• transcriptional
  • Recently, it has been shown that Id3 is expressed in quiescent satellite cells, and it has been proposed that it is a direct transcriptional target of Pax7, suggesting Id3 may be involved directly in the maintenance of the quiescent state ( 27 ). (physiology.org)
  • subset
  • PAX7 functions as a marker for a rare subset of spermatogonial stem cells, specifically a sub set of Asingle spermatogonia. (wikipedia.org)
  • Whereas many pets had been sacrificed at selected period factors (varying from 10 to 20 weeks after transplantation) for phenotype evaluation and crop of JMML cells, a subset of rodents was euthanized just when in poor condition therefore as to find out about the organic disease training course. (a-443654.com)
  • PAX3-FOXO1 positive subset of ARMS occurs mostly in older children and young adults, while PAX7-FOXO1 positive subset of ARMS and fusion negative subsets occur most often in younger children. (wikipedia.org)
  • MyoD
  • One of the main actions of MyoD is to remove cells from the cell cycle (halt proliferation for terminal cell cycle arrest in differentiated myocytes) by enhancing the transcription of p21 and myogenin. (wikipedia.org)
  • MyoD is a transcription factor and can also direct chromatin remodelling through binding to a DNA motif known as the E-box. (wikipedia.org)
  • When the kinase MSK1 phosphorylates KAP1, the corepressors previously bound to the scaffold are released allowing MyoD and Mef2 to activate transcription. (wikipedia.org)
  • PAX3 mediates the transcription of c-Met and is responsible for the activation of MyoD expression-one of the functions of MyoD is to promote the regenerative ability of satellite cells (described below). (wikipedia.org)
  • skeletal muscle
  • Confocal immunofluorescence microscopy revealed that activated Pax7 + myoblasts coexpressed nuclear pSmad1/5/8, Id1, and Id3 in injured mouse skeletal muscle sections. (physiology.org)
  • adult
  • Although we did not observe differences in the numbers of quiescent Pax7 + satellite cells in adult uninjured hindlimb muscles, we did observe a significant reduction in the number of proliferating Pax7 + cells in the Id-mutant mice after muscle injury compared with either wild-type or Id3-null mice. (physiology.org)
  • mice
  • However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. (wikipedia.org)
  • Additionally, mice lacking PAX7 had delayed recovery of spermatogenesis following exposure to busulfan when compared to control mice. (wikipedia.org)
  • proliferate
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)
  • cells
  • Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. (frontiersin.org)
  • Hematopoietic and CD45 − /VEGFR2 + cells (known as endothelial progenitor cells or circulating angiogenic cells) have been reported to contribute to angiogenesis through the paracrine secretion of proangiogenic factors, as well as incorporate into new vessels, although luminal incorporation appears to be a relatively rare event ( 48 , 55 ). (physiology.org)
  • In resting muscle, these quiescent mononuclear cells express the paired box transcription factor Pax7 and, in some muscle types, Pax3. (physiology.org)
  • Current thinking is that most satellite cells express PAX7 and PAX3. (wikipedia.org)
  • fibroblast
  • For SHH to be expressed in the developing embryo limbs, a morphogen called fibroblast growth factors must be secreted from the apical ectodermal ridge. (wikipedia.org)
  • role
  • demonstrate the importance of peripheral clock regulation in chondrocytes and report that the circadian transcription factor BMAL1 plays an essential role in maintaining the integrity of cartilage tissue. (jci.org)