OrganismsDiseasesChemicals and DrugsInformation Science
Orf virusEcthyma, ContagiousParapoxvirusPseudocowpox virusPoxviridae InfectionsGoatsSheepViral ProteinsRNA VirusesGoat DiseasesVaccinia virusMolecular Sequence Data
ParapoxvirusContagious pustular dGenesZoonoticEncodesIsolatesGenomeSheepProteinVaccinia virusLesionsClone2020CDNAGoatsMonkeypox virusTransgenicReplicationHumansCharacterizePoxviridaeSmall ruminantsMutationsCharacterizationSmallpoxMolecularGenusGenBankVivoInfectionsInfectiousProteinsImmunityHepatitis B virSequencesDiseasesTransmissionLambsScabby mouthOutbreakRecombinantBenignVaccineHerpesDiseaseSubstancesOccursFrequencyClinicalGenomicChamois
Parapoxvirus8
Contagious pustular d4
  • Orf, also known as ecthyma contagiosum, contagious pustular dermatitis, infectious labial dermatitis, scabby mouth, or sore mouth, is a viral disease first described in humans in 1934 by Newson and Cross. (medscape.com)
  • Contagious ecthyma or alternatively called contagious pustular dermatitis is a viral disease of sheep and goat caused by Orf virus which belongs to the family of poxviridae and based on the classification of international committee on taxonomy of viruses(ICTV), it is one of the notifiable viral disease known to have a zoonotic importance [ 1 , 3 , 4 ]. (biomedcentral.com)
  • Contagious ecthyma (contagious pustular dermatitis) is caused by orf virus, a poxvirus that infects ruminants (most often sheep and goats). (msdmanuals.com)
  • Contagious ecthyma (contagious pustular dermatitis) is caused by orf virus. (msdmanuals.com)
Genes7
  • Virus Genes , 13 (1), 5-17. (psu.edu)
  • The three genes completely deleted were a homologue of dUTPase, a gene that encodes a protein containing ankyrin-like repeats and a homologue of the 5K gene of the vaccinia virus WR strain. (microbiologyresearch.org)
  • African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. (mdpi.com)
  • ORF-2 contains genes encoding the capsid. (medscape.com)
  • Retroviruses are viruses that contain RNA, the cousin of DNA, which encodes for genes that helps it insert itself into the host DNA. (databasefootball.com)
  • LOCUS SOUCAPPRO 7708 bp ss-RNA linear VRL 27-MAR-1996 DEFINITION Southampton virus capsid protein, polyprotein, and ORF genes, complete cds. (cdc.gov)
  • Orthopoxviruses and Monkeypox virus were detected in the organs by PCR using consensus primers targeting the virus surface membrane haemagglutinin (HA) genes, while Leptospira species were detected by PCR using primers targeting the rrs and lfb1 genes. (bvsalud.org)
Zoonotic2
  • Orf is a zoonotic disease, meaning humans can contract this disorder through direct contact with infected sheep and goats or with fomites carrying the orf virus. (wikipedia.org)
  • Human monkeypox is a viral zoonotic infection caused by monkeypox virus, an enveloped double-stranded DNA virus of the genus Orthopoxvirus and family Poxviridae that also contain smallpox, cowpox, Orf, and vaccinia viruses. (bvsalud.org)
Encodes1
  • The envelope gene (B2L) of the virus encodes for a highly immunogenic envelope protein [ 12 ]. (biomedcentral.com)
Isolates5
  • After injection into primary lamb keratinocytes ( 4 ), the in wild ruminants in Stelvio Park, Italy, we sequenced and viruses showed signs of cytopathic effect after at least 1 compared the DNA of several isolates. (cdc.gov)
  • PCR was used to amplify the PPV B2L gene encoding that the red deer isolates are closely related to the parapox a major envelop protein ( 3,5 ), and a specifi c amplifi cation of red deer in New Zealand virus. (cdc.gov)
  • orf virus (OV), bovine papular stomatitis virus (BPSV), The PPV isolates from chamois and ibex were closely pseudocowpox virus (PCPV), and parapox of red deer related to OV with 98.2%-99.3% identity at the nt level in New Zealand virus (PVNZ). (cdc.gov)
  • We amplifi ed the forms in reindeer were shown to be closely related to OV vascular endothelial growth factor ( VEGF ) gene of the virus and PCPV, excluding the circulation of PVNZ in red deer isolates ( 7 ), which enabled us to obtain a specifi c these countries ( 2 , 3 ). (cdc.gov)
  • Through restrictive endonuclease analysis of the genomes of isolates, molluscum contagiosum virus types I-IV have been identified. (medscape.com)
Genome8
  • The virus genome consists of linear double-stranded DNA ranging from 134 up to 139 kb [ 6 ]. (biomedcentral.com)
  • CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. (nature.com)
  • Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of plantain (AAB) is a major challenge for breeding and dissemination of hybrids. (nature.com)
  • It is an unenveloped, non-covalently closed, bacilliform double-stranded DNA (dsDNA) virus with a monopartite genome of ~7.2-7.8 kb encoding three open-reading frames (ORFs). (nature.com)
  • It also restricts germplasm movement of genotypes with the B genome worldwide due to this potential activation of eBSV into the episomal infectious form of virus. (nature.com)
  • Genome condensation and packaging are essential processes in the life cycle of viruses. (mdpi.com)
  • The hepatitis E virus (HEV) genome contains three open reading frames (ORFs). (medscape.com)
  • A Custom Hepatitis A Virus Assay for Whole-Genome Sequencing. (cdc.gov)
Sheep7
  • This virus primarily causes an infection in sheep and goats, although it can be transmitted to people. (cdc.gov)
  • Orf has been reported in people who prepare sheep or goats for religious feasts. (medscape.com)
  • The vaccine used in sheep to prevent orf is live and has been known to cause disease in humans. (wikipedia.org)
  • More typically, sheep will become free of orf within a week or so as the disease runs its course. (wikipedia.org)
  • a total of 400 randomly selected sheep and goat was screened for the identification of the virus using amplification of B2L gene and transfection of mammalian cells (VERO cells). (biomedcentral.com)
  • Scabby mouth (contagious ecthyma, orf) is a highly contagious, viral disease of sheep, goats and occasionally humans. (vic.gov.au)
  • The scabby mouth virus infects a sheep through abrasions in the skin. (vic.gov.au)
Protein5
  • [ 10 , 11 ] Orf also produces protein that inhibits IL-2 and granulocyte macrophage-colony stimulating factor and a vascular endothelial growth factor homolog. (medscape.com)
  • In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)
  • 2015 ) Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity. (academictree.org)
  • Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. (microbiologyresearch.org)
  • Human immunodeficiency virus Vpr product is a virion-associated regulatory protein. (microbiologyresearch.org)
Vaccinia virus6
Lesions7
  • Animals infected with orf virus tyically develop scabby sores (lesions) around their lips, muzzle, and in their mouth. (cdc.gov)
  • The orf lesions usually heal completely with no scarring in about 35 days (4-8 wk). (medscape.com)
  • Immunocompromised patients with orf can have progressive, destructive lesions requiring medical interventions such as antiviral therapy, reduction of immunosuppression, and surgical debridement. (medscape.com)
  • Skin lesions of orf and anthrax exhibit a similar appearance and course. (aafp.org)
  • Molluscum contagiosum virus causes characteristic skin lesions consisting of single or, more often, multiple, rounded, dome-shaped, pink, waxy papules that are 2-5 mm (rarely up to 1.5 cm in the case of a giant molluscus) in diameter. (medscape.com)
  • The molluscum contagiosum virus may be inoculated along a line of minor skin trauma (eg, from shaving), resulting in lesions arranged in a linear pattern (see the image below). (medscape.com)
  • In a patient who had preexisting molluscum contagiosum, the virus was inoculated along a line of minor skin trauma, resulting in the development of the 3 new lesions. (medscape.com)
Clone2
  • This clone was engineered to express the complete ORF with an expression tag. (origene.com)
  • The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). (origene.com)
20202
  • 2020 versucht ein Virus die vielfältigen Projekte lahmzulegen. (orf.at)
  • April 2020 war jene Zeit der Pandemie als man in den Nachrichten über die jeweilige Verweildauer des Virus auf Oberflächen informiert wurde und Aerosol-Videos (MNS vs FFP2) die Runde machten. (orf.at)
CDNA1
  • Original source text: Southampton virus cDNA to genomic RNA. (cdc.gov)
Goats1
  • Molecular characterization and phylogenetic evaluation of orf virus remoted from goats in Sokoto metropolis, Nigeria Purpose: The goal of this research was to molecularly characterize orf virus remoted from medical infections in goats in Sokoto metropolis. (locusdiscovery.com)
Monkeypox virus9
  • and monkeypox virus. (cdc.gov)
  • Intragenomic sequence transposition in monkeypox virus. (microbiologyresearch.org)
  • Incidence of human mpox has been increasing in West and Central Africa, including in the Democratic Republic of Congo (DRC), where monkeypox virus (MPXV) is endemic. (researchgate.net)
  • We review the evidence for respiratory transmission of monkeypox virus (MPXV), examining key works from animal models, human outbreaks and case reports, and environmental studies. (researchgate.net)
  • To investigate animal reservoirs of monkeypox virus in Nigeria, we sampled 240 rodents during 2018-2019. (researchgate.net)
  • Genetic Variability of the Monkeypox Virus Clade IIb B.1. (cdc.gov)
  • ORF-Interrupting Mutations in Monkeypox Virus Genomes from Washington and Ohio, 2022. (cdc.gov)
  • Ebola virus disease outbreak occurred in 2014 in Liberia, Guinea and Sierra Leone, Monkeypox virus in Nigeria in 2017 and most recently Lassa virus in Nigeria, Togo and Benin in 2018. (bvsalud.org)
  • Monkeypox virus was not detected from studied small mammals. (bvsalud.org)
Transgenic3
  • Expression of open reading frame (ORF) VI of cauliflower mosaic virus (CaMV) in transgenic Arabidopsis thaliana caused a typical syndrome characterised by leaf chlorosis, vein clearing, plant stunting and reduced fertility. (psu.edu)
  • In these aspects, the ORF VI transgenic plants resembled late flowering mutants. (psu.edu)
  • All these phenotypes correlated with expression of ORF VI in three lines of transgenic plants which were produced independently, with different Ti-plasmid derived vectors and with different selective markers. (psu.edu)
Replication3
  • Orf virus replication in bovine testis cells: kinetics of viral DNA, polypeptide, and infectious virus production and analysis of virion polypeptides. (microbiologyresearch.org)
  • Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. (microbiologyresearch.org)
  • The largest, ORF-1, codes for the nonstructural proteins responsible for viral replication. (medscape.com)
Humans4
  • [ 2 ] Orf is transmitted to humans through direct contact with an infected animal or, less commonly, contaminated fomites. (medscape.com)
  • Humans occasionally become infected with the scabby mouth virus. (vic.gov.au)
  • The disease in humans is called orf. (vic.gov.au)
  • Molluscum contagiosum virus causes a benign viral infection that is largely (if not exclusively) a disease of humans. (medscape.com)
Characterize1
  • Amid the global 2022 mpox outbreak, new estimates are needed to characterize the virus' epide. (researchgate.net)
Poxviridae1
  • Molluscum contagiosum virus is an unclassified member of the Poxviridae family. (medscape.com)
Small ruminants1
  • Infection with orf virus occurs throughout the world, wherever small ruminants exist. (cdc.gov)
Mutations1
  • Most of the HERV are inactive because of years of deletions and mutations that changed the virus from its original form. (databasefootball.com)
Characterization1
  • Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs. (bordet.be)
Smallpox1
  • The most well known member of the genus is variola virus, the causative agent of smallpox. (cdc.gov)
Molecular3
  • Molecular (real-time PCR) and serologic (IgM) evidence indicated orthopoxvirus infections, but presence of mon- keypox virus was not confirmed. (researchgate.net)
  • The foamy virus family: molecular biology, epidemiology and neuropathology. (microbiologyresearch.org)
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
Genus4
  • The viruses in this genus are listed by the World Organizations for Animal Health (OIE: Office International des Epizooties) as important animal diseases that require notification. (cdc.gov)
  • Swinepox virus is the sole member of the Suipoxvirus genus. (cdc.gov)
  • HEV is an RNA virus of the genus Hepevirus . (medscape.com)
  • A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
GenBank1
  • Sequence information for each virus corresponds to GenBank accession number/acronym/strain. (cdc.gov)
Vivo1
  • The project focussed on the development and testing of recombinant virus vectors to deliver T. gondii antigens in vivo to stimulate specific protective immune responses. (europa.eu)
Infections1
  • The majority of orf infections go unreported because the disease is self-limited, and those infected are able to recognize orf and do not seek medical attention. (medscape.com)
Infectious2
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
Proteins1
Immunity1
  • The orf virus is able to produce a homolog of anti-inflammatory cytokine, interleukin (IL)‒10, which contributes to localized suppression of immunity. (medscape.com)
Hepatitis B vir1
  • Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives. (cdc.gov)
Sequences1
  • Here, we report a strategy to inactivate the eBSV by editing the virus sequences. (nature.com)
Diseases3
  • Virus diseases caused by the HERPESVIRIDAE. (lookformedical.com)
  • A general term for diseases produced by viruses. (lookformedical.com)
  • Viral diseases likely encountered on the job include animal respiratory viruses, poxviruses, enteroviruses, and arboviruses. (cdc.gov)
Transmission2
  • Transmission of leporipoxviruses is primarily through the mosquito although other biting insects such as fleas may also transmit virus. (cdc.gov)
  • Molluscum contagiosum virus transmission through direct skin contact between children sharing a bath and between athletes sharing gymnasium equipment and benches has been reported. (medscape.com)
Lambs6
  • Agarose gel (1.5%) electrophoresis of 627-bp PCR products from samples from persons exposed to Orf virus while butchering or preparing lambs as part of a religious practice for Eid al-Adha (the Muslim Feast of Sacrifice), Marseil e, France, 2011. (cdc.gov)
  • Phylogeny of Orf virus isolated from 5 persons who butchered/prepared lambs as part of a religious practice for Eid al-Adha (the Muslim Feast of Sacrifice), Marseille, France, 2011. (cdc.gov)
  • Orf is very common among shepherds, veterinary surgeons, and farmers' wives who bottle-feed young lambs, as well as in butchers, cooks, and meat porters from handling infected carcasses. (medscape.com)
  • Orf in the mouths of lambs may prevent suckling and cause weight loss, and can infect the udder of the mother ewe, thus potentially leading to mastitis. (wikipedia.org)
  • A live virus vaccine (ATCvet code: QI04AD01 (WHO)) is made from scab material and usually given to ewes at the age of two months, but only to lambs when there is an outbreak. (wikipedia.org)
  • 2007. Antiviral activity of HPMPC (cidofovir) against orf virus infected lambs . (hutton.ac.uk)
Scabby mouth1
  • Orf virus infection in animals is commonly referred to as sore mouth, scabby mouth, or contagious ecthyma. (cdc.gov)
Outbreak1
  • In one case it was shown that a severe form of orf virus caused an outbreak involving the gastrointestinal tract, lungs, heart, as well as the buccal cavity, cheeks, tongue and lips. (wikipedia.org)
Recombinant2
  • The project achieved the successful preparation of recombinant viral contructs using both pox viruses and lentiviruses expressing selected T. gondii antigens. (europa.eu)
  • Immunisation of mice with the recombinant viruses did result in induction of specific antibody responses showing that the approach had some efficacy and would be worth pursuing with the long term aim of producing a safe and effective vaccine against T. gondii tissue cysts in food animals. (europa.eu)
Benign1
  • While orf is usually a benign self-limiting illness which resolves in 3-6 weeks, in the immunocompromised it can be very progressive and even life-threatening. (wikipedia.org)
Vaccine1
  • Despite efforts made over past decades, there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an urgent need to develop novel strategies. (mdpi.com)
Herpes1
  • Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice. (invivogen.com)
Disease1
  • Currently, there are live Orf vaccines which can control the disease, but it has a spreading potential to the environment and increasing the risk of another animals [ 7 ]. (biomedcentral.com)
Substances1
Occurs1
  • Orf occurs more commonly in men owing to the fact that men more likely to have an occupational exposure (eg, ranching, veterinary medicine, animal slaughter). (medscape.com)
Frequency1
  • Heidmann and the other researchers identified the human exogenous MER34 (medium reiteration frequency family 34) ORF. (databasefootball.com)
Clinical2
  • A typical clinical presentation of a reddish weeping nodule of orf located on the thumb is shown in the image below. (medscape.com)
  • Recently, the causative viruses of the clinical characterized the red deer viral strains. (cdc.gov)
Genomic1
  • 7708 /organism="Southampton virus" /mol_type="genomic RNA" /db_xref="taxon:11984" 5'UTR 1. (cdc.gov)
Chamois1
  • Results showed that and 99.6% identical at the nt level and 96.55 and 98.8% the viruses isolated from chamois ( Rupicapra rupicapra ) identical at the aa level, respectively, which showed that and ibex ( Capra ibex ) were closely related to OV, whereas multiple strains are circulating in Stelvio Park. (cdc.gov)