• Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and. (targetmol.com)
  • The immense increase in the intracellular phosphorylated intermediate compounds of glycolysis concurrently inhibits rephosphorylation of adenine nucleotides, activating the nucleic acid degradation pathway and resulting in increased uric acid, the end product. (medscape.com)
  • HIV-1 reverse transcriptase (RT) polymorphism 172K, suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and nonnucleoside RT inhibitors. (neb.com)
  • Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-Triazole Thioacetanilide Derivatives as Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. (neb.com)
  • Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (neb.com)
  • Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (neb.com)
  • Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (neb.com)
  • 6-Mercaptopurine anhydrous is a Nucleoside Metabolic Inhibitor. (targetmol.com)
  • 09. Which one of the following drugs is a nucleoside reverse transcriptase inhibitor? (medparhlo.com)
  • Why, then, do cosubstrates so often possess nucleotides as their binding tags, rather than for example amino acids or peptides? (heresy.is)
  • 2004. Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors . (ub.edu)
  • engineering proteins, nucleic acids, or nanomaterials with novel structures, dynamics, and functions for basic biology/biomedical applications and effective therapeutic approaches. (umassmed.edu)
  • Our investigation of structure-activity relationships led to the identification of potent inhibitors 14c, 14h and 16e. (rcsb.org)
  • To understand and combat the HIV-1 Protease drug resistance at the molecular level to design potent inhibitors. (umassmed.edu)
  • Family I PPases are essential enzymes found in all kingdoms of life and are responsible for maintaining the correct pyrophosphate equilibrium necessary to carry out nucleic acid and protein synthesis, and facilitate fatty acid beta oxidation. (bioassaysys.com)
  • Repression of protein synthesis by miRNAs: just how many mechanisms? (geogise.com)
  • Clofarabine inhibits DNA synthesis by decreasing cellular deoxynucleotide triphosphate pools through an inhibitory action on ribonucleotide reductase, and by terminating DNA chain elongation and inhibiting repair through incorporation into the DNA chain by competitive inhibition of DNA polymerases. (drugcentral.org)
  • Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. (targetmol.com)
  • Because malonyl CoA inhibits transport of fatty acid into the mitochondrion, beta-oxidation of fatty acids for energy to support the hypoglycemic cells does not occur. (medscape.com)
  • 3] This antagonism might be related to topoisomerase I inhibition of DNA synthesis, which is required for the cytotoxic effect of topoisomerase II-induced cleavable complexes. (cancernetwork.com)
  • The compound WC-9, a squalene synthase inhibitor, showed potential inhibition of T. cruzi replication. (sciencegate.app)
  • Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. (harvard.edu)
  • They are analogs of natural amino acids ( Tajti and Keglevich, 2018 ). (japsonline.com)
  • Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-14 C-heptanoyl]-oxy)-benzoic acid methyl ester, [14 C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor. (harvard.edu)
  • The objective of this work was to design conjugates of anti-HIV nucleosides conjugated with fatty acids and cell-penetrating poly- L -arginine (polyArg) peptides. (uri.edu)
  • Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. (targetmol.com)
  • Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular p. (targetmol.com)
  • The treatment included 200 µmol of heavy metals (Pb and Cd) alone and in combination with 200 µM SNP: NO donor, 0.1% Hb, bovine hemoglobin (NO scavenger), and 50 µM L-NAME, N(G)-nitro-L-arginine methyl ester (NO synthase inhibitor) in four replications in comparison to controls. (sciencegate.app)
  • Severe hypoglycemia stimulates epinephrine secretion, which activates lipoprotein lipase and the release of free fatty acids. (medscape.com)
  • These fatty acids are transported to the liver, where they are used for triglyceride synthesis and are exported as very-low-density lipoprotein (VLDL), which is elevated in these patients. (medscape.com)
  • Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16-19 March 1970. (wikipedia.org)
  • Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs. (neb.com)
  • Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. (neb.com)
  • 2005. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease . (ub.edu)
  • Being susceptible to potential inhibitors from clinical specimens. (medixbiochemica.com)
  • Nucleic acids were recovered from clinical specimens cies in this study were selected for further study (Table 1). (cdc.gov)
  • One of these targets is bacterial DNA, and we call these medications DNA inhibitors or nucleic acid inhibitors. (osmosis.org)
  • Penicillins inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins. (medscape.com)
  • 2004. Molecular modelling approaches to the design of acetylcholinesterase inhibitors: new challenges for the treatment of Alzheimer's disease . (ub.edu)
  • 1995). Diisocyanates and acid anhydrides cyanates has a low association with atopy, low prevalence are among the most common low molecular weight (LMW) with specific IgE antibodies and a mixed Th1-Th2 response classes of chemicals responsible for occupational asthma. (cdc.gov)
  • 3] This is believed to constitute an important mechanism of resistance to topoisomerase I inhibitors in malignant cells. (cancernetwork.com)
  • Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma. (harvard.edu)
  • For high-throughput inhibitor screening and evaluation of pyrophosphatase modulators. (bioassaysys.com)
  • Inhibitors of Nucleic Acid Synthesis: Biophysical and Biochemical Aspects. (wikipedia.org)
  • 13 , 14 Despite the presence of amino acid mutations in its receptor binding domain, multiple key amino acids are changed. (medsci.org)
  • 13 , 14 However, the amino acid perfectly maintains the stability of the mutual structural conformation of the virus S-protein and the ACE2 receptor in a holistic manner. (medsci.org)
  • Targets can be reliably amplified from a variety of sources without a purification step, because the polymerase exhibits a strong tolerance to common PCR inhibitors. (medixbiochemica.com)
  • Design and synthesis of Small Molecule Viral Protease Inhibitors. (umassmed.edu)
  • Understanding the complexity behind inhibitor design to mitigate formation of resistance in hyper-mutating viruses. (umassmed.edu)
  • 2005. SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors . (ub.edu)
  • The accumulation of lactic acid in blood can cause true acidosis with a large anion gap, a characteristic of glycogen-storage disease type I. (medscape.com)
  • Paradoxically, even in the face of hypoglycemia, patients with glycogen-storage disease I do not develop significant ketosis because the abundance of acetyl coenzyme A (CoA) derived from glycolysis activates the acetyl CoA carboxylase enzyme that produces malonyl CoA in the first step of fatty acid synthesis. (medscape.com)
  • For two-step RT-qPCR, the LunaScript ® RT SuperMix Kit ( NEB #E3010 ) offers a fast (less than 15 min), robust, and sensitive option for cDNA synthesis upstream of your Luna qPCR experiment. (neb.com)
  • Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. (targetmol.com)
  • The procedure involves incubation of enzyme and inhibitor, addition of a single working reagent and incubation for 30 min. (bioassaysys.com)
  • In this sense, this work aims to identify possible inhibitors of the SARS-CoV-2 RdRp enzyme using in silico approaches. (bvsalud.org)
  • Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site. (neb.com)
  • Finally, these findings are useful to guide structural modifications aiming to improve the potential of these compounds to act as inhibitors of SARS-CoV-2.Communicated by Ramaswamy H. Sarma. (bvsalud.org)
  • RNA synthesis, which is also called DNA transcription, is a highly selective process. (targetmol.com)
  • Table 35-2 describes the mode of action of antiviral drugs that block early events in viral replication, and Table 35-3 describes the mode of action of antiviral drugs that block viral nucleic acid synthesis. (mhmedical.com)
  • Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors--Hit to Lead Exploration. (rcsb.org)
  • I'll be wildly optimistic and assume that you remember a thing or two about nucleic acids, so we will mostly skip this topic. (heresy.is)
  • Chemical Synthesis and Enzymic Properties. (biolog.de)
  • 06. Which one of the following drugs is an inhibitor of cell wall synthesis? (medparhlo.com)