• biosynthesis
  • More recently, several groups have reported the crystal structure of Nampt/PBEF/visfatin and they all show that this protein is a dimeric type II phosphoribosyltransferase enzyme involved in NAD biosynthesis. (wikipedia.org)
  • activity
  • NAD-dependent inhibition of the NAD-glycohydrolase activity in A549 cells. (unicam.it)
  • We have identified a NAD-glycohydrolase activity associated with the outer surface of the plasma membrane in human lung epithelial cell line A549. (unicam.it)
  • This activity is negatively regulated by its substrate beta-NAD but not by alpha-NAD. (unicam.it)
  • 2010). NAD, a universal energy-and signal-carrying molecule and its phosphorylated form, NADP, are required in several intracellular processes such as redox reactions, DNA repair, G-protein coupled receptor signaling, intra-cellular calcium-mobilizing molecules, transcriptional regulation, mono-adenosine diphosphate (ADP)-ribosylation in immune response, and activity of poly-ADP ribosyltransferases and deacetylases (sirtuins) with roles in regulating cell survival and cytokine responses (Garten et al. (atlasgeneticsoncology.org)