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  • premenstrual
  • The most common dose-dependent side effects associated with treatment discontinuation in clinical trials for the treatment of premenstrual dysphoric disorder with controlled-release paroxetine 25 mg compared with 12.5 mg included nausea, somnolence, impaired concentration, dry mouth, dizziness, decreased appetite, sweating, tremor, and yawn. (drugs.com)
  • selective
  • In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. (nih.gov)
  • dose
  • On June 28, 2013, the U.S. Food and Drug Administration approved low-dose paroxetine for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause. (wikipedia.org)
  • She agreed to a rechallenge test with paroxetine at a reduced dose of 10 mg. (bmj.com)
  • Brisdelle contains a low dose of paroxetine that is especially formulated to treat hot flashes associated with menopause . (medicinenet.com)
  • adults
  • however, paroxetine is contraindicated in women who may become pregnant due to its teratogenicity and its high risk of withdrawal syndrome in both adults and neonates. (thefullwiki.org)
  • behavior
  • Pharmacokinetic behavior of paroxetine has not been evaluated in subjects who are deficient in CYP2D6 (poor metabolizers). (nih.gov)
  • drugs
  • Which drugs or supplements interact with paroxetine (Brisdelle)? (medicinenet.com)
  • SAN ANTONIO -- Breast cancer patients who took the antidepressant paroxetine during their course of tamoxifen therapy were up to 91% more likely to die from their disease than were those who did not take the two drugs together, according to a retrospective, population-based cohort study conducted in the Canadian province of Ontario. (thefreedictionary.com)
  • concentrations
  • To our knowledge, the only published report of postural hypotension associated with paroxetine relates to its increasing trimipramine concentrations when prescribed with trimipramine. (bmj.com)
  • primarily
  • Paroxetine metabolism is mediated in part by CYP2D6, and the metabolites are primarily excreted in the urine and to some extent in the feces. (nih.gov)
  • Patients
  • At six weeks, 71% of SJW patients, compared to 60% of paroxetine patients, showed a 50% or greater reduction in depressive symptoms. (thefreedictionary.com)
  • Emerging evidence shows that antipsychotics can be used as a supplement or alternative to paroxetine in patients with generalised anxiety disorder. (thefullwiki.org)