• neurons
  • 2008 Sep;295(3):C679-91 Like Substance P [SP], Neurokinin A is present in excitatory neurons and secretory cells of the hypothalamic-pituitary-adrenal axis. (wikipedia.org)
  • It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI. (curehunter.com)
  • Third, in contrast to intradermal capsaicin injections, light, dynamic mechanical stimuli applied under disinhibition did not produce neurokinin 1 (NK1) receptor internalization in dorsal horn neurons. (jneurosci.org)
  • Recent studies from our group and others point out Kiss1 neurons in the ARC as the plausible generator of GnRH pulses through a system of pulsatile kisspeptin release shaped by the coordinated action of neurokinin B (NKB) and dynorphin A (Dyn) that are co-expressed in Kiss1 neurons (so-called KNDy neurons). (harvard.edu)
  • Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. (wikipedia.org)
  • secretion
  • Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone. (wikipedia.org)
  • Studies have shown that stress-induced activation of the noradrenergic prefrontal lobe system may be under the control of both endogenously released corticotrophin-releasing hormone and SP and neurokinin A. This study directly links the secretion of neurokinin A and SP to certain forms of depression characterized by the corticoid receptor hypothesis of depression. (wikipedia.org)
  • dynorphin
  • Neurokinin b is expressed along with the peptides kisspeptin and dynorphin A in the neuronal cells of the arcuate nucleus. (wikipedia.org)
  • A review of neurokinin B and its sister peptides, kisspeptin and dynorphin, in sheep found that these KNDy cell groups (kisspeptin, neurokinin B, dynorphin), are in direct contact with the GnRH neuronal bodies in both the preoptic area and the mediobasal hypothalamus. (wikipedia.org)
  • Due to the high percentage of co-localization found with neurokinin B cell bodies and receptor groups, it is suggested that Neurokinin b along with kisspeptin and dynorphin play a role in the release of GnRH. (wikipedia.org)
  • tissues
  • Inflammation, tissue healing and cell proliferation have been linked to both SP and neurokinin A release into surrounding tissues. (wikipedia.org)
  • Neurokinin A was shown to be a potent chemo attractor for T-cells increasing the migration into infected tissues. (wikipedia.org)
  • inflammatory
  • Additionally both SP neurokinin A is found in the neurosensory system and modulates a wide range of inflammatory and tissue repairing processes . (wikipedia.org)
  • Neurokinin A has been associated with the chemokines interleukin-1 and interleukin-6, both of which are heavily involved in the inflammatory process during infections. (wikipedia.org)
  • amino
  • The deduced amino acid sequence of neurokinin A is as follows: His Lys Asp Ser Phe Val Gly Leu Met (HKTDSFVGLM) with amidation at the C-terminus. (wikipedia.org)
  • role
  • Role of neurokinin B in the control of female puberty and its modulation by metabolic status. (nih.gov)