• sensory nerve
  • Yu and his research team discovered that in the diabetic mouse cornea, the density of sensory nerve fibers and their endings are drastically reduced, similar to patients with DPN. (medindia.net)
  • Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. (ovid.com)
  • diabetic nerve
  • In vitro, treatment of wild-type bone marrow-derived macrophages with advanced glycation end products (AGEs), which accumulate in diabetic nerve tissue, increased M1 and decreased M2 gene expression in a RAGE-dependent manner. (diabetesjournals.org)
  • Tissue
  • A PNS injury at the time of spinal cord damage will only promote growth of nerve fibers into the spinal cord lesion, but not into the tissue beyond it. (rxpgnews.com)
  • Tissue engineering related to growth factors has arisen as an alternative approach for triggering and improving nerve regeneration. (go.jp)
  • Here, we tested the hypothesis that RAGE suppresses effective axonal regeneration in superimposed acute peripheral nerve injury attributable to tissue-damaging inflammatory responses. (diabetesjournals.org)
  • These considerations prompted us to hypothesize that RAGE action in superimposed acute injury to the peripheral nerve, particularly in diabetes, attenuates neurite outgrowth and axonal regeneration via tissue-damaging inflammatory mechanisms. (diabetesjournals.org)
  • ZFP activation of VEGF-A has been demonstrated to stimulate angiogenesis or blood vessel growth, to have direct neurotrophic and neuroprotective properties in several models that assess nerve integrity and health, and may play an important role in stem cell mobilization and thereby tissue repair. (bio-medicine.org)
  • myelination
  • MAG is believed to be involved in myelination during nerve regeneration. (wikipedia.org)
  • During the development of the peripheral nervous system, the regulatory mechanisms of myelination are controlled via feedforward interaction of specific genes, influencing transcriptional cascades and shaping the morphology of the myelinated nerve fibers. (wikipedia.org)
  • distal
  • Hindlimb motor function was evaluated weekly by assessing sciatic functional indices, and the proximal and distal portions of the sciatic nerve were used for morphometric analysis. (scielo.br)
  • RESULTS: After an initial T2 signal increase of the nerves in both groups, the coapted group demonstrated a major T2 signal decrease in the distal part of the nerve after postoperative day 21, whereas in the unrepaired group a signal decrease was not observed until postoperative day 42. (biomedsearch.com)
  • mice
  • Over-production of this growth factor through gene therapy has resulted in regeneration of nerve connections in mice. (wisegeek.com)
  • Consistent with key roles for RAGE-dependent inflammation, reconstitution of diabetic wild-type mice with RAGE-null versus wild-type bone marrow resulted in significantly improved axonal regeneration and restoration of function. (diabetesjournals.org)
  • Diabetic RAGE-null mice displayed higher numbers of invading macrophages in the nerve segments postcrush compared with wild-type animals, and these macrophages in diabetic RAGE-null mice displayed greater M2 polarization. (diabetesjournals.org)
  • Adult mice were injected with AAV2-Cre into the vitreous of the eye to activate B-RAF signaling in the RGCs, and 14 days later were subjected to proximal crush lesion of the optic nerve. (arvojournals.org)
  • fibers
  • Key to the research is an important difference in the properties of the nerve fibers of the central nervous system (CNS), which consists of the brain and spinal cord, and those of the peripheral nervous system (PNS), which is the network of nerve fibers that extends throughout the body. (rxpgnews.com)
  • Regeneration occurs because PNS cell bodies are sensitive to damage to their nerve processes, and they react by sending out a signal that triggers the nerve fibers to regrow, explains Allan Basbaum, PhD, senior study author and chair of the UCSF Department of Anatomy. (rxpgnews.com)
  • The researchers took advantage of an unusual class of nerve fibers that has both a PNS and a CNS branch. (rxpgnews.com)
  • The recovered function of regenerated peripheral nerve fibers and reinnervated mechanoreceptors may differentially influence recovery of sensory modalities. (ovid.com)
  • methods
  • By Methods include stem cell therapy, direct nerve repair, nerve grafting and others. (sbwire.com)
  • increasing number of geriatric individuals alongside developing interest for holding youthful and beauty and the advantages of Reconstructive surgery such as reduction from possibly harmful surgical methods, reduce the surgical danger for elderly patients are also growing the market for nerve reconstructive. (sbwire.com)
  • PTEN
  • The puzzle of optic nerve regeneration will probably be solved, at least in part, by manipulating molecular pathways in the body, and several promising ideas in this area involve the phosphatase and tensin homolog (PTEN) gene, the brain-derived neurotrophic factor (BDNF) gene, and a growth factor called oncomodulin. (wisegeek.com)
  • F) Optic nerve regeneration in absence of PTEN. (arvojournals.org)
  • growth
  • Building nerve grafts and manipulating enzymes and other molecular components involved in cell growth are some of the techniques which are being investigated to attempt to engineer optic nerve regeneration. (wisegeek.com)
  • BDNF is a growth factor expressed by the BDNF gene, and is important in neuronal development in the optic nerve. (wisegeek.com)
  • To make this finding clinically useful, we wanted to understand what was triggering the growth, so we could achieve nerve regeneration without causing an injury," Benowitz says. (medica-tradefair.com)
  • Therefore, the aim of this review is to provide a comprehensive analysis related to growth factors as tools for optimizing the regeneration process. (go.jp)
  • Studies and reviews on the use of growth factors for nerve regeneration were compiled over the course of the review. (go.jp)
  • inflammatory
  • They cited studies showing that TNF receptors are expressed in many types of cells in the CNS and are intimately involved in inflammatory responses that also play a role--perhaps harmful, perhaps beneficial to regeneration or recovery--in regulating response to injury. (innovations-report.com)
  • significantly
  • Regeneration of the optic nerve is currently impossible in humans, but research in this area has advanced significantly in the last few years and several promising ideas exist. (wisegeek.com)
  • Upon nerve conduit implantation, the NCSC group showed significantly higher electrophysiological recovery at 1 month as well as better gastrocnemius muscle recovery at 5 months than the acellular group, but the NCSC-SC group didn't. (berkeley.edu)
  • conduction
  • Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands. (ovid.com)
  • cells
  • Scarring occurs due to the activation, change in shape, and stiffness of cells, called astrocytes, which are the major nerve support cells in the spinal cord. (labspaces.net)
  • The team, however, found that these cells secrete heparan sulfate sugars, which promote scarring reactions and could reduce the effectiveness of nerve repair. (labspaces.net)
  • Nerve cells normally grow when they are young and stop when they are mature. (rxpgnews.com)
  • therapeutic
  • Sangamo BioSciences Announces ZFP Therapeutic Data From Nerve Regeneration Program at Society for Neuroscien. (bio-medicine.org)
  • SGMO ) announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience. (bio-medicine.org)
  • We are excited by the statistically significant improvements in measures of both nerve health and, more importantly, nerve function after treatment with our VEGF ZFP TF," said Dale Ando, M.D. Sangamo's vice president of therapeutic development and chief medical officer. (bio-medicine.org)
  • recovery
  • Nerve injuries result in functional loss in the innervated organ or body parts, and recovery is difficult unless surgical treatment has been done. (go.jp)