• Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. (wikipedia.org)
  • Product Information: NITROPRESS(R) injection, sodium nitroprusside injection. (rxwiki.com)
  • If hypotension persists more than a few minutes after discontinuation of the infusion of sodium nitroprusside injection, sodium nitroprusside injection is not the cause, and the true cause must be sought. (medlibrary.org)
  • This experiment was conducted to determine morphological and physiological responses of perennial ryegrass ( Lolium perenne L.) at the germination and early seedling growth stage to drought stress and sodium nitroprusside (nitric oxide donor) application in horticultural science department at the University of Zanjan in 2015. (ac.ir)
  • Like other vasodilators, sodium nitroprusside can cause increases in intracranial pressure. (medlibrary.org)
  • Nitroprusside is an injectable prescription medication used to treat hypertension and congestive heart failure. (rxwiki.com)
  • Nitroprusside is a prescription medication used to treat high blood pressure (hypertention) and congestive heart failure. (rxwiki.com)
  • Sodium nitroprusside is also indicated for producing controlled hypotension in order to reduce bleeding during surgery.Sodium nitroprusside is also indicated for the treatment of acute congestive heart failure. (medlibrary.org)
  • Sodium nitroprusside should not be used for the treatment of acute congestive heart failure associated with reduced peripheral vascular resistance such as high-output heart failure that may be seen in endotoxic sepsis. (medlibrary.org)
  • Sodium nitroprusside is intravenously infused in cases of acute hypertensive crises. (wikipedia.org)
  • The acute and chronic effects of sodium nitroprusside (SNP) are well characterized for vascular smooth muscle cells (VSMC). (scirp.org)
  • Aims: Despite evidence of hemodynamic benefit of sodium nitroprusside (SNP) treatment for acute heart failure (AHF), there are limited data about its efficacy and safety. (unimib.it)
  • While the use of general anesthetic agents or regional anesthesia is an alternative, management of controlled hypotension with sodium nitroprusside (SNP) ( Degoute, 2007 ) has been common strategy in pediatrics for many years. (frontiersin.org)
  • Common side effects of nitroprusside include excessively low blood pressure (hypotension), cyanide toxicity, and injection site irritation. (rxwiki.com)
  • Sodium nitroprusside should not be used to produce hypotension during surgery in patients with known inadequate cerebral circulation, or in moribund patients (A.S.A. Class 5E) coming to emergency surgery. (medlibrary.org)
  • Small transient excesses in the infusion rate of sodium nitroprusside can result in excessive hypotension, sometimes to levels so low as to compromise the perfusion of vital organs. (medlibrary.org)
  • Patients with conditions associated with a higher cyanide/thiocyanate ratio (e.g. congenital (Leber's) optic atrophy, tobacco amblyopia) should only be treated with sodium nitroprusside with great caution. (wikipedia.org)
  • Some evidence suggests sodium nitroprusside use in critically ill children may be safe, even without monitoring of cyanide level. (wikipedia.org)
  • Treatment of sodium nitroprusside overdose includes the following: Discontinuing sodium nitroprusside administration Buffering the cyanide by using sodium nitrite to convert haemoglobin to methaemoglobin as much as the patient can safely tolerate Infusing sodium thiosulfate to convert the cyanide to thiocyanate. (wikipedia.org)
  • Nitroprusside can cause cyanide toxicity which can be lethal. (rxwiki.com)
  • As described in CLINICAL PHARMACOLOGY above, sodium nitroprusside infusions at rates above 2 mcg/kg/min generate cyanide ion (CN - ) faster than the body can normally dispose of it. (medlibrary.org)
  • Most patients reported to have experienced such toxicity have received relatively prolonged infusions, and the only patients whose deaths have been unequivocally attributed to nitroprusside-induced cyanide toxicity have been patients who had received nitroprusside infusions at rates (30 to 120 mcg/kg/min) much greater than those now recommended. (medlibrary.org)
  • Hydroxocobalamin can be administered to reduce the risk of thiocyanate toxicity induced by nitroprusside. (wikipedia.org)
  • The vasodilative response to the endothelium-dependent vasodilator, methacholine chloride, was depressed in the hypercholesterolemic group, whereas endothelium-independent vasodilation, induced by nitroprusside, was similar in each group. (jci.org)
  • Nitroprusside produces vasodilation and increases the inotropic activity of the heart. (medscape.com)
  • Treatment with intravenous sodium nitroprusside, heparin, and morphine was started. (erowid.org)
  • This study is aimed to study the effects of nitroprusside (NO donor), on the ionic currents and arrhythmogenic activity of single cardiomyocytes from the PVs. (biomedcentral.com)
  • however, it seemed that a similar hemodynamic profile could be achieved by the combination of both dobutamine and sodium nitroprusside. (lww.com)
  • A total of 51 high quality spectra, recorded and calibrated with the sodium nitroprusside standard Na 2 [Fe(CN) 5 NO]·2H 2 O (SNP), have yielded for the quadrupole splitting the value ΔE Q = +1.854(1) mm/s and for the isomer shift relative to SNP the value IS = +0.006(1) mm/s (-0.251 mm/s relative to the α-Fe standard at room temperature). (uni-luebeck.de)
  • These rare conditions are probably associated with defective or absent rhodanase, and sodium nitroprusside should be avoided in these patients. (medlibrary.org)
  • Sodium nitroprusside is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. (medlibrary.org)
  • Hypertensive patients, and patients concomitantly receiving other antihypertensive medications, may be more sensitive to the effects of sodium nitroprusside than normal subjects. (medlibrary.org)
  • Sodium nitroprusside application at 400 and 600 µM ameliorate adverse effects of drought stress in all factors. (ac.ir)
  • Nitroprusside inhibited L-type calcium currents, transient outward currents and transient inward current, but increased delayed rectified potassium currents. (biomedcentral.com)
  • However, it is not clear whether nitroprusside may have direct electrophysiological effects on PV cardiomyocytes. (biomedcentral.com)
  • Therefore, the purpose of this study was to study the effects of nitroprusside on the ionic currents and arrhythmogenic activity of single PV cardiomyocytes. (biomedcentral.com)
  • Serious side effects have been reported with nitroprusside. (rxwiki.com)
  • This is not a complete list of nitroprusside side effects. (rxwiki.com)
  • The effects of forskolin were investigated by invasive techniques using the thermodilution catheter method and compared to the β 1 -receptor agonist dobutamine and the vasodilator sodium nitroprusside in an intraindividual comparison. (lww.com)
  • In patients whose intracranial pressure is already elevated, sodium nitroprusside should be used only with extreme caution. (medlibrary.org)
  • Nitroprusside regulates the electrical activity of PV cardiomyocytes, which suggests that NO may play a role in PV arrhythmogenesis. (biomedcentral.com)
  • The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. (ox.ac.uk)
  • BACKGROUND: Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. (ox.ac.uk)
  • Concomitant longer-acting antihypertensive medication should be administered so that the duration of treatment with sodium nitroprusside can be minimized. (medlibrary.org)
  • abstract = "The electronic structure of Na2[Fe(CN)5NO] ·2H2O (sodium nitroprusside: SNP) was investigated by using soft X-ray absorption (XA) spectroscopy. (elsevierpure.com)
  • L-arginine did not alter the effect of nitroprusside in either group. (jci.org)
  • Epithelium removal had no effect on the sensitivity of tracheal strips to papaverine or salbutamol, but significantly enhanced sensitivity to isoproterenol and sodium- nitroprusside. (cdc.gov)
  • Stockand, JD & Sansom, SC 1996, ' Role of large Ca 2+ -activated K + channels in regulation of mesangial contraction by nitroprusside and ANP ', American Journal of Physiology - Cell Physiology , vol. 270, no. 6 39-6, pp. (uthscsa.edu)
  • Like all our NARK narcotic field tests, the Sodium Nitroprusside Reagent is meant for presumptive field drug testing. (sirchie.com)
  • This amount of sodium nitroprusside is administered in less than an hour when the drug is administered at 10 mcg/kg/min (the maximum recommended rate). (medlibrary.org)
  • Nitroprusside belongs to a group of drugs called antihypertensives. (rxwiki.com)
  • Sodium nitroprusside was discovered as early as 1850 and found to be useful in medicine in 1928. (wikipedia.org)
  • Add a few drops of sodium nitroprusside solution, make alkaline with ammonia, then saturate with ammonium sulphate crystals. (dictionary.com)
  • The action potential and ionic currents were investigated in isolated single canine PV cardiomyocytes before and after sodium nitroprusside (80 μM,) using the whole-cell patch clamp technique. (biomedcentral.com)
  • The crystal structure of tetrabutylammonium nitroprusside dihydrate (TBANPDH, [(C4H9)4N]2[Fe(CN)5NO]·2H2O) was determined by single crystal X-ray diffraction (XRD) and the compound was also studied, as well as the anhydrous salt (TBANP), by room and low temperature Fourier Transform Infra-Red (FTIR) and room temperature Fourier Transform Near Infra-Red Raman (FTNIRR) spectroscopies. (conicet.gov.ar)
  • The theory of the angle-dependent Mössbauer spectroscopy on nitroprusside-like single crystals has been complemented with expressions for the nuclear resonant cross-sections in case of the wave vector of the γ-radiation lying in the low symmetric non-mirror planes. (uni-luebeck.de)
  • They have been tested by rotation experiments in these planes using guanidinium nitroprusside (CN 3 H 6 ) 2 [Fe(CN) 5 NO], (GNP) single crystal. (uni-luebeck.de)
  • Sodium nitroprusside is light sensitive, so it needs to be shielded from light to prevent degradation. (wikipedia.org)
  • Turfgrass seeds were soaked for six hours in 0 (distilled water), 200, 400 and 600 µM of sodium nitroprusside solutions, and for drought stress treatments, germination and early seedling growth was done over the water potential range of 0 (distilled water), -1, -4 and -8 bar by polyethylene glycol. (ac.ir)
  • Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits. (illumina.com)