• vaccines
  • Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. (redorbit.com)
  • WIPO Re:Search claims that "valuable IP and expertise" will be shared with "the global health research community" to promote development of new drugs, vaccines and diagnostics to treat neglected tropical diseases, malaria and tuberculosis. (pharmatimes.com)
  • Dr. Maria-Elena Bottazzi , Deputy Director of Texas Children's Hospital Center for Vaccine Development, said, "The scientific knowledge exchange from this partnership will catalyze and accelerate the product development of much-needed vaccines against the diseases of poverty. (medindia.net)
  • In 2011, Baylor launched the National School of Tropical Medicine, which together with Texas Children's Hospital Center for Vaccine Development is leading an innovative product development partnership model for the research & development of new vaccines to combat the world's neglected tropical diseases. (medindia.net)
  • Product development partnerships (PDPs), also called public-private partnerships (PPPs) aim to implement and accelerate the research and development (R&D) into health tools (diagnostics, vaccines, drugs) for diseases that are neglected, by enabling new collaborations between private industry, academia, and the public sector. (wikipedia.org)
  • The Michelson Neglected Disease Vaccine Initiative has gifted over $3 million to the Sabin Vaccine Institute Product Development Partnership to fund the development of vaccines against neglected tropical diseases. (wikipedia.org)
  • Vaccines for Biodefense and Emerging and Neglected Diseases. (wikipedia.org)
  • However, Wakefield's work has been characterized as "an elaborate fraud", and parental fears over vaccines sparked by the controversy, and by continued advocacy of the disproven theory by groups such as Generation Rescue despite, have led, in turn, to decreased immunization rates and an increased incidence of whooping cough and measles, a highly contagious and sometimes deadly disease. (wikipedia.org)
  • human African trypano
  • Of these 20, two were targeted for eradication (dracunculiasis (guinea-worm disease) by 2015 and yaws by 2020), and four for elimination (blinding trachoma, human African trypanosomiasis, leprosy and lymphatic filariasis by 2020). (wikipedia.org)
  • DNDi
  • Basel, Switzerland - 7 September After having built the world's largest drug development pipeline for the most neglected diseases, the Drugs for Neglected Diseases initiative (DNDi) has unveiled plans for a more flexible, dynamic portfolio approach, integrating various operating models to better respond to the needs of patients, notably in low- and middle-income countries. (eurekalert.org)
  • Having recently transferred its malaria activities to the Medicines for Malaria Venture (MMV), DNDi will soon be launching new research and development (R&D) projects for hepatitis C and mycetoma, two very different diseases that share, with other important global health issues such as anti-microbial resistance, one key challenge: the existing system of biomedical innovation has failed to deliver safe, effective, quality products that are affordable to poor populations. (eurekalert.org)
  • DNDi will remain focused on reaching our treatment targets for the most neglected diseases, but we are now in a position to apply new R&D models, where patient needs drive drug development over profits, and where prices of drugs are delinked from the cost of their development,' he added. (eurekalert.org)
  • DNDi will continue developing its pipeline of over 30 projects for the most neglected diseases. (eurekalert.org)
  • As the organization matures, DNDi will continue to learn, innovate, and adapt its operational models to guarantee that R&D capacity is built where needed while continuously identifying and addressing neglected patients' needs through the best science. (eurekalert.org)
  • To date, DNDI has delivered six new treatments and built a large drug pipeline for neglected diseases with both improvements on existing drugs and entirely new chemical entities. (wikipedia.org)
  • Drugs for Neglected Diseases Initiative (DNDi): A global research and development organisation with headquarters at Geneva will actively work for development of new drugs (such as oxaborole, fexinidazole) and perform clinical trials. (wikipedia.org)
  • Mundo Sano played a central role in registering benznidazole with the U.S. Food and Drug Administration (FDA), in close collaboration with Exeltis (Chemo US-based pharmaceutical division), with the support of the Drugs for Neglected Diseases initiative (DNDi), a non-profit drug development organization. (wikipedia.org)
  • world's poorest
  • Simultaneously, through the work of Global Network collaborators, hundreds of millions of the world's poorest people are currently receiving a low-cost rapid-impact package of essential NTD drugs, enabling them to break out of a devastating cycle of poverty and disease. (wikipedia.org)
  • Hotez
  • The authors, led by Peter Hotez of the US-based Human Hookworm Vaccine Initiative, say that cheap and effective ways of treating many neglected diseases already exist. (scidev.net)
  • Hotez and colleagues argue that integrating efforts to tackle these diseases and the big three makes even more sense since they often overlap geographically. (scidev.net)
  • Established in 2007 by founding editor Peter Hotez, with US$1.1 million in grant support from the Bill & Melinda Gates Foundation, PLOS Neglected Tropical Diseases was created to be "both catalytic and transformative in promoting science, policy, and advocacy for these diseases of the poor. (wikipedia.org)
  • After reading an article written by Sabin Vaccine Institute President Peter Hotez published in the Los Angeles Times, Michelson became one of the principal supporters of the Institute's fight against Neglected Tropical Diseases. (wikipedia.org)
  • endemic
  • Eradicating the disease, according to WHO, would result into a 29 percent jump in economic returns for the agricultural sector of countries where it is no longer endemic. (nextbillion.net)
  • For-profit companies see little economic justification to invest in treating diseases that affect the poor, but "creative capitalism," as Gates put it, could lure companies into solving some of the world's most pressing problems by bringing to market new treatments for endemic tropical diseases. (bmj.com)
  • The organization was set up by key research and health institutions, notably from the public sector in neglected-disease-endemic countries - the Oswaldo Cruz Foundation from Brazil, the Indian Council of Medical Research, the Kenya Medical Research Institute, the Ministry of Health of Malaysia and France's Pasteur Institute, with seed funding from Médecins sans Frontières's 1999 Nobel Peace Prize. (wikipedia.org)
  • PLOS Neglected Tropical Diseases is a peer-reviewed open access scientific journal devoted to the study of neglected tropical diseases, including helminth, bacterial, viral, protozoan, and fungal infections endemic to tropical regions. (wikipedia.org)
  • burden
  • They conclude, 'Despite substantial political attention towards the burden of neglected diseases, we detected no evidence of a substantial improvement in research and development activity compared with previous decades. (voanews.com)
  • Accidental envenoming by snakes and scorpions, fluorosis, hypothyroidism, and organo phosphate poisoning represent a large proportion of the disease burden in rural states such as Maharashtra, Andhra Pradesh, Tamil Nadu, and Puducherry," says his letter. (fluoridealert.org)
  • He points out that the burden of thyroid disease in India in the post-iodisation phase is about 42 million. (fluoridealert.org)
  • One showed that only 1.1% of new drugs were approved specifically for neglected diseases over a period of 25 years (1975 to 1999) despite the fact that these diseases represented 11.4% of the global burden. (wikipedia.org)
  • developing countries
  • As most patients with such diseases live in developing countries and are too poor to pay for drugs, the pharmaceutical industry has traditionally ignored these diseases. (bmj.com)
  • In PLoS Medicine today (31 January), they say that 'neglected diseases' - which affect millions of people in developing countries but get little attention from funding bodies and scientists - often make the big three more lethal. (scidev.net)
  • The World Health Organization last week (27 May) agreed to begin work on a strategy to support "needs-driven" research on diseases that particularly affect developing countries. (scidev.net)
  • In line with the commission's findings, the resolution acknowledges that although intellectual property rights provide an incentive for innovation, this is not enough to encourage companies to develop products to fight diseases that primarily affect the poor in developing countries. (scidev.net)
  • Economic and social development, not to mention quality of life, in developing countries are constrained by many factors, including disease. (edu.au)
  • aims
  • It aims to encourage research activities that lead to equal health access to the populations that are exposed to diseases which can be prevented, and to develop strategic policies leading to changes in the overall communities' quality of life. (wikipedia.org)
  • pharmaceutical
  • C&EN Senior Editor Lisa Jarvis explains that just a decade ago major pharmaceutical companies had largely abandoned developing treatments for these neglected diseases. (redorbit.com)
  • For those diseases where there are no or poor interventions available, the pharmaceutical and medical technology industries have chosen not to develop new and better interventions because there is no money to pay for them - no profit. (edu.au)
  • As people suffering from neglected diseases do not represent a lucrative market for pharmaceutical companies, the incentives to invest in research and development are lacking for these diseases. (wikipedia.org)
  • The original endorsers with their basic strategies were: Abbott: A US-based global pharmaceutical and health care company works for the prevention, diagnosis and treatment of all major neglected diseases. (wikipedia.org)
  • However, the major stakeholders in NTD drug development-governments, foundations, pharmaceutical companies, academia, and NGOs-are involved in activities to help address the research and development shortfall and meet the many challenges presented by neglected tropical diseases. (wikipedia.org)
  • eradication
  • Bill & Melinda Gates Foundation: Perhaps the single most enthusiastic individual for the declaration, Bill Gates and his private foundation, will support funding towards eradication programmes of all the diseases. (wikipedia.org)
  • rabies
  • The World Health Organization's 2010 report dedicated to neglected tropical diseases offers an expanded list including dengue, rabies, yaws, cysticercosis, echinococcosis, and foodborne trematode infections. (wikipedia.org)
  • Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. (wikipedia.org)
  • More than 99% of rabies cases in countries where dogs commonly have the disease are caused by dog bites. (wikipedia.org)
  • In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms. (wikipedia.org)
  • infections
  • with Baylor College of Medicine ( Texas , U.S.) and its vaccine product development partnership (PDP), Texas Children's Hospital Center for Vaccine Development (Texas Children's CVD), to advance vaccine research and development for neglected and emerging infections. (medindia.net)
  • disability
  • Accidental Death and Disability: The Neglected Disease of Modern Society was an influential report published in 1966 by the National Academy of Sciences and is considered a landmark in the development of the emergency medical services system in the United States. (wikipedia.org)
  • drug
  • Infectious diseases can be considered "neglected" when there is a lack of effective, affordable, or easy to use drug treatments. (bmj.com)
  • At the 2008 World Economic Forum in Davos, Gates highlighted a new US Food and Drug Administration (FDA) law that rewards sponsors of drugs for tropical diseases with a voucher that entitles the bearer to a "priority review" of another new drug application. (bmj.com)
  • Alternatives to profit-driven drug development emerged in the years 2000 to provide an answer to the needs of these neglected patients. (wikipedia.org)
  • NTD interventions include both programs to address environmental and social determinants of health (e.g., vector control, water quality, sanitation), and programs offering mass drug administration for disease prevention and treatment. (wikipedia.org)
  • research and develop
  • The resolution follows a proposal made in January by Brazil and Kenya to create a new global framework for essential health research and development (see Brazil and Kenya push for neglected-disease research ). (scidev.net)
  • The collaboration includes training and exchange of technical know-how in process development and formulation, filling knowledge gaps that exist from research and development to manufacturing, with a focus on neglected and emerging diseases. (medindia.net)
  • Furthermore, the time that drugs are approved for use averages seven years out of the twenty years on-patent, meaning a tendency for the market to focus on diseases of developed nations where high prices can be used to recoup research and development costs, and subsidize failed R&D efforts. (wikipedia.org)
  • treatment
  • Violence not only disrupts delivery of preventive care and sufficient disease management and surveillance but also endangers the lives of health workers and hampers access to treatment. (nextbillion.net)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • rampant
  • These diseases are most rampant in the economically deprived regions of the world and affect 1.4 billion people, and are responsible for the persistent backwardness in human development. (wikipedia.org)
  • Mundo Sano Foundation was founded in 1993 by Dr Roberto Gold with the aim of improving of the quality of life in Argentina, where human helminthic diseases were rampant. (wikipedia.org)
  • control
  • Nevertheless, in 2010 it was estimated that control of neglected diseases would require funding of between US$2 billion and US$3 billion over the subsequent five to seven years. (wikipedia.org)