• Nitrosourea derivatives sudh as BCNU and CCNU have been in clinical trials for many years. (ntnu.edu.tw)
  • Newly synthesized 3'-nitrosourea analogues of thymidine have shown greater inhibitory activity against some cancer cells than BCNU. (ntnu.edu.tw)
  • The magnitude of phenol -induced PBN-spin-trapped radical adducts in skin of mice with diminished levels of GSH (either pre-treated with DL-buthionine sulfoximine, BSO, or 1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU) was remarkably higher as compared to those in mice treated with phenol alone. (cdc.gov)
  • At its twentieth meeting, the Committee considered the reports of a WHO task group and of a working group of the International Agency for Research on Cancer on N- nitroso compounds but concluded that they did not provide sufficient evidence to revise the temporary status of the ADI. (inchem.org)
  • it observed, however, that quantitative data were available only on those N- nitroso compounds that are readily formed endogenously, such as N- nitrosoproline, which is not carcinogenic. (inchem.org)
  • As there was no quantitative evidence of the endogenous formation of carcinogenic N- nitroso compounds at the levels of intake of nitrite and nitrosatable precursors achievable in the diet, a quantitative risk assessment of nitrite on the basis of endogenously formed N- nitroso compounds was considered to be inappropriate. (inchem.org)
  • Introduction: N-methyl-N-nitrosourea (MNU) is the oldest member of the nitroso compounds. (uevora.pt)
  • However, it was aware that nitrite is formed in the human body by reduction of nitrate and that N-nitroso compounds can also be formed from nitrite and N-nitrosatable compounds under certain conditions. (inchem.org)
  • Thus, the assessment of the health risk of nitrate to humans should encompass the toxicity of both nitrite and N-nitroso compounds, and the animal species used for safety evaluation should be closely related to humans with respect to the toxicokinetics of nitrate and the conversion of nitrate to nitrite. (inchem.org)
  • Furthermore, in the toxicological evaluation of nitrate, it should be considered in conjunction with nitrite and potential endogenously formed N-nitroso compounds. (inchem.org)
  • Ynamines, enamines, allenes, and N-nitroso compounds are some of the organic functional groups described in the text. (elsevier.com)
  • Miscellaneous Preparations References Chapter 16/C-Nitroso Compounds 1. (elsevier.com)
  • Recent hypotheses for the development of gastric cancer suggest that exposure in the stomach to direct-acting genotoxic N-nitroso compounds, formed endogenously, may be involved. (taylorfrancis.com)
  • Organic compounds containing the nitroso (-N=O) group attached to an organic moiety. (bvsalud.org)
  • However, the taxanes are extremely anaphylactogenic due to the use of Cremaphor-EL to solubilize the formulation of the drugs, which are not water-soluble compounds. (vin.com)
  • They are water soluble compounds based on a unit involving carbon ring structures containing phenols (-OH) groups. (positivehealth.com)
  • Nitrosoureas are chemotherapeutic alkylating agents, widely used in the treatment of malignant diseases. (jpionline.org)
  • Managed several discovery oncology projects, supervised several associates, and characterized with comprehensive in vitro and in vivo techniques numerous novel compounds for a variety of chemotherapeutic targets. (environmentalchemistry.com)
  • 1 Nitrate taken from diet and secreted into saliva is converted into nitrite by bacteria in the oral cavity, 2 , 3 which may serve as an agent to produce carcinogenic compounds by reaction with their precursors under gastric conditions. (taylorfrancis.com)
  • It was later decided to include nitions of carcinogens were based on pollution, occupational exposure to a review of lifestyle factors that are the January 2013 list of agents classified carcinogenic compounds, and lifestyle known to influence cancer risk. (who.int)
  • Kaithwas, Gaurav 2019-10-24 00:00:00 Background: This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis. (sagepub.com)
  • Many anticancer drugs, such as platinum compounds, alkylating agents and nitrosoureas, cause direct damage to the structural integrity of the DNA, and resistance to these compounds results from activation of DNA repair systems. (nature.com)
  • This paper reports the synthesis of some nitrosourea analogues of 5-amino-methyl-2'-deoxyuridine as potential anticancer agents. (ntnu.edu.tw)
  • Discovering and optimizing therapeutic efficacy, or elucidating toxicity, for new and existing compounds through drug metabolism and pharmacokinetic/pharmacodynamic analyses. (environmentalchemistry.com)
  • The biochemical mechanisms of dermal toxicity of phenolic compounds are not well understood. (cdc.gov)
  • The full range of antioxidants found in the body include vitamins C and E, carotenes, glutathionine, uric acid, taurine, and plant flavonoids and flavonoid derivatives, and some other compounds. (positivehealth.com)
  • A number of phenolic compounds that are utilized in industry (e.g., for production of resins, paints, lacquers, cosmetics and pharmaceuticals) are toxic to skin (i.e., can cause rash, dermal inflammation, contact dermatitis, leucoderma, and/or cancer promotion). (cdc.gov)
  • 5 , 6 Direct-acting genotoxic N-nitrosamidines and nitrosamides such as N-alkyl-N′-nitro-N-nitrosoguanidine and N-alkyl-A-nitrosourea have been known to induce cancer in the glandular stomach of experimental animals. (taylorfrancis.com)
  • RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
  • Les risques de cancer les plus élevés pour les Qatariens proviendraient de facteurs associés aux modes de vie, en particulier l'obésité, la sédentarité et le tabagisme. (who.int)
  • Tannic acid, a plant derived polyphenolic compound, is one such agent which embodies characteristics of being harmless and environmentally friendly combined with being a good reducing and stabilizing agent. (hindawi.com)
  • Tannic acid, a plant derived polyphenolic compound [ 11 ] (Figure 1 ), has also been exploited as a reductant of metal salt solutions. (hindawi.com)
  • 7 - 10 These types of direct-acting genotoxic compounds can be produced by reaction of their precursors if present in foods with nitrite under acidic conditions similar to those of gastric juice. (taylorfrancis.com)
  • The ecological risks of the substances in the Furan Compounds Group in this assessment were characterized using the ecological risk classification of organic substances (ERC). (canada.ca)
  • essential nutritional dietary compounds such as vitamin C, and small plant-derived substances which intercept free radicals and prevent them from causing damage. (positivehealth.com)
  • Pursuant to section 68 or 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health conducted a screening assessment of four of five substances referred to collectively under the Chemicals Management Plan as the Furan Compounds Group. (canada.ca)
  • Results: On the grounds of hemodynamic recordings and morphology, n-methyl n-nitrosourea treated group showed distorted changes along with distorted morphological parameters. (sagepub.com)
  • As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute. (wikipedia.org)
  • In vivo studies included oral and systemic delivery of novel agents to small and large animals to determine the pharmacokinetics for compound optimization and prediction of human clearance mechanisms and dosing regimens. (environmentalchemistry.com)
  • This article considers only the flavonoids, which are small compounds synthesised by plants, but not animals, so must be taken in our diet. (positivehealth.com)
  • It is considered a complete, potent and direct alkylating compound, able to alkylate the DNA without metabolic activation. (uevora.pt)
  • We created the algorithm for the development of a lyophilised antitumor drug, which allowed to obtain an appropriate pharmaceutical dosage form of a nitrosourea compound, aranoza, purposed for the treatment of neuroendocrine tumours. (jpionline.org)
  • We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210 BCR-ABL cells to compare incidence and types of KD mutants emerging in the presence of imatinib mesylate, dasatinib, and nilotinib, alone and in dual combinations. (elsevierpure.com)
  • We synthesised a nitrosourea compound, aranoza, which has been effective in preclinical studies on experimental tumour models. (jpionline.org)
  • However, many studies to modify nitrosourea agents have been undergoing mainly due to their side effects. (ntnu.edu.tw)
  • The study on the structure of nitrosourea analogues by NMR is also reported. (ntnu.edu.tw)