• lineage
  • An additional WGD experienced in the teleost lineage led to two copies of pax2 , each of which retained a large proportion of these CNEs. (biologists.org)
  • Activation of the pathway at the cerebellar ventricular zone led to a reduction in the number of cells expressing the glial lineage markers Sox9 and GFAP and the interneuron marker Pax2, but had no consistent effect on either proliferation or apoptosis. (biomedsearch.com)
  • GDNF
  • The glial cell line-derived neurotrophic factor (GDNF) from the metanephric mesenchyme binds to the C-ret receptor on the branching ureteric bud and is responsible for the branching and elongation of the ureteric bud. (medscape.com)
  • GFAP
  • their differentiation into GFAP + cells is induced by ciliary neurotrophic factor (CNTF) or by leukemia inhibitory factor (LIF). (jneurosci.org)
  • In addition, purified APCs do not differentiate constitutively in serum-free culture but are induced to differentiate into GFAP + astrocytes by CNTF or by leukemia inhibitory factor (LIF). (jneurosci.org)
  • apoptosis
  • The loss of slit diaphragm components as well as the activation of transforming growth factor-β may lead to transdifferentiation, detachment, and apoptosis. (physiology.org)
  • kidney
  • Mammalian protein Pax2, a probable transcription factor that may have a role in kidney cell differentiation. (ebi.ac.uk)
  • In the case of human ES cells, kidney-like structures have been observed in teratomas formed from human ES cells [ 23 - 25 ] and reverse transcription-polymerase chain reaction (RT-PCR) analyses of heterogeneous human ES cell-derived populations in embryoid bodies have indicated the presence of transcripts associated with kidney development [ 26 ]. (pubmedcentralcanada.ca)
  • Pax2 misexpression is frequently observed in proliferative disorders of the kidney. (wikipedia.org)
  • For example, Pax2 is highly expressed in polycystic kidney disease (PKD), Wilms' tumor (WT), and renal cell carcinoma (RCC). (wikipedia.org)
  • The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney. (wikipedia.org)
  • midbrain
  • The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei. (wikipedia.org)
  • interacts
  • Many of these GTFs do not actually bind DNA, but rather are part of the large transcription preinitiation complex that interacts with RNA polymerase directly. (wikipedia.org)
  • regulation
  • The transcription factors predicted to bind the TM6SF2 promoter suggest this protein functions in growth and tumor regulation as well as sex determination to a lesser extent. (wikipedia.org)
  • MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (wikipedia.org)
  • proliferation
  • By comparing to the control non-target shRNA cancer cell lines and the parental cell lines, Pax2 knockdown cell lines have significant reduction in growth rate as measured by WST cell proliferation assay. (aacrjournals.org)
  • humans
  • In this paper, we will focus on the knowledge derived from the study of syndromic and non-syndromic forms of CAKUT in humans and mouse mutants to discuss the role of genetic, epigenetic, and in utero environmental factors in the pathogenesis of non-syndromic forms of CAKUT in children with particular emphasis on the genetic contributions to CAKUT. (hindawi.com)
  • Paired box gene 2, also known as PAX2 is a protein which in humans is encoded by the PAX2 gene. (wikipedia.org)
  • Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene. (wikipedia.org)
  • gene promoter
  • Pathologically, Pax2 has been demonstrated to activate hepatocyte growth factor (HGF) gene promoter, and both have been indicated as playing a role in human prostate cancers. (wikipedia.org)
  • utero
  • The major factors influencing in utero environment that are associated with a low final nephron number include uteroplacental insufficiency, maternal low-protein diet, hyperglycemia, vitamin A deficiency, exposure to or interruption of endogenous glucocorticoids, and ethanol exposure. (biomedsearch.com)