AlkaptonuriaExogenousAortic valve stBluish-black pigmentationMelasmaHydroquinoneConnectiveOccursSkinClinicalCartilageMedicalSide effectArticleIncludeFeaturePigmentationAlkaptonuricOcularHomogentisic acidHydroquinone induced ochronosisEndogenousDiscolorationCutaneousManifestationsBluishFindingsCarcinogenicityDescriptorGoutTissuesCase ReportTerm
Alkaptonuria6
- Ochronosis is the bluish-black discoloration of certain tissues, such as the ear cartilage and the ocular tissue, seen with alkaptonuria , a metabolic disorder. (medscape.com)
- Alkaptonuria is a rare genetic disorder in which there is a deficiency of the enzyme homogentisic acid oxidase, resulting in the accumulation of homogentisic acid and a characteristic blue-black discoloration of the skin and cartilage, called ochronosis. (medscape.com)
- Ochronosis was defined by Virchow who histologically described the connective tissue in alkaptonuria, given the cartilage's ochre, or yellow, hue under the microscope. (medscape.com)
- Endogenous ochronosis (EO) or alkaptonuria is an inherited autosomal recessive disease caused by the insufficiency of the enzyme homogentisic acid dioxygenase. (cdlib.org)
- At the present state of knowledge, no medical therapy for ochronosis and alkaptonuria is available. (medscape.com)
- Felbor U, Mutsch Y, Grehn F, Müller CR, Kress W. Ocular ochronosis in alkaptonuria patients carrying mutations in the homogentisate 1,2-dioxygenase gene. (medscape.com)
Exogenous16
- The two types of ochronosis are endogenous and exogenous. (wikipedia.org)
- Exogenous ochronosis is an avoidable dermatitis that can be caused by the topical application of compounds such as hydroquinone or phenols. (wikipedia.org)
- Hydroquinone-induced exogenous ochronosis was found in 1975 by Findlay, who observed the condition in patients who used skin lightening creams containing the compound. (wikipedia.org)
- The three clinical stages of exogenous ochronosis are: Erythema and mild hyperpigmentation Hyperpigmentation and "caviar-like" lesions Papulonodular lesions Skin: The pigment is deposited throughout the skin, but only becomes apparent in certain locations, where the concentration is great enough to be seen clinically. (wikipedia.org)
- In exogenous ochronosis, the hyperpigmentation is localized to the area where the inciting agent is applied. (wikipedia.org)
- Symptoms of exogenous ochronosis include: Yellow-brown, banana-shaped fibers Caviar-like papules Brown-grey or blue-black hyperpigmentation Most of the lesions are seen on areas of the body that get the most sun. (wikipedia.org)
- Dermoscopy has proved useful in exogenous ochronosis. (medscape.com)
- With exogenous cutaneous ochronosis induced by topical hydroquinones, carbon dioxide lasers and dermabrasion have been reported to be helpful. (medscape.com)
- Bruce S, Tschen JA, Chow D. Exogenous ochronosis resulting from quinine injections. (medscape.com)
- Bongiorno MR, Aricò M. Exogenous ochronosis and striae atrophicae following the use of bleaching creams. (medscape.com)
- Exogenous ochronosis and pigmented colloid milium from hydroquinone bleaching creams. (medscape.com)
- Zawar VP, Mhaskar ST. Exogenous ochronosis following hydroquinone for melasma. (medscape.com)
- Charlin R, Barcaui CB, Kac BK, Soares DB, Rabello-Fonseca R, Azulay-Abulafia L. Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. (medscape.com)
- Exogenous ochronosis, in which bluish black pigmentation of cartilage is noted iatrogenically by exogenous agents, has been seen after exposure to noxious substances, including phenol, trinitrophenol, benzene, and hydroquinone. (medscape.com)
- Exogenous Ochronosis is a black mark and patch due to discoloration of the connective tissue. (ioraclinic.com)
- Unfortunately, for some people, this substance lead to a new condition, namely exogenous ochronosis. (ioraclinic.com)
Aortic valve st1
- Ochronosis and aortic valve stenosis. (horizonnb.ca)
Bluish-black pigmentation1
- Some of the serious effects include blistering, cracking of the skin and ochronosis (bluish black pigmentation on the skin). (medindia.net)
Melasma2
- Hydroquinone can work well for Ochronosis in the same way it works for Melasma. (ncddr.org)
- Looks similar to melasma, in ochronosis generally appears the dark brown spots like small coffee beans. (ioraclinic.com)
Hydroquinone4
- Ochronosis occurs because of deposition of phenols (such as homogentisic acid and hydroquinone) as plaques in the matrix of cartilage. (wikipedia.org)
- In April, the FDA issued warning letters to 12 companies that sold hydroquinone in concentrations not generally recognized as safe and effective, because of other concerns including rashes, facial swelling, and ochronosis (skin discoloration). (medscape.com)
- Other than hormones and sun exposure, the use of cosmetics consists of specific ingredients such as hydroquinone, mercury, and others could lead to ochronosis in some people. (ioraclinic.com)
- Ochronosis usually caused by exposure to or use of substances and ingredients in a cosmetic product containing phenol, trinitrophenol, resorcinol, mercury (mercury), picric acid benzene, and hydeoquinone (hydroquinone). (ioraclinic.com)
Connective3
- Ochronosis is a syndrome caused by the accumulation of homogentisic acid in connective tissues. (wikipedia.org)
- Ochronosis occurs when the homogentisic acid builds up inside connective tissue. (ncddr.org)
- Ochronosis, a buildup of dark pigment in connective tissues such as cartilage and skin, is also characteristic of the disorder. (medlineplus.gov)
Occurs1
- Deposition also occurs at non-collagenous sites, suggesting that factors other than the presence of HGA in the tissues may favour or promote ochronosis. (bmj.com)
Skin4
- Ochronosis is another skin condition that creates an uneven skin tone . (ncddr.org)
- Not only is it dangerous, it is also responsible for ochronosis, which may cause skin to darken. (xtend-life.com)
- Chemical skin whiteners can be tough on your skin, making it dry and possibly resulting in more serious skin conditions, such as ochronosis (when the skin becomes darker). (fairandflawlessskin.com)
- It also has been linked with ochronosis, a medical condition in humans known as skin darkening and disfiguration, when it is applied topically. (dermatologytimes.com)
Clinical2
- Koçyigit H, Gürgan A, Terzioglu R, Gürgan U. Clinical, radiographic and echocardiographic findings in a patient with ochronosis. (medscape.com)
- Bhangle S, Panush RS, Berman E, Schumacher HR. Clinical images: Synovial fluid clues to ochronosis. (medscape.com)
Cartilage1
- Cartilage: Darkening and hardening of ear cartilage is a prominent feature of ochronosis. (wikipedia.org)
Medical1
- Due to concerns about its side effects, it was almost banned by the FDA in 2006, as medical issues of carcinogenicity and reports of disfiguring ochronosis existed. (wikipedia.org)
Side effect1
- The other dreaded side effect is ochronosis, and that has not happened (in my practice) with even low amounts. (dermatologytimes.com)
Article1
- Please submit any comments about the article Ochronosis The StatPearls content team will be working hard to evaluate the comment and make corrections when appropriate. (statpearls.com)
Include1
- The histologic features of localized argyria include swollen and homogenized collagen bundles resembling ochronosis, "pseudo-ochronosis," which may be more common than previously recognized. (qxmd.com)
Feature1
- The purpose of this study is to report a series of 5 patients with localized argyria with the histologic feature of "pseudo-ochronosis. (qxmd.com)
Pigmentation2
- Ochronosis causes a blue-black pigmentation and caviar-like spots to develop on the skin. (medicalnewstoday.com)
- Some of the serious effects include blistering, cracking of the skin and ochronosis (bluish black pigmentation on the skin). (medindia.net)
Alkaptonuric3
- Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. (nih.gov)
- Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. (qxmd.com)
- Our model allows the opening of new anti-oxidant therapeutic strategies to treat alkaptonuric ochronosis. (qxmd.com)
Ocular4
- We therefore aim to evaluate the frequency and clinical significance of ocular findings in ochronosis and discuss possible therapeutic options. (medscape.com)
- Rohrbach JM, Röck D. Ocular Ochronosis. (medscape.com)
- Cutaneous and ocular ochronosis followed the prolonged, high-dose supplementation of EGCG in this patient. (jcadonline.com)
- Lindner M, Bertelmann T. On the ocular findings in ochronosis: a systematic review of literature. (medscape.com)
Homogentisic acid5
- Ochronosis is a syndrome caused by the accumulation of homogentisic acid in connective tissues. (wikipedia.org)
- Ochronosis occurs because of deposition of phenols (such as homogentisic acid and hydroquinone) as plaques in the matrix of cartilage. (wikipedia.org)
- Ochronosis is the result of an autosomal recessive inherited disorder that causes the affected patient to be deficient in the enzyme homogentisic acid oxidase. (pediagenosis.com)
- This leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, which in turn become characterized by the presence of melanin-like pigments (ochronosis). (qxmd.com)
- Other endogenous pigmentary disorders are attributable to metabolic substances (eg, hemosiderin [iron]) in purpuric processes, to homogentisic acid in ochronosis, and bile pigments. (mhmedical.com)
Hydroquinone induced ochronosis1
- Diagnostic utility of dermatoscopy in hydroquinone induced ochronosis. (medscape.com)
Endogenous1
- Both the clinical presentation and histopathology appearance are superimposable with endogenous ochronosis or alcaptonuria, a hereditary disease in which ochronotic pigment deposition occurs at a multisystemic level. (cdlib.org)
Discoloration2
- Hydroquinone may cause unwanted and untreatable skin discoloration ( ochronosis ). (sisterhoodagenda.com)
- Symptoms of this disease include ochronosis, eye sclera discoloration, tendonitis, and long-standing conditions leading to arthritis. (abnewswire.com)
Cutaneous1
- Georgiadou N, Singh S, Wagner B, Goggin P, Katsarma E, Singh M. Occupational Localized Cutaneous Argyria With Pseudo-Ochronosis in a Jeweler. (medscape.com)
Manifestations1
- Severe osteoarthritic manifestations of ochronosis]. (nih.gov)
Bluish1
- This bluish hue is a condition known as ochronosis. (brightwhiteskin.com)
Findings1
- The findings on skin biopsy are pathognomonic for ochronosis. (pediagenosis.com)
Carcinogenicity1
- Due to concerns about its side effects, it was almost banned by the FDA in 2006, as medical issues of carcinogenicity and reports of disfiguring ochronosis existed. (wikipedia.org)
Descriptor1
- Ochronosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Gout1
- The RMA has defined a depositional joint disease as gout , pseudogout , haemochromatosis , Wilson's disease or ochronosis . (dva.gov.au)
Tissues3
- Recent anecdotal evidence of macroscopic renal ochronosis in a mouse model of tyrosinaemia led us to perform histological analysis of tissues of these mice that are known to be affected in human AKU. (elsevierpure.com)
- months showed no sign of macroscopic ochronosis of tissues. (elsevierpure.com)
- Conclusions: Here we present the first data showing ochronosis of tissues in a murine model of AKU. (elsevierpure.com)
Case Report2
- AbdulKarim FAJ, Ibrahim SM, Hill AA, Ajmal N. Bilateral Breast Ochronosis: a Case Report. (medscape.com)
- Ochronosis and Osteoporosis: A Case Report. (nih.gov)
Term1
- Long-term use of hydroquinone could give rise to ochronosis. (medicalnewstoday.com)