Citric acidUrinaryAciduriaAsparticExcretionAmino acidUrea cycle diFatty acidsAdenosineCarboxylic acidGlycineUracilEnzymesNucleicOrotateEnzymeAnhydrousPyrimidineMagnesiumExtracted and purifiedLactic acidGlutamineAmmoniaUrineDeterminationBileNuclearOxidationMilkMetabolicLiverInhibitionMutantArginineToxicConvertsLewisDerivativeSalt
Citric acid6
- There's also lithium citrate , which is a chemical compound of lithium and citric acid. (lifeextension.com)
- This highly advanced, iron-free formula contains a unique blend of Asporotate™ minerals, which are minerals combined with aspartic acid, citric acid and orotic acid (milk). (vitanetonline.com)
- It is a building block of proteins, participates in the citric acid and urea cycles, and is a neurotransmitter. (unboundmedicine.com)
- Solaray Zinc Asporotate 15mg 100 Capsules Zinc Asporotate contains Zinc which has been merged with aspartic acid, citric acid, and a special delactosed whey protein concentrate containing orotic acid. (bestpricenutrition.com)
- Magnesium citrate - This is a magnesium that's combined with a citric acid. (iast.net)
- The catabolism of pyrimidines produces citric acid cycle intermediates. (msdmanuals.com)
Urinary6
- This leads to an increased serum ammonia level, increased serum and urinary orotic acid levels and a decreased serum blood urea nitrogen level. (wikipedia.org)
- This also leads to an increased urinary orotic acid excretion, because the orotic acid is not being properly utilized and must be eliminated. (wikipedia.org)
- Urinary orotic acid generally is very elevated in babies with OTC deficiency and normal or even low in infants with CPS deficiency. (nih.gov)
- Urinary orotic acid is measured to distinguish CPSI deficiency and NAGS deficiency from OTC deficiency. (nucdf.org)
- The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped. (unboundmedicine.com)
- DTX301 has been shown in preclinical studies to normalize levels of urinary orotic acid, a marker of plasma ammonia, which if uncontrolled can cause serious neurological and metabolic deficiencies in patients. (nlvpartners.com)
Aciduria3
- A buildup of orotic acid can lead to orotic aciduria and acidemia. (wikipedia.org)
- Orotic aciduria is a cause of megaloblastic anaemia. (wikipedia.org)
- The presence of hyperammonemia, hyperglutaminemia, hyperalaninemia and orotic aciduria in a critically ill infant affords strong presumptive evidence for OTC deficiency. (nih.gov)
Aspartic2
- Lithium aspartate is derived from aspartic acid, which is an amino acid. (lifeextension.com)
- C 10 H 18 N 4 O 6 , a compound intermediate in the synthesis of arginine, formed from citrulline and aspartic acid. (unboundmedicine.com)
Excretion2
- Possible mechanisms mainly included enhancement of fatty acids ß- oxidation and cholesterol catabolism through bile acids synthesis and excretion, suppression of lipogenesis and cholesterol uptake. (bvsalud.org)
- Patients with OTC deficiency have increased excretion of orotic acid because carbamyl phosphate spills into the cytoplasm, where it enters the pathway of pyrimidine synthesis. (nih.gov)
Amino acid5
- Sources of ammonia include bacterial hydrolysis of urea and other nitrogenous compounds in the intestine, the purine-nucleotide cycle and amino acid transamination in skeletal muscle, and other metabolic processes in the kidneys and liver. (medscape.com)
- The hepatic urea cycle is the major route for waste nitrogen disposal, which is chiefly generated by protein and amino acid metabolism. (medscape.com)
- Plasma quantitative amino acid analysis can be used to help diagnose a specific urea cycle disorder. (nucdf.org)
- C 4 H 7 NO 4 , a nonessential amino acid. (unboundmedicine.com)
- The drug is intended for patients who cannot be managed by a protein-restricted diet or amino acid supplements alone, and it must be used in conjunction with a protein-restricted diet and, in some cases, dietary supplements. (medscape.com)
Urea cycle di1
- In ornithine transcarbamylase deficiency, an X-linked inherited and the most common urea cycle disorder, excess carbamoyl phosphate is converted into orotic acid. (wikipedia.org)
Fatty acids5
- Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats. (bvsalud.org)
- In this study, fatty acids -treated HepG2 cells and orotic acid -treated rats were used to investigate the lipid -lowering effects of sea cucumber saponin derivatives. (bvsalud.org)
- in diabetic ketoacidosis, when the conversion of fatty acids to ketones increases. (unboundmedicine.com)
- Carboxyl-bearing low-molecular-weight compounds such as keto acids, fatty acids, and other organic acids are involved in a myriad of metabolic pathways owing to their high polarity and solubility in biological fluids. (encyclopedia.pub)
- Fatty acids are integral components of lipids, and consist of carboxylic acids with long aliphatic chains. (encyclopedia.pub)
Adenosine1
- The hyperammonemia depletes alpha-ketoglutarate leading to the inhibition of the tricarboxylic acid cycle (TCA) decreasing adenosine triphosphate (ATP) production. (wikipedia.org)
Carboxylic acid2
- Orotic acid (/ɔːˈrɒtɪk/) is a pyrimidinedione and a carboxylic acid. (wikipedia.org)
- For example, the tricarboxylic acid (TCA) cycle, which is the principal energy-producing process in cells, involves nine carboxylic acid compounds. (encyclopedia.pub)
Glycine1
- It is synthesised in the body from the amino acids: L-arginine, glycine and L-methionine. (mz-store.com)
Uracil2
- Orotic acid is a precursor to a RNA base, uracil. (wikipedia.org)
- The mutant yeasts which are resistant to 5-fluoroorotic acid require a supply of uracil. (wikipedia.org)
Enzymes2
- In subsequent steps, other enzymes modify orotic acid to produce pyrimidines. (medlineplus.gov)
- C 20 H 32 O 2 , an omega-6 fatty acid formed by the action of enzymes on phospholipids in cell membranes. (unboundmedicine.com)
Nucleic1
- Nucleic acids components and their analogues. (cas.cz)
Orotate5
- Orotic acid is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. (wikipedia.org)
- The pentahydrate nickel orotate coordination complex converts into a polymeric trihydrate upon heating in water at 100 °C. Crystals of the trihydrate can be obtained by hydrothermal treatment of nickel(II) acetate and orotic acid, when the reactions are run with bidentate nitrogen ligands such as 2,2'-bipyridine present other solids can be obtained. (wikipedia.org)
- Lithium orotate is a salt of lithium and orotic acid. (thecarlatreport.com)
- Orotate is a technically a salt that comes from orotic acid. (lifeextension.com)
- Magnesium Orotate - This type of magnesium is very beneficial to the human heart because of the orotic acid found in the product. (iast.net)
Enzyme1
- Dihydroorotate is synthesized to orotic acid by the enzyme dihydroorotate dehydrogenase, where it later combines with phosphoribosyl pyrophosphate (PRPP) to form orotidine-5'-monophosphate (OMP). (wikipedia.org)
Anhydrous1
- China Leader Biochemical Group latest company news about 3000KG Orotic Acid Anhydrous will be on the way to Russia by sea for our client Viktoriya. (leaderbio-ingredients.com)
Pyrimidine1
- It is reasoned that the smoking causes the pyrimidine biosynthesis process in the mother to be altered thus causing the orotic acid concentration to increase. (wikipedia.org)
Magnesium1
- It binds itself to an abundant amount of amino acids otherwise known as protein and used to restore you magnesium levels. (iast.net)
Extracted and purified1
- Humic-Monolaurin Complex combines a specially extracted and purified humic acid with monolaurin, olive leaf extract, and Lactobacillus rhamnosus cell wall fragments. (nutricology.com)
Lactic acid1
- Owing to its buffering properties, it counteracts the harmful effects of lactic acid. (mz-store.com)
Glutamine1
Ammonia2
Urine1
- C 4 H 8 O 3 , any of the acids present in the urine, esp. (unboundmedicine.com)
Determination1
- Hence, highly sensitive and selective methods for the determination of biologically important carboxylic acids are required for biological investigations, and, thus far, numerous analytical methods have been developed. (encyclopedia.pub)
Bile1
- Any of the complex acids that occur as salts in bile, e.g., cholic, glycocholic, and taurocholic acids. (unboundmedicine.com)
Nuclear1
- It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA. (bvsalud.org)
Oxidation2
- Detecting fatty acid oxidation disorders and several organic acidurias. (kkh.com.sg)
- Evaluating and monitoring patients with fatty acid oxidation and organic acid disorders. (kkh.com.sg)
Milk2
- The Breast milk of smokers has a higher concentration of orotic acid than that of a non smoking woman. (wikipedia.org)
- ABBR: AHA Any of a class of water-soluble acids derived from fruit or milk, having a hydroxyl moiety in the first position in the molecule. (unboundmedicine.com)
Metabolic1
- Low-molecular-weight carboxylic acids are involved in various metabolic pathways. (encyclopedia.pub)
Inhibition1
- Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection. (expasy.org)
Mutant1
- 2016). Production of orotic acid by a Klura3δ mutant of Kluyveromyces lactis . (up.pt)
Arginine1
- Compound 5 is fumaric acid generated in the reaction that converts ASA to arginine (6), which is mediated by ASA lyase. (medscape.com)
Toxic2
- A modified orotic acid (5-fluoroorotic acid) is toxic to yeast. (wikipedia.org)
- Boric acid is toxic and should be used only rarely. (unboundmedicine.com)
Converts1
- Specifically, dihydroorotate dehydrogenase converts a molecule called dihydroorotate to a molecule called orotic acid. (medlineplus.gov)
Lewis2
- The addition of Lewis acid, hydrochloric acid, silica gel, etc. as a cocatalyst improves the yield. (google.com)
- a Lewis acid. (unboundmedicine.com)
Derivative1
- Saccharin is a derivative of this acid. (unboundmedicine.com)
Salt1
- An acid reacts with a metal to form a salt, neutralizes bases, and turns litmus paper red. (unboundmedicine.com)