Neuromuscular junction diseases. Medical search. Frequent questions

In diseases such as myasthenia gravis, the end plate potential (EPP) fails to effectively activate the muscle fiber due to an autoimmune reaction against acetylcholine receptors, resulting in muscle weakness and fatigue. (wikipedia.org)
The most studied diseases affecting the human acetylcholine receptor are myasthenia gravis and some forms of congenital myasthenic syndrome. (wikipedia.org)
citation needed] The neuromuscular junction diseases present within this subset are myasthenia gravis, and Lambert-Eaton syndrome. (wikipedia.org)
Myasthenia gravis is an autoimmune disease from the neuromuscular junction (NMJ) due to antibodies that assault Maraviroc the different parts of the postsynaptic membrane impair neuromuscular transmitting and result in weakness and exhaustion of skeletal muscle tissue. (healthweeks.com)
Her current commitments include improving the diagnosis and treatment of adult and pediatric patients with neuromuscular diseases, especially Duchenne Muscular Dystrophy, myasthenia gravis, ALS, limb girdle muscular dystrophies, myotonic dystrophy, FSHD, and spinal muscular atrophy. (rochester.edu)
She has national and international expertise in conducting clinical trials in adult and pediatric neuromuscular diseases including Duchenne Muscular Dystrophy, Myasthenia Gravis, periodic paralyses, nondystrophic myotonias, myotonic dystrophy and FSHD. (rochester.edu)
Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction. (nih.gov)
They may be associated with myasthenia gravis, a disease of the neuromuscular junctions. (mountsinai.org)
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction in which circulating antibodies cause fluctuant skeletal muscle weakness. (medscape.com)
[ 1 , 2 ] Ninety percent of patients with myasthenia gravis develop ophthalmologic manifestations of the disease, a disorder of neuromuscular transmission characterized by weakness and fatigability of skeletal muscles. (medscape.com)
Myasthenia gravis (MG) is an autoimmune disease causing muscle weakness due to impaired transmission at the neuromuscular junction. (tidsskriftet.no)
Behandling av pasienter med myasthenia gravis er en spesialistoppgave, men alle leger vil kunne komme i kontakt med pasientgruppen i forbindelse med andre tilstander. (tidsskriftet.no)
Nedenfor gir vi en oversikt over de vanligste medikamentene som kan utløse eller forverre myasthenia gravis (fig 1). (tidsskriftet.no)
This research has led us into rare diseases like myasthenia gravis, where patients typically suffer fatigue and a combination of symptoms impacting their quality of life, their ability to be active and function," Charl explains. (pharmaphorum.com)
Rare disease database: Myasthenia gravis. (firdapsehcp.com)
The document notes that acquired myasthenia gravis is a disorder of neuromuscular transmission, resulting from binding of autoantibodies to components of the neuromuscular junction, most commonly the acetylcholine receptor. (medscape.com)
A neurologist described these clinical findings as consistent with myasthenia gravis or Miller Fisher syndrome, a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. (cdc.gov)

Neuromuscular junction diseases can also be referred to as end plate diseases or disorders. (wikipedia.org)
citation needed] Among neuromuscular diseases some can be autoimmune disease, or hereditary disorders. (wikipedia.org)
She has a clinical research interest in the best treatment of patients with Duchenne Muscular Dystrophy, the course and outcome of pregnancy in women with muscular dystrophies, and sleep disorders in neuromuscular diseases. (rochester.edu)
[ 1 ] beginning with a summary of key general considerations, proceeding to a review of the main neurologic complications that may arise in pregnant people who were previously free of neurologic disease, and concluding with a discussion of individual neurologic disorders in the context of pregnancy. (medscape.com)
Considerable scientific progress across neurological diseases and disorders was reported at the recent 74th American Academy of Neurology (AAN) Annual Meeting. (pharmaphorum.com)
Evoli A, Vincent A. Disorders of neuromuscular transmission. (adam.com)
Warner WC, Sawyer JR. Neuromuscular disorders. (adam.com)
The molecular pathways of these lysosomal storage disorders and their relation to Parkinson's disease are not fully understood. (neuroproof.com)
An excess of exogenous corticosteroid can result from steroid treatment for asthma, chronic obstructive pulmonary disease, and inflammatory processes, such as polymyositis, connective tissue disorders, and rheumatoid arthritis. (medscape.com)
Disorders of neuromuscular transmission due to natural environmental toxins. (firdapsehcp.com)
In addition to the acquired causes, inherited disorders like hereditary sensory-autonomic neuropathy (HSAN), familial amyloid polyneuropathy (FAP), Tangier disease, and Fabry disease also exist. (medscape.com)

The neuromuscular junction is a specialized synapse between a neuron and the muscle it innervates. (wikipedia.org)
In the neuromuscular junction, the diseases will either act on the presynaptic membrane of the motor neuron, the synapse separating the motor neuron from the muscle fiber, or the postsynaptic membrane (the muscle fiber). (wikipedia.org)
We developed healthy and diseased frog and mouse neuromuscular synapse models. (aps.org)
MuSK antibodies are predominantly IgG4 and cause disassembly of the neuromuscular junction by disrupting the physiological Maraviroc function of MuSK in synapse maintenance and adaptation. (healthweeks.com)
MuSK mediates the agrin-induced clustering of AChRs during synapse formation, and is also expressed at the mature neuromuscular junction. (nih.gov)
The neuromuscular junction is a reliable synapse in which reliability derives from the summed activity of numerous unreliable elements, each consisting of a synaptic vesicle and associated voltage gated calcium channels (VGCCs). (psc.edu)
The neuromuscular junction (NMJ) is a tripartite synapse comprised of an α-motor neuron (the presynapse), extrafusal muscle fiber (the postsynapse), and specialized synaptic glia called perisynaptic Schwann cells (PSCs) or terminal Schwann cells. (elifesciences.org)
Neuromuscular junction (NMJ) is the functional contact (synapse) between an axon of motor neuron and muscle fiber. (intechopen.com)
So, according to numerous studies, not only ACh (which by the way does not always lead to a contraction of the muscle fiber) is released in the vertebrate neuromuscular synapse, but also a number of other synaptically active molecules. (intechopen.com)
However, the neuromuscular junction is a specific synapse between the motor neuron and the muscle fiber. (scopeheal.com)
Thus, the neuromuscular junction is a connection or synapse between the somatic motor neuron and the muscle fiber, where the transformation of a chemical impulse to an electrical stimulation causes the contraction of the muscle fiber. (scopeheal.com)

Autoimmune diseases occur when the body's immune system begins to target its own cells, often causing harmful effects. (wikipedia.org)
reference 26) In each of these diseases, a receptor or other protein essential to normal function of the junction is targeted by antibodies in an autoimmune attack by the body. (wikipedia.org)
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that reduces reliability, leading to muscle weakness. (psc.edu)
This article gives an overview of some autoimmune neurologic diseases and explores the clinical evidence supporting the use of IVIG. (nursingcenter.com)
It has the potential to bind many common pathogens and modulate a wide range of effectors of autoimmune disease. (nursingcenter.com)
Patient A had been treated for 12 days for suspected autoimmune disease. (cdc.gov)

We used our control MCell model (validated by its ability to predict physiology) as a starting point for modeling the current treatments for the neuromuscular disease Lambert-Eaton Myasthenic Syndrome (LEMS). (aps.org)
Long-term disease history, clinical symptoms, health status, and healthcare utilization in patients suffering from Lambert Eaton myasthenic syndrome: results of a patient interview survey in Germany. (firdapsehcp.com)

Congenital Myasthenic Syndromes (CMSs) are rare inherited diseases of the neuromuscular junction characterized by muscle weakness. (istem.eu)
Congenital myasthenic syndromes are rare genetic diseases involving pathologic proteins in the neuromuscular junction. (bvsalud.org)

A myopathy is a muscle disease unrelated to any disorder of innervation or neuromuscular junction. (medscape.com)
Steroid myopathy is usually an insidious disease process that causes weakness mainly to the proximal muscles of the upper and lower limbs and to the neck flexors. (medscape.com)

Further, degeneration of neuromuscular junctions, of synapses, and of axonal regions are features of SMA disease. (nih.gov)
Statistical data analysis revealed 65 specific alterations in the proteome of the central synapses at the early onset stage of disease. (nih.gov)
These pathways represent potential targets for therapy development with the goal of providing stability to the central synapses, thereby preserving neuronal integrity in the context of SMA disease. (nih.gov)
Synapses and neuromuscular junctions are physiologically similar processes. (scopeheal.com)
We are also interested in the formation and regulation of synapses at the neuromuscular junction, work that may provide insights into the causes of neurodegenerative diseases. (sfu.ca)
Making the connection - shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses. (sfu.ca)

This category divides neuromuscular diseases into three broad categories: immune-mediated disease, toxic/metabolic and congenital syndromes. (wikipedia.org)

The first relies on its mechanism of action, or how the action of the diseases affects normal functioning (whether it is through mutations in genes or more direct pathways such as poisoning). (wikipedia.org)
Charl believes we are witnessing the 'decade of the brain' with significant leaps in scientific understanding of disease pathways and genetic correlations. (pharmaphorum.com)
Neuroinflammation looks at the neuromuscular junction with inflammation where different pathways get expressed in different diseases and may cause dysfunctionality. (pharmaphorum.com)

They can affect either presynaptic mechanisms or postsynaptic mechanisms, preventing the junction from functioning normally. (wikipedia.org)
Besides nerve localization in the peripheral nervous system, it occurs in diseases of the presynaptic neuromuscular junction such as botulism and myasthenic syndrome. (medscape.com)

The diagnosis and care of a neuromuscular disorder can be challenging. (chihealth.com)
Malignant hyperthermia susceptibility is a genetic disorder involving a hypermetabolic response to volatile anesthetics and depolarizing neuromuscular blocking agents. (bvsalud.org)

With thousands of clinical trials to date, gene therapy is a flourishing strategy with great promise for the treatment of diseases impacting the nervous system. (frontiersin.org)
A change in an animal's ability to sense its environment can be caused by disease in either the central nervous system or the peripheral nervous system. (merckvetmanual.com)

Its use is supported by a series of randomized and controlled trials assessing diseases that affect the peripheral nerve, neuromuscular junction, and skeletal muscle. (nursingcenter.com)

Other diseases include the Lambert-Eaton syndrome and botulism. (wikipedia.org)
Predisposing factors for enteric botulism in children ≥ 1 year of age and in adults include previous bowel or gastric surgery, anatomic bowel abnormalities, Crohn disease, inflammatory bowel disease, antimicrobial therapy, and immunosuppressive medications. (merckmanuals.com)
Botulinum neurotoxins (BoNTs) are bacterial proteins that cause the life-threatening disease botulism 1 . (cdc.gov)
Foodborne botulism is a rare disease typically caused by consumption of improperly prepared and processed foods, including low-acid canned vegetables. (cdc.gov)

These antibodies cause loss of AChR numbers and function, and lead to failure of neuromuscular transmission with muscle weakness. (nih.gov)
The serum level of creatinine starts to decrease before the onset of muscle weakness, followed by the emergence of hand tremor, a prodromal sign of the disease. (kennedysdisease.org)
Nonetheless, the definition of ocular MG proposed by consensus is based on any ocular muscle weakness attributed to MG at a specified point in time and not dependent on the duration of disease. (medscape.com)
Based on a literature search in PubMed and the authors' own clinical experiences, we provide an overview focusing on the most frequently used drugs that may exacerbate weakness in patients with MG. In our experience, symptomatic MG-patients who have a generalised disease are especially vulnerable to drug-induced exacerbations, while stable MG patients with few symptoms more seldom are. (tidsskriftet.no)
Neuromuscular diseases affect nerves and muscles, and can cause sensory loss, weakness and even loss of muscle control. (chihealth.com)
In motor neuron diseases, nerve cells called motor neurons progressively lose function and cause weakness. (chihealth.com)

Development of a diagnostic framework for vestibular causes of dizziness and unsteadiness in patients with multisensory neurological disease: a Delphi consensus. (ucl.ac.uk)
Patients with Gaucher's disease also experience neurological symptoms that can not be treated by enzyme replacement or substrate reduction therapies because of their missing capacity to cross the blood-brain barrier. (neuroproof.com)
The providers at the CHI Health Neurological Institute understand that quality of life is important and that neuromuscular diseases can make every day things like walking, talking and breathing more difficult. (chihealth.com)
The Neurological Institute at CHI Health Immanuel offers routine clinic visits with our neuromuscular specialist to determine the best treatment options for each individual patient. (chihealth.com)

The complement system is a crucial component of innate immunity and is associated with pathogenesis of numerous diseases, including amyotrophic lateral sclerosis (ALS). (mdaconference.org)
Adducin at the neuromuscular junction in amyotrophic lateral sclerosis: hanging on for dear life. (sfu.ca)

These toxins inhibit the release of neurotransmitters at the neuromuscular junction by cleaving soluble NSF attachment protein receptor (SNARE) complex proteins in nerve cells, which prevents the fusion of neurotransmitter containing vesicles to cell membranes 2 . (cdc.gov)

Here we discuss how knowledge of neuromuscular junction structure and function has fed into understanding the mechanisms of AChR and MuSK antibodies. (healthweeks.com)
AChR antibodies are typically of the immunoglobulin (Ig)G1 and IgG3 (human) subclasses can lead to complement-mediated attack and being able to bind divalently to adjacent AChRs around the muscle surface can also increase the rate of AChR internalisation (for a review of the earlier history of MG research see 2 The resulting loss of AChRs at the neuromuscular junction (NMJ) impairs neuromuscular transmission (see Physique 1). (healthweeks.com)
outlined in 4 help define post-synaptic mechanisms in both AChR and MuSK antibody forms of the disease but models are required to study the effects of the antibodies around the Maraviroc electrophysiology of neuromuscular transmission. (healthweeks.com)
Our results indicate the involvement of MuSK antibodies in the pathogenesis of AChR-Ab-seronegative MG, thus defining two immunologically distinct forms of the disease. (nih.gov)

New GBA mutation-based disease models open opportunities for more physiologically adequate screening methods. (neuroproof.com)

When the nerve is usually electrically stimulated neuromuscular transmission can be detected as a brief rise in membrane potential called the endplate potential (EPP 5 Spontaneous miniature EPPs (mEPPs) which are much smaller in amplitude than the (evoked) EPP provide a measure of the response of the postsynaptic AChRs to release of a single synaptic vesicle-load (quantum) of acetylcholine. (healthweeks.com)
Muscles contain the synaptic connection between lower motor neurons and muscle fibers, i.e., the neuromuscular junction (NMJ), as well as specialized sensory nerve endings (e.g., muscle spindles). (frontiersin.org)
This neuromuscular junction plays an elementary role in transmitting nerve signals or impulses from the motor neuron to the muscle fiber that causes muscle contraction. (scopeheal.com)
Thus, we can say that the neuromuscular junction is associated with the motor neuron or nerve cell and muscle fiber. (scopeheal.com)

The human-on-a-chip neuromuscular system is an in vitro platform with superoxide dismutase (SOD1) (E100G) or TAR DNA binding protein (TDP-43) motoneurons derived from iPSCs and wild-type (WT) microglia separated by microtunnels from iPSC-derived SOD1 (E100G) skeletal muscle, Schwann cells, and THP-1 monocytes/macrophages. (mdaconference.org)
Glycogen storage disease type III (GSDIII) is a rare inborn error of metabolism affecting liver, skeletal muscle, and heart due to mutations of the AGL gene encoding for the glycogen debranching enzyme (GDE). (istem.eu)

In 2023, advancing research on rare and ultra-rare monogenic diseases requires the mobilization of significant human and technological resources. (istem.eu)

We obtained a comprehensive MCell model, which provides a detailed understanding of the relationship between AZ structural changes caused by LEMS, and the resulting functional disease state. (psc.edu)
In the new journal article, researchers from UCF and Cornell University describe a functional neuromuscular junction (NMJ) disease model comprising motoneurons derived from induced pluripotent stem cells (iPSCs) of ALS patients and wild type primary human muscle fibers housed in a compartmentalized chambered system. (neurosciencenews.com)
A functional mini-GDE transgene corrects impairment in models of glycogen storage disease type III. (istem.eu)
Cortical neurons derived from this disease cell line showed clear functional different activity patterns compared to a wild-type cell line. (neuroproof.com)
NeuroProof expands its human iPSC-derived functional disease models with GBA mutation cell lines. (neuroproof.com)

Animal studies also suggest that hyperactivation of Src, alteration of autophagy and a mitochondrial deficit underlie the neuromuscular degeneration in SBMA and provide alternative therapeutic targets. (kennedysdisease.org)

In this review, we discuss our current understanding of the contribution of NMJ dysfunction in SMA disease pathogenesis, and also provide an overview of therapies currently under preclinical and clinical development for treatment of SMA. (benthamscience.com)
She has been involved in clinical care, research, education and advocacy related to neuromuscular diseases for the past 15 years. (rochester.edu)
His focus is basic, translational, and clinical research on Huntington's Disease, as well as invertebrate neuromuscular junction research. (nih.gov)

She trained at Columbia University in mitochondrial diseases, then at Duke University where she completed her Neurology Residency and Neuromuscular/EMG Fellowships. (rochester.edu)

Neuromuscular disease genetics in underrepresented populations: increasing data diversity. (ucl.ac.uk)

Drugs may interfere with the neuromuscular transmission through several mechanisms, either by affecting pre- or postsynaptic ion channels or by affecting acetylcholinesterase. (tidsskriftet.no)
We are currently pursuing two different mechanisms to address that disease, a complement inhibitor and an anti-FcRn, that essentially aim to reduce inflammation and create normal functionality for MG patients. (pharmaphorum.com)
TDP-43 proteins play an essential role in the mechanisms of this severe disease. (neuroproof.com)

It is called the neuromuscular junction that occurs between the motor neuron and the muscle fiber. (scopeheal.com)

Kennedy's disease or spinal bulbar muscular atrophy is a rare, inherited and slowly progressive multisystem disease mostly manifesting with a motor neuron disease phenotype leading to disability. (kennedysdisease.org)

ALS is a progressive disease that damages nerves and over time causes the loss of muscle control and eventual death. (neurosciencenews.com)

Moreover, USP7 knockdown suppressed disease phenotypes in SBMA and spinocerebellar ataxia type 3 (SCA3) fly models, and monoallelic knockout of Usp7 ameliorated several motor deficiencies in transgenic SBMA mice. (kennedysdisease.org)
These observations suggest that the CIC-2 currents are affected in SBMA, an alteration that may contribute and potentially determine the pathophysiology of the disease. (kennedysdisease.org)

Assessing neuromuscular transmission. (healthweeks.com)

Detection of in situ protein-protein complexes at the Drosophila larval neuromuscular junction using proximity ligation assay. (sfu.ca)

Dr. Ciafaloni is a Professor of Neurology and Pediatrics who specializes in the diagnosis and treatment of Neuromuscular Diseases in adults and children. (rochester.edu)

To our knowledge, this is the first study to demonstrate that while different ALS mutations display various phenotypes, all have the common point-of-origin deficit at the NMJ for each mutation, which is useful for not only the familial form of the disease but potentially sporadic as well" said Hickman. (neurosciencenews.com)
Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN. (istem.eu)
GBA mutations with relevance in Gaucher's and Parkinson's disease. (neuroproof.com)
GBA mutations of the glucocerebrosidase enzyme (GCase) are responsible for Gaucher's disease but are also relevant in Parkinson's disease. (neuroproof.com)
Heterozygous and homozygous mutations cause different symptoms and severity of diseases. (neuroproof.com)

Upregulation of complement proteins in ALS rodent models has been linked to neuroinflammation, although the contribution of disease progression is still unclear. (mdaconference.org)

For more detailed, up-to-date information about a specific disease, visit the Muscular Dystrophy Association's disease information centers . (globalgenes.org)

This study using a human-on-a-chip model is anticipated to generate the earliest evidence that modulating C3 has a role in ALS disease progression. (mdaconference.org)
Evaluation of muscle and fat using MRI, in addition to biochemical indices such as serum creatinine level, are promising biomarkers to track the disease progression. (kennedysdisease.org)
During your visit, you will be evaluated by our team and they work together to identify the areas that need to be addressed to maximize quality of life and independence throughout the continuum of disease progression. (chihealth.com)

We have used a combination of electrophysiological recording and MCell computer simulations to examine structure-function relationships, the disease LEMS, and novel LEMS treatment strategies. (psc.edu)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Between 12,000-15,000 people in the nation are diagnosed with ALS with about 5,000 new cases every year, according to the Centers for Disease Control and Prevention. (neurosciencenews.com)
The centers also include a collection of current news articles and other content on the MDA website relating to each disease. (globalgenes.org)
1 Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341. (cdc.gov)
2 Battelle Memorial Institute under contract for Centers for Disease Control and Prevention, Atlanta, Georgia, 30341. (cdc.gov)

citation needed] The second classification method divides the diseases according to the location of their disruption. (wikipedia.org)

She is Co-Director of the MDA Neuromuscular Clinic and Program Director of the ACGME Accredited Neuromuscular Medicine Fellowship Program. (rochester.edu)

Diabetes Mellitus in Dogs and Cats Diabetes mellitus is a common endocrine disease in dogs and cats, occurring in about 1 of every 300 patients. (merckvetmanual.com)
[ 9 ] Hence, patients who keep having strictly ocular symptoms for 3 or more years are unlikely to revert to the generalized aspect of the disease. (medscape.com)
About 50% of patients present solely with ocular symptoms, and about 50-60% of these patients will progress to develop generalized disease. (medscape.com)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
To support the wide range of patients this complex disease impacts, who suffer from a diverse range of symptoms, it is critical that research into this area continues. (pharmaphorum.com)
Phenotypic screening of human iPSC-derived motor neurons from patients with familial history is an excellent opportunity for screening new therapies for this severe disease. (neuroproof.com)
More than 10% of patients with Parkinson's disease carry a GBA mutation. (neuroproof.com)

With its 20-plus year legacy in creating an understanding of this complex disease and the heterogeneous population it affects, UCB went from an initial focus on arresting the symptoms to stopping seizures from happening altogether. (pharmaphorum.com)
It's really important that people have access to a wide spectrum of therapies, from treating emergencies to relieving symptoms like reducing seizure frequency, to addressing the root cause of the disease. (pharmaphorum.com)
Treatment will depend on your type of neuromuscular disease and what symptoms you are experiencing. (chihealth.com)

In vertebrates, the neuromuscular junction is always excitatory, therefore to stop contraction of the muscle, inhibition must occur at the level of the efferent motor neuron. (wikipedia.org)
In this study, the power spectral density of simulated data which contain neuromuscular diseases and normal motor unit (i.e. control group) scenarios was calculated using Welch's method. (arel.edu.tr)

Neuroproof can now deliver screening services with human iPSC-derived glutamatergic neuron disease models, starting with a GBA null/null mutation and others following soon. (neuroproof.com)

Some genetic diseases cause the neurons to degenerate slowly and irreversibly in the first year of life. (merckvetmanual.com)

It is important to identify the correct subset of the disease and to use the therapy appropriate for that subset. (medscape.com)

Anatomy3

Organisms1

Diseases1

Chemicals and Drugs1

Myasthenia17

Disorders11

Synapse11

Autoimmune6

Lambert-Eaton My2

Myasthenic Syndromes2

Myopathy2

Synapses6

Syndromes1

Pathways3

Presynaptic2

Disorder2

Nervous system2

Peripheral nerve1

Botulism4

Weakness6

Neurological4

Amyotrophic2

Toxins1

Antibodies4

Physiologically1

Nerve4

Skeletal2

20231

Functional5

Degeneration1

Clinical3

Mitochondrial diseases1

Genetics1

Mechanisms3

Muscle fiber1

Bulbar muscular atrophy1

Nerves1

SBMA2

Transmission1

Assay1

Neurology1

Mutations5

Neuroinflammation1

Muscular dystrophy1

Progression3

LEMS1

Centers6

Classification1

Clinic1

Patients7

Symptoms3

Motor2

Neuron1

Genetic diseases1

Subset1