• Together with norvaline, norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. (wikipedia.org)
  • In Miller-Urey experiments probing prebiotic synthesis of amino acids, norleucine and especially norvaline are formed. (wikipedia.org)
  • Leucines, description of the isomers of leucine norvaline, isomer of valine that has similar biochemistry to that of norleucine. (wikipedia.org)
  • Lazcano, Antonio "Norvaline and Norleucine May Have Been More Abundant Protein Components during Early Stages of Cell Evolution" Origins of Life and Evolution of Biospheres 2014, volume 43, 363-375. (wikipedia.org)
  • One included amino acids with linear side chains such as norvaline and norleucine. (acs.org)
  • Norleucine (abbreviated as Nle) is an amino acid with the formula CH3(CH2)3CH(NH2)CO2H. (wikipedia.org)
  • The use of the name norleucine is discouraged as it is a misnomer, given than nor is defined for an amino acid with one less methylene group than found in the proteinogenic form. (wikipedia.org)
  • Elongation of the side chain (glycine - L-norleucine) strengthened binding. (uandes.cl)
  • A study showed that with the substitution of the methionine at the 35 position with norleucine the neurotoxic effects of the Aβ peptides were completely negated. (wikipedia.org)
  • For this reason, norleucine has been used to probe the role of methionine in Amyloid-β peptide (AβP) the central constituent of senile plaques in Alzheimer's disease. (wikipedia.org)
  • Like most other α-amino acids, norleucine is chiral. (wikipedia.org)
  • DON (6-diazo-5-oxo-l-norleucine), a glutamine antagonist, was demonstrated to exhibit analgesic, antibacterial, antiviral and anticancer properties. (nih.gov)
  • 1. Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines. (nih.gov)
  • 2. Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase. (nih.gov)
  • 6. Transport and membrane binding of the glutamine analogue 6-diazo-5-oxo-L-norleucine (DON) in Xenopus laevis oocytes. (nih.gov)
  • 12. Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine. (nih.gov)
  • 14. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. (nih.gov)
  • The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) has shown robust efficacy in both preclinical animal models and exploratory clinical studies. (issx.org)
  • Strutural modelling of TTL revealed that residues Met-114 and Met-142 are in close vicinity of the active site and their replacement by the norleucine could modulate the catalytic activity of the enzyme. (frontiersin.org)
  • Here, we construct the optimal coordinate and the associated free-energy profile for all-helical proteins HP35 and its norleucine (Nle/Nle) double mutant, based on realistic equilibrium folding simulations [Piana et al. (whiterose.ac.uk)
  • A study showed that with the substitution of the methionine at the 35 position with norleucine the neurotoxic effects of the Aβ peptides were completely negated. (wikipedia.org)