• estrogen
  • Data obtained from patients with three different sporadic cancers, from four independent case studies, support this hypothesis, providing an example for the genetic basis of gender differences in cancer and showing that the genotype at a specific locus can affect how hormones, like estrogen, affect tumorigenesis in humans. (aacrjournals.org)
  • The regulation of MDM2 expression by estrogen, as well as by thyroid hormone, is mediated, at least in part, through a well-characterized region of the MDM2 promoter ( 20 , 22 - 24 ). (aacrjournals.org)
  • Fibroids are dependent on estrogen and progesterone to grow and therefore relevant only during the reproductive years. (wikipedia.org)
  • The high-dose formulations are used to treat prostate cancer and certain other androgen-related indications while the low-dose formulations which also have an estrogen are used as combined birth control pills and are used in menopausal hormone therapy for the treatment of menopausal symptoms. (wikipedia.org)
  • secretion
  • Several types of effects were described including impairment of sodium dependent phosphate transport in both intestinal and renal brush border membrane vesicles, inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of parathyroid hormone. (wikipedia.org)
  • High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. (wikipedia.org)
  • therapy
  • Cyproterone acetate (abbreviated as CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills. (wikipedia.org)
  • CPA is also widely used as a component of feminizing hormone therapy for transgender women. (wikipedia.org)
  • breast
  • In this study we determined its activity in various models of hormone-dependent malignancies including those of the prostate and the breast. (uni-regensburg.de)
  • Common side effects of non-contraceptive (i.e., high) dosages of CPA in men include gynecomastia (breast development) and feminization in general and in both men and women include low sex hormone levels, reversible infertility, sexual dysfunction, mental symptoms like depression, fatigue, and irritability, vitamin B12 deficiency, and elevated liver enzymes. (wikipedia.org)
  • Cells
  • During Mitosis CDK1 phosphorylate PTTG1 at Ser-165.PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125. (wikipedia.org)
  • androgen
  • One important objective of prostate cancer (PCa) research is to understand the molecular basis underlying the progression of these cancers from an androgen dependent to an androgen independent state. (umassmed.edu)
  • Transcriptional silencing of antitumor genes via CpG island hypermethylation could be a mechanism mediating PCa progression from an androgen-dependent to an androgen-independent state. (umassmed.edu)
  • The androgen-dependent (AD, as defined as the inability of celill to proliferate in the absence of androgen) PCa cell line LNCaP gives rise to the androgen-independent (AI) subline LNCaP cs generated by maintaining LNCaP in medium with charcoal-stripped (CS) serum for over 30 passages. (umassmed.edu)
  • An alternative silencing mechanism for PMP24 other than the interference with transcription factor binding by methylation is therefore likely involved at this androgen-dependent stage. (umassmed.edu)
  • 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. (novusbio.com)
  • CPA is used in the treatment of prostate cancer, precocious puberty, androgen-dependent skin and hair conditions such as acne, seborrhea, hirsutism (excessive hair growth), and androgenic alopecia (pattern hair loss), hyperandrogenism (e.g., in PCOS), and to reduce sex drive in sex offenders or men with paraphilias or hypersexuality. (wikipedia.org)
  • In the U.S., where CPA is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer. (wikipedia.org)
  • growth
  • PAX8 releases the hormones important for regulating growth, brain development, and metabolism. (wikipedia.org)
  • insufficient growth hormone in children and adolescents leads to diminished stature but which can have many other explanations. (wikipedia.org)
  • blood
  • Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. (wikipedia.org)
  • levels
  • Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. (ox.ac.uk)
  • However, fibroids run in families and appear to be partly determined by hormone levels. (wikipedia.org)
  • less
  • the gradual reduction in normal activities due to decreased production of hormones is rather less evident. (wikipedia.org)
  • several
  • Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. (wikipedia.org)
  • relevant
  • Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours. (ox.ac.uk)