• synapses
  • Following transcription, Arc mRNA is transported out of the nucleus and localized to neuronal dendrites and activated synapses, a process dependent on the 3' UTR, polymerization of actin, and ERK phosphorylation. (wikipedia.org)
  • Reorganization
  • Our findings will provide novel insight into the neuronal reorganization that takes place post-injury, which is needed if patients with peripheral nerve and central spinal deafferentation injuries are to be treated more effectively. (grantome.com)
  • role
  • They will explore plasticity in higher-order auditory cortical fields, and investigate the possible role of top-down signals from frontal cortex in modulating adaptive plasticity in the auditory cortex. (umd.edu)
  • D2R agonist-induced increases in GAD67 and SYN neuropil expression were blocked when PSA was previously removed, indicating a role for PSA-NCAM in this plasticity. (uv.es)
  • This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (wikipedia.org)
  • Baltes argues there are seven key features which affect human development across the life span, namely: (1) development occurs across one's entire life, (2) multidirectionality and multidimensionality, (3) development as growth and decline, (4) the role plasticity plays in development, (5) the influence of socio-cultural condition on development, (6) the interactions of age-graded, history-graded, and nonnormative historical influences on development, and (7) the multidisciplinary nature of human development. (wikipedia.org)
  • In 2000, Shatz and colleagues identified Class I MHC molecules as important in neuronal plasticity, a surprising new role for molecules previously thought to have only immune system function. (wikipedia.org)
  • Several studies suggest it has a role in neuronal plasticity. (wikipedia.org)
  • inhibitor
  • Using a combination of electrophysiological and optical imaging techniques, we show here that vinpocetine, a PDE type I inhibitor, restores ocular dominance plasticity in the ferret model of fetal alcohol exposure. (jneurosci.org)
  • Here, we try to restore ocular dominance plasticity in alcohol-exposed ferrets using the PDE type 1 inhibitor vinpocetine. (jneurosci.org)
  • exon
  • The 3' UTR of the mRNA contains a cis-acting element required for the localization of Arc to neuronal dendrites, as well as sites for two exon junction complexes (EJCs) that make Arc a natural target for nonsense mediated decay (NMD). (wikipedia.org)
  • neural
  • To receive news and publication updates for Neural Plasticity, enter your email address in the box below. (hindawi.com)
  • Among the numerous candidate molecules that have been identified for mediating this neuronal remodeling, cell adhesion molecules and, specially, the neural cell adhesion molecule (NCAM), are of particular interest. (uv.es)
  • glutamate
  • Extracellular signaling to neuronal dendrites activates postsynaptic sites to increase Arc levels through a wide variety of signaling molecules, including mitogens such as epidermal growth factor (EGF), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF), glutamate acting at NMDA receptors, dopamine through activation of the D1 receptor subtype, and dihydroxyphenylglycine (DHPG). (wikipedia.org)
  • Glutamate and neurotrophic factors exert their effects on neuronal plasticity and survival by modulating cellular calcium homeostasis. (wikipedia.org)
  • cognitive
  • Although these studies showed the efficacy of VINP in enhancing plasticity in normal subjects, little is known about the effectiveness of PDE inhibitors to improve plasticity in cases of severe cognitive impairment. (jneurosci.org)
  • This neuronal structural plasticity seems to be the basis for many cognitive processes and it is crucial for adaptive responses to aversive experiences and recovery from brain damage and disease. (uv.es)
  • induction
  • They will also test the idea that top-down influences from frontal areas contribute to the induction of rapid adaptive plasticity in the auditory cortex during auditory tasks, reflecting both the nature of the stimuli and goals of the tasks. (umd.edu)
  • It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. (wikipedia.org)
  • studies
  • They will extend studies of task-related plasticity in the auditory cortex to a variety of new tasks involving speech stimuli, new behavioral paradigms (contrasting discrimination versus recognition). (umd.edu)
  • Preliminary studies from simultaneous neuronal recordings of single units and local field potentials in the auditory and frontal cortex have already led to exciting new insights, and may lead to progress in understanding the interactions within an extended neuronal network that give rise to adaptive plasticity. (umd.edu)
  • behavioral
  • modifications in intrinsic neuronal properties also subserve learning-related behavioral changes. (jneurosci.org)
  • The exact form of this plasticity depends on the behavioral context, and the spectrotemporal features of the salient acoustic stimuli. (umd.edu)
  • expression
  • For this reason, the main objectives of this thesis are to study the influence of dopaminergic neurotransmission on the neuronal plasticity of prefrontocortical circuits and to evaluate whether changes in the expression of PSA-NCAM are responsible for these neuroplastic changes. (uv.es)
  • Chronic treatment with a D2R agonist has the opposite effects and induced temporal differences in the expression of many other plasticity related genes. (uv.es)
  • The latter also decreases reelin expression in neuronal culture. (wikipedia.org)
  • injury
  • The results obtained in Pr5, the VPM, and the cortex strongly suggest that the higher the station in the neuraxis, the greater the degree of plasticity after infraorbital nerve injury. (mtak.hu)
  • Animals
  • These animals proved viable and exhibit no gross malformations in neuronal architecture, but express higher levels of the GluR1 subunit and increased miniature excitatory postsynaptic currents (mEPSCs) in addition to displaying deficiencies in long-term memory. (wikipedia.org)
  • change
  • Currently, Rhodes has also established a marine biology laboratory to research brain plasticity in clownfish undergoing sex change as a result of removal of the largest female from the group. (wikipedia.org)
  • ROCK therefore does not become activated and cannot change transcription patterns to inhibit neuronal outgrowth. (wikipedia.org)
  • specific
  • It has been found that tumor formation can induce the synthesis of a new complement of ganglioside, and very low concentrations of a specific ganglioside can induce differentiation of cultured neuronal tumor cells. (wikipedia.org)