• otic
  • Therapy with neomycin otic preparations should be administered cautiously in patients with chronic otitis media or a perforated tympanic membrane. (drugs.com)
  • ototoxicity
  • Patients with impaired renal function have a high risk of developing nephrotoxicity and ototoxicity with oral neomycin. (drugs.com)
  • Ototoxicity is often delayed in onset and patients developing cochlear damage will not have symptoms during therapy to warn them of developing eighth nerve destruction and total or partial deafness may occur long after neomycin has been discontinued. (egeneralmedical.com)
  • The concurrent use of neomycin with potent diuretics such as ethacrynic acid or furosemide should be avoided, since certain diuretics by themselves may cause ototoxicity. (egeneralmedical.com)
  • neosamine
  • Neomycin B is composed of four linked parts: D-neosamine, 2-deoxystreptamine (2-DOS), D-ribose, and L-neosamine. (wikipedia.org)
  • Neomycin A, also called neamine, contains D-neosamine and 2-deoxystreptamine. (wikipedia.org)
  • Neosamine B (L-neosamine B) is most likely biosynthesized in the same manner as the neosamine C (D-niosamine) in neamine biosynthesis, but with an additional epimerization step required to account for the presence of the epimeric neosamine B in neomycin B. Neomycin C can undergo enzymatic synthesis from ribostamycin. (wikipedia.org)
  • dose
  • The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 25 μg per dose. (wikipedia.org)
  • renal
  • Absorbed neomycin distributes to tissues and concentrates in the renal cortex. (drugs.com)
  • Caution should be used when administering neomycin to patients with renal impairment. (drugs.com)
  • Neomycin should be used with caution in patients with hearing impairment, renal impairment or neuromuscular disorders. (drugs.com)
  • enzyme
  • Neomycin C transaminase (EC 2.6.1.95, neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase. (wikipedia.org)
  • This enzyme catalyses the following chemical reaction neomycin C + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 6'''-deamino-6-oxoneomycin C + L-glutamate The reaction occurs in vivo in the opposite direction. (wikipedia.org)
  • occur
  • Damage to hearing, sense of balance, and kidneys is more likely to occur in premature infants and neonates, who are more sensitive than adults to the effects of neomycin. (mayoclinic.org)
  • Serious side effects, such as damage to hearing, sense of balance, and kidneys may occur in elderly patients, who are usually more sensitive than younger adults to the effects of neomycin. (mayoclinic.org)
  • patients
  • Patients treated with neomycin should be under close clinical observation because of the potential toxicity associated with their use. (egeneralmedical.com)
  • The possibility of the occurrence of neuromuscular blockage and respiratory paralysis should be considered if neomycin is administered, especially to patients receiving anesthetics, neuromuscular blocking agents such as tubocurarine, succinylcholine, decamethonium, or in patients receiving massive transfusions of citrate anticoagulated blood. (egeneralmedical.com)
  • component
  • Neomycin exhibits a high binding affinity for phosphatidylinositol 4,5-bisphosphate (PIP2), which is a phospholipid component of cell membranes. (wikipedia.org)
  • and its epimer neomycin C, the latter component accounting for some 5-15% of the mixture. (wikipedia.org)