• In this study, novel bisnapthoquinone derivatives (5a-o) were synthesized through a multi-component cascade reaction of two molecules of 2-hydroxy-1,4-naphthoquinone with an aromatic aldehyde in basic media using triethylamine as a catalyst. (cumhuriyet.edu.tr)
  • Present study is aimed at finding the antioxidant and hypoglycaemic potential of some novel derivatives of 2-phenylamino-1,4- naphthoquinones (PAN) including chloro, nitro, methyl and bromo (5a-d) derivatives synthesized by single pot experiment. (bvsalud.org)
  • Naphthoquinone derivatives are known to have antibacterial activity and are likely to succeed a new class of compound that can be applied as antimicrobial agents. (istanbul.edu.tr)
  • 6. Errante G, Motta GL, Lagana C, Wittebolle V, Sarciron MÉ, Barret R. Synthesis and evaluation of antifungal activity of naphthoquinone derivatives. (istanbul.edu.tr)
  • A silver-catalyzed three-component difunctionalization of alkenes by using 2-amino- and 2-hydroxy-1,4-naphthoquinone derivatives as the radical-trapping reagents is reported. (figshare.com)
  • Naphthoquinone derivatives possess anti-bacterial and anti-tumor properties. (naturalremedies.org)
  • 1,4-naphthoquinone derivatives occur naturally in the form of vitamin K. (naturalremedies.org)
  • 1947 ) The addition of sulfhydryl derivatives to 2-methyl-1,4-naphthoquinone. (academictree.org)
  • Naphthoquinones constitute a class of organic compounds structurally related to naphthalene. (wikipedia.org)
  • The current authors investigated the effects of naphthoquinone (NQ), one of the extractable chemical compounds of DEP, on antigen-related airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin (Ig) production in mice. (ersjournals.com)
  • In this thesis, bioassay-guided isolation studies were performed on Onosma aksoyii and Onosma isaurica to obtain naphthoquinone type cytotoxic compounds and investigate their topoisomerase inhibitory properties. (iyte.edu.tr)
  • The purpose of this experiment was to evaluate the potential antimicrobial, antibiofilm, anticancer, and cytotoxic activities of six naphthoquinone compounds previously reported in the literature. (istanbul.edu.tr)
  • The potent killing power of the two compounds, called naphthoquinones, was discovered during an international research programme to screen wild plants for potential new insecticides. (newscientist.com)
  • Another option, says Simmonds, might be to grow plants that make compounds that are easily converted into the naphthoquinones. (newscientist.com)
  • They are a class of compounds that contain the naphthoquinone structure. (naturalremedies.org)
  • The present work verified the cytotoxic and antioxidant potential of biflorin, an o-naphthoquinone isolated from C. biflora collected in the northeast region of Brazil. (degruyter.com)
  • Naphthoquinones are naturally widespread secondary metabolites deriving from some higher plants, fungi and bacteria, and have shown significant biological activities such as cytotoxic, antibacterial, antifungal and wound healing. (iyte.edu.tr)
  • Phytochemical studies have revealed that Onosma species possess various constituents including alkaloids, naphthoquinones, polyphenols, phytosterols, terpenoids and fatty acids. (iyte.edu.tr)
  • The naphthoquinone constituents may cause gastric (stomach) irritation. (pfaf.org)
  • Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5hydroxy-/5-methoxy-1,4-naphthoquinones. (istanbul.edu.tr)
  • 2,3-disubstituted-1,4-naphthoquinones containing an arylamine with trifluoromethyl group: synthesis, biological evaluation, and computational study. (istanbul.edu.tr)
  • 7. Bayrak N. Novel straight-chained sulfanyl members of arylamino1,4-naphthoquinones: synthesis and characterization. (istanbul.edu.tr)
  • These results provide the first experimental evidence that naphthoquinone can enhance antigen-related airway inflammation in vivo , and that naphthoquinone can, to some extent, partly play a role in the pathogenesis of diesel exhaust particle toxicity on the condition. (ersjournals.com)
  • Naphthoquinone (NQ) is another extractable compound from DEP 25 . (ersjournals.com)
  • Several enzymatic activation pathways yield to reactive metabolites like 1,2-naphthoquinone (1,2-NphQ), an oxygenated derivative of the parent compound. (hal.science)
  • Plumbagin (a naphthoquinone) also showed high trypanicidal activity and has previously been recognized as a leismaniacidal, bactericidal and fungicidal, compound. (bvsalud.org)
  • Naphthoquinones possessing strong antioxidant properties have been employed as candidates for diabetes therapy . (bvsalud.org)
  • From the observed shifts, equilibrium constants and number of MeOH molecules bonded to anion and dianion of the naphthoquinone were calculated. (org.pk)
  • Various alkenes and 2-amino- or 2-hydroxy-1,4-naphthoquinones with diverse structures and electronic properties are applied to the reaction. (figshare.com)
  • In another part of the programme, at the Royal Botanic Gardens, Kew, Monique Simmonds and her team are investigating the potential for growing C. andina as a source of naphthoquinones in Britain. (newscientist.com)
  • Methyl-phytyl-naphthoquinone and methyl-naphthoquinone gave equivalent results. (wikigenes.org)
  • The British Technology Group, which patents and licenses inventions, has patented the naphthoquinones. (newscientist.com)
  • The group of vitamin K vitamins have a methylated naphthoquinone ring structure. (naturalremedies.org)
  • The naphthoquinone is the functional group, which makes the structure of action similar in all K-vitamins. (naturalremedies.org)
  • The root cultures likewise produced the known alkaloids dioncophylline A (8) 5-O-demethyldioncophylline A (9) dioncopeltine A (10) habropetaline A (11) and 5-O-methyldioncophylline D (12a/b) the naphthalene glucoside plumbaside A (2) and the naphthoquinones plumbagin (13) droserone (14) and 8-hydroxydroserone (15). (lianaecologyproject.com)
  • Many of the compounds found in the Venus flytrap, including the naphthoquinone plumbagin (also present in Plumbago zeylanica [Plumbaginaceae] and other plants) and the phenolic acids ellagic acid (also present in pomegranate [Punica granatum, Lythraceae] and many other plants) and salicylic acid (also present in Salix spp. (google.com)
  • Plumbagin, a potent naphthoquinone from Nepenthes plants with growth inhibiting and larvicidal activities. (mpg.de)
  • Two common isomers of parent naphthoquinones are1, 2- Naphthoquinone and 1,4- Naphthoquinone. (solutionpharmacy.in)
  • Other notable compounds include anthraquinones, naphthoquinones and isoprenoid quinones. (naturalnews.com)
  • Vitamin K occurs in several different forms, but all share the menadione ring structure (2-naphthoquinone). (kcl.ac.uk)
  • The biologically active naphthoquinones lapachol, α-lapachone, and β-lapachone (pictured) were originally isolated from the bark of the lapacho tree ( Tabebuia sp. (chemistryviews.org)
  • 1,2-naphthoquinone (1,2-NQ) and 1,4-naphthoquinone (1,4-NQ) are clinically promising biologically active chemicals that have been shown to stimulate the aryl hydrocarbon receptor (AhR) signaling pathway, but whether they are direct or indirect ligands or activate the AhR in a ligand-independent manner is unknown. (nih.gov)
  • Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group. (mcw.edu)
  • A molecular docking study of compound NK3 revealed key interactions between NK3 and IDO1, with the naphthoquinone-oxime moiety coordinating with the heme iron. (myjournals.org)
  • From this fungus four naphthoquinone spiroketals were isolated. (usda.gov)
  • Bioassay-guided isolation from the culture of Edenia gomezpompae, a new endophytic fungus isolated from the leaves of Callicarpa acuminata (Verbenaceae) from the ecological reserve El Eden, Quintana Roo, Mexico, led to the isolation of four naphthoquinone spiroketals, including three new compounds. (usda.gov)
  • 14. Tubulin-perturbing naphthoquinone spiroketals. (nih.gov)
  • In this study, we synthesized three novel 2-amino-1,4-naphthoquinone amide-oxime derivatives and identified them as dual inhibitors of IDO1 and STAT3. (myjournals.org)
  • Corrigendum to "1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma" [Eur. (tmu.edu.tw)
  • The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. (elsevierpure.com)
  • All members of the vitamin K group share a methylated naphthoquinone ring structure and vary in the aliphatic side chain attached at the 3-position. (uspharmacist.com)
  • Light-Controlled Traceless Protein Labeling via Decaging Thio-o-naphthoquinone Methide Chemistry. (mpg.de)
  • Fosse Céline, Le Texier Laurence, Roy Sébastien, Delaforge Marcel, Grégoire Sébastien, Neuwels Michel, Azerad Robert: Parameters and mechanistic studies on the oxidative ring cleavage of synthetic heterocyclic naphthoquinones by Streptomyces strains. (cas.cz)
  • Katritzky Alan R., Fan Wei‐Qiang: A reexamination of the reactions of 2,3‐dichloro‐1,4‐naphthoquinone with thioamides. (cas.cz)
  • Genetic Toxicity Evaluation of 2-Hydroxy-1,4-naphthoquinone in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells. (nih.gov)
  • Strong adsorption properties of 8-hydroxy-l,2-naphthoquinone- 3,6-disulfonic acid on mercury electrode, which have been found previously, are now used up practically. (lodz.pl)
  • To complement these experimental studies, theoretical studies of naphthoquinone reactivity toward an amino group were conducted. (utc.edu)
  • For each naphthoquinone, the first step of both 1,2- and 1,4-additions at all possible C=O positions were examined. (utc.edu)
  • This naphthoquinone, however, has apparently not been tested for its biological activity. (google.com)