• These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. (ox.ac.uk)
  • Enzymatic analysis of cortex homogenates from Mo(vbr) mice showed an approximately twofold decrease in cytochrome c oxidase and a 1.4-fold decrease in NADH:cytochrome c reductase activities as compared with controls. (ox.ac.uk)
  • Thus, the two substrates of this enzyme are NADPH and NAD + , whereas its two products are NADP + and NADH . (wikipedia.org)
  • K m -values for NADP + and NADPH are at least 800-fold lower than those for NAD + and NADH [1,4]. (enzyme-database.org)
  • The four substrates of this enzyme are (+)-abscisate, NADPH, H + , and O 2 , whereas its three products are 8'-hydroxy-abscisate, NADP + , and H 2 O. (alchetron.com)
  • At the highest OTR condition, a decrease in the NADPH/NADP + ratio of threefold was observed, probably as a response to the high respiration rate induced by the respiratory protection of the nitrogenase under diazotrophic conditions, correlating with a high expression of the uncoupled respiratory chain genes ( ndhII and cydA ) and induction of the expression of the genes encoding the nitrogenase complex ( nifH ). (biomedcentral.com)
  • The Oxidoreductases group of enzymes usually utilizes NADP or NAD as cofactors. (wellnessadvantage.com)
  • The enzymes from the fungi Neurospora crassa, Emericella nidulans and Candida nitratophila can use either NADPH or NADH as electron donor. (expasy.org)
  • These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
  • Carbonyl groups are reduced by an array of distinct NADPH-dependent enzymes, belonging to several oxidoreductase families. (ox.ac.uk)
  • In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. (lookformedical.com)
  • In enzymology , Oxidoreductase Acting on CH-CH Donors (EC 1.3 Enzyme subclass ) in the Oxidoreductase Class of enzymes are a subclass of oxidoreductase enzyme which includes all dehydrogenases acting on carbon-carbon bonds. (wellnessadvantage.com)
  • The Oxidoreductases Acting on CH-CH Group Donors enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds. (wellnessadvantage.com)
  • In biochemistry, the EC 1.8 Enzyme subclass in the Oxidoreductase Class of enzymes. (wellnessadvantage.com)
  • Alcohol dehydrogenase (ADH) contributes significantly to NADH-dependent C-nitroso reduction by cytosol relative to NAD(P)H: quinone oxidoreductase (NQOR). (lsu.edu)
  • NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. (dundee.ac.uk)
  • Whereas the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), induced NADPH-oxidase-catalyzed superoxide (O2-) formation in human neutrophils, purine and pyrimidine nucleotides per se did not stimulate NADPH oxidase but enhanced O2- formation induced by submaximally and maximally stimulatory concentrations of fMet-Leu-Phe up to fivefold. (uni-regensburg.de)
  • The production of superoxide anion in response to NADH as a substrate was markedly increased in the vascular homogenates, but NADPH, arachidonic acid, xanthine, and succinate produced only small increases in chemiluminescence. (diabetesjournals.org)
  • In line with these results, studies using various enzyme inhibitors, such as DPI, allopurinol, rotenone, N G -monomethyl- l -arginine, and indomethacin, suggest that the predominant source of superoxide anion in vascular particulate fraction is NADH-dependent membrane-bound oxidase. (diabetesjournals.org)
  • 9 Atorvastatin protects against cerebral infarction via inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived superoxide in transient focal ischaemia. (radcliffecardiology.com)
  • In our body, Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. (wellnessadvantage.com)
  • The electrons of NADH can be used to produce ATP by oxidative phosphorylation in the mitochondria. (mysite.com)
  • This enzyme belongs to the family of oxidoreductases , specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. (wikipedia.org)
  • The systematic name is based on donor:acceptor oxidoreductase. (lookformedical.com)
  • In biochemistry, an Oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). (wellnessadvantage.com)
  • and ethanol via NADH- and NADPH-linked alcohol dehydrogenase. (wikipedia.org)
  • This enzyme differs from EC 1.1.1.105 , retinol dehydrogenase, which prefers NAD + and NADH. (enzyme-database.org)
  • Previously we also observed that ethanol production inhibited glycolysis at the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reaction, and that the GapDH enzyme from T. saccharolyticum was less sensitive to inhibition by NADH, compared to the native C. thermocellum enzyme [ 12 ]. (biomedcentral.com)
  • oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39). (ebi.ac.uk)
  • the enzyme which in a multistep process generates nitric oxide (*NO) from NADPH, oxygen, and arginine. (mysite.com)
  • The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. (enzyme-database.org)
  • Nor1p catalyzed the reduction of NO to N2O using NADH as the direct reductant. (nih.gov)
  • The reaction does not occur when NADPH is substituted for NADH. (qmul.ac.uk)
  • Inhibitor titrations were used to determine flux control coefficients of NADH:CoQ oxidoreductase and cytochrome c oxidase on the rate of mitochondrial respiration. (ox.ac.uk)
  • These findings suggest that upregulated expression of p22phox mRNA and enhanced NADH oxidase activity contribute to the impaired endothelium-dependent vasodilation in OLETF rats. (diabetesjournals.org)
  • structurally, it belongs to the homodimeric NADH:flavin mononucleotide (FMN) oxidoreductase-like fold family. (canada.ca)
  • Oxidoreductases Acting on Sulfur Group Donors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Harvard Catalyst Profiles by year, and whether "Oxidoreductases Acting on Sulfur Group Donors" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Profiles. (harvard.edu)
  • This enzyme belongs to the family of oxidoreductases, to be specific those acting on paired donors, with O 2 as oxidant and incorporation or reduction of oxygen. (alchetron.com)
  • The oxygen incorporated need not be derived from O 2 with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. (alchetron.com)
  • The systematic name of this enzyme class is abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating) . (alchetron.com)
  • NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. (ecmdb.ca)
  • These studies showed that changes in the ratio of NADH/NAD + determined the metabolic products. (biomedcentral.com)
  • To our knowledge, there have been no studies about the relationship between NADH and NADPH levels and the metabolic behavior of A. vinelandii . (biomedcentral.com)
  • Also, NADPH and NADH are central components in the cytosolic metabolic pathways, which connect the two largest biochemical processes on earth, photosynthesis and respiration in plants. (lu.se)
  • In vitro kinetic assays on crude hktE - pgdx - H. influenzae Rd extracts revealed the presence of NAD(P)H:peroxide oxidoreductase activity, which, however, appears to be physiologically insignificant because of its low affinity for H 2 O 2 ( K m = 1.1 mM). (biomedcentral.com)
  • Interaction with C4 dicarboxylic acids and identification of a novel L -aspartate: fumarate oxidoreductase activity. (enzyme-database.org)
  • NADPH-dependent pNSP reduction by liver cytosol of ADH+ animals is mostly dicumarol-sensitive which implicates NQOR as the major NADPH-dependent activity. (lsu.edu)
  • These mutations typically reduced NADH-linked ADH activity. (biomedcentral.com)
  • About half of the ethanol tolerance phenotype could be attributed to the elimination of NADH-linked activity based on a targeted deletion of adhE . (biomedcentral.com)
  • Application of amobarbital to titrate the activity of NADH:CoQ oxidoreductase showed very similar flux control coefficients for control and mutant animals. (ox.ac.uk)
  • An enzyme that utilizes NADH or NADPH to reduce FLAVINS. (bvsalud.org)
  • Both NAC and cys are important precursors to numerous oxidoreductases and transcription factors which possess thiol groups. (mysite.com)
  • Oxidoreductases with specificity for oxidation or reduction of SULFUR COMPOUNDS. (harvard.edu)
  • However, it is well known that the NADPH is consumed during PHB biosynthesis and the alginate biosynthesis produces NADH in this bacterium. (biomedcentral.com)
  • d1mokb1 c.3.1.5 (B:2-192,B:314-383) NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase {Xanthobacter sp. (berkeley.edu)
  • Catalyzes the reduction of tetrazolium compounds in the presence of NADH . (nih.gov)
  • Oxidoreductases that are specific for the reduction of NITRATES. (lookformedical.com)
  • Mitochondrial NADH:ubiquinone oxidoreductase (complex I) from bovine heart is a complicated multisubunit, membrane-bound assembly. (ox.ac.uk)
  • similar to NADH with an extra phosphate group. (mysite.com)
  • One of the most central nodes of plant function is the distribution of energy and redox via the molecules NADPH and NADH, because this connects both to growth and to the many systems that protect plants. (lu.se)
  • The initial two steps leading to the sequential formation of 2-hydroxy/aminobenzoate and 3-HAA are catalyzed by a NADPH-dependent 2-NBA nitroreductase (NbaA) and 2-hydroxylaminobenzoate mutase (NbaB), respectively. (canada.ca)