• Mechanisms
  • In the present study, changes in the expression of major renal Na transporters were examined in a rat model with 24 h of unilateral ureteral obstruction ( UUO ) to clarify the molecular mechanisms of the marked natriuresis seen after release of UUO . (ndif.org)
  • kidney
  • In conclusion, downregulation of major renal Na transporters in rats with UUO may contribute to the impairment in urinary concentrating capacity and natriuresis after release of obstruction, and reduced levels of Na-K-ATPase and NaPi-2 in the contralateral nonobstructed kidney may contribute to the compensatory increase in water and Na excretion from that kidney during UUO and after release of obstruction. (ndif.org)
  • rats
  • Method Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and RPT cells were stimulated or blocked through D 1 -like dopamine and gastrin receptors to observe Na + -K + -ATPase activity and natriuresis. (bmj.com)
  • response
  • These data demonstrate that RI addition of PC-18 to Ang II enables natriuresis mediated by the AT 2 R, and that conversion of Ang II to Ang III is critical for this response. (ahajournals.org)