• nucleotide
  • In myotonic dystrophy a nucleotide expansion of either of two genes, related to type of disease, results in failure of correct expression (splicing of the mRNA) of the ClC-1 ion channel, due to accumulation of RNA in the cytosol of the cell. (wikipedia.org)
  • Insulin
  • The changes in insulin resistance are discussed in relation to cellular membrane changes present in myotonic dystrophy. (cun.es)
  • Toxic RNA can lead to a vast range of medical effects including those of insulin resistance, tumors, muscular wasting seen in myotonic dystrophies, impairment of motor skills seen in FXTAS, a variety neurodegenerative syndromes, and more. (wikipedia.org)
  • distinct
  • This new edition retains the same successful structure, but now includes new material on the recognition of the distinct 'type 2 myotonic dystrophy', which had only just been identified at the time of the first edition. (ebooks.com)
  • Myotonic dystrophy is distinct in having widespread effects throughout the systems of the body. (yale.edu)
  • aims
  • Treatment of myotonic muscular dystrophy aims to prevent deformity of the spine and joints to maintain the patient's ability to walk and keep him physically and emotionally healthy, explains the University of Maryland Medical Center. (reference.com)
  • Antisense
  • Antisense therapy can reverse some aspects of myotonic dystrophy (DM): That's the conclusion from a new study in a mouse model, reported in the July 17 issue of Science . (lww.com)
  • There are currently no established treatments, but, one study, focused on myotonic dystrophy type 1, suggests that the use of antisense oligonucleotides (ASOs) known as gapmers can aid in decreasing the mutant RNA repeat transcripts. (wikipedia.org)