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  • transcriptional
  • Recently, it has been shown that Id3 is expressed in quiescent satellite cells, and it has been proposed that it is a direct transcriptional target of Pax7, suggesting Id3 may be involved directly in the maintenance of the quiescent state ( 27 ). (physiology.org)
  • postnatal
  • We have previously reported that postmitotic expression of a local isoform of insulin-like growth factor 1 (mIGF-1) induces myocyte hypertrophy ( 16 ), increases mass and strength of postnatal muscle, and preserves regenerative capacity in senescent and dystrophic mice ( 17 - 19 ). (pnas.org)
  • PAX7 directs postnatal renewal and propagation of myogenic satellite cells but not for the specification. (wikipedia.org)
  • MyoD
  • One of the main actions of MyoD is to remove cells from the cell cycle (halt proliferation for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of p21 and myogenin. (wikipedia.org)
  • MyoD is a transcription factor and can also direct chromatin remodelling through binding to a DNA motif known as the E-box. (wikipedia.org)
  • When the kinase MSK1 phosphorylates KAP1, the corepressors previously bound to the scaffold are released allowing MyoD and Mef2 to activate transcription. (wikipedia.org)
  • PAX3 mediates the transcription of c-Met and is responsible for the activation of MyoD expression-one of the functions of MyoD is to promote the regenerative ability of satellite cells (described below). (wikipedia.org)
  • mice
  • Although we did not observe differences in the numbers of quiescent Pax7 + satellite cells in adult uninjured hindlimb muscles, we did observe a significant reduction in the number of proliferating Pax7 + cells in the Id-mutant mice after muscle injury compared with either wild-type or Id3-null mice. (physiology.org)
  • However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. (wikipedia.org)
  • Additionally, mice lacking PAX7 had delayed recovery of spermatogenesis following exposure to busulfan when compared to control mice. (wikipedia.org)
  • skeletal muscle
  • Confocal immunofluorescence microscopy revealed that activated Pax7 + myoblasts coexpressed nuclear pSmad1/5/8, Id1, and Id3 in injured mouse skeletal muscle sections. (physiology.org)
  • We investigated the mechanism whereby expression of a transgene encoding a locally acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle damage. (pnas.org)
  • proliferate
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)
  • cells
  • Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. (frontiersin.org)
  • Hematopoietic and CD45 − /VEGFR2 + cells (known as endothelial progenitor cells or circulating angiogenic cells) have been reported to contribute to angiogenesis through the paracrine secretion of proangiogenic factors, as well as incorporate into new vessels, although luminal incorporation appears to be a relatively rare event ( 48 , 55 ). (physiology.org)
  • In resting muscle, these quiescent mononuclear cells express the paired box transcription factor Pax7 and, in some muscle types, Pax3. (physiology.org)
  • Current thinking is that most satellite cells express PAX7 and PAX3. (wikipedia.org)
  • Fusion
  • The PAX7-FOXO1 fusion is often amplified in tumors (about 70 percent of all PAX7-FOXO1 fusion positive tumors) and the PAX3-FOXO1 fusion is rarely amplified (only in 5 percent of all PAX3-FOXO1 fusion positive tumors). (wikipedia.org)
  • This fusion causes a dysregulation of transcription and acts as an oncogene promoting cancer formation. (wikipedia.org)
  • Patients who have metastatic ARMS positive with PAX3-FOXO1 fusion often have a poorer outcome than patients positive with PAX7-FOXO1 fusion, with a four-year survival rate of 8 percent and 75 percent respectively. (wikipedia.org)
  • muscle
  • Indeed, the transplantation of bone marrow-derived SCs into the mdx dystrophic mouse model had a limited impact on muscle cell replacement ( 10 ), suggesting that the poor recruitment of circulating SCs is one of the limiting factors for tissue repair ( 10 , 11 ). (pnas.org)
  • role
  • demonstrate the importance of peripheral clock regulation in chondrocytes and report that the circadian transcription factor BMAL1 plays an essential role in maintaining the integrity of cartilage tissue. (jci.org)
  • Pax6
  • The transcription factors Pax2 and Pax6 are co-expressed in the entire optic vesicle (OV) prior and concomitant with the establishment of distinct neuroretinal, retinal, pigmented-epithelial and optic-stalk progenitor domains, suggesting redundant functions during retinal determination. (biologists.org)
  • protein
  • This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. (genecards.org)
  • MyoD
  • PAX3 mediates the transcription of c-Met and is responsible for the activation of MyoD expression-one of the functions of MyoD is to promote the regenerative ability of satellite cells (described below). (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • One of the main actions of MyoD is to remove cells from the cell cycle (halt proliferation for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of p21 and myogenin. (wikipedia.org)
  • When the kinase MSK1 phosphorylates KAP1, the corepressors previously bound to the scaffold are released allowing MyoD and Mef2 to activate transcription. (wikipedia.org)
  • adult
  • The role for Pax7 in adult muscle regeneration in vertebrates indicates that Pax group III genes may be appropriate candidates to study in muscle regeneration in C. destructor. (edu.au)
  • differentiation
  • There is evidence that the control of smooth muscle cell differentiation by MiR-1 may be mediated by the down regulation of Kruppel-like factor 4 (KLF4), since a MiR-1 recognition site is predicted in the 3' UTR of KLF4 and inhibition of MiR-1 results in reversed down-regulation of KLF4 and an inhibition of smooth muscle cell differentiation. (wikipedia.org)
  • However, Pax7 is expressed prominently after satellite cell differentiation. (wikipedia.org)
  • However
  • However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. (wikipedia.org)
  • regulation
  • Later on Mitf and Chx10 continue to be expressed in adjacent regions of the eye, suggesting a reciprocal regulation between these two factors ( Nguyen and Arnheiter, 2000 ). (biologists.org)
  • domains
  • MEGF10 contains 17 atypical epidermal growth factor-like domains, each of which contains eight cysteine residues that likely form disulfide bonds. (springer.com)