CeramidesSphingolipidsGangliosidesAntigensGlycolipidsFattyBiosynthesisGlobotriaosylceramideLipidLysosomalNegatively chargedActivation of neutral sphingomyelinaseSphingomyelinaseAccumulateSialic acidCharacterizationEndothelialMetabolismBrainParkinson'sStructuralComplexDiffusionClassCellRoleHumanDailyMultipleSpecific
Ceramides3
- The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes. (yeastrc.org)
- 1- The purification of ceramides is efficiently processed by elution with 5 ml of chloroform/methanol (95/5, v/v) after the elution of the other neutral lipids with pure chloroform. (gerli.com)
- The following procedure may be used to efficiently separate ceramides from the other neutral lipids (except monoglycerides), fatty acids but also complex sphingolipids (sphingomyelin and glycosphingolipids). (gerli.com)
Sphingolipids2
- Glycosphingolipids are a group of lipids (more specifically, sphingolipids) and are a part of the cell membrane. (wikipedia.org)
- Biochemical Studies on Sphingolipids of Artemia franciscana: Novel Neutral Glycosphingolipids │ J. Lipid Res. (ritsumei.ac.jp)
Gangliosides1
- Glycosphingolipids include: Cerebrosides Gangliosides Globosides Gangliosides are mainly found in the cell membranes of the central nervous system, where their carbohydrate group is responsible for the interaction between individual cells and for signaling. (wikipedia.org)
Antigens2
- Neutral glycosphingolipids are also important, for example as blood type antigens. (wikipedia.org)
- The NOR phenotype-related antigens are unique neutral glycosphingolipids recognized by these antibodies and Griffonia simplicifolia IB4 isolectin (GSL-IB4). (slu.se)
Glycolipids2
- Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine. (wikipedia.org)
- Glycosphingolipids (GSLs) are a subclass of glycolipids that are found in cell membranes of various organisms ranging from bacteria to humans. (springer.com)
Fatty3
- True neutral lipids are eluted by 5 ml of the same mixture and free fatty acids are eluted by 5 ml of isooctane/ethyl acetate/acetic acid (75/25/2, v/v). (gerli.com)
- 3- When analyses of low (trace) levels of fatty acids or other compounds are planned after neutral lipid fractionation, it is recommended to wash the silica gel before use by 3 successive suspensions and decantation in pure methanol followed by desiccation under vacuum lands drying at 110°C. Keep the washed silica gel in a tightly closed vessel. (gerli.com)
- Fatty acids called glycosphingolipids prevent infection from developing within the GI system. (isitbadforyou.com)
Biosynthesis1
- Induction of glycosphingolipid biosynthesis and neurite outgrowth of primary cultured neurons by L- threo -1-phenyl-2-decanoylamino-3-morpholino-1 propanol (L-PDMP). (or.jp)
Globotriaosylceramide2
- Deficiency or absence of alpha-galactosidase A (α-GAL A) activity as a result of gene mutations in the GLA gene (Xq21.3-q22) leads to lysosomal accumulation of neutral glycosphingolipids, most notably globotriaosylceramide (G3b). (medscape.com)
- As a consequence of the αGal A deficiency, neutral glycosphingolipids, mainly globotriaosylceramide (Gb3), accumulate in a variety of cells and tissues, leading to a wide clinical spectrum of clinical manifestations [ 4 ]. (biomedcentral.com)
Lipid4
- In contrast, globosides are neutral lipid molecules. (springer.com)
- It has been reported that Aβ generation and accumulation occur in membrane microdomains, called lipid rafts, which are enriched in cholesterol and glycosphingolipids. (elsevierpure.com)
- The same silica gel column as described before for the separation of all lipid classes may be adapted for the separation of the different neutral lipid fractions of a complex lipid extract. (gerli.com)
- Below is described an efficient procedure to isolate quite all neutral lipid fractions of a complex lipid mixture. (gerli.com)
Lysosomal2
- Angiokeratoma corporis diffusum is the cutaneous hallmark of Fabry disease, an X-linked inherited disorder caused by a deficiency in the lysosomal enzyme alpha-galactosidase A. Decreased or absent enzyme activity causes uncleaved glycosphingolipids to accumulate in various cell types, particularly in the vascular endothelium, smooth muscle cells, and pericytes, causing ischemia and infarction of tissues. (medscape.com)
- A new hydrolytic lysosomal neutral glycosphingolipid-specific enzyme for Fabry disease. (therapeuticresearch.com)
Negatively charged1
- In general, glycosphingolipids can be categorized into two groups: neutral glycosphingolipids (also called glycosphingolipids) and negatively charged glycosphingolipids. (wikipedia.org)
Activation of neutral sphingomyelinase2
- Jana A, Pahan K. Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. (rush.edu)
- Jana A, Pahan K. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. (rush.edu)
Sphingomyelinase2
- Jana A, Pahan K. Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease. (rush.edu)
- Jana A, Pahan K. Oxidative stress kills human primary oligodendrocytes via neutral sphingomyelinase: implications for multiple sclerosis. (rush.edu)
Accumulate2
- These glycosphingolipids accumulate in many different types of cells. (medscape.com)
- Persons with Fabry disease who have type AB or B blood also accumulate blood group B glycosphingolipids (those with alpha-galactosyl-terminated residues) and can have more severe Fabry disease (related to greater body substrate mass) than patients with blood group A. This is because these blood groups have two additional terminal alpha-galactosyl moieties. (medscape.com)
Sialic acid1
- Glycosphingolipid binding specificities of rotavirus: identification of a sialic acid-binding epitope. (expasy.org)
Characterization2
- Characterization of a Novel Rhamnose-containing Acidic Glycosphingolipid from the Ascidian Halocynthia aurantium. (ritsumei.ac.jp)
- Structural characterization of neutral glycosphingolipids from 3T3-L1 adipocytes. (ritsumei.ac.jp)
Endothelial1
- Glycosphingolipid deposits in lysosomes of endothelial, perithelial, and smooth muscle cells of blood vessels cause swelling into the blood vessel lumen. (medscape.com)
Metabolism1
- Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson's disease (PD). (nature.com)
Brain1
- Neprilysin (NEP), a neutral endopeptidase, is one of the major Aβ-degrading enzymes in the brain. (elsevierpure.com)
Parkinson's1
- Guest editor Sandro Sonnino introduces the contents of the issue in a fascinating interview conducted by Ioannis Tsagakis, starting with eight Review articles that focus on the role of glycosphingolipids in diseases as diverse as Parkinson's disease, cystic fibrosis, infertility, and parasite infections. (febs.org)
Structural2
- Structural analysis of neutral glycosphingolipids from the silkworm Bombyx mori and the difference in ceramide composition between larvae and pupae. (ritsumei.ac.jp)
- Glycosphingolipids were once considered to play a purely structural role in cell membranes, but it has since become apparent that they play a key role in the nervous system and are associated with several diseases. (febs.org)
Complex3
- In this review, strategies to synthesize these complex glycosphingolipids are presented. (springer.com)
- Increasing levels of neutral complex VLC-PUFA GSLs also correlated with the progression of spermatogenesis in a series of male sterile mutants with arrests at different stages of spermatogenesis. (ox.ac.uk)
- The separation of neutral lipids is only a part of complex recipes which are described to separate all kinds of lipids, the analyst may thus choose only the part adapted for his problem in running the procedure from the beginning to the specific step. (gerli.com)
Diffusion1
- Deposition of glycosphingolipids can be attributed to both endogenous production and diffusion of material from the circulation. (medscape.com)
Class1
- Members of the class of neutral glycosphingolipids. (umassmed.edu)
Cell1
- Extended globo-series glycosphingolipids that mediate cell adhesion and signaling. (or.jp)
Role1
- Glycosphingolipids play also important role in oncogenesis and ontogenesis. (wikipedia.org)
Human1
- Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora. (kegg.jp)
Daily2
- neutral pH for daily use. (lepaniervertqc.com)
- Earth science ceramide care shampoo, volumizing is a color-safe, gentle shampoo with neutral ph for daily use. (zafra.com)
Multiple1
- Multiple glycosphingolipids determine the tissue tropism of parvovirus B19. (expasy.org)
Specific1
- Gb 3 glycosphingolipids are the specific receptors for bacterial Shiga toxin. (springer.com)