• genetics
  • Wild type and mutant stocks of Aspergillus nidulans, (with R.W. Barratt and W.N. Ogata), 1965, Genetics 52: 233-234 Purification and characterization of glutamic acid dehydrogenase from Escherichia coli strain K-12. (wikipedia.org)
  • backbone
  • Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pentose sugar, either ribose or deoxyribose, and one of four nucleobases. (wikipedia.org)
  • Although these oligonucleotides have a different backbone sugar or, in the case of PNA, an amino acid residue in place of the ribose phosphate, they still bind to RNA or DNA according to Watson and Crick pairing, but are immune to nuclease activity. (wikipedia.org)
  • RNA may be too complex to be the first nucleic acid, so before the RNA world several simpler nucleic acids that differ in the backbone, such as TNA and GNA and PNA, have been offered as candidates for the first nucleic acids. (wikipedia.org)
  • This is partly because the extra oxygen in RNA increases the propensity for hydrogen bonding in the nucleic acid backbone. (wikipedia.org)
  • bases
  • Most often, H-phosphonate building blocks are protected at the 5'-hydroxy group and at the amino group of nucleic bases A, C, and G in the same manner as phosphoramidite building blocks (see below). (wikipedia.org)
  • amino acid seq
  • 5. The method according to claim 1, wherein the glycosylated polypeptide is selected from the group consisting of a polypeptide having a primary amino acid sequence of a human glycosylated polypeptide, a primary amino acid sequence of a non-human glycosylated polypeptide, a primary amino acid sequence of an antibody or an active fragment thereof, a primary amino acid sequence of a non-mammalian glycosylated polypeptide, and combinations thereof. (freepatentsonline.com)
  • cytosine
  • With support data, the current model of cytosine acting as a general acid within the reaction to donate a proton to the 5'-bridging oxygen. (wikipedia.org)
  • base
  • In this review article we will introduce the study of nucleic acid base self-assembly by scanning tunneling microscopy (STM) at vacuum and ambient condition (the liquid/solid interface), respectively. (nih.gov)
  • However, nucleic acid design has the advantage of being a much computationally simpler problem, since the simplicity of Watson-Crick base pairing rules leads to simple heuristic methods which yield experimentally robust designs. (wikipedia.org)
  • Similar to the hairpin ribozyme, the HDV ribozyme functions by acid-base catalysis. (wikipedia.org)
  • energy
  • This structured region was first discovered in a bioinformatics survey of influenza A based on thermodynamic folding free energy and amino acid codon suppression. (wikipedia.org)
  • design
  • Almost all nucleic acid design tasks are aided by computers, and a number of software packages are available for many of these tasks. (wikipedia.org)
  • Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries. (wikipedia.org)
  • length
  • Sequence symmetry minimization divides the nucleic acid sequence into overlapping subsequences of a fixed length, called the criterion length. (wikipedia.org)