• It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription in response to retinoids. (wikipedia.org)
  • It belongs to a group of three closely related orphan receptors, the NR4A family (NR4A). (wikipedia.org)
  • In addition, the regulatory relationship between miR-21-5p and orphan nuclear receptor 4A1 (Nr4a1) was revealed by several assays, including the dual-luciferase reporter assay, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot. (referencecitationanalysis.com)
  • A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. (wakehealth.edu)
  • The Liver X Receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. (indigobiosciences.com)
  • Degeneration of dopaminergic neurons in Parkinson's disease (PD) is associated with decreased expression of the orphan nuclear receptor Nurr1 (NR4A2), which is critical for both homeostasis and development of dopamine (DA) neurons. (houstonmethodist.org)
  • The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. (wikipedia.org)
  • The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. (wikipedia.org)
  • The immunogen of 22576-1-AP is androgen receptor Fusion Protein expressed in E. coli. (ptglab.com)
  • Liver X Receptor Alpha (LXRα) is a nuclear receptor protein encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). (indigobiosciences.com)
  • Variants in the SMCHD1 gene on chromosome 18, which encodes a protein known as structural maintenance of chromosomes flexible hinge domain containing 1, have been associated with FSHD2. (arkansasbluecross.com)
  • CPEB-1 is an RNA-binding protein that interacts with the cytoplasmic polyadenylation element (CPE), a short U-rich motif in the 3' untranslated regions (UTRs) of certain mRNAs. (nih.gov)
  • CPEB-4 is an RNA-binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation. (nih.gov)
  • The nuclear receptor-related 1 protein is mostly expressed in the subplate in the dorsal cortex, but also in lower layer 6 in the lateral and perirhinal cortex, and can be detected from 12 PCW. (ox.ac.uk)
  • arginine and serine rich protein 1 [So. (gsea-msigdb.org)
  • adhesion G protein-coupled receptor E5. (gsea-msigdb.org)
  • Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)
  • Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. (biomedcentral.com)
  • Cellular response to estrogens is mediated through estrogen receptors (ERα and ERβ), which upon binding to ligand and DNA hormone response elements, recruit coactivator and corepressor proteins that regulate the expression of steroid hormone target genes. (biomedcentral.com)
  • In this study, we systematically screened the coding exons of steroid hormone receptor coactivator and corepressor genes in a multiethnic panel of women with breast cancer in an attempt to identify and catalogue potentially functional coding polymorphisms that may serve as genetic markers of breast cancer risk. (biomedcentral.com)
  • After encountering antigen, naïve CD4 + T cells differentiate into CD4 + effector T cells, which can take the form of well-defined subgroups that express distinct cytokine profiles: T helper 1 (Th-1), Th-2, Th-9, T follicular helper (Tfh) cells, and Th-17 cells ( Figure 1 ) [ 4 ] . (encyclopedia.pub)
  • The NK Cell Research Toolkit enables researchers to examine the effects of distinct molecules on NK cells' targeting and eradication of discrete tumor cell types, and to design novel chimeric antigen receptors to modify endogenous signaling pathways. (freegenes.org)
  • Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. (thermofisher.com)
  • The NK cell research toolkit product contains three classes of genes: ligands, surface receptors, and transcription factors. (freegenes.org)
  • The genes listed here can be expressed on NK cells, feeder cells, or tumor cells to study individual NK cell signaling pathways, strengths of activation of different receptor-ligand interactions, and whether certain NK cells are more or less resistant to inhibitory cues from cancer cells. (freegenes.org)
  • Mechanistically, NR4A1 was found to regulate the expression of the proreductant genes thioredoxin domain-containing 5 (TXNDC5) and isocitrate dehydrogenase 1 (IDH1), which are downregulated in RMS cells following NR4A1 knockdown or inhibition. (houstonmethodist.org)
  • There are thirteen subfamilies of Wnt genes in metazoans and t. (biomedcentral.com)
  • Boehm, MF Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. (bindingdb.org)
  • This subfamily corresponds to the RRM1 of the CPEB family of proteins that bind to defined groups of mRNAs and act as either translational repressors or activators to regulate their translation. (nih.gov)
  • Based on sequence similarity, RNA-binding specificity, and functional regulation of translation, the CPEB proteins have been classified into two subfamilies. (nih.gov)
  • The first subfamily includes CPEB-1 and related proteins. (nih.gov)
  • The other two members are Nuclear receptor 4A2 (NR4A2) and Nuclear receptor 4A3 (NR4A3). (wikipedia.org)
  • Data expand the understanding of the mechanism by which the NR4A2 nuclear receptor can facilitate DNA DSB repair. (cusabio.com)
  • An amino terminal transactivation domain is encoded in exon 2, a DNA-binding domain in exons 3 and 4, and dimerisation and ligand-binding domains is exons 5 to 7. (wikipedia.org)
  • The C-terminal ligand-binding domain is conserved to a lesser extent at 60% and the N-terminal AB region is not conserved, differing in each member. (wikipedia.org)
  • Androgen receptor (AR) also konwn as Dihydrotestosterone receptor (DHTR), Nuclear receptor subfamily 3 group C member 4 (NR3C4).It is one of steriod hormoen receptors, which are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (ptglab.com)
  • Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • iNKT cells constitutively express high levels of Nr4a1-encoded Nur77, a transcription factor that integrates signal strength downstream of the T cell receptor (TCR) within activated thymocytes and peripheral T cells. (ox.ac.uk)
  • Nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in rhabdomyosarcoma (RMS), and inactivation of NR4A1 (siNR4A1) or treatment with the NR4A1 antagonist 1,1-bis (30-indoly)-1-(p-hydroxy-phenyl)methane (DIM-C-pPhOH) has antiproliferative and proapoptotic effects on RMS cells. (houstonmethodist.org)
  • Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
  • We used logistic regression to estimate odds ratios for allelic effects in ethnic-pooled analyses as well as in subgroups defined by disease stage and steroid hormone receptor status. (biomedcentral.com)
  • Nuclear receptor 4A1 and the rest of the NR4A family are structurally similar to other nuclear receptor superfamily members, but contain an extra intron. (wikipedia.org)
  • Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. (wikipedia.org)
  • Whereas most nuclear receptors have a hydrophobic surface that results in a cleft, NR4A1 has a hydrophilic surface. (wikipedia.org)
  • Along with the two other NR4A family members, NR4A1 is expressed in macrophages following inflammatory stimuli. (wikipedia.org)
  • Overexpression of Nuclear receptor 4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against tumor and chronic virus. (wikipedia.org)
  • Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses effector gene expression by inhibiting AP-1 function. (wikipedia.org)
  • NR4A1 may play a role in Drug-induced gingival overgrowth associated with exposure to phenytoin, nifedipine, and cyclosporine A. Nuclear receptor 4A1 binds as a monomer or homodimer to response element NBRE and as a homodimer to NurRE. (wikipedia.org)
  • The binding sites on the response elements for NR4A1, which are common to the two other members of the NR4A family, are: NBRE - 5'-A/TAAAGGTCA, NurRE - a AAAT(G/A)(C/T)CA repeat, RXR - DX, a motif. (wikipedia.org)
  • Nuclear receptor 4A1 has the systematic HUGO gene symbol NR4A1. (wikipedia.org)
  • The DNA-binding domain at exons 3 and 4 of the NR4A1 gene is conserved among all members of the nuclear receptor. (wikipedia.org)
  • PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
  • 12 , 13 ] Polymorphic variants in these mediators of hormonal responsiveness could affect the functional activity of estrogen receptors following stimulation by endogenous or exogenous (i.e. (biomedcentral.com)
  • This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS). (ptglab.com)
  • CTLs) that produce cytokines and cytotoxic enzymes (perforin, granzyme B) that eliminate pathogens or target cells (including pathogen-infected host cells and tumor cells) and can develop into memory T cells ( Figure 1 ) [ 12 ] . (encyclopedia.pub)
  • Memory T cells can be subdivided into effector memory T cells (T EM ) or central memory T cells (T CM ) based on different surface markers ( Figure 1 ) [ 12 ] . (encyclopedia.pub)
  • It functions as a translational repressor that governs the synthesis of the AMPA receptor GluR2 through binding GluR2 mRNA. (nih.gov)
  • PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
  • This sequence is not conserved in PPAR gamma-1. (thermofisher.com)
  • cholinergic receptor nicotinic gamma s. (gsea-msigdb.org)
  • Immature SP thymocytes undergo further differentiation to generate either MHC Class II restricted CD4 SP helper or MHC Class I restricted CD8 SP cytotoxic lineage cells [ 1 ] . (encyclopedia.pub)
  • The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. (ptglab.com)
  • This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular response to stress. (wikipedia.org)
  • Our results suggest that connective tissue growth factor- and nuclear receptor-related 1-positive cells are two distinct cell populations of the human subplate. (ox.ac.uk)
  • Ageing is accompanied by a progressive decline in immune function that may significantly impact overall human health, increasing the risk of autoimmune disorders, infection, and mortality [ 1 ]. (biomedcentral.com)
  • This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Liver X Receptor Alpha (LXR). (indigobiosciences.com)
  • The principle application of this LXRα assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against the human liver x receptor alpha. (indigobiosciences.com)
  • Human cytomegalovirus (CMV) is 1 of 8 human herpesviruses. (medscape.com)
  • It is a member of the beta-herpesvirus subfamily, which also includes the roseolaviruses, human herpesvirus type 6, and human herpesvirus type 7. (medscape.com)
  • However, several high-risk groups, including immunocompromised organ transplant recipients and individuals infected with human immunodeficiency virus (HIV), are at risk of developing life-threatening and sight-threatening CMV disease. (medscape.com)
  • Nuclear receptor 4A1 has a high degree of structural similarity with other family members at the DNA-binding domain with 91-95% sequence conservation. (wikipedia.org)
  • C-type lectin domain family 4 member F. (gsea-msigdb.org)
  • Due to high sequence similarity, members in this subfamily may share similar expression patterns and functions. (nih.gov)
  • Ensembl chr 4:124,608,960. (mcw.edu)
  • Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.Defects in AR are the cause of androgen insensitivity syndrome (AIS).Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1). (ptglab.com)
  • iNKT cells in bone marrow chimeras that reconstituted thymic cellularity developed beyond stage 0 precursors and yielded IL-4-producing NKT2 cell subset but not IFN-γ-producing NKT1 cell subset. (ox.ac.uk)
  • Following a series of DN (1-4) stages, DP cells develop into naïve CD4 + , naïve CD8 + , or natural killer T cells (NKT). (encyclopedia.pub)
  • The activating or inhibitory receptors can similarly be transduced or transfected into NK cells to perturb their behavior. (freegenes.org)
  • CPEB-4 is overexpressed in a large variety of tumors and is associated with many mRNAs in cancer cells. (nih.gov)
  • The synthetic, phytochemical-based compound, 1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane (C-DIM12) activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. (houstonmethodist.org)
  • The other mutations are much less common, occurring in about 1% of cases. (msdmanuals.com)