• Microarray analysis also revealed that lipid infusion caused a significant overexpression of extracellular matrix genes and connective tissue growth factor. (elsevierpure.com)
  • These data suggest that an experimental increase in FFAs decreases the expression of PGC-1 and nuclear encoded mitochondrial genes and also increases the expression of extracellular matrix genes in a manner reminiscent of inflammation. (elsevierpure.com)
  • The nuclear factor kappa-B (NF-κB) pathway is a critical regulator of many immune- and addiction-related genes such as the extracellular matrix enzyme matrix metalloproteinase-9 (MMP-9), which is a known modulator of learning, memory, and synaptic plasticity. (elsevierpure.com)
  • Dr. Kenneth Yamada's research focuses on discovering novel mechanisms and regulators of cell interactions with the extracellular matrix and their roles in craniofacial development and disease. (nih.gov)
  • Dr. Yamada's group explores how coordination between the three-dimensional (3D) extracellular matrix of connective tissue or basement membranes, integrins, signal transduction, and cytoskeleton mediates or regulates key biological processes - cell adhesion, migration, matrix remodeling, tissue morphogenesis, and cancer cell invasion. (nih.gov)
  • Dr. Yamada's research emphasizes the characterization of the dynamic movements of cells and their extracellular matrix as tissues are remodeled in 3D in real time. (nih.gov)
  • We examined the correlation between nuclear deformation and cell functions such as cell proliferation, transfection and extracellular matrix protein type I collagen production. (cdc.gov)
  • Fibrosis generally occurs due to dysregulation of mechanisms that control the usual extracellular matrix (ECM) turnover 11 . (bvsalud.org)
  • IPF is characterized by damaged distal lung epithelium with excessive tissue scarring and extracellular matrix remodeling. (lu.se)
  • Interestingly, we found epithelial YT signaling to be actively involved in extracellular matrix remodeling in the fibrotic lung epithelium through modulation of lysyl oxidase expression, a collagen crosslinking enzyme. (lu.se)
  • Evidence for such a structure was recognised as long ago as 1948, and consequently many proteins associated with the matrix have been discovered. (wikipedia.org)
  • The presence of intra-cellular proteins is common ground, and it is agreed that proteins such as the Scaffold, or Matrix Associated Proteins (SAR or MAR) have some role in the organisation of chromatin in the living cell. (wikipedia.org)
  • According to some sources, most, if not all proteins found in nuclear matrix are the aggregates of proteins of structures that can be found in the nucleus of living cells. (wikipedia.org)
  • Such structures are nuclear lamina, which consist of proteins termed lamins which can be also found in the nuclear matrix. (wikipedia.org)
  • The nuclear matrix proteome consists of structural proteins, chaperones, DNA/RNA-binding proteins, chromatin remodeling and transcription factors. (wikipedia.org)
  • S/MARs (scaffold/matrix attachment regions), the DNA regions that are known to attach genomic DNA to variety of nuclear proteins, show an ever increasing spectrum of established biological activities. (wikipedia.org)
  • In this study we focused our attention on the behavior of four nuclear matrix proteins during the various stages of apoptosis in the HL-60 cell line exposed to the DNA topoisomerase I inhibitor, camptothecin. (nih.gov)
  • A most important question, however, remains the nature of the matrix proteins involved in the specific binding of the MARs. (nebraska.edu)
  • It is shown that the major matrix proteins are practically the same in both salt‐ and LIS‐extracted matrices. (nebraska.edu)
  • The immunological approach applied here allowed us to identify some of the individual MAR‐binding matrix proteins. (nebraska.edu)
  • 3409. V.C. Cordes, H.R. Rackwitz, S. Reidenbach, 'Mediators of nuclear protein import target karyophilic proteins to pore complexes of cytoplasmic annulate lamellae,' Exp. (nanomedicine.com)
  • 3419. M.A. Mancini, D. He, I.I. Ouspenski, B.R. Brinkley, 'Dynamic continuity of nuclear and mitotic matrix proteins in the cell cycle,' J. Cell Biochem. (nanomedicine.com)
  • 3422. J.H. Hughes, M.B. Cohen, 'Nuclear matrix proteins and their potential applications to diagnostic pathology,' Am. J. Clin. (nanomedicine.com)
  • The nuclear matrix is a network of proteins that provides structural support for the nucleus and aids in several important nuclear functions. (medlineplus.gov)
  • However, the relative MAR‐binding activity of the individual protein components may be different, depending on the method of matrix preparation. (nebraska.edu)
  • The MAR in the first intron is enriched with sequences closely related to the cleavage consensus of topoisomerase II, and contains the binding site of nuclear factor-α, a sequence-specific DNA binding protein reported previously. (elsevierpure.com)
  • This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. (nih.gov)
  • The purpose of this study was to systematically review the effects of bladder tumor antigen (BTA) stat and nuclear matrix protein (NMP) 22 as a screening method in an asymptomatic population. (researchsquare.com)
  • It also analyzes the strengths and weaknesses of screening methods and associated results using two non-invasive screening methods for bladder cancer-bladder tumor antigen (BTA) stat and nuclear matrix protein 22 (NMP 22)-in an asymptomatic population and in patients with suspicion of or a history of BC. (researchsquare.com)
  • Nuclear matrix protein (NMP) 22 is an unspecific test that is used for the identification of BC. (researchsquare.com)
  • E) Immunogold labeling of the nuclear tubules by using an antibody against the matrix protein. (cdc.gov)
  • 3407. S.A. Rutherford, M.W. Goldberg, T.D. Allen, 'Three-dimensional visualization of the route of protein import: the role of nuclear pore complex substructures,' Exp. (nanomedicine.com)
  • The MATR3 gene provides instructions for making a protein called matrin 3, which is found in the nucleus of the cell as part of the nuclear matrix. (medlineplus.gov)
  • BLM encodes 1417 amino acids that code for a protein in the nuclear matrix of growing cells, which is a member of the RecQ family of helicases. (medscape.com)
  • These results show that, in addition to the well-known chromatin changes, nuclear organization undergoes other rearrangements during the apoptotic process. (nih.gov)
  • abstract = "The recent discovery of DNA sequences responsible for the specific attachment of chromosomal DNA to the nuclear skeleton (MARs/SARs) was an important step towards our understanding of the functional and structural organization of eukaryotic chromatin [Mirkovitch et al. (nebraska.edu)
  • Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to compartmentalize the chromatin into structural and functional domains. (researchgate.net)
  • 3420. J.R. Davie, 'Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin,' Mol. (nanomedicine.com)
  • After receiving his bachelor's degree in physics at the University of Science and Technology of China in 1994, Li came to MIT and earned his Ph.D. in Nuclear Engineering in 2000. (mit.edu)
  • The 10th Latin American Symposium on Nuclear Physics and Applications will be held on December 1-6, 2013 in Montevideo, Uruguay. (sissa.it)
  • The use of S-matrices is essential in analyzing nuclear physics experiments, but their meanings can be opaque. (aapt.org)
  • My main research interest is in fundamental physics mainly theoretical particle physics but also nuclear physics, general relativity and cosmology. (lu.se)
  • This is very much alike the approach as in modern nuclear physics today. (lu.se)
  • In biology, the nuclear matrix is the network of fibres found throughout the inside of a cell nucleus after a specific method of chemical extraction. (wikipedia.org)
  • The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs. (medlineplus.gov)
  • The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (bvsalud.org)
  • Further, we demonstrated that cell proliferation, transfection, and type I collagen production were strongly associated with the nuclear volume, indicating that the nucleus serves as a critical mechanosensor for cell regulation. (cdc.gov)
  • Our study delineated the relationships between focal adhesions, nucleus and cell function and highlighted that the nanotopography could regulate cell phenotype and function by modulating nuclear deformation. (cdc.gov)
  • In this context, the phenomenological studies of hard processes in proton-nucleus (pA) collisions can provide us with an additional quantitative information about various nuclear effects expected also in HICs. (lu.se)
  • 3408. N. Pante, U. Aebi, 'Sequential binding of import ligands to distinct nucleopore regions during their nuclear import,' Science 273(20 September 1996):1729-1732. (nanomedicine.com)
  • Histone H1 and nuclear actin are shown to be not only important components of the matrix, but to be involved in a highly efficient interaction with MAR‐sequences as well. (nebraska.edu)
  • The selection of the nuclei for the next generation of $0\nu\beta\beta$-decay experiments should be done taking into account {\it also} considerations regarding the possibility to test the nuclear matrix element calculations. (sissa.it)
  • However, as early as 2 h after dilution into fresh medium, a striking prereplicative increase of the two activities was seen in the nuclear matrix fraction but not in cytosol or isolated nuclei. (neb.com)
  • Overall, the nuclear matrix was the cell fraction where the highest induction (about 10-fold) of both enzymatic activities was seen at 30 h after dilution, whereas in cytosol and isolated nuclei the increase was about two- and fourfold, respectively. (neb.com)
  • Such a set of coupled equations, describing the motions of nuclei (in a molecule often nuclear vibrations), arises when the Born-Oppenheimer approximation breaks down. (citizendium.org)
  • In the first step the nuclei of the system are fixed in a certain constellation and the nuclear kinetic energies are dropped from the problem, i.e., the nuclei are assumed to be at rest. (citizendium.org)
  • Thus to reproduce Coulomb effects in 1f7/2 mirror nuclei is really a test for the nuclear shell model. (lu.se)
  • Although the cause and effect relationship between FFAs and insulin resistance is complex, plasma FFA is negatively correlated with the expression of peroxisome proliferator activated receptor-γ cofactor-1 (PGC-1) and nuclear encoded mitochondrial genes. (elsevierpure.com)
  • 3411. P.C. Park, U. De Boni, 'A specific conformation of the territory of chromosome 17 locates ERBB-2 sequences to a DNase-hypersensitive domain at the nuclear periphery,' Chromosoma 107(May 1998):87-95. (nanomedicine.com)
  • Along with the nuclear lamina, it supposedly aids in organizing the genetic information within the cell. (wikipedia.org)
  • 3412. L.G. Koss, 'Characteristics of chromosomes in polarized normal human bronchial cells provide a blueprint for nuclear organization,' Cytogenet. (nanomedicine.com)
  • We, herein, engineered nanotopographies of various shapes (gratings and pillars) and dimensions (feature size, spacing and height), and thoroughly investigated cell spreading, focal adhesion organization and nuclear deformation of human primary fibroblasts as the model cell grown on the nanotopographies. (cdc.gov)
  • In quantum chemistry , the solution of a set of coupled nuclear motion Schrödinger equations can be eased by a diabatic transformation . (citizendium.org)
  • This paper seeks to help physicists develop a better understanding of these matrices by applying them to classical and quantum mechanical scattering problems. (aapt.org)
  • The nuclear matrix composition on human cells has been proven to be cell type and tumor specific. (wikipedia.org)
  • For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
  • Reference: Prereplicative increase of nuclear matrix-bound DNA polymerase-alpha and primase activities in HeLa S3 cells following dilution of long-term cultures. (neb.com)
  • We investigated the association of DNA polymerase and DNA primase activity with the nuclear matrix in HeLa S3 cells diluted with fresh medium after having been cultured without any medium change for 7 days. (neb.com)
  • DNA polymerase and DNA primase activity associated with the nuclear matrix prepared from cells just before dilution represented about 10% of nuclear activity. (neb.com)
  • Activating the nuclear piston mechanism of 3D migration in tumor cells. (nih.gov)
  • 3406. H. Ris, 'High-resolution field-emission scanning electron microscopy of nuclear pore complex,' Scanning 19(August 1997):368-375. (nanomedicine.com)
  • It has been clearly demonstrated that the nuclear matrix composition in a tumor is different from its normal counterparts. (wikipedia.org)
  • As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
  • Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
  • A possible model independent test of the theoretically calculated nuclear matrix elements of $0\nu\beta\beta$-decay is proposed. (sissa.it)
  • The role of nuclear energy in Brazilian energy matrix: enviro. (iaea.org)
  • Elected a Fellow of the AAAS in 1991, Dr. Yamada received the first Senior Investigator Award of the American Society for Matrix Biology in 2004, Distinguished Scientist Award of the American Association for Dental Research in 2008, and promotion to NIH distinguished investigator in 2011. (nih.gov)
  • 3405. D. Stoffler, B. Fahrenkrog, U. Aebi, 'The nuclear pore complex: From molecular architecture to functional dynamics,' Curr. (nanomedicine.com)
  • Most of the recent studies focused on the low rank matrix approximation via the nuclear norm. (projecteuclid.org)
  • In summary, when the Born-Oppenheimer approximation breaks down because of the presence of close lying potential energy surfaces, the solution of the nuclear motion problem requires the solution of a coupled set of Schrödinger equations. (citizendium.org)
  • Après des études de physique à l'EPFL suivies d'une thèse de doctorat en physique à l'EPFL également, dans le domaine de la microscopie électronique, j'ai rejoint le Centre de Microscopie Electronique et de Microanalyse de l'Université d'Australie Occidentale à Perth en 2000, pour y étudier par EFTEM les propriétés quantiques de nanoparticules de CdSe élaborées par processing mécano-chimique. (epfl.ch)
  • Our model uses the minimal nuclear norm of representation error image as a criterion, and the alternating direction method of multipliers method to calculate the regression coefficients. (arxiv.org)
  • Compared with the current regression methods, the proposed Nuclear Norm based Matrix Regression (NMR) model is more robust for alleviating the effect of illumination, and more intuitive and powerful for removing the structural noise caused by occlusion. (arxiv.org)
  • In this paper, we propose a novel matrix completion method, which combines the nuclear norm with the local geometric regularizer to solve the problem of matrix completion for redundant texture images. (projecteuclid.org)
  • Indirect immunofluorescence experiments were performed to follow these nuclear matrix antigens during apoptosis. (nih.gov)
  • While the antibody to the nucleolar isoform of DNA topoisomerase II gave a fluorescent pattern that was well-maintained until the late phases of apoptosis, the other three nuclear antigens showed marked modifications in their distribution. (nih.gov)
  • There is evidence that the nuclear matrix is involved in regulation of gene expression in Arabidopsis thaliana. (wikipedia.org)
  • We have identified DNA fragments which bind specifically to the nuclear matrix in vitro, termed matrix association regions (MARs), in the first and fourth introns of rat α 2 -macroglobulin gene. (elsevierpure.com)
  • Ito, T & Sakaki, Y 1987, ' Nuclear matrix association regions of rat α2-macroglobulin gene ', Biochemical and Biophysical Research Communications , vol. 149, no. 2, pp. 449-454. (elsevierpure.com)
  • We further found the Hippo pathway to be dysregulated in the fibrotic lung epithelium which led to increases in nuclear YT as well as known downstream targets. (lu.se)
  • To make use of this low-rank structural information, this paper presents a two-dimensional image matrix based error model, i.e. matrix regression, for face representation and classification. (arxiv.org)
  • In the latter representation the nuclear kinetic energy operator is (almost) diagonal, but the equations are still coupled, this time by off-diagonal diabatic potential terms. (citizendium.org)
  • Newly appointed BEA Professor of Nuclear Science and Engineering Ju Li will straddle the two, as he applies his groundbreaking research into atomic-scale materials behavior to a broad range of challenges, including energy storage, waste management, and reactor materials. (mit.edu)
  • But for engineering systems, you need to predict behavior over years, or even thousands of years for nuclear waste treatment. (mit.edu)
  • Besides the nuclear attenuation of produced dileptons at large energies and forward rapidities emerging due to the onset of shadowing effects, we predict a strong suppression at large pT , dilepton invariant masses and Feynman xF caused by the Initial State Interaction effects in kinematic regions where no shadowing is expected. (lu.se)
  • The manifestations of nuclear effects are investigated also in terms of the correlation function in azimuthal angle between the dilepton pair and a forward pion for different energies, dilepton rapidites and invariant dilepton masses. (lu.se)
  • Traditionally, the purpose of these symposia is the dissemination of major theoretical and experimental advances in nuclear science, with emphasis on research topics carried out by Latin American groups or in collaborations involving institutions from Latin America. (sissa.it)
  • In contrast to the cytoskeleton, however, the nuclear matrix has been proposed to be a dynamic structure. (wikipedia.org)
  • These findings, which are at variance with our own previous results obtained with cell cultures synchronized by either a double thymidine block or aphidicolin exposure, strengthen the contention that DNA replication is associated with an underlying nuclear structure and demonstrate the artifacts that may be generated by procedures commonly used to synchronize cell cultures. (neb.com)
  • This makes the study of knot polynomials the next task after the structure of conformal blocks themselves more or less understood in terms of the Dotsenko-Fateev matrix models [ 45 - 55 ] and other similar representations [ 56 , 57 ]. (hindawi.com)
  • To form nuclear states with increasing spin the valence particles align their spin towards the same direction. (lu.se)
  • In analysis of complex nuclear forensic samples containing lanthanides, actinides and matrix elements, rapid selective extraction of Am/Cm for quantification is challenging, in particular due the difficult separation of Am/Cm from lanthanides. (northumbria.ac.uk)
  • Reduced E2 matrix elements coupling populated yrast and non-yrast states were extracted, including their relative signs. (lu.se)
  • The life of every terrestrial organism is being threatened with the steadily growing possibility of nuclear war because after the fall of the USSR a few imperialists decided that US unipolar hegemony needs to be maintained at all cost. (caitlinjohnstone.com)
  • Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. (nih.gov)
  • Changing sufficiently often the nuclear constellation of the system under study and solving the electronic Schrödinger equations over and over again, gives the electronic energies as functions of the nuclear coordinates. (citizendium.org)
  • Results: In contrast to the results of the L-PRP-free groups, the histomorphometric results of the L-PRP groups demonstrated intense fibrotic deposition along with hindered bone matrix deposition. (bvsalud.org)
  • Nanotopographical modulation of cell function through nuclear deformation. (cdc.gov)
  • en] Due to the great increase demand for energy in the world, the continuous expansion of industrialization and the increase of consumption, together with the indispensable search for the sustainability of human acts, the need for diversification of the energy matrix and the search for less polluting energy comes increasing. (iaea.org)
  • Patterned cell and matrix dynamics in branching morphogenesis. (nih.gov)
  • Also discussed are matrices on Paul LaViolette's galactic superwave theory. (revelation13.net)
  • The study was initiated to examine the feasibility of using this nuclear related method based on X-Ray absorptiometry to measure Pb levels in aerosols and to compare the validity of this method with EDXRF, AAS and dithizone extraction. (who.int)
  • Thus, 129I represents only a very small fraction of the total fission product inventory in the nuclear fuel cycle. (cdc.gov)