• The systematic name of this enzyme class is AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming). (wikipedia.org)
  • Other names in common use include adenosine phosphosulfate reductase, adenosine 5'-phosphosulfate reductase, APS-reductase, APS reductase, AMP, sulfite:(acceptor) oxidoreductase, and (adenosine-5'-phosphosulfate-forming). (wikipedia.org)
  • Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (mcw.edu)
  • In biochemistry, an Oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). (wellnessadvantage.com)
  • The systematic name is based on donor:acceptor oxidoreductase. (lookformedical.com)
  • However, some pre- three copper ions located at the corners of a near-isosceles tri- vious microbiological evidence showed that thiocyanate may be angle and facilitates a direct thiocyanate conversion into cya- degraded by cell-free extracts of haloalkaliphilic thiocyanate- nate, elemental sulfur, and two reducing equivalents without utilizing SOB in the presence of an electron acceptor via a involvement of molecular oxygen . (docslib.org)
  • Adenylyl-sulfate reductase (EC 1.8.99.2) is an enzyme that catalyzes the chemical reaction of the reduction of adenylyl-sulfate/adenosine-5'-phosphosulfate (APS) to sulfite through the use of an electron donor cofactor. (wikipedia.org)
  • The products of the reaction are AMP and sulfite, as well as an oxidized electron donor cofactor. (wikipedia.org)
  • This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. (repositoriosalud.es)
  • All nitrogenases have an iron- and sulfur-containing cofactor that includes heterometal atom in the active site (e.g. (bionity.com)
  • Structural convergence between human VKOR and the disulfide donors is found to underlie cofactor reduction, disulfide generation, and electron transfer. (cornell.edu)
  • Dissimilatory and assimilatory pathways both use APS reductases as a metabolic tool to produce a sulfur source and amino acids, respectively. (wikipedia.org)
  • Sulfur is a vital component in biological life and a key element in amino acids cysteine and methionine. (wikipedia.org)
  • The Oxidoreductases group of enzymes usually utilizes NADP or NAD as cofactors. (wellnessadvantage.com)
  • In enzymology , Oxidoreductase Acting on CH-CH Donors (EC 1.3 Enzyme subclass ) in the Oxidoreductase Class of enzymes are a subclass of oxidoreductase enzyme which includes all dehydrogenases acting on carbon-carbon bonds. (wellnessadvantage.com)
  • The Oxidoreductases Acting on CH-CH Group Donors enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds. (wellnessadvantage.com)
  • In biochemistry, the EC 1.8 Enzyme subclass in the Oxidoreductase Class of enzymes. (wellnessadvantage.com)
  • A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (lookformedical.com)
  • Here we present an unpreviously reported type of a Copper enzymes comprise a rather diverse, but not numerous, polynuclear center consisting of three copper ions, which form group of biocatalysts. (docslib.org)
  • Over 20 copper-containing enzymes that the active site of a not previously described enzyme, thiocya- catalyze a wide-ranging group of chemical reactions have been nate dehydrogenase. (docslib.org)
  • Through dedicated relay pathways, the disulfide is generated in donor enzymes, passed to carrier enzymes, and subsequently delivered to target proteins. (cornell.edu)
  • In prokaryotes, disulfide generation is coupled to quinone reduction, catalyzed by intramembrane donor enzymes, DsbB and VKOR. (cornell.edu)
  • The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. (genome.jp)
  • This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other acceptors. (wikipedia.org)
  • This enzyme participates in selenium metabolism and sulfur metabolism. (wikipedia.org)
  • In fact, studies have shown that when cells are starved of sulfur, APS reductase gene expression fluctuates, indicating that when the plants are exposed to metabolic and regulatory stress, APS reductase is likely a crucial enzyme in producing hydrogen sulfide and restoring homeostasis. (wikipedia.org)
  • Some sulfur- Here we report the discovery and characterization of a pre- oxidizing bacteria (SOB) known to play an important role in viously undescribed copper center that forms the active site of global geochemical cycles can utilize thiocyanate as the sole a copper-containing enzyme thiocyanate dehydrogenase (sug- source of energy and nitrogen . (docslib.org)
  • Both forms are toxic: arsenite disrupts sulfhydryl groups of proteins and interferes with enzyme function, whereas arsenate acts as a phosphate analog and can interfere with phosphate uptake and transport. (easyreport.in)
  • An IRON-containing protein that uses siroheme and 4Fe-4S iron-sulfur centers as prosthetic groups. (lookformedical.com)
  • The 30-kDa membrane-bound c-type cytochrome protein of mitochondria that functions as an electron donor to CYTOCHROME C GROUP in the mitochondrial and bacterial RESPIRATORY CHAIN. (lookformedical.com)
  • Nitrogenase associates with a second protein, and each cycle transfers one electron from an electron donor which is enough to break one of the nitrogen chemical bonds. (bionity.com)
  • During oxidative protein folding, disulfide bond formation is catalyzed by thiol oxidoreductases. (cornell.edu)
  • Oxidoreductases with specificity for oxidation or reduction of SULFUR COMPOUNDS. (harvard.edu)
  • In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. (genome.jp)
  • Dissimilatory sulfate reduction takes sulfate and transforms it into sulfide, a sulfur source that can be distributed throughout the body. (wikipedia.org)
  • Oxidoreductases that are specific for the reduction of NITRATES. (lookformedical.com)
  • Although arsenic is generally toxic to life, it has been demonstrated that microorganisms can use arsenic compounds as electron donors or electron acceptors, and that they can possess arsenic detoxification mechanisms [3-6]. (easyreport.in)
  • Compounds having the nitro group, -NO2, attached to carbon. (lookformedical.com)
  • however, research suggests that the reverse reaction requires two AMP molecules (one acting on the substrate and one inhibiting the forward reaction). (wikipedia.org)
  • In our body, Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. (wellnessadvantage.com)
  • gives sulfate as the final sulfur reaction product . (docslib.org)
  • A molecular mechanism of ca- chemical reaction producing cyanate and elemental sulfur as final talysis is suggested based on high-resolution three-dimensional products (21, 22): structures, electron paramagnetic resonance (EPR) spectroscopy, quantum mechanics/molecular mechanics (QM/MM) simulations, - - 0 + - N ≡ C-S + H2O → N ≡ C-O + S + 2H + 2e [1] kinetic studies, and the results of site-directed mutagenesis. (docslib.org)
  • APS reductase controls the rate limiting step of endogenous sulfur assimilation, which is the process of producing hydrogen sulfide from sulfite. (wikipedia.org)
  • Nitrogenase thus breaks the triple bond by getting electron donors for each of the three bonds, and then bonds the nitrogen to hydrogen atoms. (bionity.com)
  • When the iron-sulfur cluster is present, it is required for catalytic activity and coordinated to the four cysteine residues in the conserved motif on the other side of the active site cleft. (wikipedia.org)
  • These metabolic changes are independent of the presence of sulfur aminoacids, are confirmed in mouse models, and are recapitulated by overexpression of SQOR, further proving that the metabolic effects of CoQ10 supplementation are mediated by the overexpression of SQOR. (repositoriosalud.es)
  • A flavoprotein oxidase complex that contains iron-sulfur centers. (ouhsc.edu)
  • It has also been reported in small quantities in some sulfur bacteria performing anaerobic photosynthesis. (microbenotes.com)
  • APS reductase controls the flow of inorganic sulfur to cysteine, which is involved in many biological processes in plants such as growth, development, and responses to biotic and abiotic stresses. (wikipedia.org)
  • This graph shows the total number of publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Harvard Catalyst Profiles by year, and whether "Oxidoreductases Acting on Sulfur Group Donors" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Profiles. (harvard.edu)
  • To catalyze de novo disulfide formation, these different disulfide donors show striking structural convergence at several levels. (cornell.edu)
  • The P-loop, or phosphate-binding loop, is an especially important consecutive sequence of resides which aids in the recognition of the phosphate group in APS and, as a result, influences the substrate specificity for APS reductase. (wikipedia.org)
  • The substrate that is oxidized is regarded as a hydrogen donor. (lookformedical.com)
  • Hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group. (lookformedical.com)
  • This finding leads us to hypothesize that the therapeutic effects of CoQ10, frequently administered to patients with primary or secondary mitochondrial dysfunction, might be due to its function as cofactor for sulfide:quinone oxidoreductase (SQOR), the first enzyme in the sulfide oxidation pathway. (repositoriosalud.es)
  • Dissimilatory and assimilatory pathways both use APS reductases as a metabolic tool to produce a sulfur source and amino acids, respectively. (wikipedia.org)
  • In fact, studies have shown that when cells are starved of sulfur, APS reductase gene expression fluctuates, indicating that when the plants are exposed to metabolic and regulatory stress, APS reductase is likely a crucial enzyme in producing hydrogen sulfide and restoring homeostasis. (wikipedia.org)
  • These metabolic changes are independent of the presence of sulfur aminoacids, are confirmed in mouse models, and are recapitulated by overexpression of SQOR, further proving that the metabolic effects of CoQ10 supplementation are mediated by the overexpression of SQOR. (repositoriosalud.es)
  • When the iron-sulfur cluster is present, it is required for catalytic activity and coordinated to the four cysteine residues in the conserved motif on the other side of the active site cleft. (wikipedia.org)
  • Sulfur is a vital component in biological life and a key element in amino acids cysteine and methionine. (wikipedia.org)
  • The P-loop, or phosphate-binding loop, is an especially important consecutive sequence of resides which aids in the recognition of the phosphate group in APS and, as a result, influences the substrate specificity for APS reductase. (wikipedia.org)
  • Cytochrome P450 proteins can also be grouped by two different schemes. (embl.de)
  • APS reductase controls the rate limiting step of endogenous sulfur assimilation, which is the process of producing hydrogen sulfide from sulfite. (wikipedia.org)
  • Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. (drugbank.com)
  • therefore, these iron-sulfur clusters are not present within PAPS reductase. (wikipedia.org)
  • The group of uninoculated ts 1 survivors present as a high proportion of individuals with cytotoxic T-lymphocyte reactivity against both uninoculated and CVB3(m) inoculated skin fibroblasts. (nih.gov)
  • APS reductase controls the flow of inorganic sulfur to cysteine, which is involved in many biological processes in plants such as growth, development, and responses to biotic and abiotic stresses. (wikipedia.org)
  • LiCKO and controls were split into eight groups based on genotype (con, LiCKO), diet (normal diet, HFC), and diet duration (12 weeks, 20 weeks). (bvsalud.org)