• N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in human cells, and many mammalian cells. (wikipedia.org)
  • Neuraminic acid N-Glycolylneuraminic acid Sialic acid Severi E, Hood DW, Thomas GH (2007). (wikipedia.org)
  • Thus, in the present research we performed two different approaches in order to obtain polymeric (poly(d,l-lactide-co-glycolide), PLGA) NPs surface decorated with the sialic acid N-acetylneuraminic acid (Neu5Ac). (unimore.it)
  • Thus, the new Neu5Ac-modified PLGA polyester represent a useful starting material for the preparation of NPs surface decorated with this sialic acid. (unimore.it)
  • Sialic acid is a class of natural carbohydrate compounds widely present in biological systems, and plays a very important biological function in physiological processes such as cell differentiation, maturation, and intercellular interactions. (peptidepowders.com)
  • In the pharmaceutical industry, derivatives with sialic acid as precursors are increasingly used in antiviral drugs, drugs for the treatment of neurological diseases, and diagnostic reagents. (peptidepowders.com)
  • The Leganqing product is a patented product produced by the British Glanso Company, and the main raw material for the production of Leganqing is sialic acid. (peptidepowders.com)
  • The addition of sialic acid to infant milk powder is essential to ensure the normal growth and development of infants, to help the baby's memory form a more stable structural basis, and to strengthen the development of the nervous system. (peptidepowders.com)
  • Sialic acid storage disease is an inherited disorder that primarily affects the nervous system. (medlineplus.gov)
  • People with sialic acid storage disease have signs and symptoms that may vary widely in severity. (medlineplus.gov)
  • This disorder is generally classified into one of three forms: infantile free sialic acid storage disease, Salla disease, and intermediate severe Salla disease. (medlineplus.gov)
  • Infantile free sialic acid storage disease (ISSD) is the most severe form of this disorder. (medlineplus.gov)
  • Salla disease is a less severe form of sialic acid storage disease. (medlineplus.gov)
  • Sialic acid storage disease is a very rare disorder. (medlineplus.gov)
  • Mutations in the SLC17A5 gene cause all forms of sialic acid storage disease. (medlineplus.gov)
  • Sialin moves a molecule called free sialic acid, which is produced when certain proteins and fats are broken down, out of the lysosomes to other parts of the cell. (medlineplus.gov)
  • Free sialic acid means that the sialic acid is not attached (bound) to other molecules. (medlineplus.gov)
  • Approximately 20 mutations that cause sialic acid storage disease have been identified in the SLC17A5 gene. (medlineplus.gov)
  • SLC17A5 gene mutations that reduce or eliminate sialin activity result in a buildup of free sialic acid in the lysosomes. (medlineplus.gov)
  • It is not known how this buildup, or the disruption of other possible functions of sialin in the brain, causes the specific signs and symptoms of sialic acid storage disease. (medlineplus.gov)
  • Adams D, Wasserstein M. Free Sialic Acid Storage Disorders. (medlineplus.gov)
  • EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc). (univ-lorraine.fr)
  • Sialic Acid/N-acetylneuraminic acid ke lentsoe le akaretsang bakeng sa N- kapa O-substituted derivatives of neuraminic acid, e robong carbon monosaccharide.Hape ke lebitso la setho se tloaelehileng sa sehlopha sena, N-acetylneuraminic acid (Neu5Ac kapa NANA) mme lena ke lebitso le sebelisoang ke CIMA. (zhuoerchem.com)
  • Ke lokela ho nka Nutrition Supplement Sialic Acid/N-acetylneuraminic Acid CAS 131-48-6 joang? (zhuoerchem.com)
  • Gangliosides, complex glycosphingolipids on the plasma membrane containing one or more sialic acid residues, are key components of microdomains. (jneurosci.org)
  • Preclinical studies in rodent and pigs reported that supplementation with HMO's including 3'SL resulted in an enriched sialic acid content in the brain. (dsm.com)
  • This may be important for infants serving as an important source of sialic acid for brain development (5,6). (dsm.com)
  • Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets. (dsm.com)
  • Vancova M., Sterba J., Dupejova J., Simonova Z., Nebesarova J., Novotny M.V., Grubhoffer L.: Uptake and incorporation of sialic acid by the tick Ixodes ricinus . (jcu.cz)
  • We have developed novel methods for large-scale production of N -acetylneuraminic acid (Neu5Ac) and N -acetyl-D-mannosamine (ManNAc). (go.jp)
  • CMP-β-D- N -Acetlylneuraminic acid (CMP-Neu5Ac) is a nucleotide sugar and the donor substrate for eukaryotic and prokaryotic sialyltransferases. (biolog.de)
  • Removal of sialic acids exposes underlying disaccharide galactose- N -acetylglucosamine, a ligand for a ubiquitous galactoside-binding lectin galectin-1. (aspetjournals.org)
  • Aceneuramic acid has been used in trials studying the treatment of Distal Myopathy, Nonaka Type, Hereditary Inclusion Body Myopathy, and Distal Myopathy With Rimmed Vacuoles. (rcsb.org)
  • N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (goldbio.com)
  • N-acetylneuraminic acid is an N-acyl derivative of neuraminic or acid amino sugar derivative, derived from N-acetylmannosamine and pyruvic acid. (goldbio.com)
  • McNally DJ, Schoenhofen IC, Houliston RS, Khieu NH, Whitfield DM, Logan SM, Jarrell HC, Brisson JR. CMP-pseudaminic acid is a natural potent inhibitor of PseB, the first enzyme of the pseudaminic acid pathway in Campylobacter jejuni and Helicobacter pylori. (umassmed.edu)
  • This mini-review describes selectin antagonists, where the N-acetylneuraminic acid moiety of the natural ligand sialyl Lewisx is replaced by mimetics containing the essential carboxylic acid function. (chimia.ch)
  • This region contained 55 genes, including SLC17A5, the gene encoding the lysosomal N-acetylneuraminic acid transport protein. (clinicforspecialchildren.org)
  • Manufacturer of peptides - Amino Acids - SARMS - NOOTROPICS , DROPPPERS , NASAL SPRAY , CAPSULES . (austropeptide.com)
  • Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction. (umassmed.edu)
  • Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be identified in a site-specific manner from individual glycopeptides using ion mobility-mass spectrometry analysis of diagnostic fragment ions. (fu-berlin.de)
  • An analysis of the sialic acids present in the cells' own glycoconjugates revealed a decrease in the percentage of Neu5Gc residues from 4% in the parental cells to less than 1% in the CHO-AsUH2 cell line. (univ-lorraine.fr)
  • 1997. Food additive-additive interactions involving sulphur dioxide and ascorbic and nitrous acids: a review. (cdc.gov)
  • A list of these acetylneuraminic acid manufacturer articles makes it easy for you to quickly access relevant information. (zhenyibio.com)
  • We have prepared the following professional acetylneuraminic acid manufacturer , hoping to help solve your questions and better understand the product information you care about. (zhenyibio.com)
  • Other forms, such as N-Glycolylneuraminic acid, may also occur in cells. (wikipedia.org)
  • 1989. Health effects of air pollutants: Sulfuric acid, the old and the new. (cdc.gov)
  • 1989. Furnace-generated acid aerosols: Speculation and pulmonary effects. (cdc.gov)
  • Effects of Feeding Sialyllactose and Galactosylated N-Acetylneuraminic Acid on Swimming Learning Ability and Brain Lipid Composition in Adult Rats. (dsm.com)
  • Neuraminic acid N-Glycolylneuraminic acid Sialic acid Severi E, Hood DW, Thomas GH (2007). (wikipedia.org)
  • Sialic acid (also known as neuraminic acid, or Neu5Ac) has long been recognized to participate in the regulation of immune cell function. (frontiersin.org)
  • An N-acyl derivative of neuraminic acid. (bvsalud.org)
  • Adak A, Balasaria S, Mukhopadhyay B. ( 2022 ) Concise synthesis of the tetrasaccharide repeating unit of the O-antigen from Escherichia coli O131 containing N-acetyl neuraminic acid. (academictree.org)
  • Gangliosides, spin labelled on N-acetylneuraminic acid residues or on random-headgroup sugars, have been used to study their physical behavior in three lines of cultured cells. (uwo.ca)
  • Rees, Michael A. / Terminal sialic acid residues on human glycophorin A are recognized by porcine Kupffer cells . (umn.edu)
  • NEU1 is part of the sialidase family that are exoglycosidases removing terminal sialic acid residues from glycoproteins, glycolipids and oligosaccharides. (biomedcentral.com)
  • The strategy involves orthogonal techniques: total N-glycan profiling and quantitative analysis of neutral monosaccharides and sialic acids, where a mAb is used as a model glycoprotein and this workflow can be applied throughout a biopharmaceutical's product life cycle. (ludger.com)
  • Nonulosonic acids (NulOs) are a group of nine-carbon monosaccharides with different functions in nature. (fiocruz.br)
  • Monosaccharides present on human glycophorin A, neuraminyl lactoses, bovine and porcine submaxillary mucins (BSM and PSM), and hyaluronic acid as well as proteoglycan N-linked glycosidase F(PNGaseF)- and sialidase A-treated human erythrocyte glycoproteins (hEGP) and human erythrocytes were all tested for inhibitory potential in the resetting assay. (umn.edu)
  • Our results provide a proof of concept in sialic acid-related molecular therapy with synthetic monosaccharides. (duke.edu)
  • This disorder is generally classified into one of three forms: infantile free sialic acid storage disease, Salla disease, and intermediate severe Salla disease. (medlineplus.gov)
  • Infantile free sialic acid storage disease (ISSD) is the most severe form of this disorder. (medlineplus.gov)
  • Sialic acid-containing glycolipids, known as gangliosides, play important structural and functional roles. (frontiersin.org)
  • In addition, hemagglutination by coronaviruses can be inhibited by pretreatment of erythrocytes with Arthrobacter ureafaciens or Clostridium perfringens neuraminidase or by addition of sialic acid-containing gangliosides. (mssm.edu)
  • We previously found that urinary creatine riboside (CR), N-acetylneuraminic acid (NANA), cortisol sulfate (CS) and as-yet-unidentified metabolite 561+ have diagnostic and prognostic significance for lung cancer. (nih.gov)
  • Total protein and sialic acid were increased in cell-free lavage after 20, 30, or 40 ppm NO2. (nih.gov)
  • The amounts of protein, sialic acid, and acid phosphatase recovered by airway lavage were equal to the amounts found in 0.7 ml of plasma, consistent with transudation of this volume of plasma into airways as a source of these parameters. (nih.gov)
  • 5. [Evaluation of immunosuppressive acid protein in genitourinary malignant diseases]. (nih.gov)
  • 9. Serum immunosuppressive acid protein predicts lymph node metastases in patients with renal cell carcinoma. (nih.gov)
  • Lipid-associated sialic acid (LASA-P) and the S-100 protein (S-100) were evaluated as tumor markers for melanoma with the goal of early detection of recurrence. (duke.edu)
  • Here, using GM1, GM3, and GD3 ganglioside micelles as models, we show that the sugar distributions and cationic amino acids within Aß N-terminal region modulate oligomerization of Aß temporally, and dictate the stability and maturation of oligomers. (bvsalud.org)
  • Cell-free lavage fluid contained elevated amounts of lactate dehydrogenase (LDH), malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), glucose-6-phosphate dehydrogenase (GDH), acid phosphatase (AP), and aryl sulfatase (AS) after 30 or 40 ppm NO2. (nih.gov)
  • Effect of changing amino acid concentration on urea and glucose release in sheep liver. (nhri.org.tw)
  • These results suggest that, like influenza C viruses, human coronavirus OC43 and bovine coronavirus recognize O-acetylated sialic acid or a similar derivative as cell receptor. (mssm.edu)
  • Some bacteria can also produce other NulOs named pseudaminic and legionaminic acids, through the NeuB homologues PseI and LegI, respectively. (fiocruz.br)
  • CMP-N-acetylneuraminic acid:lactosylceramide (α2-3) sialyltransferase (G(M3)-synthase) was purified to homogeneity from a Triton CF-54 extract of young rat brain. (elsevierpure.com)
  • Final purification of G(M3)-synthase was achieved by chromatography on a 'lactosylceramide acid'-Sepharose column and specific elution with lactosylceramide. (elsevierpure.com)
  • We use this same methodology to retrieve sialic acid synthase sequences from Archaea and Eukarya. (fiocruz.br)
  • These are organic compounds containing phosphoric acid ester functional group, with the general structure R1P(=O)(R2)OR3. (hmdb.ca)
  • AISI 316L and 316Ti stainless steel coil sheet plate Description:316Ti is a metallic material, which is added to SUS316 steel to improve the intergranular corrosion resistance.Used to resist sulfuric acid, phosphoric acid, acetic acid equipment. (chinalane.org)
  • Railway Tank Wagons Phosphoric Acid Tank Wagon Railroad High-capacity Tank Car Mineral Oil Rail Tank Car Description of Phosphoric Acid Tank Wagon: Phosphoric acid tank Wagon is specially designed and manufactured to transport phosphoric acid. (chinalane.org)
  • The existing paradigm is that 'sialidase-sensitive' animal rotavirus strains bind to glycans with terminal sialic acid (Sia), whereas 'sialidase-insensitive' human rotavirus strains bind to glycans with internal Sia such as GM1 (ref. 3). (nih.gov)
  • Terminal sialic acid on human erythrocytes is a target recognized by porcine Kupffer cells, suggesting a role for a sialic-acid receptor in innate cellular recognition of xenogeneic epitopes. (umn.edu)
  • 8 . It is a monomer of peptidoglycan in most bacterial cell walls , which is built from alternating units of N -acetylglucosamine (GlcNAc) and N -acetylmuramic acid, cross-linked by oligopeptides at the lactic acid residue of MurNAc. (wikipedia.org)
  • Early reports dubbed increases in B cell antigen sensitivity a "neuraminidase effect," ( Cowing and Chapdelaine, 1983 ) and recent evidence has ascribed this phenomenon to sialic acid acting as a negative regulator of immune cell interactions ( Bagriacik and Miller, 1999 ). (frontiersin.org)
  • Sialin moves a molecule called free sialic acid, which is produced when certain proteins and fats are broken down, out of the lysosomes to other parts of the cell. (medlineplus.gov)
  • In cows and sheep and GTC's bioreactor of choice, the goat, the oligosaccharide decoration on proteins typically contains N-glycolylneuraminic acid (NGNA), a monomer virtually absent in native human proteins. (lobbywatch.org)
  • Human DCs display high content of sialic acids, which inhibits their maturation and co-stimulation capacity. (unl.pt)
  • 14. Determination of serum total lipid and free N-acetylneuraminic acid in genitourinary malignancies by fluorimetric high performance liquid chromatography. (nih.gov)
  • N-Acetylneuraminic acid determination by various methods. (msk.ru)
  • Merkur'eva R.V., Bazanov E.A. (1968) N-Acetylneuraminic acid determination by various methods. (msk.ru)
  • 1975. Long-term exposure to sulfur dioxide, sulfuric acid mist, fly ash, and their mixtures: Results of studies in monkeys and guinea pigs. (cdc.gov)
  • 1969. Toxicologic appraisal of particulate matter, oxides of sulfur, and sulfuric acid. (cdc.gov)
  • 1989. Health effects of air pollutants: Sulfuric acid, the old and the new. (cdc.gov)
  • N -Acetylmuramic acid (MurNAc) is part of the peptidoglycan polymer of bacterial cell walls. (wikipedia.org)
  • Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. (calixar.com)
  • Utilizing Tay-Sachs ganglioside labeled with (14)C in the N-acetylgalactosaminyl portion or (3)H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sachs ganglioside may be initiated by either the removal of the molecule of N-acetylgalactosamine or N-acetylneuraminic acid. (eurekamag.com)
  • Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy. (duke.edu)
  • The choice for the preferred molecule, however, was limited probably by the complex pharmacokinetics of sialic acids and the lack of biomarkers that could clearly show dose response. (duke.edu)
  • Relying on the plasma technology derived from EAST device, the biological team has broken through a number of key technical barriers and mastered a large batch of key core technologies after nearly 10 years of painstaking research and development of N-acetylneuraminic acid. (ipp.ac.cn)
  • The stereoselective synthesis of sialic acid glycoconjugates is still a challenge in the field. (nih.gov)
  • MSEA identifies fatty acid biosynthesis as the type 2 diabetes complications-associated biological pathway (P? (cdc.gov)
  • Product Name DIATRIZOIC ACID Model No SIL019M Cas No. 117-96-4 Assay 98% Molecular Structural DIATRIZOIC ACID Details: Product Name:DIATRIZOIC ACID MF:C11H9I3N2O4 MW:613.91 MP:>300°C storage temp:Amber Vial, -20°C Freezer Usage:Density gradient reagent. (chinalane.org)
  • In fact, only in rabbits and chickens are the oligosaccharides more human-like (containing N-acetylneuraminic acid). (lobbywatch.org)
  • N-acetylneuraminic acid (sialic acid, bird's nest acid) is an important new food ingredient which is considered to be a necessary nutritional factor for human health. (ipp.ac.cn)
  • The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. (dundee.ac.uk)
  • In the DMRV/hIBM mouse model, which exhibits hyposialylation in various tissues in addition to muscle atrophy, weakness, and degeneration, we recently have demonstrated that the myopathic phenotype was prevented by oral administration of N-acetylneuraminic acid, N-acetylmannosamine, and sialyllactose, underscoring the crucial role of hyposialylation in the disease pathomechanism. (duke.edu)
  • Adams D, Wasserstein M. Free Sialic Acid Storage Disorders. (medlineplus.gov)
  • NEU3 was able to modify the sialic acid content of purified LFA-1 in vitro . (frontiersin.org)
  • 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (HEDP) CAS No. 2809-21-4 Molecular Formula: C2H8O7P2 Molecular weight:206.02 Structural Formula: Properties: HEDP is an organophosphoric acid corrosion inhibitor. (chinalane.org)
  • Folic acid supplementation is advisable in individuals with cold agglutinin disease to meet the increased requirements for red blood cell production, due to hemolytic anemia. (medscape.com)
  • Sialic acids (Sia) are present on the cell surfaces in all vertebrates and higher invertebrates. (invitrojobs.com)
  • Sialic acid storage disease is an inherited disorder that primarily affects the nervous system. (medlineplus.gov)
  • People with sialic acid storage disease have signs and symptoms that may vary widely in severity. (medlineplus.gov)
  • Salla disease is a less severe form of sialic acid storage disease. (medlineplus.gov)
  • Sialic acid storage disease is a very rare disorder. (medlineplus.gov)
  • Mutations in the SLC17A5 gene cause all forms of sialic acid storage disease. (medlineplus.gov)
  • Approximately 20 mutations that cause sialic acid storage disease have been identified in the SLC17A5 gene. (medlineplus.gov)
  • It is not known how this buildup, or the disruption of other possible functions of sialin in the brain, causes the specific signs and symptoms of sialic acid storage disease. (medlineplus.gov)