Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. (wikipedia.org)
In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. (ox.ac.uk)
In situ hybridization is used to survey the tissue-specific and developmental expression of the cloned mouse gene Sparc, coding for a protein homologous to the bovine Ca++-binding protein, osteonectin. (ox.ac.uk)
Detects mouse SPARC/Osteonectin in direct ELISAs. (rndsystems.com)
SPARC, an acronym for "secreted protein, acidic and rich in cysteine", is also known as osteonectin or BM-40 (1‑5). (rndsystems.com)
Secreted modular calcium binding protein 1 (SMOC1) is an osteonectin/SPARC associated matricellular protein, whose expression is regulated by miR-223. (ncbcs.org)
Osteonectin is a 40 kDa acidic and cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca2+ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an EF hand motif at the carboxy terminus region (domain IV). (wikipedia.org)
Protein2
This pattern of differential gene expression demands a reassessment of the function originally proposed for osteonectin, and predicts a much wider role for the protein in a variety of biological processes. (ox.ac.uk)
Isolation and characterization of piscine osteonectin and downregulation of its expression by PTH-related protein. (ualg.pt)
Acidic1
Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. (wikipedia.org)
Osteopontin1
Sections of bone immunostained for osteopontin (SPP-I), osteonectin, and decorin did not reveal multiple patterns or alterations in staining with gender or increasing age. (jci.org)
Extracellular matrix1
Osteonectin is an extracellular matrix adhesion glycoprotein. (cryopep.com)
Glycoprotein1
Osteonectin is a glycoprotein in the bone that binds calcium. (wikipedia.org)
Collagen5
Osteonectin also shows affinity for collagen in addition to bone mineral calcium. (wikipedia.org)
In vitro, osteonectin binds type I collagen, calcium and hydroxyapatite. (cryopep.com)
In situ hybridization techniques have already shown that dermal fibroblasts have the ability to differentiate into osteoblasts and even to produce collagen type 1 and osteonectin [ 1 ]. (hindawi.com)
On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
Tumor1
Additional functions of osteonectin beneficial to tumor cells include angiogenesis, proliferation and migration. (wikipedia.org)
Osteoblasts1
High levels of immunodetectable osteonectin are found in active osteoblasts and marrow progenitor cells, odontoblasts, periodontal ligament and gingival cells, and some chondrocytes and hypertrophic chondrocytes. (wikipedia.org)
Expression4
A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found. (wikipedia.org)
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-b1, and BMP2/4. (bvsalud.org)
Ontogeny of osteonectin expression in embryos and larvae of sea bream (Sparus auratus). (ualg.pt)
This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesions. (medicaljournals.se)
Antibodies1
Results: Osteonectin and BMP2/4 antibodies were positive in all cases. (bvsalud.org)
Proteins1
The best characterized of these bone proteins is osteonectin. (wikipedia.org)
Osteonectin has been localized in a variety of tissues, but is found in greatest abundance in osseous tissue, tissues characterized by high turnover (such as intestinal epithelium), basement membranes, and certain neoplasms. (wikipedia.org)
Human1
Overexpression of osteonectin is reported in many human cancers such as breast, prostate, colon and pancreatic. (wikipedia.org)
Found2
Osteonectin has also been found to decrease DNA synthesis in cultured bone. (wikipedia.org)
A statistically significant difference in serum osteonectin between T1/T2 and T3/T4 tumours was found. (lancs.ac.uk)
Activity1
Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. (wikipedia.org)
Size1
Tumour size was a significant predictor of serum osteonectin. (lancs.ac.uk)
Cancer1
This prospective pilot study was performed to determine the feasibility of serum osteonectin as a screening tool for pancreatic cancer. (lancs.ac.uk)
Osteocalcin3
7. Osteocalcin and Osteonectin Expression in Canine Osteosarcoma. (nih.gov)
Additionally, autophagy also plays a role in osteogenesis by regulating vascular calcification, which in turn regulates expression of proteins related to bone development, such as osteocalcin, osteonectin, etc. and regulated by mTOR, EphrinB2 and RhoA. (biomedcentral.com)
Bone10
Osteonectin is a glycoprotein in the bone that binds calcium. (wikipedia.org)
Osteonectin also shows affinity for collagen in addition to bone mineral calcium. (wikipedia.org)
Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. (wikipedia.org)
Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. (wikipedia.org)
The best characterized of these bone proteins is osteonectin. (wikipedia.org)
Osteonectin has also been found to decrease DNA synthesis in cultured bone. (wikipedia.org)
The purified active factor from bone and from marrow stromal-cell-conditioned medium is a low glycosylated osteonectin that specifically promotes the invasive ability of bone-metastasizing prostate (and breast) cancer cells but not that of non-bone-metastasizing tumor cells. (nih.gov)
Because osteonectin specifically enhances matrix metalloprotease activity in prostate and breast cancer cells (and not in other tumor cell types), we conclude that prostate cancer cell metastasis to the bone is, in part, mediated by the ability of osteonectin to promote migration, protease activity, and invasion. (nih.gov)
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-b1, and BMP2/4. (bvsalud.org)
Tumor cells1
Additional functions of osteonectin beneficial to tumor cells include angiogenesis, proliferation and migration. (wikipedia.org)
CDNA1
A ) Schematic representation of the human osteonectin cDNA, and the characterized SNPs at bases 1046, 1599 and 1970 (grey triangles). (nih.gov)
Levels2
To this end, we studied the extent of changes in osteonectin (ON) protein levels induced in BEAS 2 B-cells by CSC treatment and its timing to changes occurring in the anchorage independent cloning efficiency. (nih.gov)
In addition, miR-29a inhibitor loaded scaffolds elevated osteonectin production and levels of Igf1 and Tgfb1 mRNA. (lckinhibitor.com)