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  • NADPH
  • In its 'physiological' form (i.e. in 1.0 m -potassium chloride), and also in 1.0 m -sodium chloride, the reaction mechanism is ordered with NADP + the first substrate added and NADPH the last product released. (biochemj.org)
  • Binding of the substrate 6-phospho-d-gluconate (6PG), the inhibitors 5-phospho-d-ribonate (5PR) and 4PE, and the coenzymes NADP, NADPH and NADP analogue 3-amino-pyridine adenine dinucleotide phosphate to 6-phospho-d-gluconate dehydrogenase from T. brucei was studied using isothermal titration calorimetry. (unife.it)
  • isocitrate
  • Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. (nih.gov)
  • PMID
  • NADP-dependent H4MPT DH catalyzes the dehydrogenation of methylene-H4MPT and methylene-tetrahydrofolate (H4F) with NADP+ as cofactor [ PMID: 12176390 ]. (ebi.ac.uk)
  • similarity
  • The closest homologue that has a known structure is the E. coli NADP-dependent IDH, which has only 2 subunits and a 13% identity and 29% similarity based on the amino acid sequences, making it dissimilar to human IDH and not suitable for close comparison. (wikipedia.org)
  • found
  • It was subsequently found that most dehydrogenases that utilize NAD or NADP contain this same structurally conserved Rossmann fold motif. (wikipedia.org)
  • specific
  • However, C. glutamicum was recorded as having ten times as much activity than E. coli and seven times more affinitive/specific for NADP. (wikipedia.org)