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  • stimulates neurogenesis
  • Despite a lack of direct evidence for this, the findings have opened up an avenue for the development of new treatments for depression: earlier this year, for example, a company in San Diego began a clinical trial to test the efficacy of a compound which stimulates neurogenesis . (scienceblogs.com)
  • regulation
  • QIAGEN provides a broad range of assay technologies for neurogenesis research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • The molecular and genetic factors influencing neurogenesis notably include the Notch signaling pathway, and many genes have been linked to Notch pathway regulation. (wikipedia.org)
  • antidepressants
  • Others have demonstrated that the beneficial effects of some antidepressants are blocked when neurogenesis is prevented. (bioedonline.org)
  • As well as showing that the effectiveness of antidepressants is indeed dependent on their ability to stimulate neurogenesis, the findings may also begin to shed light on why a large proportion of depressed patients do not respond to medication. (scienceblogs.com)
  • pathway
  • GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. (wikipedia.org)
  • cognitive
  • This might sound somehow counterintuitive, since one would expect that increased neurogenesis may lead to improved cognitive functions. (plos.org)
  • functional
  • Although the functional significance of abnormal neurogenesis in these and other medical conditions is not yet understood, it is an intense area of research that may one day yield new treatments for these disorders. (bioedonline.org)
  • This page discusses the methods utilized in studying adult neurogenesis, the pros and cons of presently used animal models of this research, and the possible functional roles it plays in humans. (wikipedia.org)
  • response
  • Extensive research has been implemented in several classical animal models to further the understanding of neurogenesis, particularly in response to damage. (wikipedia.org)
  • reduction
  • These and other observations suggest that a reduction of neurogenesis could be an underlying cause of depression. (bioedonline.org)
  • Suga and Wasterlain, 1980 ) demonstrated a reduction of cell number with seizures during early development, suggesting that neonatal seizures may result in a reduction rather than an increase in neurogenesis. (jneurosci.org)