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  • clinical
  • Nondepolarizing neuromuscular blocking drugs in the intensive care unit: a clinical review. (springer.com)
  • Obligate Acceleromyography and Pharmacologic Reversal of All Neuromuscular Blocking Agents: Really, and Where Is the Clinical Outcome? (asahq.org)
  • Recovery is a composite of dissipation of the clinical effects of all anesthetic agents, as well as the imposition of the surgical events: Indeed, frequently patients remain intubated because of surgical trespass, narcotics, sedatives, or preoperative/perioperative infirmity. (asahq.org)
  • The discovery program initiated by Singh initially led to the synthesis of the bis-quaternary non-depolarizing agent HS-342 (4,17a-dimethyl-4,17a-diaza-D-homo-5α-androstane dimethiodide) that was equipotent with tubocurarine and with one-third its duration of action, but not suitable for further clinical evaluation. (wikipedia.org)
  • Unfortunately, upon further preclinical evaluation in the cat and isolated preparations, HS-626 demonstrated a slightly more desirable neuromuscular blocking profile than that of candocuronium, but its overall improvement was insufficient to warrant advancement to clinical testing. (wikipedia.org)
  • The Marshall group then explored other modifications at the 3- and 16-positions of the androstane nucleus, but the work has not yet yielded an agent worthy of expanded evaluation to clinical testing in this azasteroidal class of neuromuscular blocking agents. (wikipedia.org)
  • Reversal Agent
  • MALVERN, PA, July 2017 - Recro Pharma, Inc. (Nasdaq:REPH), a revenue generating specialty pharmaceutical company focused on therapeutics for hospital and other acute care settings, today announced the acquisition of exclusive global rights to two novel neuromuscular blocking agents (NMBs) and a proprietary chemical reversal agent from Cornell University. (recropharma.com)
  • postoperative
  • Among patients who receive these agents, nonreversal is associated with an increased risk of postoperative pneumonia. (asahq.org)
  • compounds
  • Mivacurium belongs to a class of compounds that is commonly and most erroneously referred to as "benzylisoquinolines" when, in fact, it is a bisbenzyltetrahydroisoquinolinium agent, often abbreviated to bbTHIQ. (wikipedia.org)
  • patients
  • Sedative and neuromuscular blocking drug use in critically ill patients with head injuries. (springer.com)
  • an order to 'continue same meds' upon transfer from a critical care unit has led to continued use (sometimes fatal) of neuromuscular blocking agents for restless, but extubated patients. (thefreedictionary.com)
  • No patient was examined prior to use of NMB for preexistent abnormalities, and it does not appear that any of the study patients required or were given reversal agents, despite the "findings" of residual NMB. (asahq.org)
  • A great deal of neuromuscular and pharmacokinetic reserve is evident in many healthy, muscular patients yet not evident in debilitated geriatric patients, who will need complete reversal. (asahq.org)
  • We look forward to working with Recro Pharma Inc. to commercialize a series of proprietary neuromuscular blocking agents that may benefit patients and the medical community," said Dr. Brian Kelly, the Director of Cornell's Center for Technology Licensing at Cornell University. (recropharma.com)
  • proprietary
  • The replacement of both the N-methyl groups with N-allyl moieties yielded N,N-diallyl-bis-nortoxiferine, now recognized as alcuronium (and at one time marketed as the proprietary agent called Alloferin). (wikipedia.org)
  • Nimbex
  • By the time of its approval for human use, in 1995, by the US Food and Drug Administration, Burroughs Wellcome Co. had merged with Glaxo Inc., and cisatracurium was approved to be marketed as Nimbex by GlaxoWellcome Inc. The trade name "Nimbex" was derived from inserting an "i" to the original proposal "Nmbex," which stood for excellent Neuromuscular blocker. (wikipedia.org)
  • e.g., cisatracurium (Nimbex) is one such agent that does not elicit histamine release even up to 5xED95 doses. (wikipedia.org)
  • acute
  • These novel agents may meaningfully reduce the patient's post-procedure time in the operating room or post-acute care unit and could provide valuable cost savings to hospitals and ambulatory surgical centers. (recropharma.com)
  • citation needed
  • citation needed] Most commonly, the histamine release following administration of these agents is associated with observable cutaneous flushing (facial face and arms, commonly), hypotension and a consequent reflex tachycardia. (wikipedia.org)
  • medications
  • Less common causes include: physical factors, biological agents such as semen, latex, hormonal changes, food additives such as monosodium glutamate and food colors, and topical medications. (wikipedia.org)