• Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. (medlineplus.gov)
  • Steroidogenesis in hepatic mucinous cystic neoplasm: Aim Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. (elsevierpure.com)
  • H-scores of cytochrome P450 17α-hydroxylase/c17-20 lyase (P450c17) and 5α-reductase-1 (5αRED-1) in the stroma were significantly higher in OLS of hepatic and pancreatic MCN than in the stroma of ovarian MCN and normal ovary. (elsevierpure.com)
  • A struma ovarii (also known as goitre of the ovary or ovarian goiter) is a rare form of mature teratoma that contains mostly thyroid tissue. (wikipedia.org)
  • Borderline ovarian tumors (BOTs) are abnormal cells or growths that develop in the tissue encapsulating an ovary. (medicalnewstoday.com)
  • Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. (hindawi.com)
  • Most tumors are confined to the ovary at diagnosis, and malignant Brenner tumors have a better prognosis than other epithelial ovarian carcinomas. (cap.org)
  • subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
  • This can be easily mistaken for neoplasm, in which case the appropriate treatment will be removal of the whole ovary. (who.int)
  • The study included 982 patients with benign, borderline, and malignant ovarian neoplasms and normal ovary. (biomedcentral.com)
  • Both tubal structures (hydrosalpinx, hydatids) and congenital broad ligament cystic masses (paramesonephric remnants) can appear to be ovarian cysts if the ovary is not seen in imaging separately on that side. (wdxcyber.com)
  • Neoplasms of the ovary occur infrequently but when they do, they usually are painless and are found only on routine examination. (wdxcyber.com)
  • Because ovarian neoplasms can show different pathologic features in the various areas of the neoplasm, the entire neoplasm is submitted for pathological examination which means removal of that entire ovary. (wdxcyber.com)
  • While it is possible that this represents a ovarian mass with mostly solid components, it is much more commonly a benign process involving the bowel, tube or adhesive disease around the ovary. (wdxcyber.com)
  • The question of whether platinum-based adjuvant chemotherapy can improve outcomes in patients with early-stage epithelial ovarian cancer is an important one. (nih.gov)
  • We carried out a multicenter, open randomized trial to determine whether adjuvant chemotherapy would improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer. (nih.gov)
  • These results suggest that platinum-based adjuvant chemotherapy improves survival and delays recurrence in patients with early-stage ovarian cancer. (nih.gov)
  • Histologically confirmed International Federation of Gynecology and Obstetrics (FIGO) stage (67) III or IV ovarian epithelial cancer or primary peritoneal cancer at presentation. (bayer.com)
  • Histologic subtypes of ovarian cancer other than epithelial (i.e. sarcoma, lymphoma, germ cell). (bayer.com)
  • What is ovarian cancer? (medlineplus.gov)
  • What are the types of ovarian cancer? (medlineplus.gov)
  • There are a few different types of ovarian cancer. (medlineplus.gov)
  • These two cancers are similar to ovarian cancer, and they have the same treatments. (medlineplus.gov)
  • So some medical experts also consider those two types as ovarian cancer. (medlineplus.gov)
  • Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)
  • Ovarian cancer happens when there are changes (mutations) in the genetic material (DNA). (medlineplus.gov)
  • Ovarian cancer that is caused by inherited genetic changes is called hereditary ovarian cancer. (medlineplus.gov)
  • There are also certain genetic changes that can raise your risk of ovarian cancer, including changes called BRCA1 and BRCA2 . (medlineplus.gov)
  • Besides genetics, your lifestyle and the environment can affect your risk of ovarian cancer. (medlineplus.gov)
  • Who is more likely to develop ovarian cancer? (medlineplus.gov)
  • Certain people are more likely to develop ovarian cancer. (medlineplus.gov)
  • What are the symptoms of ovarian cancer? (medlineplus.gov)
  • Ovarian cancer may not cause early signs or symptoms. (medlineplus.gov)
  • How is ovarian cancer diagnosed? (medlineplus.gov)
  • Often the only way to know for sure that you have ovarian cancer is by having a biopsy of the tissue. (medlineplus.gov)
  • What are the treatments for ovarian cancer? (medlineplus.gov)
  • Your provider may suggest that you have genetic testing to look for the gene changes that raise the risk for ovarian cancer. (medlineplus.gov)
  • Histological Classification of Ovarian Cancer. (ijmedicine.com)
  • Ovarian Cancer Development and Metastasis. (ijmedicine.com)
  • Epidemiology and screening of ovarian cancer. (ijmedicine.com)
  • Basic E, Kozaric H, Kozaric M, Suko A. Ovarian-cancer incidence and surgical approach to treatment at clinic for Gynecology and Obstetrics of Clinical Center of University of Sarajevo in 2009.Mater Sociomed, 2010;22:101-4. (ijmedicine.com)
  • According to the National Cancer Institute (NCI), around 75% of borderline ovarian tumors are stage 1 at the point of diagnosis, meaning tumors are confined to the ovaries or fallopian tubes. (medicalnewstoday.com)
  • Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). (nature.com)
  • Fig. 1: Complete gross tumour resection is associated with improved prognosis in advanced stage high-grade serous ovarian cancer patients. (nature.com)
  • British Gynaecological Cancer Society (BGCS) epithelial ovarian/fallopian tube/primary peritoneal cancer guidelines: recommendations for practice. (nature.com)
  • Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. (nature.com)
  • Veliparib with first-line chemotherapy and as maintenance therapy in ovarian cancer. (nature.com)
  • Ovarian cancer is the most common gynaecological malignancy with over 5000 new cases diagnosed every year in the UK and 22 000 in the. (annals.edu.sg)
  • Dr. Santin's translational research program in ovarian cancer has been funded multiple times by federal agencies including the Department of Defense (DoD), the National Institute of Health (NIH) as well as private National and International Foundations. (yale.edu)
  • Newer markers for ovarian cancer are on the horizon. (medscape.com)
  • In women desiring future fertility who have stage IA low-risk ovarian cancer, conservative surgical therapy is appropriate, provided that close follow-up can be maintained. (medscape.com)
  • Ovarian cancer & prostate cancer / C. Annunziata, J. Gulley. (nih.gov)
  • p class=\'abstract\'>BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer and is associated with high mortality rates. (stanford.edu)
  • 225 primary ovarian cancer patients with well annotated clinical data and a complete debulking rate of 60% were compiled for a clinical cohort. (stanford.edu)
  • Patient and non-patient-associated co-factors, surgical skills, and center experience remain the main determining factors when considering the surgical outcome at primary debulking in high-grade serous ovarian cancer patients. (stanford.edu)
  • BACKGROUND: The serum marker CA 125 is still the most widely used biomarker for ovarian cancer (OC) diagnosis in gynecological and oncological setting, but its predictive role in early-stage OC is still debated. (minervamedica.it)
  • To further evaluate the safety and efficacy of KU-0059436 in an expanded cohort of BCRA-enriched population, primarily ovarian cancer patients. (astrazenecaclinicaltrials.com)
  • Scholars@Duke publication: Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. (duke.edu)
  • The protein kinase C inhibitor UCN-01 (7-hydroxystaurosporine) has shown higher efficacy against slow proliferating and/or quiescent ovarian cancer cells. (duke.edu)
  • In this study, tumorigenic potential was assessed using anchorage-independent growth assays and spheroid-forming capacity, which was determined with ovarian cancer cell lines as well as primary ovarian cancers. (duke.edu)
  • By live in vivo imaging, ovarian cancer xenograft tumors were reduced after primary treatment with carboplatin. (duke.edu)
  • CHICAGO -- Lymph node dissection had no impact on survival among women with completely resected ovarian cancer and clinically negative nodes, a large randomized trial showed. (medpagetoday.com)
  • Note that the results suggest that systematic lymph node evaluation of clinically negative lymph nodes in patients with advanced ovarian cancer and complete resection should be omitted. (medpagetoday.com)
  • Surgery to achieve macroscopic complete resection is the major therapeutic goal in patients with primary advanced ovarian cancer. (medpagetoday.com)
  • Eligible patients had FIGO IIB-IV ovarian cancer considered feasible for macroscopic complete resection, clinically and radiographically negative pelvic and para-aortic lymph nodes, no prior chemotherapy, and no prior lymph node dissection. (medpagetoday.com)
  • Several CTAs, including NY-ESO-1, MAGE-A3, and MAGE-A4, have been or are being studied as target antigens in vaccine clinical trials for various types of tumors, including non-small-cell lung cancer, ovarian cancer, gastrointestinal carcinoma, and urothelial carcinoma ( 7, 9 - 13 ). (aacrjournals.org)
  • For ovarian/fallopian tube cancer, the staging system developed by the International Federation of Obstetrics and Gynecology (Federation Internationale de Gynecologie et d'Obstetrique, or FIGO) is used. (cancer.net)
  • No cancer is found on the ovarian or fallopian tube surface or in the abdomen. (cancer.net)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • BOT typically occurs in women 10 years younger than those with epithelial ovarian cancer, and the majority of the women with BOT are diagnosed in the earlier stages, with 75% diagnosed at stage I [1, 2]. (researchsquare.com)
  • Prior small studies have shown increased expression of sperm protein 17 (Sp17) in epithelial ovarian cancer (EOC) tissue and suggest Sp17 as a potential biomarker for EOC. (biomedcentral.com)
  • Epithelial ovarian cancer (EOC) is the fifth most common cause of female cancer-related deaths. (biomedcentral.com)
  • One CTA that has been proposed as a potential biomarker for ovarian cancer is sperm protein 17 (Sp17). (biomedcentral.com)
  • Surgery is the initial modality of treatment for stage I-IVA epithelial ovarian cancer. (medscape.com)
  • However, only a small percentage of women with epithelial ovarian cancer can be treated with surgery alone. (medscape.com)
  • Women with any stage of epithelial ovarian cancer should be considered for clinical trials if available. (medscape.com)
  • 1 cm) stage III ovarian cancer after front-line surgery. (medscape.com)
  • En 11 annees (1er janvier 1998-31 decembre 2008) 9946 patientes ont ete operes dans notre servie dont 29 pour le cancer de l'ovaire soit 0;29. (bvsalud.org)
  • Masses that are symptomatic or do not resolve may need to be removed surgically to be treated and checked for ovarian cancer. (msdmanuals.com)
  • Diagnosis Ovarian cancer is often fatal because it is usually advanced when diagnosed. (msdmanuals.com)
  • The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (msdmanuals.com)
  • Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (wikipedia.org)
  • Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (wikipedia.org)
  • It has been noted that fetiform teratoma is reported more often (by gynecologists) in ovarian teratomas, and fetus in fetu is reported more often (by general surgeons) in retroperitoneal teratomas. (wikipedia.org)
  • In the remaining cases, angiosarcoma was associated with ovarian teratoma or epithelial neoplasm [ 2 , 4 ]. (hindawi.com)
  • Recurrent ovarian immature teratoma in a 12-year-old girl: Implications for management. (cam.ac.uk)
  • OBJECTIVE: To evaluate the ability of a consensus-based preoperative risk stratification algorithm to discriminate between benign and malignant ovarian pathology and decrease unnecessary oophorectomies. (childrensmercy.org)
  • At present, serum CA-125 is the most extensively used biomarker to preoperatively discriminate between benign and malignant ovarian neoplasms, detect recurrence, and monitor response to treatment. (biomedcentral.com)
  • To our knowledge, less than 40 cases of ovarian angiosarcoma have been reported in English literature [ 1 - 3 ]. (hindawi.com)
  • Comparison of Nexavar with a placebo as maintenance therapy for patients with advanced Ovarian or primary Peritoneal cancers in complete remission following surgery and one regimen of chemotherapy. (bayer.com)
  • Most ovarian cancers are caused by genetic changes that happen during your lifetime. (medlineplus.gov)
  • Prevalence of malignancy was 29% (49 primary invasive epithelial ovarian cancers, 18 borderline ovarian tumours, and 7 metastatic tumours). (nature.com)
  • Doctors also describe ovarian/fallopian tube cancers by their grade. (cancer.net)
  • They are very different from high-grade cancers and represent about 10% to 15% of epithelial ovarian/fallopian tube neoplasms, which are abnormal growths of cells. (cancer.net)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
  • ces cancers ont ete diagnostiques au stade avance d'ou les difficultes dans leur prise en charge chirurgicale. (bvsalud.org)
  • En consequence notre objectif a ete d'etudier la place et les caracteres de la chirurgie dans la prise en charge de ces cancers. (bvsalud.org)
  • Publications] Kobayashi M: 'Ovarian clear-cell carcinoma prodncing estradiol and human choionic bonadotrop in. (nii.ac.jp)
  • Serous cystadenoma was the commonest benign tumour and serous papillary carcinoma was the commonest malignant ovarian tumour. (ijmedicine.com)
  • He is currently funded by NIH to evaluate the potential use of Clostridium Perfringens Enterotoxin (CPE) as a novel therapy against chemotherapy resistant ovarian carcinoma. (yale.edu)
  • Most ovarian enlargement is discovered either on pelvic examination or on imaging studies such as pelvic ultrasound or CAT scans obtained for various reasons. (wdxcyber.com)
  • A pelvic the anthrax toxin is being evaluated as a choice for tumor ultrasonograph showed a left ovarian complex mass meas- cell surface targeting in chemoresistant neoplasms (5). (cdc.gov)
  • Furthermore, two of 7 postmenopausal women with epithelial ovarian tumors responded to the hCG loading test. (nii.ac.jp)
  • The steroid levels were compared with the values in postmenopausal women without ovarian tumors. (nii.ac.jp)
  • Virilizing ovarian tumors (VOT) and ovarian stromal hyperthecosis (OH) are the most common hyperandrogenism etiologies in the postmenopausal women. (usp.br)
  • Due to the difficulties in establishing the differential diagnosis between VOT and OH, bilateral oophorectomy is the treatment of choice in postmenopausal women with hyperandrogenism of ovarian origin. (usp.br)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • CA 125 is usually measured in postmenopausal women with an ovarian mass, but its use in premenopausal women requires clinical judgment. (msdmanuals.com)
  • The most frequently encountered neoplastic pancreatic cysts include intraductal papillary mucinous neoplasm (IPMN), serous cystadenoma (SCA), mucinous cystic neoplasm with ovarian stroma (MCN), and solid pseudopapillary epithelial neoplasm. (medscape.com)
  • Note the smooth external contour typical of a mucinous cystic neoplasm. (medscape.com)
  • Methods Both steroid receptors and steroidogenic factors were immunohistochemically evaluated using H-scores and results were compared with those in 15 ovarian MCNs and 10 normal ovaries. (elsevierpure.com)
  • Results Androgen receptor (AR) H-scores in OLS were significantly higher in hepatic, pancreatic, and ovarian MCN than those in normal ovaries. (elsevierpure.com)
  • [ 5 ] Other, rarer cystic lesions, such as solid pseudopapillary epithelial neoplasm and cystic pancreatic neuroendocrine tumor (cPNET), tend to harbor features that suggest a specific diagnosis, usually leading to surgical removal. (medscape.com)
  • Angiosarcoma may present a challenge in intraoperative frozen section diagnosis of an ovarian mass. (hindawi.com)
  • Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
  • Mucinous cystic neoplasms are known to harbor ovarian-like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. (elsevierpure.com)
  • The ovarian stroma showed extensive oedema. (who.int)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • Benign ovarian masses include functional cysts (eg, corpus luteum cysts) and neoplasms (eg, benign teratomas). (msdmanuals.com)
  • Ovarian cysts or other ovarian masses are a common gynecologic issue. (msdmanuals.com)
  • is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (msdmanuals.com)
  • Testicular and immature ovarian teratomas are also frequently treated with chemotherapy. (wikipedia.org)
  • The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of ovarian neoplasms specifically related to the management of peritoneal surface malignancy. (northwestern.edu)
  • Chicago Consensus Working Group 2020, ' The Chicago Consensus on Peritoneal Surface Malignancies: Management of Ovarian Neoplasms ', Annals of surgical oncology , vol. 27, no. 6, pp. 1780-1787. (northwestern.edu)
  • Shah S, Hishikar VA. Incidence and management of ovarian tumours. (ijmedicine.com)
  • Complications may include ovarian torsion, testicular torsion, or hydrops fetalis. (wikipedia.org)
  • patients often present with ovarian torsion. (medscape.com)
  • Fig. 07 - CEUS - demonstrated the absence of vascularization of the internal echogenic mass (thus defined as a clot) and the absence of the ovarian torsion, which could occur in this case taking into consideration the voluminous cyst. (efsumb.org)
  • Her primary ted to the hospital because of a left ovarian mass torsion. (cdc.gov)
  • B. anthracis ovarian mass torsion. (cdc.gov)
  • Pancreatic cystic neoplasms represent a small yet increasingly detected entity of pancreatic abnormalities. (medscape.com)
  • Approximately 70% of pancreatic cystic neoplasms are discovered incidentally. (medscape.com)
  • The purpose of this study is to evaluate the diagnostic performance of the International Ovarian Tumour Analysis (IOTA) logistic regression model (LR2), ultrasound Simple Rules (SR), the Risk of Malignancy Index (RMI) and subjective assessment (SA) for preoperative characterisation of adnexal masses, when ultrasonography is performed by examiners with different background training and experience. (nature.com)
  • MAIN OUTCOMES AND MEASURES: Unnecessary oophorectomies, defined as oophorectomy for a benign ovarian neoplasm based on final pathology or mass resolution. (childrensmercy.org)
  • Malignant struma ovarii is a rare ovarian neoplasm composed predominantly of mature thyroid tissue. (nel.edu)
  • Leydig cell tumors are rare ovarian steroid cell neoplasms. (scite.ai)
  • A failure to intraoperatively recognize this malignant neoplasm may result in incomplete surgical staging procedure or inappropriate clinical management. (hindawi.com)
  • This study aimed to evaluate the effect of clinicopathologic and surgical factors on the prognosis and fertility outcomes of patients with borderline ovarian tumour (BOT). (researchsquare.com)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Benign Brenner tumors account for approximately 5% of all benign ovarian epithelial tumors and are typically found incidentally in women in the 5th to 7th decades of life. (cap.org)
  • Non neoplastic ovarian lesions were excluded. (ijmedicine.com)
  • Thakkar N, Shah S. Histopathological Study of Ovarian Lesions. (ijmedicine.com)
  • Retrospective and prospective study of ovarian tumors and tumor-like lesions. (ijmedicine.com)
  • Moreover, imaging may not accurately characterize these ovarian lesions. (usp.br)
  • Borderline ovarian tumour (BOT) is a peculiar type of tumour with a more favourable prognosis than malignant ovarian tumours. (researchsquare.com)
  • We present the case of a 30-year-old woman with findings of massive ovarian oedema on ultrasound imaging, and a discussion and literature review aiming to clarify that this is a benign tumour-like condition which every gynaecologist can encounter and that the most appropriate treatment is conservative surgery. (who.int)
  • Ultrasound examination showed a large left ovarian hypoechoic homogenous solid mass lesion 7 × 6 cm ( Figure 1 ), which showed poor vascularity on colour Doppler scan. (who.int)
  • The hLH and hFSH binding characteristics of the ovarian tumors were similar to those of the normal ovarian tissue. (nii.ac.jp)
  • Similar to other epithelial ovarian tumors, Benner tumors are classified as benign, borderline/atypical proliferative, or malignant. (cap.org)
  • Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
  • A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules. (hindawi.com)
  • A macroscopic hemorrhagic area in an ovarian mucinous tumor should be evaluated with care, and the possibility of angiosarcoma should be borne in mind. (hindawi.com)
  • Gross and microscopic histopathological examination was done for ovarian neoplasms. (ijmedicine.com)
  • Histopathological profile of ovarian tumours: A twelve year institutional experience. (ijmedicine.com)
  • Histopathological study of ovarian tumors in Ajmer region. (ijmedicine.com)
  • DESIGN, SETTING, AND PARTICIPANTS: Pre/post interventional study of a risk stratification algorithm in patients aged 6 to 21 years undergoing surgery for an ovarian mass in an inpatient setting in 11 children's hospitals in the United States between August 2018 and January 2021, with 1-year follow-up. (childrensmercy.org)
  • Treatment of coccyx, testicular, and ovarian teratomas is generally by surgery. (wikipedia.org)
  • Most ovarian teratomas are mature. (wikipedia.org)
  • Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (wikipedia.org)