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  • Schwann
  • Schwann cells harvested from the sural nerve of the participant will be autologously transplanted into the epicenter of the participant's spinal cord injury. (clinicaltrials.gov)
  • sensory nerve
  • Yu and his research team discovered that in the diabetic mouse cornea, the density of sensory nerve fibers and their endings are drastically reduced, similar to patients with DPN. (medindia.net)
  • Dispersed maturation of sensory nerve fibers with desynchronized inputs to the CNS also contributes to the poor recovery of tactile gnosis. (ovid.com)
  • Moreover
  • Moreover, the regenerative capacity of corneal nerves following wounding is impaired in the corneas of diabetic patients compared to normal B6 mouse corneas. (medindia.net)
  • Moreover, the continuity of coapted nerves or an explicit gap in the unrepaired group was detectable at every time point. (biomedsearch.com)
  • myelination
  • MAG is believed to be involved in myelination during nerve regeneration. (wikipedia.org)
  • During the development of the peripheral nervous system, the regulatory mechanisms of myelination are controlled via feedforward interaction of specific genes, influencing transcriptional cascades and shaping the morphology of the myelinated nerve fibers. (wikipedia.org)
  • mice
  • Over-production of this growth factor through gene therapy has resulted in regeneration of nerve connections in mice. (wisegeek.com)
  • Consistent with key roles for RAGE-dependent inflammation, reconstitution of diabetic wild-type mice with RAGE-null versus wild-type bone marrow resulted in significantly improved axonal regeneration and restoration of function. (diabetesjournals.org)
  • Diabetic RAGE-null mice displayed higher numbers of invading macrophages in the nerve segments postcrush compared with wild-type animals, and these macrophages in diabetic RAGE-null mice displayed greater M2 polarization. (diabetesjournals.org)
  • Adult mice were injected with AAV2-Cre into the vitreous of the eye to activate B-RAF signaling in the RGCs, and 14 days later were subjected to proximal crush lesion of the optic nerve. (arvojournals.org)
  • fibers
  • Key to the research is an important difference in the properties of the nerve fibers of the central nervous system (CNS), which consists of the brain and spinal cord, and those of the peripheral nervous system (PNS), which is the network of nerve fibers that extends throughout the body. (rxpgnews.com)
  • Regeneration occurs because PNS cell bodies are sensitive to damage to their nerve processes, and they react by sending out a signal that triggers the nerve fibers to regrow, explains Allan Basbaum, PhD, senior study author and chair of the UCSF Department of Anatomy. (rxpgnews.com)
  • The researchers took advantage of an unusual class of nerve fibers that has both a PNS and a CNS branch. (rxpgnews.com)
  • The recovered function of regenerated peripheral nerve fibers and reinnervated mechanoreceptors may differentially influence recovery of sensory modalities. (ovid.com)
  • methods
  • By Methods include stem cell therapy, direct nerve repair, nerve grafting and others. (sbwire.com)
  • increasing number of geriatric individuals alongside developing interest for holding youthful and beauty and the advantages of Reconstructive surgery such as reduction from possibly harmful surgical methods, reduce the surgical danger for elderly patients are also growing the market for nerve reconstructive. (sbwire.com)
  • CNTF
  • Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells. (medindia.net)
  • Dendritic cells mediate sensory nerve innervation and regeneration through direct cell-to-cell contact and CNTF secretion. (medindia.net)
  • Yu further mentioned that the study showed that the application of exogenous CNTF - and, more strikingly, its soluble receptor CNTFR-alpha - can partially reverse the adverse effects of diabetes on sensory nerve and nerve regeneration. (medindia.net)
  • The regeneration effects of oncomodulin outcompetes other neurotrophic factors like BDNF, CNTF, and GDNF. (wikipedia.org)
  • PTEN
  • The puzzle of optic nerve regeneration will probably be solved, at least in part, by manipulating molecular pathways in the body, and several promising ideas in this area involve the phosphatase and tensin homolog (PTEN) gene, the brain-derived neurotrophic factor (BDNF) gene, and a growth factor called oncomodulin. (wisegeek.com)
  • F) Optic nerve regeneration in absence of PTEN. (arvojournals.org)
  • growth
  • Building nerve grafts and manipulating enzymes and other molecular components involved in cell growth are some of the techniques which are being investigated to attempt to engineer optic nerve regeneration. (wisegeek.com)
  • BDNF is a growth factor expressed by the BDNF gene, and is important in neuronal development in the optic nerve. (wisegeek.com)
  • Tissue engineering related to growth factors has arisen as an alternative approach for triggering and improving nerve regeneration. (go.jp)
  • Therefore, the aim of this review is to provide a comprehensive analysis related to growth factors as tools for optimizing the regeneration process. (go.jp)
  • Studies and reviews on the use of growth factors for nerve regeneration were compiled over the course of the review. (go.jp)
  • D) Regenerative growth in lesioned kaB-RAF expressing optic nerve. (arvojournals.org)
  • Tissue
  • In vitro, treatment of wild-type bone marrow-derived macrophages with advanced glycation end products (AGEs), which accumulate in diabetic nerve tissue, increased M1 and decreased M2 gene expression in a RAGE-dependent manner. (diabetesjournals.org)
  • conduction
  • Quantitative sensory hand function and sensory conduction studies by near-nerve technique, including tactile stimulation of mechanoreceptors, were followed for 2 years, and results were compared to noninjured hands. (ovid.com)
  • signals
  • Both increased microtubule density and reduced microtubule stability were still observed in transgenic mouse nerves, indicating that signals beyond synaptogenesis and the mere presence of compact myelin are required for normal regulation of the axonal microtubule cytoskeleton. (jneurosci.org)
  • wound
  • We have recently reported the development of a zebrafish model of type I diabetes mellitus and characterized this model to show that diabetic zebrafish not only display the known secondary complications including the changes associated with diabetic retinopathy, diabetic nephropathy and impaired wound healing but also exhibit impaired caudal fin regeneration. (jove.com)
  • cord
  • The central nervous system consists of two ganglia above the mouth, one on either side, connected to a nerve cord running back along its length to motor neurons and sensory cells in each segment. (wikipedia.org)
  • damage
  • Neurogenic atrophy, which has a similar effect, is muscle atrophy resulting from damage to the nerve which stimulates the muscle, causing a shriveling around otherwise healthy limbs. (wikipedia.org)
  • Classification of nerve damage was well-defined by Sir Herbert Seddon and Sunderland in a system that remains in use. (wikipedia.org)
  • study
  • citation needed] During World War II, responding to the large number of nerve injuries sustained by soldiers in combat and drawing on his work in comparative anatomy and the regrowth of damaged nerves in squids and octopuses, Young set up a unit at the University of Oxford to study nerve regeneration in mammals. (wikipedia.org)
  • attenuated the expression
  • The 30 administration of the Notch inhibitor 31 N-N-(3,5-difluorophenacetyl-l-alanyl)-S-phenylglycine-t-butyl ester (DAPT) (i.v. 30 minutes 32 before MI and then daily until sacrifice) decreased the number of macrophages and 33 significantly increased the M2 macrophage activation profile in the early stages as well as 34 attenuated the expression of nerve growth factor (NGF). (semanticscholar.org)
  • muscle
  • In epilepsy, nerve cells in the brain signal abnormally and cause repeated seizures that can include strange sensations, severe muscle spasms and loss of consciousness. (innovations-report.com)
  • pain
  • In 1812 Napoleon's Surgeon General noted that half-frozen soldiers from the Moscow battle were able to tolerate amputations with reduced pain and in 1851, ice and salt mixtures were promoted by Arnott for the treatment of nerve pain. (wikipedia.org)
  • cells
  • After their four-year-old son dies, a couple take part in an experiment to clone a new embryo from their dead son's brain and nerve cells, and implant it as a new pregnancy. (wikipedia.org)
  • electrical
  • There are many commercial electrical stimulation devices available, which are commonly referred as transcutaneous electrical nerve stimulation units. (biomedcentral.com)