• In recent years, oncolytic viruses have been used in immunotherapeutic approaches to treat cancer. (eliasanimalhealth.com)
  • Oncolytic viruses can kill tumor cells specifically or induce anticancer immune response. (figshare.com)
  • Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses. (wikipedia.org)
  • Oncolytic viruses also have the ability to affect the tumor micro-environment in multiple ways. (wikipedia.org)
  • A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents. (wikipedia.org)
  • Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the senecavirus, resulting in clinical trials. (wikipedia.org)
  • As the technology to create a custom virus did not exist, all early efforts focused on finding natural oncolytic viruses. (wikipedia.org)
  • The field of virotherapy was nearly abandoned for a time, as the technology required to modify viruses didn't exist whereas chemotherapy and radiotherapy technology enjoyed early success. (wikipedia.org)
  • Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. (biomedcentral.com)
  • OVT has its unique advantages and prospects, because oncolytic viruses (OVs) preferentially infect and replicate in tumor cells and destroy them, while leaving healthy cells largely untouched [ 7 ]. (biomedcentral.com)
  • The first application of virotherapy with the engineered thymidine kinase (TK)-deficient herpes simplex viruses (HSV) was initiated in 1991 [ 10 ]. (biomedcentral.com)
  • Oncolytic viruses (OVs) and phytochemical ursolic acid (UA) are two efficacious therapeutic candidates in development against breast cancer, the deadliest women's cancer worldwide. (tmu.edu.tw)
  • This review integrates most experimental studies and clinical trials of various oncolytic viruses (OVs) in the diagnosis and treatment of GC. (frontiersin.org)
  • Systemic delivery is a major goal in the field of oncolytic viruses. (karger.com)
  • The team is working to enhance the potency of oncolytic virotherapy by using tumor-homing MSCs as carriers for delivery of viruses. (mayo.edu)
  • Oncolytic viruses are biological agents that can exclusively eliminate cancer cells without harming normal cells. (thecurestartsnow.org)
  • These viruses, called oncolytic viruses (OV), can be used as a form of-and catalyst for-immunotherapy. (accesshealthworldwide.org)
  • First, the oncolytic viruses kill cancer cells directly when they infect these cells and cause them to burst. (accesshealthworldwide.org)
  • Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. (stembook.org)
  • An oncolytic adenovirus, a genetically modified adenovirus named H101, was approved in China in 2005 for the treatment of head and neck cancer. (wikipedia.org)
  • Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer. (ox.ac.uk)
  • The oncolytic adenovirus ICOVIR-15K was engineered to express an EGFR-targeting BiTE (cBiTE) antibody under the control of the major late promoter, leading to generation of ICOVIR-15K-cBiTE, which retained its oncolytic properties in vitro . (aacrjournals.org)
  • These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)
  • As a common strategy of enhancing monotherapeutic anticancer efficacy, we explored the combinatorial chemovirotherapeutic approach of combining oncolytic measles virus (MV), which targets the breast tumor marker Nectin-4, and the anticancer UA against breast adenocarcinoma. (tmu.edu.tw)
  • Dr. Peng's team is currently working on the oncolytic measles virus (Edmonston strain) and vesicular stomatitis virus (Indiana strain). (mayo.edu)
  • The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
  • The company develops two oncolytic virus platforms such as Vesicular Stomatitis Virus (VSV) and Measles Virus (MV-NIS). (pharmaceutical-technology.com)
  • Join us at 7th Oncolytic Virotherapy Summit to discuss your project and GMP availability for 2023! (maticabio.com)
  • There are a large number of clinical trials to study the application of immunotherapy such as immune checkpoint inhibitors, peptide vaccine, adoptive T cell transfer and oncolytic virus in esophageal cancer. (nih.gov)
  • Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer. (nih.gov)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • These results confirmed the feasibility of applying the described pipeline for the selection of peptide candidates and generation of therapeutic oncolytic cancer vaccine, filling a gap in the field of cancer immunotherapy, and paving the way to translate our pipeline into human therapeutic approach. (elifesciences.org)
  • Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. (ox.ac.uk)
  • Here, we describe for the first time a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumor cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. (elifesciences.org)
  • For these reasons, we hypothesize that the combination of Delta-24-RGDOX with inhibitors of IDO shall potentiate the therapeutic effect of oncolytic virotherapy for DIPG. (thecurestartsnow.org)
  • Genelux is a clinical-stage biopharmaceutical company focused on developing a pipeline of next-generation oncolytic immunotherapies for human patients suffering from aggressive and/or difficult-to-treat solid tumor types. (eliasanimalhealth.com)
  • From targeted immunotherapies like oncolytic virotherapy (OV) and CAR-T cell therapy to the latest in genetic testing, here are the top innovations that have the potential to dramatically shift the paradigm of cancer care in the coming years. (accesshealthworldwide.org)
  • Genelux has completed seven Phase I & II clinical trials in humans with their oncolytic virus technology, and they are currently enrolling a Phase III ovarian cancer trial. (eliasanimalhealth.com)
  • From a clinical point of view, our findings indicate that a successful, single agent virotherapy requires a strong inhibition of the host immune response and the use of potent virus species with a high intratumoral mobility. (figshare.com)
  • In 1996, the first approval was given in Europe for a clinical trial using the oncolytic virus HSV1716. (wikipedia.org)
  • The conference brought together many of the major players in oncolytic virotherapy from all over the world, addressing all stages of research and development-from aspects of basic science and cellular immunology all the way through to early- and late-phase clinical trials. (ox.ac.uk)
  • Today, both preclinical and early-stage clinical trials are intensively investigating the approach to improve oncolytic virotherapy. (slideshare.net)
  • Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
  • Vyriad is a clinical stage bio-pharmaceutical company that develops viral-based novel oncolytic therapies for the treatment of cancer. (pharmaceutical-technology.com)
  • The company also develops oncolytic virus in clinical phases of development. (pharmaceutical-technology.com)
  • "The G207 oncolytic herpes virus was tested in adults with gliomas with much less efficacy," Dr. Wen continued. (ascopost.com)
  • Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)
  • Treatment with genetically engineered oncolytic herpes simplex virus type 1 (HSV-1) G207 alone or with radiation resulted in encouraging outcomes in a small study of pediatric patients with high-grade glioma. (ascopost.com)
  • In 2015, talimogene laherparepvec (OncoVex, T-VEC), an oncolytic herpes virus which is a modified herpes simplex virus, became the first oncolytic virus to be approved for use in the United States and the European Union, for the treatment of advanced inoperable melanoma. (wikipedia.org)
  • An oncolytic virus is a virus that can infect and kill cancer cells, but not normal cells. (eliasanimalhealth.com)
  • The treatment, called oncolytic virotherapy, involves injecting cancer lesions with a virus modified so it inhibits tumour growth and induces an anti-cancer immune response in the body. (liverpoolecho.co.uk)
  • In this study, we evaluated the toxicity, biodistribution and shedding of intravenously injected oncolytic NDVs in non-human primates (Macaca fascicularis). (eur.nl)
  • Our findings revealed that in vitro co-treatment with UA synergistically potentiated the killing of human breast cancer cells by oncolytic MV, without UA interfering the various steps of the viral infection. (tmu.edu.tw)
  • This oncolytic potentiation was partly attributed to the enhanced autophagic flux induced by the UA-NP and MV combined treatment. (tmu.edu.tw)
  • Our study thus highlights the potential value of oncolytic MV and UA-based chemovirotherapy for further development as a treatment strategy against breast cancer, and the feasibility of employing nanoformulation to enhance UA's applicability. (tmu.edu.tw)
  • Richardson, assistant professor of Neurological Surgery, joined the team of multidisciplinary neurooncology specialists and will create an independent research laboratory focusing on gene therapy and oncolytic virotherapy strategies for the treatment of adult and pediatric brain tumors. (iu.edu)
  • GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Oncolytic Virus to Target CD46 and SLC5A5 for Oncology LoA Report. (pharmaceutical-technology.com)
  • Blood tests are necessary, easy-to-perform and low-cost alternatives for monitoring of oncolytic virotherapy and other biological therapies in translational research. (uni-wuerzburg.de)
  • The project is innovative in its approach because it counteracts an ad-hoc resistance mechanism to virotherapy identified in our laboratories that has not been examined previously. (thecurestartsnow.org)
  • Early efforts also found that only certain cancers could be treated through virotherapy. (wikipedia.org)
  • Moreover, due to the discrete and stochastic nature of cells and their responses, an optimal range for viral cytotoxicity is predicted because the virotherapy fails if the oncolytic virus demands either a too short or a very large time to kill the tumor cell. (figshare.com)
  • An oncolytic virus is a virus that preferentially infects and kills cancer cells. (wikipedia.org)
  • Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy. (nih.gov)
  • In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. (aacrjournals.org)
  • Efforts to treat cancer through immunisation or virotherapy (deliberate infection with a virus), began in the mid-20th century. (wikipedia.org)
  • Nick is an international expert in pancreatic cancer with research interests in genomics molecular pathology of pancreatic cancer and the development of oncolytic virotherapy. (qmul.ac.uk)
  • The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Assistant Professor in the field of oncolytic virotherapy as per 1 January 2024 or as soon as possible thereafter. (jobs-near-me.eu)
  • Newcastle disease virus (NDV) is an avian pararnyxovirus with oncolytic potential. (eur.nl)
  • Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference. (ox.ac.uk)
  • Even less information is available about the response to oncolytic virotherapy (T-VEC). (usz.ch)
  • As Assistant Professor of oncolytic virotherapy your primary tasks will be research and research-based teaching. (jobs-near-me.eu)
  • Detailed preclinical information regarding the safety of Oncolytic NDV is scarce. (eur.nl)
  • The 11th International Oncolytic Virus Conference (IOVC) was held from April 9-12, 2018 in Oxford, UK. (ox.ac.uk)
  • We discuss the implications of these results for our study and the Use of NDV for virotherapy. (eur.nl)