AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentAnthropology, Education, Sociology and Social Phenomena
NifurtimoxNitrofuransTrypanocidal AgentsNitroimidazolesTrypanosoma cruziNitroreductasesChagas DiseaseXenodiagnosisTrypanosomiasis, AfricanParasitic Sensitivity TestsEflornithineTrypanosoma brucei bruceiAntiprotozoal AgentsChagas CardiomyopathyTrypanosomiasisHelminthsHelminthiasisHelminth ProteinsTravelDermoscopyColorimetryEye
LampitBenznidazole and nifurtimoxChagasTrypanosomaNECTEflornithine and nifurtimoxMelarsoprolFexinidazoleCombinationNeuroblastomaChagasicDosesTreatmentTrypanosomiasisParasitesRadicalReductionPregnancyLiverDrugChildrenDiseaseLevelsPeriodDrugsTabletsEflornithinePediatricMedicationsMuscle weaknessParasiteApprovalMedicationSide effectsAdverse eventsPregnantRisksTreatPatientsAuthorsPrice
Lampit1
Benznidazole and nifurtimox4
  • Two drugs are used to treat this infection: benznidazole and nifurtimox. (mountsinai.org)
  • There are currently only two medicines available to treat the disease: benznidazole and nifurtimox, which were both developed over 40 years ago. (msf.org.uk)
  • There is currently no vaccination that protects against Chagas disease for humans, but benznidazole and nifurtimox are effective in it in its early stage. (orkin.com)
  • Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. (utmb.edu)
Chagas8
  • Nifurtimox has been used to treat Chagas disease, when it is given for 30 to 60 days. (wikipedia.org)
  • Due to the low tolerance and completion rate of nifurtimox, benznidazole is now being more considered for those who have Chagas disease and require long-term treatment. (wikipedia.org)
  • In the United States nifurtimox is indicated in children and adolescents (birth to less than 18 years of age and weighing at least 2.5 kilograms (5.5 lb) for the treatment of Chagas disease (American Trypanosomiasis), caused by Trypanosoma cruzi. (wikipedia.org)
  • Nifurtimox and benznidazole treat the symptoms of Chagas disease (American trypanosomiasis). (medicalnewstoday.com)
  • As the only manufacturer of the treatments Nifurtimox and Suramin, recognized by the WHO as essential medicines, our initial focus has been on fighting the diseases these medicines treat like Chagas disease and African sleeping sickness (HAT). (bayer.com)
  • In conclusion, astaxanthin is not recommended during the acute phase of Chagas disease, either alone or in combination with nifurtimox. (parasite-journal.org)
  • The current therapy for Chagas disease is limited to the drugs benznidazole (BZ) and nifurtimox (NFX) [ 5 ], which are very toxic, and the efficacy of treatment remains low in the chronic phase of the disease. (biomedcentral.com)
  • But the CDC provided only 422 courses of benznidazole or nifurtimox used to treat Chagas during this period. (medscape.com)
Trypanosoma2
  • 2015). Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties . (up.pt)
  • In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. (lshtm.ac.uk)
NECT2
  • In 2009, results from a pivotal clinical trial sponsored by DNDi and Médecins Sans Frontières (MSF) showed that NECT, a combined treatment of Bayer's nifurtimox and Sanofi's eflornithine, was a safe and effective treatment for sleeping sickness. (dndi.org)
  • Efficacy and Safety of Fexinidazole Compared to Nifurtimox-Eflornithine Combination Therapy (NECT) in Patients With Late-stage Human African Trypanosomiasis (HAT) Due to T.b. (who.int)
Eflornithine and nifurtimox2
  • Combination therapy with eflornithine and nifurtimox is safer and easier than treatment with eflornithine alone, and appears to be equally or more effective. (wikipedia.org)
  • The most commonly used drug, pentamidine, is often used for first stage West African Sleeping Sickness, with other CDC approved drugs being uramin, melarsoprol, eflornithine and nifurtimox. (borgenproject.org)
Melarsoprol2
  • When nifurtimox is given on its own, about half of all patients will relapse, but the combination of melarsoprol with nifurtimox appears to be efficacious. (wikipedia.org)
  • Trials are awaited comparing melarsoprol/nifurtimox against melarsoprol alone for African sleeping sickness. (wikipedia.org)
Fexinidazole3
  • Nitroaromatic compounds, such as nifurtimox (in combination with eflornithine) and fexinidazole (in clinical trials), have been recently introduced for the treatment of the second stage of sleeping sickness. (bl.uk)
  • More worryingly, nifurtimox resistance led to a decreased sensitivity of these parasites to other nitroaromatic compounds, including a high level of cross-resistance to fexinidazole. (bl.uk)
  • Conversely, generation of fexinidazole resistance resulted in cross-resistance to nifurtimox. (bl.uk)
Combination1
  • For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. (wikipedia.org)
Neuroblastoma1
  • Nifurtimox is in a phase-II clinical trial for the treatment of pediatric neuroblastoma and medulloblastoma. (wikipedia.org)
Chagasic1
  • Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. (nih.gov)
Doses2
  • There is limited data shown that nifurtimox doses up to 15 mg/kg daily can cause adverse effects in breastfed infants. (wikipedia.org)
  • twelve cebus apella monkeys experimentally infected with 3 x 10 sobre 5 T. cruzi trypomastigotes Y strain, and treated with different doses of Spirogermanium and Nifurtimox during the acute phase of the infection, were subjected to hemoculture in order to test the sensitivity of this methd in comparsson. (bvsalud.org)
Treatment1
  • These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment. (nih.gov)
Trypanosomiasis1
  • Nifurtimox has also been used to treat African trypanosomiasis (sleeping sickness), and is active in the second stage of the disease (central nervous system involvement). (wikipedia.org)
Parasites2
  • L'ASTX a été testée in vitro sur des parasites cultivés axéniquement et en co-culture avec des cellules Vero. (parasite-journal.org)
  • For reference drugs, parasites were more susceptible to nifurtimox than to benznidazole and some differences in activity of benznidazole between T. cruzi strains was observed. (lshtm.ac.uk)
Radical1
  • Nifurtimox forms a nitro-anion radical metabolite that reacts with nucleic acids of the parasite causing significant breakdown of DNA. (wikipedia.org)
Reduction1
  • Nifurtimox undergoes reduction and creates oxygen radicals such as superoxide. (wikipedia.org)
Pregnancy1
  • Nifurtimox is not recommended in pregnancy or in those with significant kidney or liver problems. (wikipedia.org)
Liver1
  • Most common side effects anorexia weight loss nausea vomiting headache dizziness amnesia Less common effects rash depression anxiety confusion fever sore throat chills seizures impotence tremors muscle weakness numbness of hands or feet Nifurtimox is contraindicated in people with severe liver or kidney disease, as well as people with a background of neurological or psychiatric disorders. (wikipedia.org)
Drug1
  • Updated information on nifurtimox administration and its approval status with the U.S. Food and Drug Administration. (hiv.gov)
Children1
  • When administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox in children and adults is 5 mg/kg every 8 hours for 10 days. (msf.org)
Disease1
  • In regions of the world where the disease is common nifurtimox is provided for free by the World Health Organization (WHO). (wikipedia.org)
Levels1
  • Furthermore, in the bloodstream form of T. brucei, resistance was relatively easy to select for nifurtimox, with no concurrent loss of virulence and at clinically relevant levels. (bl.uk)
Period1
  • PNLTHA did not buy nifurtimox in this period. (cdc.gov)
Drugs5
  • Benznidazole was one of two drugs, along with nifurtimox, that the CDC has made available for antiparasitic treatment under investigational protocols . (medpagetoday.com)
  • The treatment of the disease in the acute phase is based on two drugs: nifurtimox and benznidazole. (who.int)
  • Although more effective trypanocidal drugs are needed, treatment with benznidazole (or nifurtimox) is reasonably safe and effective, and is now recommended for a widened range of patients. (nih.gov)
  • The available drugs, benznidazole (Bz) and nifurtimox, have limited effectiveness and intense side effects. (fiocruz.br)
  • Before 2018, the treatment of HAT involved four drugs including pentamidine, suramin, melarsoprol and eflornithine, and more recently, a nifurtimox-eflornithine combination therapy (NECT). (biomedcentral.com)
Tablets2
  • The nifurtimox tablets are scored so that they can easily be split into halves. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to nifurtimox, any other medications, or any of the ingredients in nifurtimox tablets. (medlineplus.gov)
Eflornithine4
  • For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. (wikipedia.org)
  • Combination therapy with eflornithine and nifurtimox is safer and easier than treatment with eflornithine alone, and appears to be equally or more effective. (wikipedia.org)
  • Thirty mothers took a full course of 30 doses of oral nifurtimox 15 mg/kg daily and all received 14 doses of intravenous eflornithine 400 mg/kg daily for 7 days for human African trypanosomiasis. (nih.gov)
  • When administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox in children and adults is 5 mg/kg every 8 hours for 10 days. (msf.org)
Pediatric1
  • Nifurtimox is in a phase-II clinical trial for the treatment of pediatric neuroblastoma and medulloblastoma. (wikipedia.org)
Medications1
  • Nifurtimox is in a class of medications called antiprotozoals. (medlineplus.gov)
Muscle weakness2
  • Most common side effects anorexia weight loss nausea vomiting headache dizziness amnesia Less common effects rash depression anxiety confusion fever sore throat chills seizures impotence tremors muscle weakness numbness of hands or feet Nifurtimox is contraindicated in people with severe liver or kidney disease, as well as people with a background of neurological or psychiatric disorders. (wikipedia.org)
  • you should know that nifurtimox may cause muscle weakness or tremors. (medlineplus.gov)
Parasite2
  • Nifurtimox forms a nitro-anion radical metabolite that reacts with nucleic acids of the parasite causing significant breakdown of DNA. (wikipedia.org)
  • Launch The flagellate protozoan parasite, includes two nitroheterocyclic derivatives, nifurtimox and benznidazole, which are Myelin Basic Protein (87-99) amazing in the severe stage of the condition, but possess limited efficiency in the chronic stage of the condition. (healthweblognews.info)
Approval1
  • Approval for nifurtimox was based on the number of treated patients who became IgG antibody negative or who showed an at least 20% decrease in optical density on 2 different IgG antibody tests against antigens of T cruzi . (medscape.com)
Medication1
Side effects2
  • However, long-term use of nifurtimox does increase chances of adverse events like gastrointestinal and neurological side effects. (wikipedia.org)
  • Nifurtimox may cause side effects. (medlineplus.gov)
Adverse events3
  • Physicians should be aware of the frequency of adverse events when prescribing nifurtimox. (cdc.gov)
  • This report summarizes CDC Drug Service reports for selected characteristics of and adverse events reported by 336 patients for whom nifurtimox was requested under the CDC IND program during January 1, 2001-January 25, 2021. (cdc.gov)
  • Physicians should take frequency of adverse events into consideration when prescribing nifurtimox and counseling patients. (cdc.gov)
Pregnant2
  • Use of nifurtimox should be avoided in pregnant women due to limited use. (wikipedia.org)
  • If you become pregnant while taking nifurtimox, call your doctor. (medlineplus.gov)
Risks1
  • Talk to your doctor about the risks of taking nifurtimox. (medlineplus.gov)
Treat1
  • Nifurtimox has also been used to treat African trypanosomiasis (sleeping sickness), and is active in the second stage of the disease (central nervous system involvement). (wikipedia.org)
Patients1
  • CDC released nifurtimox to 336 patients, 34.2% of whom were in California. (cdc.gov)
Authors2
  • Other authors do not consider breastfeeding a contraindication during nifurtimox use. (wikipedia.org)
  • Other authors consider that breastfeeding is not contraindicated during the use of nifurtimox. (nih.gov)
Price1
  • Open up in another window Amount 3 Nifurtimox A forest story displaying the pooled occurrence price of.The survRM2 package was utilized to derive the RMST estimates according to RECIST 1.1 and iRECIST (we.e. (oaxacalibre.net)