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  • MnSOD
  • Together, these data suggest upregulation of MnSOD in ovarian cancer cells is one of the mechanisms which may increase resistance to oxidative stress and apoptosis in cancer cells. (hku.hk)
  • important
  • One of the most common of these hypotheses may be the antioxidant hypothesis, that is, since oxidative modification of LDL is important, and possibly obligatory, in the pathogenesis of atherosclerotic lesions, antioxidative vitamins are protective against cardiovascular disease through their defensive effect on LDL oxidation. (ahajournals.org)
  • nitrosative
  • Similar antioxidative effects are observed with a spin trapping agent, phenyl- N - tert -butylnitrone (PBN) or chain breaking antioxidant vitamin E. This review describes the mechanisms involved in anticholinesterase-induced oxidative/nitrosative injury in target organs of OPs/CMs, and protection by various agents. (hindawi.com)
  • Among lipid peroxidation-derived products, 8-isoprostane and malondialdehyde have been the most frequently investigated, while nitrosothiols and nitrotyrosine may serve as markers of nitrosative stress. (hindawi.com)
  • metabolism
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • adaptively
  • The evidence for and importance of hormesis in physiology and health was advanced by Mark Mattson, who elucidated cellular and molecular mechanisms by which the nervous system responds adaptively to mild bioenergetic stresses such as fasting and exercise. (wikipedia.org)
  • Cells
  • Finally, AGEs can bind to RAGE (receptor for advanced glycation end products) and cause oxidative stress as well as activation of inflammatory pathways in vascular endothelial cells. (wikipedia.org)
  • Several studies have linked oxidative stress to diseases such as Alzheimer's disease, as well as cancer, These studies have found phosphogluconate dehydrogenase activity to be up-regulated, both in tumor cells and in relevant cortical regions of Alzheimer's patient brains, most likely as a compensatory reaction to highly oxidative environments. (wikipedia.org)
  • chronic
  • In recent years, it has been conceptualized that oxidative stress markers in sputum should be employed to monitor oxidative processes in patients with asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF). In this review, the use of sputum-based oxidative markers was explored and potential clinical applications were considered. (hindawi.com)
  • On the other hand, damaged antioxidative defense mechanisms, altered homeostasis of the airway surface liquid (ASL), and acute or chronic airway infections (bacterial colonization) could also contribute to enhanced oxidative stress in these diseases [ 6 , 7 ]. (hindawi.com)
  • Numerous pathological conditions have an oxidative stress component, including cardiovascular diseases, neurodegenerative diseases such as Alzheimer's disease, and chronic inflammation. (qiagen.com)
  • Although oxidative stress has been implicated in a range of chronic neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis, the two commonest of these diseases, AD and PD, will be discussed in detail in this review, and other neurodegenerative diseases will be referenced where relevant. (hindawi.com)
  • nadph
  • The pentose phosphate pathway protects the trypanosomes from oxidative stress via the generation of NADPH and provides carbohydrate intermediates used in nucleotide synthesis. (wikipedia.org)
  • pathways
  • The researchers measured plasma FlOPs at three excitation/emission wavelengths (360/420 nm, 320/420 nm, and 400/475 nm), which each reflect products from different oxidative stress pathways. (nih.gov)
  • glutathione
  • In Arabidopsis thaliana, low levels of glutathione synthetase have resulted in increased vulnerability to stressors such as heavy metals, toxic organic chemicals, and oxidative stress. (wikipedia.org)
  • Hypertension
  • Multiple clinical trials reported increased levels of antioxidants and a reduction in oxidative stress with sesame consumption, particularly for individuals with hypertension and also with type 2 diabetes. (medicalnewstoday.com)
  • antioxidants
  • The use of antioxidants to treat disease states induced by oxidative stress is controversial. (news-medical.net)
  • While studies show that that beta carotene, for example, has a pro-oxidative effect in the lungs of smokers, other epidemiological research has demonstrated an inverse relationship between levels of established antioxidants such as vitamin E and C and disease states such as cancer and cardiovascular disease. (news-medical.net)
  • markers
  • Luciana de Almeida Vittori Gouveia and coauthors, Rio de Janeiro State University and Rio de Janeiro Federal University, Brazil, assessed the published evidence on the effects of consuming sesame-based ingredients on markers of oxidative stress in people with high blood pressure , elevated cholesterol , and type 2 diabetes . (medicalnewstoday.com)
  • While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
  • Certain linoleic acid products have also been proposed to be markers for specific types of oxidative stress. (wikipedia.org)
  • oxidation
  • To find out more, the researchers prospectively assessed oxidative stress by measuring fluorescent oxidation products (FlOP) in 996 women from the Nurses' Health Study who were 60 or older at baseline blood collection between 1989 and 1990. (nih.gov)
  • gene expression
  • QIAGEN provides a broad range of assay technologies for oxidative stress research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • cell's
  • In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell's ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. (hindawi.com)
  • A-T is caused by a defect in the ATM gene, which is responsible for managing the cell's response to multiple forms of stress including double-strand breaks in DNA. (wikipedia.org)
  • mechanism
  • Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. (hindawi.com)
  • The activation of the stress system (and resulting increase in cortisol and Th2 shift) seen during an infection is believed to be a protective mechanism which prevents an over-activation of the inflammatory response. (wikipedia.org)
  • acute
  • Initially, stress induces an acute response (fight or flight) that is mediated by catecholamines. (hindawi.com)
  • clinical
  • On a clinical level, it includes various therapies, such as drugs, diet, avoidance of environmental contaminants, exercise, and alleviation of the adverse effects of life stress, all of which can cause measurable biochemical changes. (wikipedia.org)
  • Aging
  • Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis. (wikipedia.org)
  • She leads the research group working on Stress Physiology and Aging in Marine Invertebrates and also the Ecology Polar regions And Coasts in the changing Earth System (PACES) programme. (wikipedia.org)
  • fundamental
  • Diaphragmatic breathing is relaxing and therapeutic, reduces stress, and is a fundamental procedure of Pranayama Yoga, Zen, transcendental meditation and other meditation practices. (hindawi.com)
  • review
  • The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress , improving human health, according to a systematic review published in Journal of Medicinal Food , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (medicalnewstoday.com)
  • A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. (hindawi.com)
  • Medicine
  • To receive news and publication updates for Oxidative Medicine and Cellular Longevity, enter your email address in the box below. (hindawi.com)
  • state
  • The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. (wikipedia.org)
  • Response
  • The authors argue that the worms were using ethanol as an alternative energy source in the absence of other nutrition, or had initiated a stress response. (wikipedia.org)
  • It is released in response to stress and low blood-glucose concentration. (wikipedia.org)