Neuroectodermal tumors primitive peripheral. Medical search. Frequent questions

Primitive neuroectodermal tumors (PNET) are neoplasms of which medulloblastoma is the prototype. (medscape.com)
PNET of the CNS can be divided grossly into infratentorial tumors (medulloblastoma or iPNET) and supratentorial tumors (sPNET). (medscape.com)
Neuroblastoma (NB) and the Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumor (PNET) family are pediatric cancers derived from neural crest cells. (nih.gov)
PNET belongs to the Ewing family of tumors. (wikipedia.org)
additional citation(s) needed] It is classified into two types, based on location in the body: peripheral PNET and CNS PNET. (wikipedia.org)
citation needed] The peripheral PNET (pPNET) is now thought to be virtually identical to Ewing sarcoma: "Current evidence indicates that both Ewing's sarcoma and PNET have a similar neural phenotype and, because they share an identical chromosome translocation, they should be viewed as the same tumor, differing only in their degree of neural differentiation. (wikipedia.org)
After the diagnosis of a CNS PNET is confirmed, management includes neoadjuvant chemotherapy and radiation (to reduce tumor size burden), complete surgical resection with confirmed negative margins, and/or additional adjuvant post-surgical chemotherapy. (wikipedia.org)
[ 4 ] An association exists between Ewing sarcoma and primitive peripheral neuroectodermal tumor (PNET). (medscape.com)
The patient was diagnosed with primitive neuroectodermal tumor (PNET). (jbjs.org)
Ewing's sarcoma / Peripheral Primitive Neuroectodermal Tumors (PNET) of bone is a type of cancer usually found in children and young adults. (heartdiseasepreventioninstitute.org)
Extraskeletal Ewing sarcoma/Primitive neuroectodermal tumor (PNET) is an aggressive small round blue cell tumor seen primarily in adolescents and young adults. (cap.org)

A type of pPNET found in the chest is called Askin tumor. (medlineplus.gov)
It was also under development for the treatment of non-small cell lung cancer, lung adenocarcinoma, recurrent malignant glioma, liver fibrosis, endometrial cancer (monotherapy), melanoma and recurrent glioblastoma, metastatic melanoma, peripheral primitive neuroectodermal tumor (pPNET) and non-small cell lung cancer (third-line, monotherapy). (globaldata.com)

Most peripheral primitive neuroectodermal tumors (pPNETs) manifest in the thoracopulmonary region (Askin tumor), pelvis, abdomen, and extremities. (medscape.com)
Peripheral PNETs that start in the chest wall are known as Askin tumors . (cancer.org)
There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor, and Askin tumor. (medlineplus.gov)
Ewing sarcoma has also been called peripheral primitive neuroectodermal tumor, Askin tumor (Ewing sarcoma of the chest wall), extraosseous Ewing sarcoma (Ewing sarcoma in tissue other than bone), and Ewing sarcoma family of tumors . (vicc.org)
The malignant tumour known as Ewing's sarcoma, also referred to as peripheral primitive neuroectodermal tumour, Askin tumour, extraosseous Ewing sarcoma, and Ewing sarcoma family of tumours, typically develops in a bone. (beststockmarketnews.com)

Ewing's sarcoma or peripheral primitive neuroectodermal tumor. (knowcancer.com)
Tumors that demonstrate neural differentiation by light microscopy, immunohistochemistry, or electron microscopy have been traditionally labeled PNETs, and those that are undifferentiated by these analyses have been diagnosed as Ewing's sarcoma. (wikipedia.org)
Ewing's sarcoma is a poorly characterized malignant tumor with a relatively uniform histologic appearance, made up of densely packed small cells with round to oval nuclei, without distinct cell borders and without any structural differentiation. (korea.ac.kr)
More than 85% of Ewing's sarcoma and peripheral neuroectodermal tumor present a specific t(11;22)(q24;q12) balanced translocation, resulting in the production of a novel chimerical EWS/FLI-1 message. (korea.ac.kr)
Peripheral primitive neuroectodermal tumor is a rare group of tumors belonging to the Ewing's family of tumors. (bmj.com)

Further advances in immunohistochemical analyses have helped further distinguish PNETs and Ewing family of tumors (EFTs) from other small, round, poorly differentiated tumors, including rhabdomyosarcoma, neuroblastoma, and lymphoma. (medscape.com)

Ewing sarcoma, however, is more common in bone, while peripheral primitive neuroectodermal tumors (pPNETs) are more common in soft tissues. (medscape.com)
Ewing sarcoma that starts in a bone is the most common tumor in this family. (cancer.org)
The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. (nih.gov)
Mutations involving the EWSR1 gene can cause a type of cancerous tumor known as Ewing sarcoma. (medlineplus.gov)
Translocations involving the EWSR1 gene are involved in many types of soft tissue sarcoma, which are cancers that cause tumors in soft tissues such as fat, muscles, and nerves. (medlineplus.gov)
The EWSR1/WT1 fusion gene causes desmoplastic small round cell tumor, a type of soft tissue sarcoma that often occurs in the abdomen. (medlineplus.gov)
Ewing sarcoma is a highly malignant primary bone tumor that is derived from red bone marrow. (medscape.com)
The 2 most common malignant bone tumors in children are osteosarcoma and Ewing sarcoma. (medscape.com)
Ewing sarcoma accounts for approximately 5% of biopsy-analyzed bone tumors and approximately 33% of primary bone tumors. (medscape.com)
Radiograph of Ewing sarcoma of the os naviculare, a rare location for the tumor. (medscape.com)
No single morphologic or functional imaging method provides findings for a specific diagnosis of Ewing sarcoma, but the results do contribute to tumor staging. (medscape.com)
Because the clinical symptoms of Ewing sarcoma are nonspecific and because they frequently mimic osteomyelitis or other malignant tumors, such as leukemia, an initial conventional radiographic and/or magnetic resonance imaging (MRI) examination is performed. (medscape.com)
Although plain radiographs may show typical signs of Ewing sarcoma, MRI provides more accurate information about tumor size. (medscape.com)
Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. (medlineplus.gov)
These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. (medlineplus.gov)
Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. (medlineplus.gov)
Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. (medlineplus.gov)
Ewing sarcoma accounts for about 1.5 percent of all childhood cancers, and it is the second most common type of bone tumor in children (the most common type of bone cancer is called osteosarcoma). (medlineplus.gov)
These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA . (nih.gov)
Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma with poor prognosis due to their complex genetic changes, invasive growth, and insensitivity to chemo- and radiotherapies. (oncotarget.com)
Ewing sarcoma is a type of tumor that forms in bone or soft tissue. (vicc.org)
To diagnose round cell sarcoma, the tumor cells are checked for this gene change. (vicc.org)
Signs and symptoms of Ewing sarcoma include swelling and pain near the tumor. (vicc.org)
The American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 8th edition: For osteosarcoma, chondrosarcoma, and Ewing sarcoma, staging is based on distinct tumor category, histologic grade, size, nodal involvement, and metastases (TNM classification). (msdmanuals.com)
This is followed by Ewing sarcoma primitive neuroectodermal tumors of bone and chondrosarcoma. (journalmeddbu.com)
1 ] Ewing sarcoma includes atypical Ewing sarcoma and peripheral primitive neuroectodermal tumor. (journalmeddbu.com)
Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1-0.2% of all prostatic cancers. (biomedcentral.com)
Although the biological characteristics of this rare tumor have not yet been elucidated, these findings suggest prostatic stromal sarcoma can potentially show neuroectodermal differentiation. (biomedcentral.com)
In this article, prostatic stromal sarcoma has potentially neuroectodermal characteristics. (biomedcentral.com)
To gain insight into the role of the CXCR4-CXCL12 axis in Ewing sarcoma, CXCR4, CXCL12 and hypoxia-inducible factor-1α protein expression was studied in therapy-naïve and metastatic tumors by immunohistochemistry. (biomedcentral.com)
A role for the CXCR4-CXCL12 axis in Ewing sarcoma growth was suggested by our observations that i) CXCR4 expression correlated positively with tumor volume at diagnosis (p = 0.013), ii) CXCL12 was present within the microenvironment of virtually all cases, iii) CXCL12 induced proliferation of CXCR4-positive Ewing sarcoma cell lines, which could be abrogated by AMD3100. (biomedcentral.com)

Primitive neuroectodermal tumors (PNETs) are a group of highly malignant tumors composed of small round cells of neuroectodermal origin that affect soft tissue and bone. (medscape.com)
This type of tumor was first described by Dr. James Ewing in 1921, who found it was different from the more common bone tumor, osteosarcoma . (cancer.org)
[ 2 ] This disease is the second most common malignant bone tumor in young patients, and it is the most lethal bone tumor. (medscape.com)
This image demonstrates the tumor is primarily confined to the bone, with a small periosteal fraction. (medscape.com)
Some preliminary results in bone tumors suggest that FDG kinetics are modulated by the expression of chemoresistant genes MDR1 and MRP . (medscape.com)
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. (nih.gov)
This type of bone tumor usually forms in the pelvis, arms, or legs. (vicc.org)
Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)
Overview of Bone and Joint Tumors Bone tumors may be benign or malignant. (msdmanuals.com)
The Musculoskeletal Tumor Society (MSTS) staging system: Used by orthopedic oncology surgeons based on histologic grade (eg, Stage I-low-grade histology and Stage II-high-grade histology, whether the tumor is contained entirely within the bone (A) or has broken outside of the cortex into surrounding soft tissue (B), and metastases Stage III). (msdmanuals.com)
Even if multiple myeloma is considered a hematologic tumor, the identified skeletal abnormality must be differentiated from other bone tumors. (msdmanuals.com)
Tumor development and progression is usually multicentric and often involves the bone marrow so diffusely that bone marrow aspiration is diagnostic. (msdmanuals.com)
Osteosarcoma is the most common malignant primary bone tumor (if one considers myeloma a marrow cell tumor and not a primary bone tumor) and is highly malignant. (msdmanuals.com)
Primary malignant bone tumors constitute a very small part of adult cancers. (journalmeddbu.com)
However, osteosarcomas constitute approximately half of all malignant bone tumors in ages between 15 to 29 years. (journalmeddbu.com)
In this article, we aimed to discuss factors affecting the development of malignant bone tumors. (journalmeddbu.com)
Primary malignant bone tumors comprise 3% of all cancers in adolescents and young adults. (journalmeddbu.com)
Osteosarcomas account for 48% of all malignant bone tumors between the ages 15-29. (journalmeddbu.com)

some are malignant primary tumors (eg, osteosarcoma. (msdmanuals.com)
Osteosarcoma is a tumor that produces osteoid. (journalmeddbu.com)

They account for 4-17% of all pediatric soft tissue tumors. (medscape.com)
Mueller S, Chang S. Pediatric brain tumors: current treatment strategies and future therapeutic approaches. (medscape.com)
12. Remaining problems and controversies in the management of childhood head and neck soft tissue sarcomas: Retrospective (national) Multicenter Study of the Polish Pediatric Solid Tumors Group. (nih.gov)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors , non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. (ucbraid.org)
To utilize clinical and biological data to screen for eligibility to phase 2 pathway-targeting specific subprotocols of pathway-targeting agents in pediatric patients with advanced solid tumors, non-Hodgkin lymphomas, and histiocytic disorders . (ucbraid.org)
To determine the proportion of pediatric patients whose advanced tumors have pathway alterations that can be targeted by select anti-cancer drugs. (ucbraid.org)
complete response + partial response) in pediatric patients with advanced solid tumors, non-Hodgkin lymphomas, and histiocytic disorders harboring a priori specified genomic alterations treated with pathway-targeting agents. (ucbraid.org)
To estimate the progression free survival in pediatric patients receiving targeted therapies for advanced solid tumors, non-Hodgkin lymphomas, and histiocytic disorders. (ucbraid.org)
To increase knowledge of the genomic landscape of advanced pediatric solid tumors , non-Hodgkin lymphomas, and histiocytic disorders. (ucbraid.org)
To describe the genomic changes that occur in advanced pediatric cancers between the time of initial diagnosis and relapse, in cases for which paired tumor specimens are available. (ucbraid.org)
To explore approaches to diagnosing and profiling genomics of advanced pediatric cancers through evaluation of circulating tumor deoxyribonucleic acid (DNA). (ucbraid.org)
Astrocytomas of the spinal cord are rare tumors that arise from astrocytes in the spinal cord and occur in both adult and pediatric populations. (medscape.com)

Extraosseous Ewing tumors start in soft tissues around bones, but they look and act very much like Ewing sarcomas in bones. (cancer.org)
Extraosseous Ewing tumors can occur almost anywhere. (cancer.org)

This has made classifying this family of tumors challenging and controversial. (medscape.com)
peripheral primitive neuroectodermal tumors (pPNETs) and Ewing family of tumors (EFTs) are often referred to interchangeably in the literature. (medscape.com)
[ 3 ] Generally, Ewing family of tumors (EFTs) and peripheral primitive neuroectodermal tumors (pPNETs) represent different manifestations of the same tumor and have similar genetic alterations. (medscape.com)
Although peripheral primitive neuroectodermal tumors (pPNETs) are exceedingly rare, the annual incidence of tumors from the larger Ewing family of tumors (EFTs) from birth to age 20 years is 2.9 per million population. (medscape.com)
What Is the Ewing Family of Tumors? (cancer.org)
This information focuses on the Ewing family of tumors in children and teens, but most of the content here (including much of the treatment information) applies to Ewing tumors in adults as well. (cancer.org)
Medulloblastoma Ependymoma Ewing family of tumors "primitive neuroectodermal tumor" at Dorland's Medical Dictionary Smoll, N. R. (2012). (wikipedia.org)

It is also under development for solid tumors in combination with pembrolizumab and for advanced or metastatic non clear cell renal cell carcinoma who have not received any chemotherapy for advanced disease. (globaldata.com)
She developed recurrence of the tumor within a month and is now on chemotherapy. (bmj.com)
It is important to recognize this entity in the head and neck region because the main stay of treatment is wide excision of the primary tumor and not chemotherapy or regional node dissection. (ijpmonline.org)

Ewing tumors (also known as Ewing sarcomas ) are a group of cancers that start in the bones or nearby soft tissues and share some common features. (cancer.org)
Selpercatinib exerts anti-tumour activity in specific cancers through inhibition of mutated forms of RET tyrosine kinases. (drugbank.com)

Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation , and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas. (ucbraid.org)

Primitive neuroectodermal tumors (PNETs) exhibit great diversity in their clinical manifestations and pathologic similarities with other small round cell tumors. (medscape.com)
Stout first described PNETs in 1918, and these tumors were thought to arise directly from nerves. (medscape.com)
Smoll NR. Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs). (medscape.com)
The PNETs were histologically indistinguishable from the human counterparts and have been used to identify new genes involved in human brain tumor carcinogenesis. (wikipedia.org)

These are small cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (medscape.com)
Initially, these dense, cellular, embryonal tumors were thought to have a common origin from primitive neuroectodermal cells and to differ only in their location, type, and degree of differentiation. (medscape.com)
In the revised World Health Organization (WHO) classification, however, many of these tumors are given a separate niche on the basis of the assumption that these embryonal tumors also could arise from cells already committed to differentiation. (medscape.com)
A la I Conferència i Taller Internacional sobre diferenciació dels antígens leucocitaris humans , celebrada a París el 1982, fou aprovada la terminologia CD (cúmul o grup de diferenciació [18] o cluster of differentiation en anglès). (wikipedia.org)
These genes regulate cell growth and differentiation and prevent tumor-specific uncontrolled proliferation. (journalmeddbu.com)
There has not yet been a clear differentiation between PSS and STUMP due to the rarity of these tumors. (biomedcentral.com)

In contrast, only 1% of brain tumors in adults are medulloblastomas. (medscape.com)
The Swedish Cancer Registry reported, as part of a population-based study, that medulloblastomas represented 21% of all primary brain tumors in children. (medscape.com)
The incidence of medulloblastomas and primitive neurectodermal tumours in adults and children. (medscape.com)
The model was used to confirm p53 as one of the genes involved in human medulloblastomas, but since only about 10% of the human tumors showed mutations in that gene, the model can be used to identify the other binding partners of SV40 Large T- antigen, other than p53. (wikipedia.org)

Translocations that fuse the EWSR1 gene with other genes that are related to the FLI1 gene can also cause these types of tumors, although these alternative translocations are relatively uncommon. (medlineplus.gov)
These other genes, sometimes referred to as fusion partners, seem to determine the type of tumor that develops. (medlineplus.gov)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
While they are normally regulated by other genes, including tumor suppressor genes, proto-oncogenes can be activated to become oncogenes that are less sensitive to this regulation. (medscape.com)
However, the cancer driver genes located on it remain largely unknown, except the tumor suppressor gene, p16 (INK4)/CDKN2A . (oncotarget.com)
Rather than mutation of a single gene, injury to more than one gene at once (genes that increase cell count, oncogens, tumor preventing genes, and DNA repairing genes) play a role in cancer development. (journalmeddbu.com)
Another potential mechanism of carcinogenesis is loss of tumor suppressor genes and their inactivation. (journalmeddbu.com)
3 ] Mutation of various tumor suppressor genes play a role in syndromes such as hereditary retinoblastoma, Li-Fraumeni syndrome, Rothmund-Thomson syndrome, Bloom syndrome, and Werner syndrome (adult progeria). (journalmeddbu.com)
Tumor suppressor genes account for one portion of these and the p53 gene is one of them. (journalmeddbu.com)
As they lose activity due to mutations, increased risk of development of osteosarcomas and many other tumors usually manifest as osteosarcomas and soft tissue sarcomas due to abnormalities in the p53 and MDM2 genes. (journalmeddbu.com)
6 ] Tumor suppressor genes are sensitive to DNA injury and play a role as a physiological barrier in organisms. (journalmeddbu.com)
Genetic tests look at the unique genetic material (genes) of patients' tumor cells. (ucbraid.org)

Gross identification of prostatic carcinoma is often difficult, especially in small tumors. (cap.org)
Microscopically, this tumor mimicked a poorly differentiated carcinoma which is more common at this site though the patient was young for this type of tumor. (ijpmonline.org)

Medulloblastoma represents the most common type of primary solid malignant brain tumor in children (as many as 30% of all solid brain tumors). (medscape.com)
Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. (wikipedia.org)
Mouse cell line derived from mouse brain tumor. (3qbio.com)

It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. (elsevier.com)

Whereas CXCR4 was predominantly expressed by tumor cells, CXCL12 was observed in both tumor and stromal areas. (biomedcentral.com)

A translocation that creates the EWSR1/NR4A3 fusion gene causes extraskeletal myxoid chondrosarcoma, which is a rare type of soft tissue tumor that usually occurs in the lower body, such as the thighs or buttocks. (medlineplus.gov)

Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. (elsevier.com)

10. Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999. (nih.gov)
mus, have exhibited equipotent activity to inhibit ki- nase activity of mammalian target of rapamycin (mTOR), a key mediator of phosphoinositide 3-kinase signal transduction.7 Inhibition of mTOR leads to arrest of cells in the G1 phase of the cell cycle, which may in turn delay time to tumor progression or recurrence. (hormonessignaling.com)

STEP 1 (SCREENING): Patients undergo biopsy along with tumor mutational screening of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. (ucbraid.org)

Participants may be invited to join focus groups for people with the same diagnosis of rare tumors. (nih.gov)
Cohort 1: Participants with a diagnosis of a rare solid tumor (fewer than 15 cases in 100,000 people per year). (nih.gov)
The tumor will then need to be biopsied to confirm the diagnosis. (wikipedia.org)
The described nested RT-PCR method as another supportive diagnostic method enables pathologists to differentiate small blue cell tumors not only to make correct diagnosis but also to investigate retrospective archival tumor samples, using formalin fixed paraffin embedded tissue as a source of RNA. (korea.ac.kr)

Typical and atypical scoliotic curvatures can be seen in patients with a spinal cord tumor. (medscape.com)

The tumor is composed of nests and sheets of epithelioid cells with prominent nucleoli. (cap.org)

Natural killer (NK) cells are the main cytotoxic effector cells of the innate immune system, contributing to host anti-microbial and anti-tumour immune responses. (biomedcentral.com)

Researchers want to study these changes in biological samples from people with rare tumors in order to learn more about how these tumors develop. (nih.gov)
People who have a rare tumor, a family history of a rare tumor, a hereditary cancer syndrome, or a mutation that leads to rare tumors. (nih.gov)

3. Malignant and metastatic tumors of the hand. (nih.gov)

Our anesthetic goals were to maintain a deep anesthetic plane with stable hemodynamics, facilitate intraoperative neuromonitoring, manage catecholamine surges during anesthetic induction, tumor resection, and manage perioperative massive blood loss. (ruralneuropractice.com)

PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)

[1] Molecular studies for translocations in soft tissue tumors reveal that SS can present in varied sites with varied histologic patterns. (ijpmonline.org)

A phase I trial of docetaxel was performed to determine the maximum-tolerated dose (MTD), the dose-limiting toxicities, and the incidence and severity of other toxicities in children with refractory solid tumors. (nih.gov)

Histology revealed a polypoid, high grade tumor infiltrating the muscle. (ijpmonline.org)

[ 9 ] Of note, these tumors are rare in African American children and children of Asian descent, with most worldwide cases occurring in white and Hispanic children and adolescents. (medscape.com)
[ 1 ] This tumor is most frequently observed in children and adolescents aged 4-15 years and rarely develops in adults older than 30 years. (medscape.com)

Primitive neuroectodermal tumor is a malignant (cancerous) neural crest tumor. (wikipedia.org)

There were multiple areas of tumor necrosis as well as focally associated dystrophic calcification. (jbjs.org)
The H&E-stained section shows areas of tumor with nested to sheet-like growth and focal gland formation, with suggestion of cribriform pattern in areas. (cap.org)

Pheochromocytoma (PCC) is a rare neuroectodermal tumor arising from chromaffin cells in the adrenal medulla with an incidence of 2 to 8 per million. (ruralneuropractice.com)

A procedure that makes a series of detailed pictures of areas inside the body, such as the area where the tumor formed or the chest, taken from different angles. (vicc.org)
Ghattas TN, Lucas G. Peripheral primitive neuroectodermal tumor of the chest wall in a neonate: a case report. (jbjs.org)

The mutations that cause these tumors are acquired during a person's lifetime and are present only in the tumor cells. (medlineplus.gov)
To determine the frequency and spectrum of germline cancer susceptibility mutations in children with relapsed solid tumors and non-Hodgkin lymphomas and assess the feasibility of return of those results in the National Clinical Trial Network (NCTN) group setting. (ucbraid.org)

The latter occur rarely (25:1) and are more common in young adults than infratentorial tumors. (medscape.com)
It is a rare tumor, usually occurring in children and young adults under 25 years of age. (wikipedia.org)

Anatomy17

Organisms2

Diseases46

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes22

Disciplines and Occupations1

Information Science4

Health Care6

PNET11

PPNET2

Askin5

Ewing's5

Neuroblastoma1

Sarcoma31

Bone18

Osteosarcoma2

Pediatric15

Extraosseous2

Family of tumors7

Chemotherapy3

Cancers2

Patients with solid tumors1

PNETs4

Differentiation6

Medulloblastomas4

Genes12

Carcinoma2

Brain tumor3

Nerve1

Stromal1

Extraskeletal1

Types of tumors1

Recurrence2

Immunohistochemistry1

Diagnosis4

Atypical1

Epithelioid1

Anti-tumour1

Rare tumors2

Metastatic tumors1

Resection1

Cell proliferation1

Histologic1

Refractory1

Histology1

Children and adolescents2

Neural crest1

Areas of tumor2

Pheochromocytoma1

Chest2

Mutations2

Young adults2