SensitivityTissue specificityTissuesAntigenAbdominal organsLymphoid organsProteinsTransplantationCharacteristicAntibodyAutoimmuneLymphocytesDescriptorCellsMechanismsDiagnosticDysfunctionHighHerniationDifferencesInfectionsTargetCellularTransplantHumansSolidLevelsSystemsCellDamagePublicationMultipleTransportBodyStudiesDiseaseFailureAnnual
Sensitivity9
- Standardization Program (DASP, 2000, 2002, 2003), organized by WHO, the data were: 76-100% sensitivity, 90-100% specificity (100% specificity 3 times), and 100% validity for GAD65 autoantibodies (3). (cdc.gov)
- Many studies indicate a high sensitivity and specificity for US in the diagnosis of appendicitis. (springer.com)
- Organisms seen by Gram stain yielded a sensitivity of 96.6%, specificity of 88.9%, positive predictive value of 97.7% and negative predictive value of 84.2% when used to predict positive culture results for bacterial wound infection. (who.int)
- With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
- Prostate-specific membrane antigen (PSMA)-ligand PET/CT or PET/MRI provides high sensitivity and specificity for prostate cancer staging ( 1 ). (snmjournals.org)
- PURPOSE Hypertension is the most common diagnosis in ambulatory care, yet little evidence exists regarding recommended screening intervals or the sensitivity and specificity of a routine office-based blood pressure measurement, the most common screening test. (annfammed.org)
- We hypothesize that a more limited annual screening strategy may increase specificity while maintaining sensitivity. (annfammed.org)
- CONCLUSION A limited annual screening strategy for hypertension can improve specificity without sacrificing sensitivity when compared with routine screening at every visit in previously normotensive adults. (annfammed.org)
- 1 Yet there is little evidence to recommend a screening interval 2 or to define the sensitivity and specificity of the most common screening test, a routine office-based blood pressure measurement performed by manual sphygmomanometry. (annfammed.org)
Tissue specificity1
- Therefore, we investigated the impact of ApoA-I variants on cell physiology and the mechanisms driving the observed tissue specificity. (lu.se)
Tissues12
- However, the factors leading to cell/tissues damage, as well as the mechanisms behind the observed organ specificity are mostly unknown. (lu.se)
- Cells Tissues Organs (2011) 193 (4): 239-252. (karger.com)
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
- In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
- This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
- Essentially, the presence of therapeutic antibody binding in frozen ex vivo tissues is used to give an indication of potential organ toxicity in vivo . (genengnews.com)
- The damage caused by thalidomide was not mutually exclusive, with the majority of children exhibiting damage to multiple organs and tissues [ 3 , 7 ]. (hindawi.com)
- Animal cells need to be able to communicate with each other so that they can work together in tissues and organs. (elifesciences.org)
- Medical products of human origin are defined as substances that are derived wholly or in part from the human body and intended for clinical application.1 Source components in the human body range from organs, tissues, blood, cells and gametes to breast milk, hair, nails, urine and faeces. (who.int)
- Nevertheless, the available guidance is somewhat fragmented and generally oriented towards a number of specific products (e.g. blood and organs/tissues/cells). (who.int)
Antigen4
- Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. (harvard.edu)
- Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
- There are other ways that binding specificity can be assessed, for example, competing out binding by preincubation with a molar excess of soluble antigen. (genengnews.com)
- Since antigen-specific TGF-beta1 secreting cells localize to the target organ and then suppress inflammation in the local microenvironment, oral tolerization with self antigens may provide a therapeutic approach for the treatment of cell-mediated autoimmune disease which does not depend upon knowledge of the antigen specificity of the original T cell clone triggering the autoimmune cascade. (jci.org)
Abdominal organs3
- The diaphragm is a double-domed musculotendinous partition between the thoracic and abdominal organs and is composed of the central tendinous area and the peripheral muscular area. (medscape.com)
- It lacks ionising radiation, allows dynamic visualisation of the abdominal organs and is of lower cost compared with computed tomography (CT). (springer.com)
- DPL is invasive and risks iatrogenic damage to abdominal organs during the procedure. (msdmanuals.com)
Lymphoid organs2
- Expressed at lower levels in lymphoid organs, kidney, colon and liver. (abcam.com)
- Animal models have therefore been useful, as the peptide specificity of the initial immune response can be manipulated, genetically identical animals used, and the immune response over time in different lymphoid organs and in the target tissue can be assessed. (nature.com)
Proteins1
- Epitope spreading is defined as the diversification of epitope specificity from the initial focused, dominant epitope-specific immune response, directed against a self or foreign protein, to subdominant and/or cryptic epitopes on that protein (intramolecular spreading) or other proteins (intermolecular spreading). (nature.com)
Transplantation1
- As the early experience with transplantation dramatically illustrated (see History of the Procedure), modulation of the normal immune response mechanisms is a vital prerequisite to successful organ transplantation. (medscape.com)
Characteristic1
- Furthermore, training with continuous vibration does not generalize to intermittent vibration, demonstrating stimulus specificity, a characteristic of habituation. (jefferson.edu)
Antibody2
- A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
- Immucor products enable us to accurately assign HLA antibody specificities for better transplant outcomes! (immucor.com)
Autoimmune1
- Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin- dependent diabetes mellitus. (cdc.gov)
Lymphocytes2
- Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
- Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. (nature.com)
Descriptor1
- Organ Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Cells4
- Consistent with this, iNKT cells from different organs show distinct basal activation, proliferation and clonal expansion. (elifesciences.org)
- As we develop from wads of cells to fully formed humans, each of our organs goes through intricate processes to achieve the right combination and number of cells arranged in the proper way. (eurostemcell.org)
- Cells in developing organs begin without specificity and over time turn into various cell types upon receiving the right signals. (eurostemcell.org)
- p class=\'abstract\'>Barrier epithelial organs face the constant challenge of sealing the interior body from the external environment while simultaneously replacing the cells that contact this environment. (stanford.edu)
Mechanisms2
- These challenges include identifying clinically relevant but nonteratogenic forms of the drug, and the mechanisms underlying phocomelia and species specificity. (hindawi.com)
- Unlike embryonic growth, adult organ remodeling is reversible and repeatable, suggesting that it occurs through different mechanisms. (stanford.edu)
Diagnostic2
- These tests also must have sufficient specificity to protect patients with false-positive results from unwarranted diagnostic evaluations. (aafp.org)
- Clinical manifestations of MFS in other organ systems were critically evaluated for their specificity and diagnostic utility based on expert opinion and the available literature. (marfan.org)
Dysfunction2
- A mismatch between fatty acid availability and utilization leads to cellular/organ dysfunction during cardiometabolic disease states (e.g., obesity, diabetes mellitus). (nih.gov)
- After an increase in serum levels of the free chains, the protein deposits in organs, causing significant dysfunction . (medscape.com)
High2
- Genetically-encoded fluorescent sensors with high specificity for peroxide can overcome some of these problems. (plymouth.ac.uk)
- DPL has low specificity, identifying many lesions that cause bleeding but do not require operative repair, and results in a high negative laparotomy rate. (msdmanuals.com)
Herniation2
- Intrathoracic herniation of abdominal solid organs appears as mushroom-shaped, homogeneous opacities in the thorax. (medscape.com)
- On CT scans, herniation of an organ or omental fat may be visible through an abrupt discontinuity in the diaphragm. (medscape.com)
Differences1
- Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. (nature.com)
Infections1
- Les micro-organismes mis en évidence par coloration de Gram ont donné une sensibilité de 96,6 %, une spécificité de 88,9 %, une valeur prédictive positive de 97,7 % et une valeur prédictive négative de 84,2 % lorsqu'ils étaient utilisés pour prévoir les résultats de culture positifs pour les infections bactériennes des plaies. (who.int)
Target3
- Repressed (and forgotten) emotions emerged from the unconscious to target certain organs, producing psychosomatic disorders. (psychiatrictimes.com)
- We will develop nanoparticles to improve efficacy and target specificity of the therapeutic combinations. (ntu.ac.uk)
- The target organs include the gastrointestinal tract and the liver. (plymouth.ac.uk)
Cellular1
- Organoids are cellular 3D models of organs, which provide powerful in vitro platforms for the investigation of tissue and disease biology. (nature.com)
Transplant1
- Because of the increased specificity of mycophenolate mofetil, azathioprine is rarely used in current transplant immunosuppression regimens. (medscape.com)
Humans1
- The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (harvard.edu)
Solid1
- Rarely, DPL is indicated when imaging is available, such as in hypotension plus an unclear E-FAST examination result or imaging that shows free pelvic fluid but no apparent solid organ injury (eg, ascites). (msdmanuals.com)
Levels1
- One type of organ adaptation occurs through tissue growth and shrinkage, tuning an organ's functional capacity to meet variable levels of physiologic demand. (stanford.edu)
Systems1
- When faced with environmental change, an individual's physiological fitness requires that its organ systems functionally adapt. (stanford.edu)
Cell2
- In adult flies, the midgut is a stem cell-based organ analogous to the vertebrate small intestine. (stanford.edu)
- Our goal is to understand how this nutrient-driven mechanism regulates stem cell behavior for lifelong optimization of organ form and function. (stanford.edu)
Damage1
- Children also exhibited amelia in some cases (no limb) forelimb anomalies, handplate anomalies, and other damage to ears, eyes, internal organs, genitalia, and the heart [ 7 , 9 - 20 ]. (hindawi.com)
Publication1
- This graph shows the total number of publications written about "Organ Specificity" by people in Harvard Catalyst Profiles by year, and whether "Organ Specificity" was a major or minor topic of these publication. (harvard.edu)
Multiple1
- Multiple mechanosensory organs mediate VIS, and the magnitude of VIS depends on vibration frequency and genetic background. (jefferson.edu)
Transport1
- The bioavailability of ENMs in the gut lumen depends on the physico-chemical properties of the materials, the composition of the gut lumen fluids (ionic strength, pH, organic matter, etc.) and the location and specificity of the transport pathways in the gut epithelium. (plymouth.ac.uk)
Body1
- Thirdly, the article shows that the connection between pain and body is inherent to the specificity of the organ to psychoanalysis. (bvsalud.org)
Studies3
- In addition to aiding in dis- covering new pathogens, these techniques also contributed to studies of the epidemiology, pathophysiology, and treatment response of the newly recognized diseases, providing further evidence for causal relationships between disease and organ- ism (1). (cdc.gov)
- Whether such staining actually correlates with organ toxicity is still regularly debated, but TCR studies remain a requirement in the data package for an IND/CTA submission for most biotherapeutics. (genengnews.com)
- [ 7-11 ] However, prior studies looking at the examination of each organ individually have generally reported a low specificity in differentiating ADHF from other causes of acute dyspnea. (medscape.com)
Disease3
- Apolipoprotein A-I (ApoA-I) amyloidosis is a rare protein misfolding disease where fibrils of the N-terminal domain of the protein accumulate in several organs, leading to their failure. (lu.se)
- Importantly, to provide insight into human disease we will investigate the therapeutic potential of targeting KDM by employing a novel organ-on-a-chip technology. (ntu.ac.uk)
- The new scanner will allow us to push the boundaries in resolution for imaging function/ microstructure/connectivity in the brain and other organs, beyond the limits of what is currently feasible, exampled in the Figure, for understanding with higher specificity health and disease. (nottingham.ac.uk)
Failure1
- Ingestion typically leads to profuse vomiting and diarrhea followed by multisystem organ failure and possibly death within 36 to 72 hours of exposure. (cdc.gov)
Annual1
- RESULTS Specificity improved from 70.4% (95% CI, 65.5%-75.0%) for the usual practice to 82.0% (95% CI, 77.7%-85.8%) for the annual screening strategy. (annfammed.org)