic fibrosis (NSF), also known as nephrogenic fibrosing dermopathy (NFD), is a disease of fibrosis of the skin and internal organs reminiscent but distinct from scleroderma or scleromyxedema. (medscape.com)
  • The above image shows nephrogenic systemic fibrosis (NSF), or nephrogenic fibrosing dermopathy, on the leg of an affected patient. (medscape.com)
  • PGJ abrogates liver fibrosis instigated by NDEA in Wistar rats by declining oxidative stress via regulation of Nrf2 and NFκB. (nature.com)
  • Thus, targeting fibroblast cell activation and pEMT are critical strategies for attenuating fibrosis. (nature.com)
  • In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)
  • The results supported that inhibition of Plk1 ameliorated kidney fibrosis by suppressing fibroblast activation and partial EMT. (nature.com)
  • Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. (karger.com)
  • All through the development process of peritoneal fibrosis, peritoneal cells will experience changes and some of the pro inflammatory factors which act as inducers to induce fibrosis and inflammatory processes. (ukessays.com)
  • By activating a complex metabolic pathway, a study in rats found that supplementing with zinc helped prevent fibrosis. (homedialysis.org)
  • Hepatic fibrosis in rats was induced by the intra-peritoneal injection of NDEA (10 mlkg −1 b.wt. (nature.com)
  • In addition, we observed that Tamoxifen significantly reduced peritoneal thickness, angiogenesis, invasion of the compact zone by mesenchymal MCs and improved peritoneal function. (uam.es)
  • These findings point towards pomegranate as a potential and efficacious therapeutic agent against liver fibrosis. (nature.com)
  • Liver fibrosis is a serious health concern which leads to liver diseases such as cirrhosis and primary liver cancer having a worldwide mortality of approximately 1.5 million deaths per year 23 . (nature.com)
  • Now, it is high time that work should be done on these lines to garner the potential of pomegranate in order to cure liver fibrosis. (nature.com)
  • Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
  • Liver fibrosis, like pathological fibrosis in other organs, has been termed "wound healing gone bad. (cyberounds.com)
  • Constrictive pericarditis rarely occurs secondary to severe asbestos-induced fibrosis or calcification of the pericardium. (cdc.gov)
  • [ 10 ] Endothelin-1/endothelin receptor signaling plays a role in the calcification and fibrosis of nephrogenic systemic fibrosis. (medscape.com)
  • Peritoneal mesothelioma is similar to pleural mesothelioma except that it arises in peritoneal membranes. (cdc.gov)
  • 2004]. In addition, the sex difference in incidence is smaller with peritoneal mesothelioma than for pleural mesothelioma [Hillerdal 1999]. (cdc.gov)
  • Pleural and peritoneal mesothelioma is a rare, rapidly invasive tumor caused by asbestos exposure. (cdc.gov)
  • Given the fundamental role of Toll-like receptors (TLRs) and complement in inflammation, we assessed the potential of peritoneal TLR2, TLR4 and C5a receptors, C5aR and C5L2, as therapeutic targets in PD-associated fibrosis. (uni-luebeck.de)
  • These findings reveal the influence of peritoneal TLR2 and TLR4 on PD-associated fibrosis and describe a therapeutic strategy against fibrosis. (uni-luebeck.de)
  • Notably, sTLR2 treatment markedly reduced Gram- positive and -negative bacteria-induced fibrosis in vivo, inhibiting proinflammatory and fibrotic genes without affecting infection clearance. (uni-luebeck.de)
  • Patients with nephrogenic systemic fibrosis may develop large areas of indurated skin with fibrotic nodules and plaques. (medscape.com)
  • PD solution is major drawback of this treatment which contributes to development of peritoneal fibrosis in patients due to its bioincompatible nature. (ukessays.com)
  • Among these effects, TGF-β induces the epithelial-to-mesenchymal transition with prometastatic functions, contributes to the conversion of stromal cells to carcinoma-associated fibroblasts, and suppresses the function of immune cells, which compromises the antitumor immune response, leading to cancer progression and stromal fibrosis. (preprints.org)
  • In this review, we address the role of the essential TGF-β signaling pathway in the regulation of the activities of components of the tumor microenvironment of gastric cancer and how this contributes to tumor progression and stromal fibrosis. (preprints.org)
  • Experiments in knockout mice revealed a major role for TLR2, a lesser role for TLR4, a supplementary role for C5aR, and no apparent activity of C5L2 in infection-induced peritoneal fibrosis. (uni-luebeck.de)
  • Toll-like receptors (TLR), in particular TLR4 and TLR7, play a role in the development of nephrogenic systemic fibrosis. (medscape.com)
  • Hence, we used in vitro and animal model approaches to evaluate the efficacy of Tamoxifen to inhibit the MMT as a trigger of peritoneal fibrosis. (uam.es)
  • Some studies showed that blocking cell cycle progression ameliorated fibrosis. (nature.com)
  • Nephrogenic systemic fibrosis almost always occurs in patients with renal insufficiency who have had imaging studies (eg, magnetic resonance angiography) with gadolinium, a contrast agent used in imaging studies. (medscape.com)
  • Evidence for a link between nephrogenic systemic fibrosis and gadolinium was first described in a case series of 13 patients, all of whom developed nephrogenic systemic fibrosis after being exposed to gadolinium. (medscape.com)
  • The pathophysiology of nephrogenic systemic fibrosis is related to the exposure of patients with renal insufficiency to gadolinium in association with imaging studies. (medscape.com)
  • Gastric cancer is an intractable disease with a high incidence of peritoneal dissemination and obstructive symptoms (e.g. ileus, jaundice, and hydronephrosis) arising from accompanying marked fibrosis. (preprints.org)
  • Progressive fibrosis is the major pathological feature of CKD, which leads to end-stage renal disease (ESRD). (nature.com)
  • The common pathological feature of CKD is the loss of tubular cells and progressive interstitial fibrosis. (nature.com)
  • However, the role of Plk1 in kidney tubular interstitial fibrosis has not been reported. (nature.com)
  • Cor pulmonale occurs in many forms of far advanced lung disease when fibrosis of the lungs leads to increased resistance to blood flow through the capillary bed. (cdc.gov)
  • SSc is a systemic connective tissue disease characterized by vasomotor instability, fibrosis, and immunologic disturbances, as well as by atrophy of the skin, subcutaneous tissue, muscles, and internal organs. (medscape.com)
  • Histopathologically, nephrogenic systemic fibrosis resembles scleromyxedema in that it manifests with a proliferation of dermal fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers, and mucin deposition. (medscape.com)
  • Trastorno caracterizado por un amplio rango de cambios estructurales en el PERITONEO a consecuencia de procesos fibrosantes o inflamatorios. (bvsalud.org)
  • [ 5 ] It is also associated with high levels of PTH, which has been shown to inhibit erythropoiesis, induce hemolysis and cause bone marrow fibrosis in CKD states. (medscape.com)
  • The fiber-like dimensions of MWCNTs, their durability, and ability to cause peritoneal inflammation are reminiscent of asbestos, but their toxicity is incompletely investigated. (cdc.gov)
  • [ 5 ] One case of nephrogenic systemic fibrosis developed 10 years after gadolinium exposure. (medscape.com)
  • Sirius Red staining demonstrated fibrosis of granulomas and alveolar septa by 7 days post-exposure. (cdc.gov)
  • there is no clear advantage for other frequently used treatments such as routine peritoneal lavage or use of urokinase. (wikipedia.org)
  • The chelated forms of the less stable gadolinium chelates might have a significant role, but it appears that dissociated gadolinium's gradual release is pivotal in the development of nephrogenic systemic fibrosis and its sometimes delayed onset. (medscape.com)