Nk cell lectin like receptor subfamily a. Medical search. Frequent questions

KLRC3 has also been shown to have interactions with KLRD1, TYROBP, HLA-A, and HLA-C in pathways such as the antigen processing and natural killer cell mediated cytotoxicity pathways. (novusbio.com)
The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones. (bdbiosciences.com)
Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. (nih.gov)
NK cells from NOD mice induced with poly(I:C) in vivo exhibit low cytotoxicity against a range of target cells, but the genetic mechanisms controlling this defect are yet to be elucidated. (ox.ac.uk)
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (zxbiopharm.com)
Together, along the course of IBM, some inflammatory cells retained the potential for cytotoxicity whereas others indicated suppression by exhaustion, senescence, or through the PD-1 pathway. (elsevierpure.com)

Its ligands are E-cadherin and N-cadherin with similar affinities, respective markers of epithelial and mesenchymal cells. (wikipedia.org)
Regulation of ligands for the activating receptor NKG2D. (ox.ac.uk)
Most normal tissues do not express ligands for NKG2D, but ligand expression has been documented in tumour and virus-infected cells, leading to lysis of these cells. (ox.ac.uk)
Defects in the expression of NKG2D and its ligands, the RAE-1 molecules, have been hypothesized to contribute to the reduced NK function present in NOD mice. (ox.ac.uk)
The NK cell research toolkit product contains three classes of genes: ligands, surface receptors, and transcription factors. (freegenes.org)
Since its discovery in 2000, initial in vitro studies have found that the engagement of Siglec-8 with a monoclonal antibody or with selective polyvalent sialoglycan ligands induced the cell death of eosinophils and inhibited mast cell degranulation. (mdpi.com)

CD8+ T-cell mediated immune responses are important in protection against various pathogens and specific tumor antigens associated with various cancers. (flowmetric.com)
Clinically, EBV-associated malignancies such as Hodgkin's lymphoma offer a unique model to explore antigen-defined immunotherapy approaches because EBV-derived tumor antigens are specific for tumor cells only. (dukecancerinstitute.org)
It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. (lookformedical.com)

We are thus investigating specialized cytokine secretion, antigen presentation, T cell skewing, interactions with NK cells, and optimal methods of antigen delivery for vaccines using dendritic cells, in HIV, autoimmunity and cancer. (mssm.edu)
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al. (nih.gov)
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. (ox.ac.uk)
We conclude that synovial NK cells have an activated phenotype and that CD94/NKG2A is a key regulator of synovial NK-cell cytokine synthesis. (ox.ac.uk)
Results: Tregs depletion enhanced the frequency of specific IFNÎ³+ T cells (Th1 lymphocytes) and cytokine production after either the first or second vaccine dose. (bvsalud.org)
Additional studies indicate a complex genetic control of defective NOD NK cells including genes linked to the MHC and possibly those that are associated with an altered cytokine response to the TLR3-agonist poly(I:C). (ox.ac.uk)
Although the initial NKT cell response to antigen is intact in the absence of DOCK8, their ongoing proliferative and cytokine responses are impaired. (ox.ac.uk)

The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A). (bdbiosciences.com)
The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells. (exbio.cz)
Separation of human CD314 positive CD56 positive NK cells (red-filled) from CD314 negative CD56 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD314 (1D11) APC antibody. (exbio.cz)
Activated synovial NK cells produced interferon-gamma and tumour necrosis factor, and the production was further up-regulated by antibody masking of CD94/NKG2A, and down-regulated by target cells expressing human leucocyte antigen-E in complex with peptides known to engage CD94/NKG2A. (ox.ac.uk)
Phycoerythrin conjugated Mouse anti Rat CD161 antibody, clone 10/78 ( MCA1427PE ) used for the identification of NK cells in rat blood samples by flow cytometry. (bio-rad-antibodies.com)
A: 3-week-old (young) Lewis rats were injected twice with a NK cell depleting antibody (3.2.3). (bio-rad-antibodies.com)
The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation. (rndsystems.com)
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
Description: The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in the NK1.1 mouse strains including C57BL and NZB. (thermofisher.com)
For detection of NK cells in these strains the monoclonal antibody DX5 (Cat. (thermofisher.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. (wikipedia.org)
Natural Killer group 2D (NKG2D) has recently emerged as a major activating receptor on T lymphocytes and natural killer cells. (ox.ac.uk)
In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
T cell large granular lymphocytes (LGLs) are potent effector cells and cells with ultrastructure indistinguishable from LGLs were seen in the sarcoplasm along with lymphocytes undergoing degeneration. (elsevierpure.com)

The expression of CD94/NKG2A was rapidly initiated in naive CD8(+) T cells responding to peptide Ags in vitro and on many of the naive T cells that proliferate when transferred into lymphopenic (Rag-1(-/-)) hosts. (duke.edu)
Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. (uni-regensburg.de)
On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. (uni-regensburg.de)
Bennett IM, Zatsepina O, Zamai L, Azzoni L, Mikheeva T, Perussia B. Definition of a natural killer NKR-P1A+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. (bdbiosciences.com)
In this study, we show that segregation of the NK-mediated killing phenotype did not correlate with the NOD Raet1 haplotype and that the large alterations in NKG2D expression previously reported on NK cells expanded in vitro were not observed in primary, poly(I:C)-elicited NK cells in vivo. (ox.ac.uk)
Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. (rndsystems.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
Applications Reported: PK136 has been reported for use in flow cytometric analysis, depletion of NK cells, and in vitro functional studies. (thermofisher.com)

CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). (exbio.cz)
The NKG2D-ligand interaction triggers an activating signal in the cell expressing NKG2D and this promotes cytotoxic lysis of the cell expressing the ligand. (ox.ac.uk)
NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice. (ox.ac.uk)
Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis. (ox.ac.uk)
To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating T(EM) and in granulomatous lesions, respectively. (ox.ac.uk)
Cluster-like formations of "Wegener's autoantigen" PR3 were surrounded by NKG2D+ and NKG2D-ligand MIC+ cells in WG-granulomata, but not in disease controls. (ox.ac.uk)

These NK cell receptors are also expressed by certain memory phenotype CD8(+) T cells, and in some cases are up-regulated in T cells responding to viral infection. (duke.edu)
To further understand the role for NK cells in inflammation, we investigated the phenotype and function of synovial fluid (SF) NK cells from patients with chronic joint inflammation, as well as from patients with transient inflammation of the knee following trauma. (ox.ac.uk)
Matsubara, S , Suzuki, S & Komori, T 2022, ' Immunohistochemical Phenotype of T Cells Invading Muscle in Inclusion Body Myositis ', Journal of Neuropathology and Experimental Neurology , vol. 81, no. 10, pp. 825-835. (elsevierpure.com)
The transcription factors can be transduced or transfected into NK cells to alter their behavior or phenotype. (freegenes.org)

KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. (biolegend.com)
Inhibits cell activation and proliferation, marker of T cell senescence. (biolegend.com)
A specific PLEKHA4 siRNA was transfected in glioma U251 and T98G cells, and the changes in cell proliferation ability were assessed by real-time cell analysis technology and Edu experiment. (bvsalud.org)
They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. (lookformedical.com)
Using these genes, researchers can manipulate NK cells, cancer cells, and "feeder" cells (i.e. cells used to trigger NK cell proliferation). (freegenes.org)

Thus, CD94/NKG2A expression is a common consequence of CD8(+) T cell activation. (duke.edu)
However, expression of CD94 and NKG2A transgenes partially inhibited early events of T cell activation. (duke.edu)
NKG2A functions intrinsically within ECTV-specific CD8 + T cells to limit excessive activation, prevent apoptosis, and preserve the specific CD8 + T cell response. (wustl.edu)
However, compared to this PB subset the synovial NK cells express a higher degree of activation markers including CD69 and NKp44, the latter being up-regulated also on CD56(bright) NK cells in the PB of patients. (ox.ac.uk)
A. The linear model describes the activation of naïve T-cells by the presentation of antigen-peptide on major histocompatibility complex (MHC) molecules by the antigen presenting cells (APCs) during the contraction phase of a T-cell response. (flowmetric.com)
NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. (rndsystems.com)
However, little is known about how T Reg suppress T cell activation in vivo. (dukecancerinstitute.org)
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. (unil.ch)
The genes listed here can be expressed on NK cells, feeder cells, or tumor cells to study individual NK cell signaling pathways, strengths of activation of different receptor-ligand interactions, and whether certain NK cells are more or less resistant to inhibitory cues from cancer cells. (freegenes.org)
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface proteins of necroptotic cells. (biomedcentral.com)

Killer cell lectin-like receptor subfamily G member 1 is a protein that in humans is encoded by the KLRG1 gene. (wikipedia.org)
KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory CD8+ T and NK cells. (wikipedia.org)
The characterization of KLRG1 as a "senescent" marker, but other co-inhibitory receptors as "exhaustion" markers, has contributed to relatively fewer studies on this molecule. (wikipedia.org)
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). (biolegend.com)
KLRG1 is expressed by subsets of NK, effector and memory T cells. (biolegend.com)
Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors. (biolegend.com)
At the surface of muscle fibers, 79% and 48% of CD8+ cells were positive for killer cell lectin-like receptor subfamily G, member 1 (KLRG1) and CD57, respectively. (elsevierpure.com)
Finally, we showed the sE-cadherin/KLRG1 inhibitory receptor is the major pathway for necroptosis-mediated suppression of the anti-tumor activity of T cells and the promotion of metastasis. (biomedcentral.com)

The NK Cell Research Toolkit enables researchers to examine the effects of distinct molecules on NK cells' targeting and eradication of discrete tumor cell types, and to design novel chimeric antigen receptors to modify endogenous signaling pathways. (freegenes.org)

Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. (zxbiopharm.com)
Genes down-regulated in comparison of B cells versus NK cells. (gsea-msigdb.org)

NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on NK cells and activated CD8 + T cells. (wustl.edu)

In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. (uni-regensburg.de)

KLRC3 codes for a protein that works as a receptor for the recognition of MHC molecules by natural killers, and in some cases cytotoxic T-cells. (novusbio.com)
The outcome of an encounter between a cytotoxic cell and a potential target cell depends on the balance of signals from inhibitory and activating receptors. (ox.ac.uk)
CD8+KLRG1+ cells are highly differentiated cytotoxic cells. (elsevierpure.com)

Thus, through acquisition of NK-like "innate" properties, IL-15 stimulated NKG2D+ T(EM) could interact with MIC+ cells within WG-granulomata, thereby sustaining inflammation and autoimmunity and promoting self-perpetuating pathology in WG. (ox.ac.uk)
Unlike the distinctive immunogenic pathway for CD8+ T-cell memory, CD4+ T-cell memory is significantly more plastic, involving at least seven distinct cell lineages with diverse effector functions, that play roles in all aspects of adaptive immunity as well as impact many innate immune mechanisms. (flowmetric.com)
We have been interested in the role of pattern-recognition receptors including Toll-like receptors (TLRs)in innate immune recognition of these viruses as well as their signaling pathways. (dukecancerinstitute.org)
In addition, we are investigating the role of innate immune cells such as natural killer (NK) cells in innate and adaptive immune responses to these viruses. (dukecancerinstitute.org)
Natural Killer (NK) cells are part of the innate immune system with inherent cancer cell-killing capabilities, providing an exciting alternative to costly custom T cell immunotherapies. (freegenes.org)
Two additional cell types, both part of the innate immune system, are found within the sinusoids, in direct contact with the blood: a large number of macrophages, called Kupffer cells, and Pit cells, a type of natural killer (NK) cells. (helmberg.at)

Subsets of NK, effector and memory T cells. (biolegend.com)
CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells. (bdbiosciences.com)
These models describe various mechanisms for the differentiation of naïve T-cells into memory, either sequentially, or via specific cell subsets. (flowmetric.com)
This CD8+ T-cell population is made up of three subsets, naïve, effector, and memory T-cells. (flowmetric.com)
D. In the simultaneous model, the naïve T-cells differentiate into the different subsets, which further differentiate. (flowmetric.com)

This interaction inhibits natural killer cell-mediated lysis of a cell displaying HLA-E. If the leader peptide is not present in the endoplasmic reticulum, HLA-E is unstable and is degraded before it reaches the cell surface. (ox.ac.uk)
Under these circumstances, HLA-E does not reach the cell surface and the cell is then vulnerable to lysis by natural killer cells. (ox.ac.uk)

NK cells express several families of receptors that play central roles in target cell recognition. (duke.edu)
Wu J, Groh V, Spies T: T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. (exbio.cz)
Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells. (ox.ac.uk)
ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)

We confirm that synovial NK cells are similar to the well-characterized CD56(bright) peripheral blood (PB) NK-cell subset present in healthy individuals. (ox.ac.uk)
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. (lookformedical.com)
We found that blocking tumor necroptosis by MLKL deletion led to the dramatic reduction of tumor metastasis and significantly elevated anti-tumor activity of tumor-infiltrating and peripheral blood T cells. (biomedcentral.com)

Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's granulomatosis (WG) recently. (ox.ac.uk)
The cells that mediate this response are known as effector memory T-cells (T EM ). (flowmetric.com)

CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene. (bdbiosciences.com)
The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. (zxbiopharm.com)
NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. (zxbiopharm.com)

cytochrome P450 family 51 subfamily A me. (gsea-msigdb.org)

In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells expressing the integrin CD103, whereas in the liver, DOCK8-deficient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin lymphocyte function-associated antigen 1. (ox.ac.uk)

adiponectin receptor 2 [Source:HGNC Symb. (gsea-msigdb.org)

All synthesized peptides exhibit B-cell epitopes on the molecular surface of SsEno and proved to be highly reactive with the serum of infected mice with S. brasiliensis and sera of cats with sporotrichosis. (bvsalud.org)
Importantly, the increased anti-tumor activity of T cells is a key cause for the reduced metastasis as the depletion of CD8+ T cells completely restored the level of metastasis in the Mlkl KO mice. (biomedcentral.com)
Interestingly, the levels of some soluble cell surface proteins including sE-cadherin that are known to promote metastasis are also dramatically reduced in MLKL null tumors/mice. (biomedcentral.com)
Administration of ADAMs pan inhibitor reduces the levels of soluble cell surface proteins in WT tumors/mice and leads to the dramatic decrease in metastasis. (biomedcentral.com)

Simultaneous staining of C57BL/6 spleen cells with PK136 and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells. (thermofisher.com)

It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA-A, HLA-B and HLA-C. This peptide binding is highly specific and stabilizes the HLA-E protein, allowing it to migrate to the cell surface. (ox.ac.uk)
In damaged cells, such as virally infected or tumour cells, down-regulation of HLA-A, HLA-B and HLA-C production or inhibition of TAP prevents stabilization of HLA-E by the leader peptide. (ox.ac.uk)
formyl peptide receptor 2 [Sour. (gsea-msigdb.org)

When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation. (rush.edu)
The exchange of huge amounts of molecules between hepatocytes and blood is facilitated by fenestration of the endothelial cells lining wide sinusoids, allowing plasma to enter the perisinusoidal space, also known as space of Disse. (helmberg.at)

CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B). (bdbiosciences.com)

The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. (wikipedia.org)

Immune cell infiltration varies widely between different glioblastomas (GBMs). (uni-regensburg.de)
Dr. Bhardwaj's research focuses on the study of dendritic cells, which serve a crucial function as sentinels of the immune system. (mssm.edu)
They are potent antigen-presenting cells which integrate microbe sensing, antigen display, and context-dependent instruction to T cells, to direct the appropriate type of immune response. (mssm.edu)
Natural killer (NK) cells are activated early during inflammatory events and contribute to the shaping of the ensuing adaptive immune response. (ox.ac.uk)
Introduction: Regulatory T cells (Tregs) have been shown to limit the protective immune response against pathogenic species of the fungus Sporothrix spp, the causal agent of sporotrichosis. (bvsalud.org)
Once the pathogen is cleared, most of these effector cells will undergo apoptosis to maintain the balance of the immune response. (flowmetric.com)
These are referred to as CD8+ memory T-cells because they 'remember' this previous encounter with the specific antigen, and they are programmed to elicit a faster and stronger immune response to that same antigen. (flowmetric.com)
Eradication of the threat during the contraction phase results in the loss through apoptosis of the majority of the adaptive immune effector cells. (flowmetric.com)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
As a necrotic cell death, the rupture of cell plasma membrane of necroptotic cells results in the release of many cellular factors of necroptotic cells, which may trigger inflammation and immune responses [ 17 , 18 ]. (biomedcentral.com)

Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. (bdbiosciences.com)
alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system. (lookformedical.com)

NKp80 Defines a Critical Step during Human Natural Killer Cell Development. (nih.gov)
NKp80 is a marker of natural killer (NK) cell maturity in secondary lymphoid tissues and supports NK cell development through a stage 4a intermediate with ILC3-associated features. (nih.gov)
A functioning TAP (transporter associated with antigen processing) molecule is required to transport these peptides into the endoplasmic reticulum, where they can interact with HLA-E. HLA-E then migrates to the cell surface, where it interacts with CD94/NKG2A receptors on natural killer cells. (ox.ac.uk)
Because natural killer T (NKT) cells have been implicated in these diseases, we asked if these cells were affected by DOCK8 deficiency. (ox.ac.uk)

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)

BACKGROUND: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immunogenicity and vaccine efficacy. (bvsalud.org)

Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. (exbio.cz)

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. (rndsystems.com)
On an average, 27% of CD8-CD57+KLRG1+ cells at the surface were CD4+. (elsevierpure.com)
Here, we report that the ectodomain shedding of cell surface proteins of necroptotic cells is critical for the promoting effect of tumor necroptosis in tumor metastasis through inhibiting the anti-tumor activity of T cells. (biomedcentral.com)

Scholars@Duke publication: Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. (duke.edu)

us pharmacological inhibitors such as Picroto in GABAA receptor antagonist, Pertussis to in Gi protein coupled receptor pathway inhibitor, Herbimycin A tyrosine kinase inhibitor, Chelerythrine chloride protein kinase C inhibitor, not Wortmannin A phosphoinositide 3 kinase inhibitor, H 89 cAMP dependent protein kinase A inhibitor for 1 hr at 37 C with 5% CO2 in humidified air prior to the addition of human SIZP. (vegfr-3inhibitor.com)

These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. (mdpi.com)

Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles. (childrensmercy.org)
GABA type A receptor associated. (gsea-msigdb.org)

CD8 + T cells and NK cells protect from viral infections by killing virally infected cells and secreting interferon-γ. (wustl.edu)

BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)

In this model, only Foxp3(+) Tregs express eGFP and diphtheria toxin (DT) receptors, and transient Tregs depletion is achieved by DT administration. (bvsalud.org)

conversely, very few Ag-specific T cells expressed Ly49 family members. (duke.edu)

Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)

The colony-forming ability of the cells was evaluated using plate cloning assay, and cell cycle changes and cell apoptosis were analyzed with flow cytometry. (bvsalud.org)

Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. (bdbiosciences.com)

It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)

In conclusion, our data demonstrate that DOCK8 is required for the development and survival of mature NKT cells, consistent with the idea that DOCK8 mediates survival signals within a specialized niche. (ox.ac.uk)
The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE. (lookformedical.com)
The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)

PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)

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