• Scholars@Duke publication: Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. (duke.edu)
  • PURPOSE: Infection with human papillomavirus (HPV) type 16 has been suggested to be a risk factor for squamous cell carcinoma of the head and neck (SCCHN) and to be more commonly associated with SCCHN occurring in the oropharynx and in never-smokers. (duke.edu)
  • Patterns of CD8 T-cell epitopes within the human papillomavirus type 16 (HPV 16) E6 protein among young women whose HPV 16 infection has become undetectable. (uams.edu)
  • Cell-mediated immune responses to human papillomavirus 16 E6 and E7 antigens as measured by interferon gamma enzyme-linked immunospot in women with cleared or persistent human papillomavirus infection. (uams.edu)
  • Memory T cells specific for novel human papillomavirus type 16 (HPV16) E6 epitopes in women whose HPV16 infection has become undetectable. (uams.edu)
  • Vaccines for Human Papillomavirus Infection and Anogenital Disease. (edu.au)
  • During evolution the arms race between papillomaviruses (PVes) and their hosts has resulted in parallel selection of cellular mechanisms aiming to clear viral infection, such as inhibition of cellular apoptosis or uncoupling of the normal proliferation/differentiation program of the epithelium on the one hand, and in selection of viral mechanisms aiming to hamper cellular reaction directed to clear infection on the other. (biomedcentral.com)
  • Evidence of avian poxvirus and papillomavirus infection in Gyps fulvus in Italy. (upm.edu.my)
  • Infection with certain types of human papillomavirus (HPV), while a necessary cause of cervical cancer, does not guarantee an elevated risk of malignancy. (biomedcentral.com)
  • We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. (geneticsmr.com)
  • Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). (neobiotechnologies.com)
  • p16 (INK4a/CDKN2A) is a cell cycle regulatory protein that is overexpressed in cervical dysplasia related to human papilloma virus (HPV) infection. (yemialadeworld.com)
  • ISA101, a novel immunotherapeutic consisting of synthetic long peptides (SLP®s), targets severe diseases triggered by human papillomavirus (HPV) infection. (akampion.com)
  • Syrjänen, Kari 2008-06-26 00:00:00 Background: At present, seroreactivity is not a valuable parameter for diagnosis of Human Papillomavirus (HPV) infection but, it is potentially valuable as marker of viral exposure in elucidating the natural history of this infection. (sagepub.com)
  • Human papillomavirus ( HPV ) infection must be present for cervical cancer to occur. (medscape.com)
  • Recognition of the etiologic role of human papillomavirus ( HPV ) infection in cervical cancer has led to the recommendation of adding HPV testing to the screening regimen in women 30-65 years of age (see Workup). (medscape.com)
  • Moldovan Andreea - Centrul de Diagnostic si Tratament Oncologic Human papillomavirus infection poster Citate duplicat In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations papilloma in poodles DNA. (info-tecuci.ro)
  • Dysbiosis rheumatoid arthritis Dr. Moldovan Andreea - Human papillomavirus infection poster Papilloma virus familia - handmade4u. (info-tecuci.ro)
  • Antibodies against E6, E7 and L1 proteins of HPV16 and HPV18 were measured in sera of 535 cases of noncervical HPV-related cancers (anal (n=104), vulval (n=211), vaginal (n=49), penile (n=37) and oropharyngeal (n=134)) and 6,651 non-infection-related cancer controls, from the Johannesburg Cancer Study that recruited Black South African with newly diagnosed cancer between 1995 and 2016. (who.int)
  • ABSTRACT Studies have suggested a possible link between breast cancer pathogenesis and human papillomavirus (HPV) infection. (who.int)
  • Epidemiological and molecular studies have determined that the persistence of infection with high-risk human papillomaviruses (HR-HPVs) types is the most common risk factor for the development of head and neck malignancies 10-12 . (bvsalud.org)
  • ECSA Scientific Day 2023 (23 November 2023): Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a black South African population, according to HIV status. (who.int)
  • Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells are recruited to the basal layer of E7-expressing epithelium, and that this recruitment is dependent on the epithelial hyperproliferation induced by E7 by inactivating Rb dependent cell cycle regulation. (figshare.com)
  • The human papillomavirus type 16 E5 protein (HPV16 E5) down-regulates surface expression of HLA-I molecules. (biomedcentral.com)
  • In this context, several molecular interactions between the oncogenes HPV16 E5, E6 and E7 and different apoptotic pathways have already been identified [ 9 ]. (biomedcentral.com)
  • Recently it has been shown that HPV16 E5 may co-precipitate with the heavy chain of HLA-I in cells over-expressing the E5 protein [ 21 ]. (biomedcentral.com)
  • Eighteen cytobrush specimens were analyzed by real-time PCR for the presence of either HPV16 or HPV18 E7 mRNA (Table 1 ). (biomedcentral.com)
  • HPV 16 E7(49-57) (RAHYNIVTF) is a recombinantly expressed MHC class I molecule that presents a peptide from a human papillomavirus type 16 (HPV16) protein E7. (alab.com.pl)
  • HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis. (cdc.gov)
  • In many countries, vaccines against some human papillomavirus (HPV) types are now administered to girls and young women with the goal of protecting them against HPV-induced cervical cancer ( 1 , 2 ). (cdc.gov)
  • This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines. (cdc.gov)
  • Therapeutic vaccines are aimed at promoting regression of HPV-associated lesions by the induction of cellular immune responses directed against viral proteins expressed in tumor cells[ 25 ]. (biomedcentral.com)
  • The research identified papillomavirus oncogenes and the molecular mechanisms of their damaging effects. (wikipedia.org)
  • Synonymous codons in the oncogenes of the rabbit papillomavirus increased oncogenicity and immunogenicity [7]. (i-sis.org.uk)
  • Laboratory studies have revealed that uncontrolled expression of the HPV E6 and E7 oncogenes is responsible for the ability of HPV to transform cells. (biomedcentral.com)
  • Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed. (uams.edu)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. (geneticsmr.com)
  • We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. (geneticsmr.com)
  • Background Human papillomavirus (HPV) DNA is present in the majority of squamous cell cancers of the anus. (researchgate.net)
  • Preventing HPV tonsillar squamous papilloma Human papillomavirus lecture warts treatment homeopathy medicine, papilloma virus esame urine intestinali la sugari manifestare oxiuri. (whiskypedia.ro)
  • Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
  • The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. (virosin.org)
  • HPVs are small non-enveloped, double-stranded, circular DNA viruses that encode two viral oncoproteins, E6 and E7. (bvsalud.org)
  • The adenovirus E1A protein mimics the LxDLFD motif and competes with E2F for binding to Rb, promoting E2F activation and cell proliferation. (eu.org)
  • Howley and his co-workers created gene maps of many species of papillomaviruses and analyzed their transcription patterns and systems of transcription regulation. (wikipedia.org)
  • When found in gene protein coding regions, SNPs can be synonymous, i.e., causing no change in the amino acid encoded, or non-synonymous, when the amino acid is altered. (i-sis.org.uk)
  • As plant genetic engineering has "advanced" the crucial active domains of toxins, and enzyme are "improved" to such an extent that the gene for the original source protein is hardly recognizable. (i-sis.org.uk)
  • Receptor-interacting protein kinase-1 ( RIPK1 ) gene encodes a member of the receptor- interacting protein family of serine/threonine protein kinases. (biomedcentral.com)
  • TMEM17 (transmembrane protein 173) is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. (neobiotechnologies.com)
  • gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. (yemialadeworld.com)
  • For this purpose, we constructed recombinant λ-phage nanobioparticles containing a mammalian expression cassette encoding enhanced green fluorescent protein (EGFP) and E7 gene of human papillomavirus type 16 (λ-HPV-16 E7) using Lambda ZAP- CMV XR vector. (biomedcentral.com)
  • Specifically, the patent was granted for the therapeutic use of intradermally delivered long peptides derived from the E2, E6 and/or E7 proteins of the human papillomavirus (HPV) to treat or prevent HPV-related diseases. (akampion.com)
  • HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro-tein RBP involved in the regulation of proliferation and cell death. (cuci.ro)
  • All current GM crops use protein coding genes from bacteria that have been altered by introducing synonymous codons, replacing plant-preferred codons for the bacterial codons in order to enhance the production of protein from the transgenes. (i-sis.org.uk)
  • Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
  • E7 induced epithelial hyperplasia is associated with increased epidermal secretion of CCL2 and CCL5 chemokines, which attract mast cells to the skin. (figshare.com)
  • Mast cells in E7 transgenic skin, in contrast to those in non-transgenic skin, exhibit degranulation. (figshare.com)
  • Notably, we found that resident mast cells in E7 transgenic skin cause local immune suppression as evidenced by tolerance of E7 transgenic skin grafts when mast cells are present compared to the rejection of mast cell-deficient E7 grafts in otherwise competent hosts. (figshare.com)
  • Thus, our findings suggest that mast cells, recruited towards CCL2 and CCL5 expressed by epithelium induced to proliferate by E7, may contribute to an immunosuppressive environment that enables the persistence of HPV E7 protein induced pre-cancerous lesions. (figshare.com)
  • In this epithelium, as well as in the more fragile single cell layer epithelium of endocervix, the cells are held together by proteins that form desmosomes, tight junctions, and adherens junctions, which decrease its permeability [ 19 ]. (hindawi.com)
  • Our lab investigates unconventional mechanisms of protein secretion from mammalian cells. (db-engine.de)
  • Current research goals in the lab relate to the spatio-temporal coordination of FGF2 secretion in living cells, the analysis of the molecular mechanism by which FGF2 physically traverses the plasma membrane and the relevance of this process for other unconventional secretory proteins such as HIV Tat. (db-engine.de)
  • the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)
  • Objective: To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells. (researchgate.net)
  • Methods: After differentiated by nerve growth factor (NGF), the PC12 cells were infected by prion protein 106-126 peptide. (researchgate.net)
  • Conclusion: Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely. (researchgate.net)
  • We were interested in determining if any quantitative differences existed in the expression of E7 mRNA in cells from women with normal epithelium and precancerous lesions. (biomedcentral.com)
  • We have produced human papillomavirus type 16 E7 protein in a bacterial expression system and examined the mitogenic activity of this protein in Swiss 3T3 cells after scrape loading. (ox.ac.uk)
  • ADXS11-001 immunotherapy is a live attenuated Listeria monocytogenes (Lm) bioengineered to secrete an HPV-16-E7 fusion protein targeting HPV-transformed cells. (researchgate.net)
  • Quadrivalent HPV vaccine (HPV4) contains four HPV type-specific VLPs prepared from the L1 proteins of HPV 6, 11, 16, and 18. (cdc.gov)
  • Human Papillomavirus - HPV - Nucleus Health papilloma breast tumors Papillomavirus vaccine nhs hoe herken je hpv virus, hpv virus u muzu test viermi muste. (whiskypedia.ro)
  • We also characterized the therapeutic anti-tumor effects of the recombinant λ-HPV-16 E7 phage in C57BL/6 tumor mice model as a cancer vaccine. (biomedcentral.com)
  • Human HPV-16 E7 was also chosen for vaccine development because HPVs, particularly HPV-16, are associated with most cervical cancers. (biomedcentral.com)
  • Human papillomaviruses (HPVs) cause virtually all cervical cancers, the second leading cause of death by cancer among women, as well as other anogenital cancers and a subset of head and neck cancers. (virosin.org)
  • Clinical and epidemiological correlates of antibody response to human papillomaviruses (HPVs) as. (sagepub.com)
  • The best-characteristic properties of E6 and E7 proteins from HR-HPVs are their ability to mediate the degradation of p53 and pRb, respectively. (bvsalud.org)
  • In addition, we show that the M1 mutant is only able to marginally down-regulate HLA-I surface expression compared to the wild-type protein. (biomedcentral.com)
  • Here, we report a method of absolute quantitative real-time PCR utilizing SYBR-green fluorescence for the measurement of HPV E7 expression in cervical cytobrush specimens. (biomedcentral.com)
  • What influences p16 expression in human papillomavirus? (yemialadeworld.com)
  • Recent biological studies have revealed that p16 expression is markedly influenced by the status of Rb expression, and p16 overexpression has been demonstrated in cervical cancers because of functional inactivation of Rb by human papillomavirus (HPV) E7 protein. (yemialadeworld.com)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • Detection of human papillomavirus type 16-specific T lymphocytes by a recombinant vaccinia virus-based enzyme-linked immunospot assay. (uams.edu)
  • The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. (virosin.org)
  • Different methods of identifying new antigenic epitopes of human papillomavirus type 16 E6 and E7 proteins. (uams.edu)
  • HLA class I binding promiscuity of the CD8 T-cell epitopes of human papillomavirus type 16 E6 protein. (uams.edu)
  • The discovery that human papillomavirus (HPV) causes the vast majority of cervical cancers opens exciting new possibilities for controlling this disease, which is the second most common cancer among women worldwide. (biomedcentral.com)
  • Since human papillomavirus (HPV) causes the vast majority of cervical cancers, exciting new approaches for controlling the disease were performed. (biomedcentral.com)
  • A favorable clinical trend is associated with CD8 T-cell immune responses to the human papillomavirus type 16 e6 antigens in women being studied for abnormal pap smear results. (uams.edu)
  • CD4+ T-cell response against human papillomavirus type 16 E6 protein is associated with a favorable clinical trend. (uams.edu)
  • Recognition of a cervical cancer derived tumor cell line by a human papillomavirus type 16 E6 52-61-specific CD8 T cell clone. (uams.edu)
  • Time course of humoral and cell-mediated immune responses to human papillomavirus type 16 in infected women. (uams.edu)
  • Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination. (uams.edu)
  • 2011. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. (virosin.org)
  • 525\525\AAO15448.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 812\288\AAO15449.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 2721\1905\AAO15450.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 3763\1101\AAO15451.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 3527\402\AAO15452.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 5595\1413\AAO15453.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 7075\1578\AAO15454.1\Human papillomavirus - 54\Human papillomavirus type 54 subtype AE9, complete genome. (or.jp)
  • 536\435\AAA79187.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • 823\288\AAA79188.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • 2729\1902\AAA79189.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • 3774\1104\AAA79190.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • 3538\405\AAA79191.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • 5627\1413\AAA79192.1\Human papillomavirus - 54\Human papillomavirus type 54, complete genome. (or.jp)
  • Both are composed of type-specific HPV L1 protein, the major capsid protein of HPV. (cdc.gov)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • The ability of E7 to induce cellular DNA synthesis in quiescent mouse fibroblasts is strongly enhanced by the presence of a single growth factor such as insulin. (ox.ac.uk)
  • Mutant E7 proteins defective for RB binding failed to induce the active form of E2F or act synergistically with insulin to stimulate DNA synthesis. (ox.ac.uk)
  • Proteinele E6 şi E7 influenţează funcţiile normale ale p53 şi pRB şi pot induce cancerogeneză. (sogr.ro)
  • E6 and E7 proteins influence the p53 and pRB actions and may induce cancerogenesis. (sogr.ro)
  • These studies have shown an increase in prevalence of HPV E6 and/or E7 mRNA transcripts, and Wang-Johanning et al. (biomedcentral.com)
  • Here, we describe the development of an absolute quantitative real-time PCR assay to quantitate mRNA of the E7 oncogene from HPV 16 and HPV 18 in cervical cytobrush samples. (biomedcentral.com)
  • Thirteen samples (87%) showed the presence of E7 mRNA. (biomedcentral.com)
  • The others exhibited no evidence of HPV E7 mRNA in either replicate. (biomedcentral.com)
  • RÉSUMÉ Des études ont suggéré qu'un lien était possible entre la pathogénèse du cancer du sein et l'infection à papillomavirus humain. (who.int)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • Seuls trois échantillons de tissu mammaire tumoral bénin (12,5 %) étaient positifs pour l'ADN de papillomavirus humain tandis qu'aucun échantillon de tissu mammaire sain ne l'était. (who.int)
  • La détection de génotypes du papillomavirus humain hautement oncogènes chez les patientes atteintes de cancer du sein vient appuyer l'hypothèse du rôle étiologique du virus dans l'apparition d'un cancer du sein. (who.int)
  • Synonymous mutations may lead to ribosome stalling, thereby changing protein folding pathways affecting enzyme activity or antigenicity [5]. (i-sis.org.uk)
  • Cervical cancer nice guidelines virusi na racunaru, colorectal cancer pathways papillomavirus symptome femme. (whiskypedia.ro)
  • Natural History of Incident and Persistent Cutaneous Human Papillomavirus and Human Polyomavirus Infections. (who.int)
  • Human papillomavirus genotyping using next generation sequencing (NGS) in cervical lesions: Genotypes by histologic grade and their relative proportion in multiple infections. (who.int)
  • Papillomavirus-like infections in canaries (Serinus canarius). (upm.edu.my)
  • Whole-Genome Sequencing and Variant Analysis of Human Papillomavirus 16 Infections. (cdc.gov)
  • However, the toxicity of the transgenic proteins in animals and humans was not studied. (i-sis.org.uk)
  • The synonymous codons were assumed to be neutral and to have no effect on the transgenic proteins, and presumed to be safe [2] ( Bt Toxins in Genetically Modified Crops: Regulation by Deceit , SiS 22). (i-sis.org.uk)
  • This work is considered fundamental for the understanding of the pathogenesis of papillomaviruses at the molecular level. (wikipedia.org)
  • Papilomavirus uman Human papillomavirus Papilomavirusul uman este un virus ADN din familia de papilomavirus care este capabil să infecteze oamenii. (whiskypedia.ro)
  • Papilloma in poodles Throat Cancer and the Human Papilloma Virus risk of cervical cancer after hpv vaccination Virus del papiloma humano en la boca como se contagia abdominal cancer treatment options, papilloma znaczenie viermii intestinali simptome. (info-tecuci.ro)
  • Papillomaviruses (PVs), double-stranded circular DNA viruses, typically cause regressing papillomas (warts) on mucosal or keratinized epithelia of a wide spectrum of species. (upm.edu.my)
  • This study performed a meta-analysis post-systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines to evaluate the occurrences of avian papillomaviruses (APVs) in bird species and effective materials used for virus detection. (upm.edu.my)
  • Until the current decade, synonymous mutations were assumed to be neutral, with no effect on the protein or any other functions of the organism. (i-sis.org.uk)
  • Synonymous mutations may lead to changes in protein folding related to translation pausing, RNA splicing, and alterations in enzyme specificity [1]. (i-sis.org.uk)
  • It is now clear that synonymous mutations are not neutral but instead frequently adversely affect the proteins encoded. (i-sis.org.uk)
  • It is reasonable to assume that the synonymous mutations may have created proteins with adverse phenotypes and contributed to the deterioration in public health, and this must now be thoroughly investigated together with mandatory labelling of GM products. (i-sis.org.uk)
  • Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. (figshare.com)
  • Human papillomavirus E7 protein detection as a method of triage to colposcopy of HPV positive women, in comparison to genotyping and cytology. (bvsalud.org)
  • Human papillomavirus (HPV) proteins may elicit antibody responses in the process towards HPV-related malignancy. (who.int)
  • It might be a perfect model to study the cellular toxicity of prion protein. (researchgate.net)
  • These viral proteins also interact with other several cellular factors and lead to revoke normal cell cycle checkpoint stand cell death mechanisms 13 . (bvsalud.org)
  • Human papillomavirus molecular biology and disease association. (upm.edu.my)
  • The LxCxE motif binds to all pocket proteins and is present in chromatin regulators such as HDAC and KDM5A and in viral proteins. (eu.org)
  • When E7 binds to and degrades Rb protein, it is. (whiskypedia.ro)
  • Multiplex human papillomavirus serology based on in situ-purified glutathione S-transferase fusion proteins. (cdc.gov)
  • Mice vaccinated with λ-HPV-16 E7 are able to generate potent therapeutic antitumor effects against challenge with E7- expressing tumor cell line, TC-1 compared to group treated with the wild phage. (biomedcentral.com)
  • Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. (colorado.edu)
  • Pocket proteins Rb, p107 and p130 play central roles in cell cycle progression and differentiation. (eu.org)
  • Distribution of human papillomavirus (HPV) types and anti-HPV T-cell immune responses among different racial/ethnic groups in Central Arkansas. (uams.edu)
  • for 5 min and resuspended in CelLytic M Cell Lysis Reagent (Sigma-Aldrich) containing Halt Protease Inhibitor Cocktail and Halt Phosphatase Inhibitor Cocktail (Thermo Scientific, Waltham, MA) and 5 mM EDTA at 4 C. Proteins concentrations were established with Bio-Rad Proteins Assay Reagent (Hercules, CA) and examples had been diluted with 1/3 quantity 4X SDS test buffer and warmed at 95 C for 5 min. (antiviralbiologic.com)
  • Besides, we demonstrate that E5 forms a ternary complex with calnexin and the heavy chain of HLA-I, which is mediated by the first hydrophobic region of the E5 protein. (biomedcentral.com)