We described the early embryonic development of the loach, Misgurnus anguillicaudatus , based on morphological features and gene expression. (bioone.org)
The Self-Organization in Biology: Freiburg Spemann-Mangold Centennial Symposium celebrates 100 years of scientific advances rooted in Hilde Mangold's and Hans Spemann's discovery of the gastrula organizer in vertebrate development, published in 1924 and awarded the Nobel Prize in Physiology or Medicine in 1935. (elsevier.com)
German biologist, Christiane Nusslein-Volhard is renowned for elucidation of the genetic control of embryonic development of fruit flies. (wepapers.com)
Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
What Newton did for physics toward the end of the seventeenth century, and Lavoisier did for chemistry at the end of the eighteenth, was not carried out in biology until Darwin gave a mechanical explanation of evolution and the German school of Entwicklungsmechanik provided a physico-chemical model of embryonic development in the latter part of the nineteenth century. (nybooks.com)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
Due to the conserved nature of vertebrate cell behaviour, our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases - a prerequisite for the development of novel therapeutics. (exeter.ac.uk)
Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. (nature.com)
Researchers have developed a new model of early embryonic brain development. (neurosciencenews.com)
The model produces results similar to embryonic brain development at five weeks post-fertilization. (neurosciencenews.com)
The aim of the model is to study the very earliest stages of brain to understand how different regions in the brain are formed during embryonic development. (neurosciencenews.com)
Research on the early development of the human brain, from five days after the fertilisation of the cell to approximately seven weeks, have so far been difficult as researchers have not had access to human embryonic tissue from these early stages of development. (neurosciencenews.com)
For the first time, we now have access to tissue that resembles the early embryonic brain and can therefore study processes behind brain development in a way that has not been possible before. (neurosciencenews.com)
We can for instance use it for testing how chemical substances in our environment might impact on embryonic brain development. (neurosciencenews.com)
Most of our current knowledge of mammalian embryology is derived from studies of the mouse embryo, leading to astonishing discoveries of self-organizing and emergent properties ("the laws of development") manifest during embryonic development. (birs.ca)
Her PhD focused on understanding the embryonic development of the spinal cord and associated defects which resulted in 6 peer-reviewed international publications. (sciforum.net)
Spemann-Mangold1
Gastrulation movements are orchestrated by a small, heterogeneous group of cells with inductive and morphogenetic properties located in the dorsal lip of the blastopore (DBL) of the amphibian gastrula known as the Spemann-Mangold organizer or dorsal organizer. (nature.com)
Gastrula organizer5
The concept of embryonic induction, first demonstrated in the famous gastrula organizer transplantation experiments by Hilde Mangold and Hans Spemann in their 1924 landmark publication and awarded the Nobel Prize in Physiology or Medicine in 1935, has been the most influential discovery promoting 100 years of research into organization phenomena in biology. (elsevier.com)
The dorsal gastrula organizer plays a fundamental role in establishment of the vertebrate axis. (zfin.org)
We demonstrate that the zebrafish bozozok (boz) locus is required at the blastula stages for formation of the embryonic shield, the equivalent of the gastrula organizer and expression of multiple organizer-specific genes. (zfin.org)
These studies provide genetic evidence for an essential function of a homeodomain protein in ß-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarchy of zygotic genes specifying the dorsal midline of a vertebrate embryo. (zfin.org)
Spemann's1
In amphibians, Spemann's organizer, which is homologous to the node, partially overlaps with anterior endoderm cells expressing homologues of the AVE markers cerberus, Hex and Hesx1. (nih.gov)
Genes2
Deficiency of ptprk increases Wnt signaling, leading to reduced expression of Spemann organizer effector genes and inducing head and axial defects. (elifesciences.org)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)
Stages1
Agnete Kirkeby believes that the new method may be used to investigate how brain cells in the early embryonic stages react to certain chemicals surrounding us in our daily lives. (neurosciencenews.com)
Stem11
Novavax to Use Vivalis' Duck Embryonic Stem Cell Line for Vaccine. (genengnews.com)
builds a bridge to today's molecular and cellular understanding self-organization in developing systems, including gastrulation, stem cell organoids, morphogen gradients, invertebrate systems, Evo-Devo, and emerging fields deriving from the discovery of embryonic induction. (elsevier.com)
The conference will link to recent advances on organizing principles in gastruloids and organoids - from stem cells to synthetic organizers. (elsevier.com)
The US Senate has once again passed a bill to allow federal dollars to fund embryonic stem cell research. (fsrn.org)
3D reconstitution of the patterned neural tube from embryonic stem cells. (nature.com)
Stem cell researchers at Lund University in Sweden have developed a new research model of the early embryonic brain. (neurosciencenews.com)
In order to develop stem cell treatments for neurological diseases such as Parkinson's Disease, epilepsy and stroke, researchers must first understand how the human brain develops in the embryonic stage. (neurosciencenews.com)
The stem cells are cultivated in a custom-built cell culture chamber where they are exposed to an environment which resembles the environment in the early embryonic brain. (neurosciencenews.com)
In the laboratory model called MiSTR (Microfluidic-controlled Stem cell Regionalisation), we can create tissue that contains different brain regions next to each other, similar to an embryonic brain approximately four to five weeks after fertilisation. (neurosciencenews.com)
Here, we present a quantitative and comprehensive study of the abundance levels of histone PTMs during the differentiation of mouse embryonic stem cells (ESCs) using mass spectrometry (MS). We observed dynamic changes of histone PTMs including increased H3K9 methylation levels in agreement with previously reported results. (biomedcentral.com)
Embryonic stem cells (ESCs) are self-renewing, pluripotent cells derived from the inner cell mass (ICM) of a blastocyst [ 1 , 2 ]. (biomedcentral.com)
Conference organizers1
The venue provides a state-of-the-art learning environment, while conference organizers have planned informal social events to enable quality networking time and an opportunity to explore Suzhou's many ancient and contemporary attractions. (csh-asia.org)
Shield1
At 10 hpf, the germ ring and the embryonic shield were formed, indicating the stage of early gastrula. (bioone.org)
Neural1
Using a WNT-activating gradient, we generated a neural tissue exhibiting progressive caudalization from forebrain to midbrain to hindbrain, including formation of isthmic organizer characteristics. (nature.com)
Gastrulation1
Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. (nature.com)
Cells1
Ectoderm is one of three germ layers-groups of cells that coalesce early during the embryonic life of all animals except maybe sponges, and from which organs and tissues form. (asu.edu)
Inhibition1
Pharmacological inhibition of the embryonic alcohol dehydrogenase activity, prevents the oxidation of ethanol to acetaldehyde that in turn functions as a RALDH2 inhibitor. (xenbase.org)
Forebrain1
Furthermore, boz is essential for specification of dorsoanterior embryonic structures, including notochord, prechordal mesendoderm, floor plate and forebrain. (zfin.org)
Defects1
Tetraploid rescue experiments reveal that lack of β-catenin in the anterior visceral endoderm results in defects in head organizer formation. (biologists.com)
Primitive streak1
The head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the node and anterior primitive streak. (nih.gov)
Tissue1
Employing biomorphic and embryonic paradigms, Liz redefines psoas as smart, expressive tissue that is both elemental and universal. (coreawareness.com)
Proteins1
Helper proteins, or chaperones, play the role of the professional organizer who effectively keeps all the junk in the dumpster. (genengnews.com)
Cluster2
An HAProxy cluster that offloads SSL certificates to guarantee the solution's high availability and fault tolerance as well as provide secure authentication for event organizers' websites. (itransition.com)
As a cluster, the embryonic network that includes the Jordan, Palestine, and Lebanon routes could share best practices for the marking of trails, the establishment of emergency services, and the cross-promotion of hiking, according to the organizers. (jordannews.jo)
Formation4
We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)
Surprisingly, wild-type posterior visceral endoderm (PVE) in midgut- and hindgut-deficient tetraploid chimera rescues the posterior body axis truncation, indicating that the PVE is important for tail organizer formation. (biologists.com)
Link to all annotated objects annotated to Spemann organizer formation. (planteome.org)
Link to all direct and indirect annotations to Spemann organizer formation. (planteome.org)
Organs1
Organogenesis: Organogenesis is the process by which organs and organ systems develop from embryonic tissues. (microbiologynote.com)
Mouse1
Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. (genscript.com)
Initially working part-time while studying law at the University of Basel, he became interested in a full-time position in his role at MDPI and has since stepped up to become a Conference Organizer. (sciforum.net)
Function1
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. (elifesciences.org)
Union2
The AFL-CIO's Farm Labor Organizing Committee, or FLOC, says the brutal beating death of Mexican organizer Santiago Rafael Cruz was an attack on the union, not a random murder. (fsrn.org)
In these struggles, as well as a series of others that shook cities across the nation, union organizers built their power by reaching out to workers in other industries, mobilizing the citizenry to support their picket lines, allying with unemployed councils, and engaging in pitched battles with the police. (versobooks.com)