• calcitonin-gene-re
  • 1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries. (clinsci.org)
  • 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. (clinsci.org)
  • β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. (clinsci.org)
  • 4. The present findings lend further support to the theory of regional variation in the vasodilator response to calcitonin-gene-related peptide in porcine coronary arteries, which seems to be due to different densities of a single type of receptor for calcitonin-gene-related peptide. (clinsci.org)
  • Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. (arvojournals.org)
  • Using a double labeling indirect immunofluorescent technique, we studied the guinea pig trigeminal ganglion and eye for co-localization of substance P and calcitonin gene-related peptide. (arvojournals.org)
  • In the trigeminal ganglion, the number of neurons immunoreactive for calcitonin gene-related peptide significantly outnumber those immunoreactive for substance P, but virtually all substance P positive neurons are immunoreactive for calcitonin gene-related peptide. (arvojournals.org)
  • Nerve fibers immunoreactive only for calcitonin gene-related peptide tend to be concentrated in the cornea and posterior ciliary body. (arvojournals.org)
  • nucleic
  • Can pseudocomplementary peptide nucleic acid nucleases (pcPNANs) be a new tool for genetic engineering? (peerj.com)
  • genetic engineering , pseudocomplementary peptide nucleic acid nucleases , DNA double strand break , homologous recombination , error-prone nonhomologous end joining. (peerj.com)
  • Shi P. ( 2014 ) Can pseudocomplementary peptide nucleic acid nucleases (pcPNANs) be a new tool for genetic engineering? (peerj.com)
  • In this paper, we propose a new tool for genetic engineering, the pseudocomplementary peptide nucleic acid nucleases (pcPNANs), which are composed of a pseudocomplementary PNA (pcPNA) specific for a DNA target sequence, a FokI nuclease cleavage domain and a nuclear localization signal. (peerj.com)
  • These findings extend the knowledge of the variables that condition intracellular Cell-penetrating peptide mediated transport of nucleic acids, which ultimately translates into a small step towards successful non-viral gene therapy. (diva-portal.org)
  • novel
  • To be used as therapeutics, each novel cell-penetrating peptide needs to be fully characterized, including their physicochemical properties, their biological activity and their uptake mechanism. (diva-portal.org)