• However, under the severe levels of oxidative stress that cause necrosis, the damage causes ATP depletion, preventing controlled apoptotic death and causing the cell to simply fall apart. (wikipedia.org)
  • Among the most interesting of his findings was that switching off the gene for a protein called prosaposin, which normally assists with the cell's recycling of waste products, greatly increased the levels of oxidative stress. (sciencedaily.com)
  • The evidence thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. (bham.ac.uk)
  • Paternal obesity is a particularly frequent example and age, too, has been found to be associated with elevated levels of oxidative stress, alterations in methylation status and increased risk of neurological disorders - epigenetics! (my-fertility-blog.com)
  • Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. (wikipedia.org)
  • Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
  • Increasing evidence suggests that the etiology of AD may involve disruptions of zinc homeostasis, and oxidative stress facilitating reactive oxygen species production is an early and sustained event in AD disease progression. (springer.com)
  • The formation of reactive oxygen species, the damage caused by them in various tissues, the role of inflammatory mediators or enzymatic scavengers in oxidative stress pathogenesis, and the loss of integrity of antioxidant defense systems have been documented in different aspects of the critical illness. (hindawi.com)
  • Although oxygen itself is an essential element of life, molecules in cells, such as DNA and proteins, are sometimes damaged by reactive oxygen species (ROS) in what is called oxidative stress. (dojindo.com)
  • Oxidative stress, in which production of highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) overwhelms antioxidant defenses, is a feature of many neurological diseases and neurodegeneration. (unboundmedicine.com)
  • Glutathione serves as an antioxidant and protects against oxidative damage, but it can also bond covalently with proteins via its sulfhydryl moiety in the presence of reactive oxygen species (ROS). (huntingtree.co.nz)
  • When plant cells surpass stress threshold stimuli, chemically reactive oxygen species (ROS) are generated that can cause oxidative damage or act as signals. (lincoln.ac.uk)
  • Human alveolar lung A459 epithelial cells were exposed to freshly generated metal NP mixtures at a target concentration of 100?µg/m3 for 6?hr and then harvested for assessment of cytotoxicity, generation of reactive oxygen species (ROS), and alterations in the expression of genes and proteins involved in metal regulation, inflammatory responses, and oxidative stress. (cdc.gov)
  • Aβ-mediated oxidative stress results in mitochondrial dysfunction, impairment of glucose metabolism, loss of proteostasis and synaptic plasticity, altered signal transduction, neuroinflammation, and progressive loss of neurons 9 . (nature.com)
  • Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
  • there is a change in metabolism early on in AD patients - which implicates mitochondrial dysfunction and oxidative stress. (anavex.com)
  • Based on the results of their experiment, the researchers concluded that the aqueous extract of L. divaricata is capable of reversing oxidative stress induced by the administration of STZ in the submandibular glands of rats. (naturalnews.com)
  • While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
  • The thesis aimed to investigate markers of oxidative stress in AD plasma. (bham.ac.uk)
  • In view of all the aforementioned, the objective of the present work was to make a comparative analysis of the protective effects derivable from riboflavin (B 2 ) and pyridoxine (B 6 ) on 5-HIAA and dopamine levels, as well as on selected markers of oxidative stress in rats' brain regions after an induction of Huntington's disease (HD). (biomedcentral.com)
  • However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis. (wikipedia.org)
  • However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
  • Under oxidative stress, the effects of maltol on cell viability, apoptosis, and neurite outgrowth were assessed. (molvis.org)
  • Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
  • These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
  • In this study, we examined the cytoprotective effects of cyanidin-3-glucoside (C3G) isolated from mulberry fruit against pancreatic β-cell apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress. (spandidos-publications.com)
  • The MIN6 pancreatic β-cells were used to investigate the cytoprotective effects of C3G on the oxidative stress-induced apoptosis of cells. (spandidos-publications.com)
  • Taken together, our results suggest that C3G isolated from mulberry fruit has potential for use as a phytotherapeutic agent for the prevention of diabetes by preventing oxidative stress-induced β-cell apoptosis. (spandidos-publications.com)
  • Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • The sugars lactose and galactose that are found in milk can increase oxidative stress and chronic inflammation in the body - both of which are major causes of serious and chronic diseases. (diagnose-me.com)
  • Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? (mdpi.com)
  • Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. (mdpi.com)
  • Oxidative stress results from an imbalance of pro- and anti-oxidants and leads to faster skin aging, inflammation and disease. (promocell.com)
  • Oxidative stress can become a self-fuelling cycle, where the initial stress leads to dysregulation of physiological processes, inflammation and a deregulated immune system which in turn lead to various diseases that may cause further inflammation and oxidative stress. (promocell.com)
  • This thesis details analytical methods that use fluorescence derivatization in order to detect small molecule biomarkers of oxidative stress as they relate to epilepsy, inflammation, and traumatic brain injury. (ku.edu)
  • A microchip electrophoresis-fluorescence method was then developed for the detection of carnosine, an endogenous dipeptide that is involved in oxidative stress-induced inflammation following prolonged activation of macrophage cells. (ku.edu)
  • Moreover, oxidative stress also activates mechanisms that result in a glia-mediated inflammation that also causes secondary neuronal damage. (unboundmedicine.com)
  • We provide biomedical researchers with the best tools available for the analysis of Oxidative Stress and Chronic Inflammation - two of the most important risk factors that play key roles in the development of a wide range of human illness, including cancer, cardiovascular disease, diabetes and neurodegeneration. (oxfordbiomed.com)
  • After two weeks of intermittent oxygen deprivation, all animals were tested for learning, oxidative stress, and inflammation. (green-tea-health-news.com)
  • Those receiving water only showed a loss of learning in a maze test, as well as markedly increased oxidative stress and inflammation. (green-tea-health-news.com)
  • it reduced both oxidative stress and inflammation, up to 40% in some cases (Burckhardt JC, Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hyposia, American Journal of Respiratory and Critical Care Medicine, May 2008). (green-tea-health-news.com)
  • Two prominent welding fume particulate metal components are nanosized iron (Fe) and manganese (Mn) which might induce oxidative stress and inflammation resulting in pulmonary injury. (cdc.gov)
  • Assessment of gene expression demonstrated variable up-regulation in cellular mechanisms related to metal transport and storage, inflammation, and oxidative stress based upon aerosol composition. (cdc.gov)
  • Cosmic radiation is known to induce DNA and lipid damage associated with increased oxidative stress and remains a major concern in space travel. (drsircus.com)
  • Oxidative stress during pregnancy alters fetal epigenetic patterns and leads to cardiovascular disease and maternal diabetes (associated with increased oxidative stress) increases the risk of autism disorders in children - epigenetics! (my-fertility-blog.com)
  • It is well known that an excessive production of free radicals contributes to an increased burden of oxidative stress that may be implicated in the pathophysiology of tissue injury of various organs and in systemic dysfunction in critically ill patients. (hindawi.com)
  • Research suggests aging is caused by cumulative oxidative stress due to free radicals generated in biological systems both via metabolism and as a result of exposure to UV light (Stojiljkovic, 2014). (promocell.com)
  • Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. (my-fertility-blog.com)
  • The aim of this work was to determine if riboflavin (B 2 ) and pyridoxine (B 6 ) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers. (biomedcentral.com)
  • STZ has been shown to generate an imbalance between oxidative and antioxidant systems by decreasing the secretion of peroxidase in submandibular glands. (naturalnews.com)
  • Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with AD, according to one paper by Smith. (anavex.com)
  • Oxidative stress is commonly defined as an imbalance between pro- and antioxidants (Tan, 2018). (promocell.com)
  • Lipids, proteins, carbohydrates and DNA are all susceptible to oxidative damage and this damage can change gene transcription along with cell proliferation and differentiation and is involved in several diseases including diabetes and obesity, cancer and neurological disorders (Kregel, 2007). (promocell.com)
  • Saleh R, Betancor M, Roo J, Benitez-Santana T, Zamorano MJ & Izquierdo MS (2015) Biomarkers of bone development and oxidative stress in gilthead seabream larvae fed microdiets with several levels of polar lipids and α-tocopherol. (stir.ac.uk)
  • Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approaches. (bham.ac.uk)
  • Results presented in this thesis suggest that global plasma protein oxidation levels are not different when AD and control subjects are compared, but that individual plasma proteins are specific targets for oxidative modification in AD. (bham.ac.uk)
  • UV radiation that causes oxidative stress and hence aging induces the expression of matrix metalloproteinases (MMPs) that degrade dermal collagen and other proteins from the extracellular matrix (Caravalhaes Lago, 2019). (promocell.com)
  • ROS and RNS can also indirectly contribute to tissue damage by activating a number of cellular pathways resulting in the expression of stress-sensitive genes and proteins to cause oxidative injury. (unboundmedicine.com)
  • The levels of peroxisome proliferator‑activated receptor gamma coactivator (PGC)‑1α/nuclear factor erythroid‑2‑related factor 2 (Nrf2) signalling, oxidative stress and pyroptosis‑related proteins were detected by western blotting. (spandidos-publications.com)
  • Inhibition of miR‑132 activated PGC‑1α/Nrf2 signalling and inhibited oxidative stress and the expression of the pyroptosis‑related proteins NLRP3, caspase‑1 and IL‑1β, which were all reversed by inhibiting SIRT1 with EX527. (spandidos-publications.com)
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • Project 2 examines the hypothesis that A13-mediated oxidative modifications of and subsequent dysfunction of Pini are fundamental to the genesis of specific pathological features in AD. (uky.edu)
  • The review comprehensively explores the literature for evidence of the role of oxidative stress in conditions such as abortions, preeclampsia, hydatidiform mole, fetal embryopathies, preterm labour and preeclampsia and gestational diabetes. (nih.gov)
  • Our major goal is to provide you with straightforward, reliable assays for oxidative stress biomarkers and for antioxidant capacity of biological fluids. (oxfordbiomed.com)
  • The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. (wikipedia.org)
  • there is no definitive study which has shown that maltol effectively protects them from the devastating effects of oxidative stress. (molvis.org)
  • Furthermore, the impact of several drugs and treatments on the regulation of oxidative stress in critically ill patients has been evaluated in several investigations aiming to improve outcomes in critical illness. (hindawi.com)
  • The regulation of oxidative stress in the different cells is associated with the enzymatic activity of antioxidant systems related to zinc (Zn) and selenium (Se) elements. (ualg.pt)
  • Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. (wikipedia.org)
  • An intense study of the underlying mechanisms and interventions related to oxidative stress could provide further insight into the understanding of critical illness and could form the basis for novel strategic hypothesis or improved interventions in the management of critically ill patients. (hindawi.com)
  • We therefore invite authors to contribute original research articles as well as review articles that will stimulate the effort to understand thoroughly the underlying mechanisms of oxidative stress, to reveal its impact on major organs and systems, and to illustrate diagnostic and treatment interventions in the critically ill patient. (hindawi.com)
  • Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. (nature.com)
  • In response, aerobic organisms created defense mechanisms to avoid oxidative stress. (dojindo.com)
  • Oxidative stress has recently become the focus of many studies seeking to understand these defense mechanisms and the relationships between oxidative damage and disease or aging processes. (dojindo.com)
  • Measurement of these modifications is important for understanding the mechanisms of oxidative DNA damage and its biological repercussions. (dojindo.com)
  • It is designed to protect against outside damage including UV light exposure and has several defense mechanisms to protect against oxidative damage including antioxidants such as superoxide dismutases, CGT, catalases, GSH and ascorbic acid. (promocell.com)
  • A clearer appreciation of the potential therapeutic utility of antioxidants would emerge only when the complexity of their effects on mechanisms that interact to determine the extent of oxidative damage in vivo are more fully defined and understood. (unboundmedicine.com)
  • Assays for some of these oxidative stress biomarkers, as well as assays for several of the body's antioxidant defense mechanisms, have been widely used. (oxfordbiomed.com)
  • Scholars@Duke publication: Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts. (duke.edu)
  • The major hypothesis of this application is that betaamyloid peptide (Af3) is one of the pivotal mechanisms in oxidative stress/damage to neurons in AD. (uky.edu)
  • This well integrated program project will move the field of A13 and oxidative stress in AD forward and gain insights into mechanisms of neuron degeneration so that successful interventions can be developed to treat or prevent the most dehumanizing disorder to affect humans. (uky.edu)
  • Mechanisms of oxidative stress in the potentiation of noise -induced hearing loss by acrylonitrile. (cdc.gov)
  • With this in mind, the present study investigates whether maltol attenuates oxidative stress injury in primary RGCs in vitro. (molvis.org)
  • Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice. (bvsalud.org)
  • Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. (wikipedia.org)
  • DNA damage induced by ionizing radiation is similar to oxidative stress, and these lesions have been implicated in aging and cancer. (wikipedia.org)
  • Ovulation-induced oxidative base damage and damage to DNA of the ovarian epithelium can be prevented by antioxidants. (nih.gov)
  • The patho-physiological characteristic of AD is abnormal deposition of fibrillar amyloid β protein, intracellular neurofibrillary tangles, oxidative damage and neuronal death in the brain. (springer.com)
  • Increased free radical activity ( oxidative stress ) appears to fuel Alzheimer's pathology - acting simultaneously as a mediator, product, and trigger for this "clogging" process and its related neural damage. (diagnose-me.com)
  • Activation of this receptor leads to increased oxidative stress that may result in cellular damage. (diagnose-me.com)
  • The influx and subsequent activation of such inflammatory cells into the lung therefore may lead to an oxidative burst which overwhelms the pulmonary antioxidative defences, resulting in oxidative DNA damage. (ecetoc.org)
  • That's where it's most important - where the cascade effect of oxidative damage begins. (limoneira.com)
  • The in vitro test exposed the lemon peel extract to a specific type of rat heart cell with oxidative damage. (limoneira.com)
  • LPE has the potential to be developed into natural medicine or health food for the inhibition of cell oxidative damage. (limoneira.com)
  • Oxidative damage to DNA results from the interaction of DNA with ROS, in particular, hydroxy radicals. (dojindo.com)
  • However, clinical data clearly indicate that oxidative DNA damage is related to a number of disease processes such as carcinogenesis and neurodegenerative diseases. (dojindo.com)
  • Since glutathione also has superoxidescavenging activity, it contributes to a reductive atmosphere in cells and tissues to avoid oxidative damage. (dojindo.com)
  • In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
  • The most significant extrinsic factor causing accelerated skin aging is exposure to UV light leading to the production of ROS (Stojiljkovic, 2014) which cause oxidative damage. (promocell.com)
  • However, the excessive generation of ROS, such as super oxide anions (O 2 − ) and hydrogen peroxide (H 2 O 2 ) due to environmental stress results in significant oxidative damage to cell structures, such as DNA, the mitochondria and cell membranes ( 3 , 4 ). (spandidos-publications.com)
  • The activation of the antioxidant system is insufficient to combat oxidative stress damage. (ajol.info)
  • In the presence of hydrogen peroxide, myeloperoxidase can exhibit two activities: chlorination and peroxidation, both of which can result in oxidative damage. (huntingtree.co.nz)
  • Our OxiSelect™ Oxidized HDL ELISA Kits provide a fast, convenient way to measure the oxidative damage to HDL in plasma or serum samples. (huntingtree.co.nz)
  • Oxidative damage and tyrosine nitration from peroxynitrite. (scienceopen.com)
  • If these DNA-parts have been affected by oxidative damage, however, they cannot be properly detected for epigenetic highlights any more. (my-fertility-blog.com)
  • In the 12-week study , the researchers concluded that Zeropollution reduced oxidative stress-induced skin damage and that the oral intake of this supplement may be considered a complementary nutrition strategy to avoid the negative effects of environmental pollution exposure. (nutritioninsight.com)
  • Oxidative damage on the skin (lipoperoxides content). (nutritioninsight.com)
  • Abundant evidence indicates that free radical mediated oxidative damage in the brain is prominent in AD, especially in the earliest detectable clinical phase of AD - mild cognitive impairment (MCI). (uky.edu)
  • Project 4 examines the hypothesis that sustained activation of NADPH oxidase by toxic forms of Aj3 triggers a cascade linking increased ROS to altered redox-based signaling and neurotoxic oxidative damage. (uky.edu)
  • The mechanism by which ACN renders the cochlea more vulnerable to noise damage is still unknown, but we hypothesize that the decrease of GSH and/or the inhibition of SOD reduce the cochlear intrinsic anti-oxidant defenses and ultimately create oxidative stress. (cdc.gov)
  • SOD is a potential therapeutic agent in diseases related to oxidative stress and as a material for moderating the aging process, because of its high antioxidant efficiency (much higher than that of glutathione or other reducing agents) and early action in the initial stages of ROS metabolism. (dojindo.com)
  • The objective of this study was to determine the combined effect of graded levels of -tocopherol with different levels and sources of krill phospholipids (KPL) and soybean lecithin (SBL) on growth, survival, resistance to stress, oxidative status, bone metabolism-related genes expression and biochemical composition of sea bream larvae. (stir.ac.uk)
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • For this purpose, two different drugs were used: (1) Sodium thiosulfate (STS), a CN antidote commonly used in humans in case of CN poisoning and (2) 4-methylpyrazole (4MP) which blocks ACN metabolism through the oxidative pathway, preventing CN formation. (cdc.gov)
  • Oxidative stress and neuroinflammation play important roles in the pathogenesis of AD. (nature.com)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
  • There is data that indicates that the brain in AD is under increased oxidative stress, which may have a role in the pathogenesis of neuron degeneration and death in this disorder. (anavex.com)
  • Nerve terminals may play a role in early pathogenesis and presymptomatic disease - but oxidative changes also occur as a result of the normal aging process, and are not specific to AD, he cautioned. (anavex.com)
  • Oxidative stress takes part in the pathogenesis of inflammatory bowel disease (IBD). (ecco-ibd.eu)
  • These data indicate that oxidative potential via oxidative stress can potentially increase tenderization early postmortem, which may provide more tender meat with no detriment to other meat quality factors. (unl.edu)
  • They were looking specifically for downstream changes in gene expression that would produce oxidative stress in the cell, a circumstance in which highly reactive forms of oxygen can create a toxic environment. (sciencedaily.com)
  • Medivation's (NASDAQ:MDVN) Dimebon for the treatment of Alzheimer's disease (AD) may have some effect on the oxidative stress pathway, an investigator and physicians said. (anavex.com)
  • In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-κB/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. (nature.com)
  • Obviously targeting mitochondria makes sense therapeutically, if you want to target the oxidative stress pathway. (anavex.com)
  • The question as to what causes the destruction of the dopamine-producing cells has puzzled researchers for years but a consensus is now emerging that Parkinson's disease is caused by oxidative stress and metal toxicity. (diagnose-me.com)
  • In this study, we report that both nano- and micro-CoCrMo induced a time and dose-dependent toxicity in various cell types (i.e. lung epithelial cells, osteoblasts, and macrophages), and the effects of particle size on cell viability and oxidative responses were interesting and cell specific. (whiterose.ac.uk)
  • Since this mutagenic response was inhibited in the presence of catalase as antioxidant, the authors concluded that oxidative stress in form of the generation and release of ROS and/or depletion of antioxidants may significantly contribute to this response. (ecetoc.org)
  • Recent studies have demonstrated that antioxidants present in natural products protect cells by reducing H 2 O 2 -induced oxidative stress in vitro and in vivo ( 5 - 7 ). (spandidos-publications.com)
  • In addition to sticking to healthy choices well before conception , it is vital to protect vulnerable sperms and oocytes from increased oxidative stress and supply the body with ample antioxidants . (my-fertility-blog.com)
  • Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
  • 4-Hydroxy-2-nonenal (HNE), among them, is believed to be largely responsible for cytopathological effects observed during oxidative stree in vivo and has achieved the status of one of the best recognized and most studied of the cytotoxic products of lipid peroxidation. (nih.gov)
  • Previous in vitro and in vivo studies revealed that oxidative stress caused by the accumulation of Aβ contributed to the initiation of AD 8 . (nature.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • Dr Samantha Budd, director of neurology strategy at AstraZeneca (NYSE:AZN), said AstraZeneca has a broad effort in AD, but does not have approaches on oxidative stress or neuroprotection. (anavex.com)
  • Dr Mark Smith, an investigator on Dimebon's trials who has studied the oxidative stress hypothesis for more than 15 years at Case Western Reserve University, said the clinical data on Dimebon looks very promising, especially if it is hitting mitochondria. (anavex.com)
  • Our hypothesis is that those spermatogonia experiencing high oxidative stress by any stressor, differentiate into spermatozoa of low quality affecting male fertility. (ualg.pt)
  • GERMROS project will explore the first part of this hypothesis, testing the resilience of spermatogonia to oxidative stress in a marine flatfish species, the Senegalese sole (Solea senegalensis), which is a promising candidate for aquaculture production in Europe but presents reproductive disorders, making this species ideal for the study proposed. (ualg.pt)
  • This study was conducted to evaluate the relationship between animal oxidative status, using lipopolysaccharide (LPS) as a promoter for oxidation. (unl.edu)
  • Further, some reactive oxidative species act as cellular messengers in redox signaling. (wikipedia.org)
  • Of note, DAPK can activate PKD in HeLa cells under oxidative stress conditions 11 , thus suggesting that PKD activation may contribute to cellular death. (nature.com)
  • Results show lambs administered lipopolysaccharide treatments exhibited greater oxidative potential, as indicated by increased rectal temperatures, and upregulated expression of mRNA protein pathways essential for cellular differentiation, proliferation, and apoptotic events. (unl.edu)
  • G promoter SNP and potentially cellular oxidative stress. (diabetesjournals.org)
  • As such, they concluded that the aqueous extract could be used as a local or systemic preventive agent against oral diseases caused by oxidative stress in diabetic subjects. (naturalnews.com)
  • Maltol has potential as a new neuroprotective therapeutic agent for oxidative stress-related ocular diseases, including glaucoma. (molvis.org)
  • The age-related alteration of collagen-rich extracellular matrix - promoted by oxidative stress - impairs the skin's structural integrity and creates a tissue microenvironment that promotes age-related skin diseases such as poor wound healing and skin cancer. (promocell.com)
  • Our findings highlight the potential roles that nano- and micro-CoCrMo, whether exposure is due to inhalation or implant wear, and the associated oxidative stress may play in the increasingly reported implant loosening, osteolysis, and systemic complications in orthopaedic patients, and may explain the risk of lung diseases in dental workers. (whiterose.ac.uk)
  • Department of Oxidative Stress and Human Diseases, MIGAL - Galilee Research Institute and Tel Hai College, Kiryat Shmona. (who.int)
  • Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione. (wikipedia.org)
  • The high H2O2 tolerance of aerobic S. aureus cells was associated with priming by endogenous H2O2 levels, which was supported by an oxidative shift of the bacillithiol redox potential to −291 mV compared to −310 mV in microaerophilic cells. (fu-berlin.de)
  • The expression of poly(ADP-ribose) (PAR) and inducible nitric oxide (NO) synthase (iNOS) and nitrotyrosine formation were determined immunohistochemically and used as indicators of oxidative and nitrosative stress. (scienceopen.com)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • There is increasing evidence that aldehydic molecules generated endogenously during the process of lipid peroidation are causally involved in most of the pathophysiological effects associated with oxidative stress in cells and tissues. (nih.gov)
  • It is accompanied by dyslipidemia and oxidative stress leading to increase in lipid peroxidation . (bvsalud.org)
  • This study demonstrated an increased occurrence of atherogenic lipid profile and oxidative stress among hypertensive patients . (bvsalud.org)
  • But researchers from Argentina's Universidad de Buenos Aires and the Instituto de Investigaciones Biomédicas UCA-CONICET noted that the effect of the L. divaricata aqueous extract on the homeostasis in submandibular glands subjected to the effects of an oxidative stressor has not yet been studied. (naturalnews.com)
  • One of these was a control group and the other was injected with 60 milligrams per kilogram of streptozoticin (STZ), a known oxidative stressor. (naturalnews.com)
  • Isoprostanes are excellent molecular biomarkers for oxidant stress. (oxfordbiomed.com)
  • A new ingredient in some skin care products, beta-glucan, increases the skin's resistance to oxidative stress induced by UVA rays. (diagnose-me.com)
  • Complex interplay between cytokines and oxidative stress in the etiology of female reproductive disorders is discussed. (nih.gov)
  • Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
  • The intracellular redox reaction between carbon black and Fe3+ is likely responsible for the synergistic oxidative effect. (rti.org)
  • Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
  • There is a lot of literature on oxidative pathways, but very little clinical data, Budd said. (anavex.com)
  • But it would be interesting to see if there is clinical success that could be coupled to oxidative stress in AD," she noted. (anavex.com)
  • Oxidative biomarkers were correlated with clinical parameters. (ecco-ibd.eu)
  • It is therefore important to estimate and prevent the risks encountered by astronauts due to oxidative stress prior to developing clinical symptoms of disease. (drsircus.com)
  • 10 May 2021 --- Monteloeder's proprietary, polyphenol-rich dietary ingredient, Zeropollution, may improve the signs of skin aging, strengthen skin barrier function and counteract oxidative stress, according to a new clinical study. (nutritioninsight.com)
  • With that in mind, a group of researchers conducted a study on whether an aqueous extract can be used to treat oxidative stress in the submandibular glands of diabetic rats. (naturalnews.com)
  • A 2021 study by Chinese researchers added to the weight of evidence that lemon peel, rich in many bioactive compounds, can inhibit oxidative stress at the level of the cell. (limoneira.com)
  • Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging. (promocell.com)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • The aim of this study was to explore the oxidative stress mechanism of cotton smoke inhalation-induced pulmonary injury in a rat model. (ajol.info)
  • Besides, the study suggests that B 2 or B 6 vitamins restored the levels of DA and reduced oxidative stress in brain of rats. (biomedcentral.com)
  • The study was designed to assess the efficacy of oral supplementation with Zeropollution in reducing pollution-induced oxidative stress and in improving a variety of skin parameters related to skin aging. (nutritioninsight.com)
  • Thus, in this study, we aimed to assess the effects of alamandine treatment on right carotid remodeling and the expression of oxidative stress -related substances induced by TAC. (bvsalud.org)
  • Other effects of increased oxidative stress and ROS production are a decrease in CTGF, TGF-beta, and type I procollagen expression as well as an age-associated chronic progressive increase in the proinflammatory status - this is termed 'inflammaging' (Zuo, 2019). (promocell.com)
  • Indeed, dietary -tocopherol decreased the oxidative stress in the larvae as denoted by the reduction in larval TBARs contents and gene expression of SOD and CAT, but not GPX. (stir.ac.uk)
  • During particle exposure, ROS and RNS are mainly generated from the oxidative burst of pulmonary inflammatory cells, i.e. neutrophils and AMs. (ecetoc.org)
  • Co-exposure to carbon black and Fe2O3 particles causes a synergistic oxidative effect that is significantly greater than the additive effects of exposures to either particle type alone. (rti.org)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • To evaluate the neuroprotective and neurite outgrowth effects of maltol, a natural aroma compound, on retinal ganglion cells (RGCs) under oxidative stress in vitro. (molvis.org)
  • This oxidative stress significantly increased the number of TUNEL-positive RGCs, but the maltol drastically reduced the proportion of those apoptotic cells. (molvis.org)
  • However, after it was discovered that oxidative stress injury to retinal ganglion cells (RGCs) is a leading pathophysiology of glaucoma [ 2 ], researchers' attention has turned to how to directly rescue the damaged RGCs from fatal oxidative stress. (molvis.org)
  • The method was used to measure the native presence of carnosine in these cells, as well as investigate its uptake under normal and pro-oxidative conditions. (ku.edu)
  • It has been observed that the effect of oxidative stress is tissue and cell-dependant, where some specific cells are more tolerant to ROS than others. (ualg.pt)
  • Repair of oxidative damages to DNA is frequent and ongoing, largely keeping up with newly induced damages. (wikipedia.org)
  • So far a putative role for sucrose and SOS during oxidative stress has largely been neglected, as has the contribution of the vacuolar compartment. (lincoln.ac.uk)