• thyroid-stimula
  • Also, serum thyroid-stimulating hormone (TSH) levels were measured using a immunoradiometric assay designed for quantitative measurement of TSH in serum using Coat-A-Count kit containing radioactive I 125 -polyclonal anti-TSH (Diagnostics Products Coorporation, Los Angeles, CA, USA). (biomedcentral.com)
  • Humans
  • Sp1), the hypothesis that the SNP309 locus could alter the effects of hormones on tumorigenesis was tested in vivo in humans. (aacrjournals.org)
  • Data obtained from patients with three different sporadic cancers, from four independent case studies, support this hypothesis, providing an example for the genetic basis of gender differences in cancer and showing that the genotype at a specific locus can affect how hormones, like estrogen, affect tumorigenesis in humans. (aacrjournals.org)
  • androgen-dependent
  • One important objective of prostate cancer (PCa) research is to understand the molecular basis underlying the progression of these cancers from an androgen dependent to an androgen independent state. (umassmed.edu)
  • Transcriptional silencing of antitumor genes via CpG island hypermethylation could be a mechanism mediating PCa progression from an androgen-dependent to an androgen-independent state. (umassmed.edu)
  • The androgen-dependent (AD, as defined as the inability of celill to proliferate in the absence of androgen) PCa cell line LNCaP gives rise to the androgen-independent (AI) subline LNCaP cs generated by maintaining LNCaP in medium with charcoal-stripped (CS) serum for over 30 passages. (umassmed.edu)
  • An alternative silencing mechanism for PMP24 other than the interference with transcription factor binding by methylation is therefore likely involved at this androgen-dependent stage. (umassmed.edu)
  • In conclusion, STX2171 and STX1383 significantly lower plasma testosterone levels and inhibit androgen-dependent tumour growth in vivo, indicating that 17β-HSD3 inhibitors may have application in the treatment of hormone-dependent prostate cancer. (ox.ac.uk)
  • Cyproterone acetate (abbreviated as CPA), sold alone under the brand name Androcur or with ethinylestradiol (EE) under the brand names Diane or Diane-35 among others, is an antiandrogen and progestogen which is used in the treatment of androgen-dependent conditions like acne, excessive hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender women, and in birth control pills. (wikipedia.org)
  • CPA is used in the treatment of prostate cancer, precocious puberty, androgen-dependent skin and hair conditions such as acne, seborrhea, hirsutism (excessive hair growth), and androgenic alopecia (pattern hair loss), hyperandrogenism (e.g., in PCOS), and to reduce sex drive in sex offenders or men with paraphilias or hypersexuality. (wikipedia.org)
  • In the U.S., where CPA is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer. (wikipedia.org)
  • secretion
  • Several types of effects were described including impairment of sodium dependent phosphate transport in both intestinal and renal brush border membrane vesicles, inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of parathyroid hormone. (wikipedia.org)
  • High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. (wikipedia.org)
  • prostate
  • The high-dose formulations are used to treat prostate cancer and certain other androgen-related indications while the low-dose formulations which also have an estrogen are used as combined birth control pills and are used in menopausal hormone therapy for the treatment of menopausal symptoms. (wikipedia.org)
  • estrogen
  • The regulation of MDM2 expression by estrogen, as well as by thyroid hormone, is mediated, at least in part, through a well-characterized region of the MDM2 promoter ( 20 , 22 - 24 ). (aacrjournals.org)
  • growth
  • PAX8 releases the hormones important for regulating growth, brain development, and metabolism. (wikipedia.org)
  • insufficient growth hormone in children and adolescents leads to diminished stature but which can have many other explanations. (wikipedia.org)
  • gene
  • Both the ER and the thyroid hormone receptor are known to bind to this region of the promoter and activate transcription of the MDM2 gene ( 23 , 24 ). (aacrjournals.org)
  • levels
  • Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. (ox.ac.uk)
  • However, fibroids run in families and appear to be partly determined by hormone levels. (wikipedia.org)
  • less
  • the gradual reduction in normal activities due to decreased production of hormones is rather less evident. (wikipedia.org)
  • blood
  • Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. (wikipedia.org)
  • several
  • Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. (wikipedia.org)
  • role
  • Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non-hormone-dependent solid neoplasms. (readbyqxmd.com)
  • PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). (wikipedia.org)