• Efforts to treat cancer through immunisation or virotherapy (deliberate infection with a virus), began in the mid-20th century. (wikipedia.org)
  • The field of virotherapy was nearly abandoned for a time, as the technology required to modify viruses didn't exist whereas chemotherapy and radiotherapy technology enjoyed early success. (wikipedia.org)
  • Today, both preclinical and early-stage clinical trials are intensively investigating the approach to improve oncolytic virotherapy. (slideshare.net)
  • Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? (mdpi.com)
  • The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
  • Until recently, most studies have focused on the direct antitumor properties of these viruses, although there is now an increasing body of evidence that the host immune response may be critical to the efficacy of oncolytic virotherapy. (elsevierpure.com)
  • Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. (ox.ac.uk)
  • Background A major challenge in oncolytic virotherapy is to engineer potent tumor-killing viruses that can be delivered systemically for treatment of metastatic disease while leaving normal cells unharmed. (bmj.com)
  • Our oncolytic virotherapy solutions offer immense support to researchers and pharmaceutical companies dedicated to revolutionary cancer therapies. (vizagherald.com)
  • Here, we discuss strategies that are explored to further improve oncolytic virotherapy . (bvsalud.org)
  • In this review, we will describe the intricate link among oncolytic virotherapy, tumor immunology, and immunogenic cell death (ICD) and discuss ways to harness optimally their potential for future cancer therapy. (vub.be)
  • In conclusion we successfully developed novel tumor-selective oncolytic rSeV vectors constituting a new tool for virotherapy of solid tumors becoming ready for further preclinical and medical development to address unique tumor types. (siamtech.net)
  • Virotherapy centered medical studies are currently undertaken for a number of different DNA and RNA viruses [3] [10]. (siamtech.net)
  • Oncolytic immunotherapy aims to build on this potential by using genetically modified viruses to target tumors in two important and complementary ways. (amgen.com)
  • Viruses can be harnessed as vectors for oncolytic immunotherapy. (amgen.com)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • Valo Therapeutics (Helsinki and Oxford) is an immunotherapy company that is developing (neo)antigen-coated oncolytic viruses as anti-cancer therapeutic vaccines. (helsinki.fi)
  • On this basis, oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities. (elsevierpure.com)
  • Next generation oncolytic viruses Building on recent clinical success by checkpoint inhibitor antibodies, the field of cancer immunotherapy is now focussing on combination treatment regimens to further improve efficacy benefits to patients. (akamisbio.com)
  • Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy. (bvsalud.org)
  • Oncolytic viruses (OVs) are another exciting class of immunotherapy agent. (vub.be)
  • As an oncolytic viral therapy, [ Imlygic ] has a unique approach, and provides another option for treating eligible patients with unresectable disease that has recurred after initial surgery," said Dr Kaufman, who is associate director for clinical science at the Rutgers Cancer Institute of New Jersey and president of the Society for Immunotherapy of Cancer. (medscape.com)
  • The company develops two oncolytic virus platforms such as Vesicular Stomatitis Virus (VSV) and Measles Virus (MV-NIS). (pharmaceutical-technology.com)
  • Vesicular stomatitis virus (VSV) is a promising oncolytic agent that directly kills cancer cells, but which also modulates immune elements within the tumor microenvironment. (uncg.edu)
  • The primary MPS was exposed to vesicular stomatitis virus (VSV) tagged with a green fluorescent protein (GFP) for one day. (ufluidix.com)
  • We have reported earlier the safety and efficacy of recombinant vesicular stomatitis virus (VSV) vectors in a rat model of hepatocellular carcinoma (HCC). (mssm.edu)
  • A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents. (wikipedia.org)
  • An oncolytic adenovirus, a genetically modified adenovirus named H101, was approved in China in 2005 for the treatment of head and neck cancer. (wikipedia.org)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • We conducted a single-center, dose-escalation study of DNX-2401, an oncolytic adenovirus that selectively replicates in tumor cells, in patients with newly diagnosed DIPG. (cun.es)
  • DNAtrix's clinical stage oncolytic adenovirus platform and Valo's PeptiCRAd (Peptide-coated Conditionally Replicating Adenovirus) vaccination technology will be combined to generate a novel "armed oncolytic vaccine" for cancer therapy. (helsinki.fi)
  • Here we report the nonclinical characterization of ICVB-1042, an optimized E2F-dependent oncolytic adenovirus rationally engineered with specific genomic modifications to confer tumor selective replication and enhanced tumor cell killing. (bmj.com)
  • Methods Using a proprietary iterative adenovirus design and screening platform, IconOVir has engineered ICVB-1042, a potent, tumor selective oncolytic adenovirus. (bmj.com)
  • Viruses that are frequently chosen for genetic engineering include vaccinia virus, adenovirus, and herpes simplex virus. (e-crt.org)
  • In 2015, talimogene laherparepvec (OncoVex, T-VEC), an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in the United States and the European Union, for the treatment of advanced inoperable melanoma. (wikipedia.org)
  • Herpes simplex virus (HSV) was one of the first viruses to be adapted to attack cancer cells selectively, because it was well understood, easy to manipulate and relatively harmless in its natural state (merely causing cold sores) so likely to pose fewer risks. (wikipedia.org)
  • The herpes simplex virus type 1 (HSV-1) mutant 1716 lacks both copies of the ICP34.5 gene, and as a result is no longer able to replicate in terminally differentiated and non-dividing cells but will infect and cause lysis very efficiently in cancer cells, and this has proved to be an effective tumour-targeting strategy. (wikipedia.org)
  • Recently, the FDA approved Imlygic, a herpes virus based therapeutic for the treatment of melanoma and thus OVs have entered a new era where they are a weapon in the armament of the oncologist. (mcmaster.ca)
  • The therapy consists of herpes simplex 1 virus that has been genetically modified to secrete the cytokine GM-CSF, which causes cell lysis. (cgtlive.com)
  • Talimogene laherparepvec is a genetically modified herpes simplex virus type 1 that is designed to replicate within tumors and produce the immunostimulatory protein granulocyte-macrophage colony-stimulating factor (GM-CSF). (medscape.com)
  • Because it is a modified live oncolytic herpes virus therapy, herpetic infection can also occur. (medscape.com)
  • HOUSTON and HELSINKI, Nov. 13, 2018 /PRNewswire/ -- DNAtrix and Valo Therapeutics today announced an exclusive R&D collaboration to develop enhanced vaccines using DNAtrix's clinical stage viruses and Valo's proprietary antigenic peptide technology. (helsinki.fi)
  • Oncolytic viruses (OV) are replicating viral therapeutics for the treatment of cancer and have been in laboratory development for about twenty years. (mcmaster.ca)
  • The 'Armed EnAd' platform makes possible creation of a broad range of unique oncolytic immune therapeutics, including oncolytic vaccines that express one or more antibodies (AbEnAd), cytokines or other immunomodulatory proteins, or nucleotide based payloadssuch as RNAi. (akamisbio.com)
  • Creative Biolabs, a pioneering biotechnology research and development company, is excited to unveil its comprehensive oncolytic virus-based therapeutics discovery services. (vizagherald.com)
  • By synergizing expertise and resources, the objective is to accelerate breakthroughs in oncolytic virus-based therapeutics, ultimately advancing precision medicine. (vizagherald.com)
  • Talimogene laherparepvec (Imlygic) is an oncolytic virus that targets skin or lymph node melanomas when surgical removal is not possible. (medicalnewstoday.com)
  • The ability to deliver enadenotucirev systemically via intravenous infusion represents a significant advantage over other oncolytic therapies, such as Imlygic® (T-vec), that require intra-tumoural delivery. (akamisbio.com)
  • The US Food and Drug Administration (FDA) has approved talimogene laherparepvec ( Imlygic , Amgen), which is the first oncolytic viral therapy to receive approval from the agency. (medscape.com)
  • DNAtrix brings world-class expertise and experience in multiple tumor types and clinically-tested oncolytic viruses, making them an ideal partner for development of a new class of armed oncolytic vaccines. (helsinki.fi)
  • The virus can also be modified to produce human signaling proteins that summon immune cells to the site of the lysed tumors, where they encounter tumor antigens. (amgen.com)
  • A virus that can produce human signally proteins to summon immune cells to the site of the tumor and teach them to recognize and target tumors with similar antigen profiles. (amgen.com)
  • While many oncolytic viruses have also had success as antitumor agents, their impact thus far has been limited to locally restricted tumors. (virology.ws)
  • Scientists major concern about oncolytic viruses has thus been whether they must be injected at all possible tumor sites in order to combat metastatic tumors. (virology.ws)
  • What is perhaps most promising about this therapy is that it has also proved effective against tumors that have previously shown resistance to oncolytic viral therapies. (virology.ws)
  • While oncolytic adenoviruses alone offer a promising strategy to treat cancer, in combination with PeptiCRAd, superior and durable immunological protection against most forms of solid tumors is expected. (helsinki.fi)
  • Oncolytic viruses, which healthcare experts produce in a laboratory, can treat tumors locally. (medicalnewstoday.com)
  • Additionally, the virus can replicate and spread and has the ability to track the tumors. (targetedonc.com)
  • In the second study, the tumor was infused into 54 patients with unresectable tumors (NCT01156584), and the third focused on neoadjuvant intravenous administration of the virus in patients with grade III/IV glioma (NCT01985256). (targetedonc.com)
  • In tumors treated with both viruses, the researchers identified secretion of hIL-7 and mIL-12, increased IFNγ, and increased infiltration by immune cells compared to Cont-VV or either monotherapy. (acir.org)
  • injected the virus into one side of mice bearing contralateral CT26.WT tumors. (acir.org)
  • Leading drug developers such as Merck and Johnson & Johnson have piled into the oncolytic virus market over the past two years, in part because of the potential for the modality to turn cold tumors hot. (borderless.net)
  • ICVB-1042 virus particles increased in both tumors and plasma over time suggesting virus replication in tumors, which correlated with efficacy. (bmj.com)
  • For the first time, we can combine the potent tumor killing and immune stimulation triggered by viruses along with a patient specific antitumor vaccine for generating effective antitumor immunity. (helsinki.fi)
  • PsiOxus has developed a patented platform for tumour-targeted delivery based on its oncolytic vaccine, enadenotucirev. (akamisbio.com)
  • examined the antitumor activity of an oncolytic vaccinia virus called Cont-VV that had been modified to increase cancer cell-specific replication and reduce antigenicity. (acir.org)
  • Vaccinia virus has many ideal characteristics that allow for development as an oncolytic virus, such as its relatively large genome as an optimal platform for gene editing, long usage history, and well-defined safety profile [ 2 ]. (e-crt.org)
  • Oncolytic viral therapy has been evaluated in patients with pediatric gliomas elsewhere in the brain, but data regarding oncolytic viral therapy in patients with DIPG are lacking. (cun.es)
  • A team of researchers led by Dmitriy Zamarin combined checkpoint blockade, a technique aimed at enhancing antitumor immune responses, with oncolytic viral therapy, a technique that uses viruses to kill tumor cells. (virology.ws)
  • person for pharmacy in all issues related to live oncolytic viruses. (mhra.gov.uk)
  • They are currently leading a phase 1 clinical trial in children with diffuse midline glioma to evaluate the safety, delivery and efficacy of an oncolytic virus called DNX-2401. (thebraintumourcharity.org)
  • Via rigorous preclinical assessment, Creative Biolabs meticulously evaluates the safety and efficacy of oncolytic virus candidates, generating pivotal data for regulatory submissions and clinical trial design. (vizagherald.com)
  • Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
  • GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Oncolytic Virus to Target CD46 and SLC5A5 for Oncology LoA Report. (pharmaceutical-technology.com)
  • I know one trial which is used in oncology and it is a virus. (mhra.gov.uk)
  • A therapy that uses a virus to kill tumor cells can be safely given to children with a rare, incurable form of brain cancer, an early study has found. (medicalxpress.com)
  • Through a combination of oncolytic virus therapy and checkpoint blockade, the researchers overcame the limitations faced when each one is employed independently. (virology.ws)
  • By demonstrating that a tumor cell does not need to be permissive to a virus in order to be a target for therapy, Zamarin's approach greatly expands the potential applicability of NDVs and other oncolytic viruses. (virology.ws)
  • Do you mean gene therapy when you say oncolytic virus. (mhra.gov.uk)
  • Oncolytic virus (OV) therapy is one of these methods that hinges on employing natural or synthetic viruses that preferentially attack cancer cells. (ufluidix.com)
  • A better understanding of the events involved in the transport of the drug after injection as well as what occurs after the drug being delivered is essential for characterizing cancer therapy strategies such as oncolytic virus therapy. (ufluidix.com)
  • Despite encouraging developments in recent years, the limited fraction of patients responding to therapy has demonstrated the need to search for new suitable viruses. (ox.ac.uk)
  • However, the full potential of VSV therapy is limited by a sudden decline in intratumoral virus replication observed early after viral administration, a phenomenon that coincides with an accumulation of inflammatory cells within infected lesions. (mssm.edu)
  • Embracing a holistic approach to oncolytic virus therapy development, Creative Biolabs empowers clients with comprehensive services and delivers tailor-made solutions that precisely align with project-specific requirements across the entire drug discovery continuum. (vizagherald.com)
  • Creative Biolabs is a distinguished contract research organization specializing in providing comprehensive oncolytic virus-based therapy discovery services, dedicated to catalyzing innovation and expediting the development of transformative cancer therapies. (vizagherald.com)
  • Its use is contraindicated in pregnant women and immunocompromised patients, including patients with a history of primary or acquired immunodeficient states, leukemia, lymphoma, AIDS, or other clinical manifestations of infection with human immunodeficiency viruses, and patients on immunosuppressive therapy, because of the risk for life-threatening disseminated herpetic infection. (medscape.com)
  • As the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. (wikipedia.org)
  • Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. (wikipedia.org)
  • Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the senecavirus, resulting in clinical trials. (wikipedia.org)
  • In a wide range of in vivo cancer models, the HSV1716 virus has induced tumour regression and increased survival times. (wikipedia.org)
  • The review will provide a background and historical progression for the surgeon on tumour immunology, and the interplay between oncolytic viruses, immune cells, inflammation on tumourigenesis. (whiterose.ac.uk)
  • An oncolytic virus is a virus that has the ability to infect and destroy tumour cells, also known as having an "oncolytic" effect. (thebraintumourcharity.org)
  • A virus that will replicate selectively in tumor cells but not healthy cells. (amgen.com)
  • Enadenotucirev is an oncolytic virus that has been shown in phase I clinical trials to reach and selectively infect cancer cells when administered by intravenous infusion. (akamisbio.com)
  • She noted the results of the study favored T-VEC and that the low toxicity profile associated with the oncolytic virus gave it an advantage against more active but also more toxic regimens, like nivolumab (Opdivo) plus ipilimumab (Yervoy). (cgtlive.com)
  • The toxicity of oncolytic CVB3 in healthy tissues is variable and depends on the virus strain. (ox.ac.uk)
  • The researchers initially injected mice with melanoma tumor cells, followed by injection of Newcastle disease virus (NDV) directly into these tumor sites. (virology.ws)
  • In this final readout of the largest randomized neoadjuvant trial for an oncolytic virus in advanced melanoma, we report durable improvements in RFS, EFS, and overall survival at 5 years with neoadjuvant T-VEC plus surgery vs standard surgery," said Dummer. (cgtlive.com)
  • These results suggest that an intratumorally-administered oncolytic agent can elicit a meaningful long-term systemic effect and support neoadjuvant T-VEC plus surgery in advanced resectable melanoma. (cgtlive.com)
  • An oncolytic virus is a virus that preferentially infects and kills cancer cells. (wikipedia.org)
  • The virus preferentially targets cancerous cells, leaving normal cells unharmed. (thebraintumourcharity.org)
  • As a consequence IFN-sensitive viruses preferentially replicate in malignancy cells while normal cell types and cells are able to launch a powerful counterattack [9]. (siamtech.net)
  • Intratumoral infusion of oncolytic virus DNX-2401 followed by radiotherapy in pediatric patients with DIPG resulted in changes in T-cell activity and a reduction in or stabilization of tumor size in some patients but was associated with adverse events. (cun.es)
  • tested the intratumoral delivery of oncolytic viruses encoding IL-7 and IL-12, and saw encouraging local and systemic effects. (acir.org)
  • Administration of rVSV-UL141 through hepatic artery infusion in immune-competent Buffalo rats harboring orthotopic, multi-focal HCC lesions resulted in a one-log elevation of intratumoral virus replication over a control rVSV vector, which translated to enhance tumor necrosis and substantial prolongation of survival. (mssm.edu)
  • New York, USA - September 11, 2023 - Leveraging proprietary platforms and groundbreaking technologies, Creative Biolabs stands at the forefront of oncolytic virus development , offering unparalleled solutions to expedite the evolution of cancer treatment. (vizagherald.com)
  • MHC I cells are important players of the immune system, responsible for presenting fragments of virus at the surface of infected cells so that the body can recognize when a cell is infected and subsequently destroy that cell. (virology.ws)
  • These proteins are produced by your immune system to alert your body that there is a pathogen, typically a virus, in your body. (cancer.net)
  • Genetically modified and attenuated measles viruses are considered a promising platform for research and development of vector vaccines and oncolytic measles viruses. (medicalxpress.com)
  • It turns oncolytic adenoviruses into targeted tissue specific cancer vaccines without the need to generate and manufacture multiple genetically modified viruses. (helsinki.fi)
  • The prophylactic vaccines are against the hepatitis B virus, which can cause liver cancer, and against human papillomavirus types 16 and 18, which are responsible for about 70 percent of cervical cancer cases. (biomedcentral.com)
  • These anti-viral vaccines are highly effective in curbing virus infections and onset of cancer. (biomedcentral.com)
  • Live attenuated Edmonston B strain of measles virus (MV-Edm) is a potent and specific oncolytic agent, but the mechanism underlying its tumor selectivity is unknown. (elsevierpure.com)
  • Up to three different therapeutic molecules can be incorporated in each virus product in order to produce combination therapies in a single dose form. (akamisbio.com)
  • Creative Biolabs provides bespoke solutions for the modification and engineering of viral vectors to amplify their oncolytic capabilities. (vizagherald.com)
  • While a more traditional, unilateral approach employing oncolytic viruses would have stopped here, the researchers instead proceeded to couple NDV injection with antibodies to CTLA-4 cells. (virology.ws)
  • To date, PsiOxus has developed enadenotucirev-based viruses capable of producing a wide range of functioning therapeutic antibodies including anti-PDL1 and anti-CTLA4, in preclinical studies. (akamisbio.com)
  • Our outcomes indicate that replication-competent attenuated HSV-1 exerts a powerful oncolytic influence on ovarian cancers which might be additional enhanced by the use of a carrier cell delivery program predicated on amplification of viral insert and perhaps on avoidance of neutralizing antibodies. (crispr-reagents.com)
  • Viral replication and dissemination of SJ-815 were measured by plaque assay and comet assay, respectively, and compared to the backbone of SJ-815, a modified Western Reserve virus named WI. (e-crt.org)
  • Recombinant oncolytic viruses represent a promising alternative option for the treatment of malignant cancers. (mssm.edu)
  • The present study suggests the applicability of this strategy for the development of effective and safe oncolytic agents to treat multi-focal HCC, and potentially a multitude of other cancers, in the future. (mssm.edu)
  • A connection between cancer regression and viruses has long been theorised, and case reports of regression noted in cervical cancer, Burkitt lymphoma, and Hodgkin lymphoma, after immunisation or infection with an unrelated virus appeared at the beginning of the 20th century. (wikipedia.org)
  • In vitro infection, virus-induced GFP expression, and cytotoxicity by MV-h-uPA and MV-m-uPA were demonstrated in human and murine cancer cells and cancer-associated fibroblasts in a species-specific manner. (umn.edu)
  • Newcastle disease virus is an avian virus that is non-pathogenic in humans and capable of inducing a robust immune response. (virology.ws)
  • In 1996, the first approval was given in Europe for a clinical trial using the oncolytic virus HSV1716. (wikipedia.org)
  • Oncolytic viruses are an emerging class of cancer therapeutic agents that exert antitumor effects generally through tumor-specific cell lysis paired with immune stimulation [ 1 ]. (e-crt.org)
  • DNAtrix (Houston and San Diego) is a clinical stage oncolytic virus company. (helsinki.fi)
  • The exclusive platform amalgamates cutting-edge technologies and assays, facilitating high-throughput screening, characterization, and functional analysis of oncolytic viruses. (vizagherald.com)
  • More detailed information about Creative Biolabs can be accessed at https://www.creative-biolabs.com/oncolytic-virus . (vizagherald.com)
  • The released viruses or virions can infect other surrounding cancer cells to destroy the remaining cancer cells. (ufluidix.com)
  • Pursuing a "one-size fits all" approach is counter-productive to their clinical development and instead as a field we should build on the strengths of individual virus platforms. (mcmaster.ca)
  • second, an inserted transgene may introduce new antitumor mechanisms to the oncolytic virus. (e-crt.org)
  • Researchers now have developed a platform that gives a better insight into oncolytic viruses. (ufluidix.com)
  • In a research article published in the Advanced Biomaterials journal, a group of researchers reported a microfluidic device for evaluating the bystander effect caused by oncolytic viruses. (ufluidix.com)
  • CD46 mediates virus attachment, entry, and virus-induced cell-to-cell fusion. (elsevierpure.com)
  • Using engineered cells expressing a range of CD46 densities, we determined that whereas virus entry increased progressively with CD46 density, cell fusion was minimal at low receptor densities but increased dramatically above a threshold density of CD46 receptors. (elsevierpure.com)
  • Discrimination between high and low CD46 receptor density provides a compelling basis for the oncolytic specificity of MV-Edm and establishes MV-Edm as a promising CD46-targeted cancer therapeutic agent. (elsevierpure.com)
  • Doctors have long observed that certain viruses can slow the progression of cancer. (amgen.com)
  • These findings further validate the critical role of stromal uPAR in cancer progression and the potential of oncolytic viruses as antistromal agents. (umn.edu)
  • To test this hypothesis, they developed one virus encoding murine IL-12 (mIL-12-VV) and another encoding human IL-7 (hIL-7-VV), which is also functional in mice. (acir.org)