These two receptor complexes, namely gp130/LIFR and gp130/OSMR, were termed the type I and type II Oncostatin-M receptors. (wikipedia.org)
Conversely, overexpression of miR-1/133a caused the cells to terminate any cell division activity if we had previously induced it by administering the binding molecules of the two receptors, i.e. oncostatin and FGF,' explains Melissa Valussi, first author of the study. (mpg.de)
A subtype of oncostatin receptors that are formed by dimerization of ONCOSTATIN M RECEPTOR BETA SUBUNIT and CYTOKINE RECEPTOR GP130 . (nih.gov)
Receptor9
Its mechanism of action is via specific binding to gp130 and either the leukaemia inhibitory factor receptor (LIFR) or oncostatin M receptor (OSMR) systems at the cell surface to form an active signalling complex. (ox.ac.uk)
RESULTS: We report here the crystal structure of human oncostatin M (hOSM) along with mutagenesis data which map the receptor-binding epitopes of the molecule. (ox.ac.uk)
On chondrocytes from WT mice, gp130 and the oncostatin M (OSM) receptor were strongly expressed, whereas the transmembrane interleukin-6 (IL-6) receptor was expressed at much lower levels. (nih.gov)
OSM receptor type II interacts with a protein called oncostatin M (OSM). (medlineplus.gov)
also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)
Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
The two molecules, oncostatin M receptor and FGF receptor 1, control the division activity of heart muscle cells in the adult heart,' says Thomas Böttger, one of the lead authors of the study. (mpg.de)
Indeed, the expression of the genes for the oncostatin M receptor and the FGF receptor 1 increased in these cells, and with it the number of receptor molecules. (mpg.de)
This thesis describes the characterization of the interactions between the cytokine oncostatin M (OSM) and the cytokine-binding homology region (CHR) of its receptor gp130. (bl.uk)
Cytokine oncostatin2
Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. (ox.ac.uk)
BACKGROUND: The cytokine oncostatin M (OSM) inhibits growth of certain tumour-derived cells, induces proliferation in other cell types (e.g. haemangioblasts) and is a mediator of inflammatory responses. (ox.ac.uk)
Inhibits2
Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
Oncostatin M inhibits differentiation of rat stem Leydig cells in vivo and in vitro. (bvsalud.org)
Cytokines3
Oncostatin M (OSM) is a pleiotropic cytokine within the interleukin six family of cytokines , which regulate cell growth and differentiation in a wide variety of biological systems. (bvsalud.org)
Tissue inhibitor of metalloproteinases-1 (TIMP-1) can be regulated by gp130 cytokines such as IL-6 and oncostatin M (OSM). (uea.ac.uk)
We demonstrate that oncostatin M (OSM) produced by activated macrophages promotes osteoblastic differentiation and mineralization of human muscle-derived stromal cells surrounding NHOs. (jci.org)
Protein3
Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. (wikipedia.org)
The team's proposed drug would work by inhibiting the action of a protein called oncostatin M (OSM). (boisestate.edu)
There are several different types of myokines, including oncostatin M (OSM), secreted protein acidic risk in cysteine (SPARC), irisin, IL6, and IL5. (medicalnewstoday.com)
Interleukin1
Background: The synergistic degradation of cartilage by oncostatin M (OSM) in combination with either interleukin 1 (IL1) or tumour necrosis factor alpha (TNF alpha) has been previously demonstrated using bovine nasal cartilage (BNC). (ncl.ac.uk)
Induces1
Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression. (mpg.de)
Descriptor1
Oncostatin M" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Inflammatory1
Serum levels of primary inflammatory mediators were not elevated although oncostatin M, an IL-6 family cytokine and type I interferon enhancer, was increased. (cdc.gov)
Regulation1
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA, Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. (tcd.ie)
Expression2
Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
Cells1
Oncostatin M (OSM) is a cytokine secreted by differentiated histiocytic lymphoma cells [ 14 ]. (aging-us.com)
Human1
Recombinant Human Oncostatin M (227 a.a. (peprotech.com)
Signal1
They are activated specifically by ONCOSTATIN M and signal through interaction of their cytoplasmic domains with JANUS KINASES . (nih.gov)
Analysis1
Fos and Jun nuclear factors bound constitutively to this site as identified by supershift analysis in electrophoretic mobility shift assays, and oncostatin M (but not IL-6) induced an additional "complex 2" that contained c-Fos and JunD. (uea.ac.uk)
Cytokine5
We found that the cytokine oncostatin M (OSM) is highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch. (nih.gov)
We have reported that oncostatin M (OSM), a gp130 cytokine, is produced by AT macrophages and up-regulated in mouse and human obesity. (grantome.com)
In 1992, this growth factor proved to be a cytokine previously termed oncostatin M, since it had been identified earlier for its inhibitory effects on a variety of cancer cells. (medscape.com)
Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. (ptglab.com)
Serum levels of primary inflammatory mediators were not elevated although oncostatin M, an IL-6 family cytokine and type I interferon enhancer, was increased. (cdc.gov)
Inflammation1
Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation. (ox.ac.uk)
Signaling molecule1
The team found that skin samples from people with chronic itch-related conditions made high levels of an immune signaling molecule called oncostatin M (OSM). (nih.gov)
Secrete1
Primed monocytes secrete epiregulin (EREG) and oncostatin-M (OSM), while macrophages secrete heparin-binding EGF-like growth factor (HB-EGF) and OSM. (tum.de)
An immune substance called oncostatin M was found to sensitize and enhance the activity of itch-sensing neurons. (nih.gov)
Growth1
So vorbehandelte Monozyten sezernieren Epiregulin (EREG) und Oncostatin-M (OSM), während Makrophagen Heparin-binding EGF-like growth factor (HB-EGF) und OSM ausschütten. (tum.de)
Activity1
A drug that blocks oncostatin M activity reduced scratching in a mouse model of chronic itch, suggesting a treatment strategy for persistent itchy skin conditions. (nih.gov)
Effects1
Oncostatin M (OSM) has been reported to be overexpressed in psoriasis skin lesions and to exert proinflammatory effects in vitro on human keratinocytes. (ox.ac.uk)