• This peptide sequence is highly conserved in rat and mouse myosin IIA heavy chain, and the site has some homology to the conserved sites in nonmuscle myosin IIB and smooth muscle myosin heavy chains. (ecmbio.com)
  • LAB also only moves into the nucleus during the normal expression of nonmuscle myosin heavy chain (NMHC-IIA), which is associated with LAB in VSMCs. (elsevierpure.com)
  • Myocardial performance is likely affected by the relative expression of the two myosin heavy chain (MyHC) isoforms, namely {alpha}-MyHC and ß-MyHC. (umsystem.edu)
  • Skeletal muscle myosin heavy chain (MHC) content was measured and MHC isoforms were separated on SDS-PAGE gels and quantified. (josam.org)
  • Several chronic conditions leading to skeletal muscle dysfunction are known to be associated with changes in the expression of myosin heavy chain (MHC) isoforms at both the mRNA and protein level. (biomedcentral.com)
  • Virtually all eukaryotic cells contain myosin isoforms . (wn.com)
  • We have previously demonstrated that a layer of skeletal muscle cells in the EOMs demonstrate a longitudinal variation in their myosin heavy chain (MyHC) isoforms. (upenn.edu)
  • it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). (nih.gov)
  • Non-muscle myosin II is an actin-based motor protein essential to cell motility, division, migration, adhesion and polarity. (ecmbio.com)
  • By contrast, PKC phosphorylation of Ser-1/Ser-2 and Thr-9 in RLC may decrease activated myosin II interaction with actin. (ecmbio.com)
  • Filamentous actin is represented in red, and myosin in orange. (wikimedia.org)
  • Thus, although myosin was originally thought to be restricted to muscle cells (hence myo- (s) + -in ), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. (wn.com)
  • The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba . (wn.com)
  • The protein product of MYH16 is one of the heavy chain myosins, a kind of protein that works with actin to enable muscle fibers to contract. (johnhawks.net)
  • The sarcomeres contain a number of proteins, including alpha actinin, which is the major constituent of the Z band, and actin and myosin, which are the major components of the thin and thick filaments, respectively. (medscape.com)
  • This gene encodes a member of the myosin superfamily. (nih.gov)
  • Further, the degradation of myosin heavy chain (MHC) was studied. (uit.no)
  • 2. Wang, P.A., Martinez, I. and Olsen, R.L.:'Myosin heavy chain degradation during post mortem storage of Atlantic cod (Gadus morhua L.)', Food Chemistry (2009), 115, 1228-1233. (uit.no)
  • This degradation, and especially that of myosin, has an adverse effect on gel-forming ability, inhibiting the development of strong three-dimensional networks [6] [7]. (scirp.org)
  • Synthetic peptide corresponding to Human heavy chain Myosin/MYH3 aa 100-200 conjugated to keyhole limpet haemocyanin. (abcam.com)
  • Following the discovery by Pollard and Korn (1973) of enzymes with myosin-like function in Acanthamoeba castellanii , a large number of divergent myosin genes have been discovered throughout eukaryotes. (wn.com)
  • The protein is denoted as MyHC-M, for myosin heavy chain-masticatory. (johnhawks.net)
  • Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis. (thebiogrid.org)
  • Violin plots show distribution of expression levels for Myosin heavy chain (SMED30020435) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of the β-myosin heavy chain (β-MHC), a major component of the cardiac contractile apparatus, is tightly regulated as even modest increases can be detrimental to heart under stress. (unikore.it)
  • Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression. (uchicago.edu)
  • Myosins ( / ˈ m aɪ ə s ᵻ n , - oʊ - / ) comprise a family of ATP -dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other motility processes in eukaryotes . (wn.com)
  • Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. (cdc.gov)
  • Myosin content of individual human muscle fibers isolated by laser capture microdissection. (uams.edu)
  • The exons encode the α chain, with four kringle structures (highly conserved triple disulfide loop structures), a short spacer region between the α and β chains, and the β chain ( Fig. 1A ) ( 4 - 6 ). (spandidos-publications.com)
  • It encodes the inactive pre-pro-HGF, a single chain of 728 amino acids (83 kDa), which includes a signal sequence ( 1 - 31 ), a heavy α chain (69 kDa), and a light β chain (34 kDa). (spandidos-publications.com)
  • RLCs are phosphorylated at Thr-18 and Ser-19, which activates myosin II motor activity and promotes filament stability. (ecmbio.com)
  • Myosin-1A targets to microvilli using multiple membrane binding motifs in the tail homology 1 (TH1) domain. (nih.gov)
  • Korfage, JAM 2004, ' Myosin heavy chain composition of the human jaw muscles ', PhD, University of Amsterdam. (vu.nl)
  • Unphosphorylated Myosin IIA Heavy Chain (Ser-1803) synthetic peptide corresponding to amino acid residues surrounding Ser-1803 in human myosin IIA heavy chain. (ecmbio.com)
  • Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. (nih.gov)
  • The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. (uams.edu)
  • On the basis of molecular modelling, the two mutations affecting the myosin head were predicted to impose electrostatic and conformational changes, whereas the truncating mutation deleted the unique carboxy-terminal tailpiece. (nih.gov)
  • The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. (wikipedia.org)
  • This myosin forms a hexameric complex comprised of two heavy chains (NMHC-II), two essential light chains, and two regulatory light chains (RLC). (ecmbio.com)
  • May be a homodimer, which associates with multiple calmodulin or myosin light chains. (lu.se)
  • They are used for brief-duration intense activity and for carrying heavy loads and are specialized for anaerobic metabolism. (medscape.com)
  • Three embryonic class II myosin heavy chains (MYHs) were cloned from the common carp ( Cyprinus carpio L.), MYH emb1 ,MYH emb2 and MYH emb3 . (biologists.com)
  • Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. (nih.gov)
  • This graph shows the total number of publications written about "Myosin Heavy Chains" by people in UAMS Profiles by year, and whether "Myosin Heavy Chains" was a major or minor topic of these publications. (uams.edu)
  • Other names in common use include ATP:myosin-heavy-chain O-phosphotransferase calmodulin-dependent myosin heavy chain kinase MHCK MIHC kinase myosin heavy chain kinase myosin I heavy-chain kinase myosin II heavy-chain kinase [myosin-heavy-chain] kinase myosin heavy chain kinase A STK6. (wikipedia.org)